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compositionComposition:LETROZOLE-5MG
prescription
Prescription Medicine
info
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Macova-5 Tablet 10's is used to treat breast cancer in women who have gone through menopause (cessation of menses periods). It contains Letrozole, which prevents the growth of cancer cells. Thereby, it helps in preventing or stopping the growth of spreading the tumours (cancer cells) to other body parts. It may cause certain common side effects such as hypercholesterolemia (increased cholesterol levels), tiredness, weakness, increased sweating, feeling unwell, pain in joints, and hot flushes (feeling of warmth). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

LETROZOLE-5MG

Manufacturer/Marketer :

Gynofem Healthcare Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Macova-5 Tablet 10's

Macova-5 Tablet 10's is a prescription oral tablet used primarily to treat certain types of breast cancer in women who have already gone through menopause. It is specifically prescribed for hormone-receptor-positive breast cancers, which rely on hormones to grow. By lowering hormone levels in the body, this medicine helps slow down or stop the growth of cancer cells.

For this medication to work effectively, you must take it consistently at the same time every day. You can take this tablet with or without food, as eating does not affect how the medicine is absorbed. Combining this treatment with a balanced diet and regular physical activity can help support your body and manage potential side effects.

While taking Macova-5 Tablet 10's, you may experience mild side effects such as hot flashes, joint pain, or feeling unusually tired. While these are common, you should contact your doctor right away if you experience serious symptoms like severe chest pain, sudden shortness of breath, or signs of liver damage such as yellowing of your eyes or skin.

Do not take this if you are pregnant, breastfeeding, or have not yet gone through menopause. It is important to talk to your doctor before starting this medicine if you have a history of bone loss, high cholesterol, liver problems, or severe kidney disease.

This medicine can interact with other treatments, especially therapies that contain oestrogen, such as birth control pills or hormone replacement therapy, which can make this medication less effective. Older adults can safely take this medication, but your doctor will monitor your health closely during treatment to ensure your safety.
 

Uses of Macova-5 Tablet 10's

Macova-5 Tablet 10's is used to treat certain types of breast cancer in women who have already gone through menopause. The detailed uses of Macova-5 Tablet 10's are as follows:

  • Hormone-Receptor-Positive Early Breast Cancer: Used as an additional treatment in postmenopausal women who have already undergone surgery or radiation to lower the risk of the cancer returning.
  • Advanced Breast Cancer: Used as a primary treatment for postmenopausal women when the breast cancer has spread to other parts of the body.
  • Extended Breast Cancer Therapy: Prescribed for women who have already completed several years of initial cancer therapies to provide continued protection against recurrence.

Key Benefits

Macova-5 Tablet 10's helps manage hormone-sensitive breast cancer by lowering oestrogen levels in the body, reducing the signals that encourage cancer cells to grow. By supporting both treatment and long-term disease control, this medicine offers several key benefits:

  • Helps Reduce the Risk of Cancer Recurrence: For patients who have completed initial breast cancer treatment, Macova-5 Tablet 10's helps lower the risk of the cancer returning. By reducing oestrogen levels, it helps limit the growth of hormone-sensitive cancer cells and supports long-term treatment outcomes.
  • Supports Control of Advanced Breast Cancer: In patients with advanced breast cancer, this medicine can help slow tumour growth or reduce tumour size. This may help control disease progression and support ongoing cancer management.
  • Helps Maintain Quality of Life: By helping manage cancer growth and related symptoms, Macova-5 Tablet 10's can support greater physical comfort and daily functioning. This may allow patients to continue their usual activities with improved confidence and well-being during treatment.
     
Side effects of Macova-5 Tablet
  • Consult your doctor about your risk factors for bone loss and create a personalized plan.
  • Eat foods rich in vitamin D, including fatty fish, egg yolks, and fortified dairy products.
  • Include calcium-rich foods such as dairy, leafy greens, and fortified plant-based milk in your diet.
  • Quit smoking to reduce bone loss and lower osteoporosis risk.
  • Exercise regularly with weight-bearing activities like walking, running, or weightlifting to strengthen bones.
  • Schedule regular bone density scans to track progress and adjust your treatment plan.
  • Eat more plant based foods like vegetables, fruits and whole grains.
  • Reduce intake of foods containing high fat such as dairy, oil and red meat.
  • Exercise for at least 30 minutes 5 days a week.
  • Aim for weight loss and maintain healthy weight.
  • Quit smoking.
  • Control blood sugar and blood pressure.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Always wear loose-fitting clothes suitable for your activity during hot flashes.
  • Include a diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water and stay hydrated.
  • Stay calm and lower your anxiety by practising yoga or meditation.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.

Directions for Use

To get the most benefit from this medicine, follow these instructions carefully:

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet.
  • You can take this medication with or without food.
  • Try to take your dose at the same time every day to keep a steady amount of the medicine in your body.
  • Always follow your doctor's exact instructions regarding how long you should continue taking this medicine, as cancer therapies are often long-term treatments.
     

How Macova-5 Tablet 10's Works

Many breast cancers in postmenopausal women are fuelled by the hormone oestrogen. Even after menopause, the body continues to produce small amounts of oestrogen by converting other hormones using a natural enzyme called aromatase. Macova-5 Tablet 10's works by blocking this aromatase enzyme. By stopping this conversion process, the medication significantly lowers the amount of oestrogen circulating in your body. Without a sufficient supply of oestrogen, hormone-receptor-positive breast cancer cells lose their primary source of growth, causing them to shrink or stop multiplying.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Macova-5 Tablet 10's to avoid unpleasant side effects. Alcohol intake, along with Macova-5 Tablet 10's, may cause increased drowsiness.

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Pregnancy

Unsafe

Macova-5 Tablet 10's is pregnancy category D medicine so, should not be taken during pregnancy.

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Breast Feeding

Unsafe

Macova-5 Tablet 10's should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby.

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Driving

Unsafe

Macova-5 Tablet 10's may cause dizziness and drowsiness, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Safe if prescribed

It is safe to take Macova-5 Tablet 10's if prescribed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Safe if prescribed

It is safe to take Macova-5 Tablet 10's if prescribed. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Macova-5 Tablet 10's should not be used by children, as the efficacy and safety have not been established.

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Heart

Unsafe

Macova-5 Tablet 10's is not recommended for use in heart patients as it can lead to cardiovascular effects.

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Geriatrics

Caution

Caution should be exercised while taking Macova-5 Tablet 10's in geriatric patients, as it can lead to adverse effects.

What if I have taken an overdose of Macova-5 Tablet 10's

Do not take more than the prescribed dose of Macova-5 Tablet 10's as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Protect your bones: Because this medicine lowers oestrogen, it can reduce bone density. Ask your doctor about taking calcium and vitamin D supplements to help keep your bones strong.
  • Stay active: Engage in regular, weight-bearing exercises like walking or light strength training to maintain bone strength and reduce joint stiffness.
  • Monitor your cholesterol: Eat a heart-healthy diet rich in fibre, vegetables, and lean proteins, as this medicine can sometimes increase blood cholesterol levels.
  • Stay hydrated: Drink plenty of water throughout the day, which can help manage fatigue and reduce the intensity of hot flashes.
     
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How Soon It Starts Working

The time required for Macova-5 Tablet 10's to start to work: Macova-5 Tablet 10's ideally shows its action within 2 to 6 weeks after administration. The time for which the effects of Macova-5 Tablet 10's last: The effect of Macova-5 Tablet 10's lasts for 2 days.

What if you forget to take Macova-5 Tablet 10's

If you miss a dose of Macova-5 Tablet 10's, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

• Store Macova-5 Tablet 10's at room temperature, between 20°C and 25°C (68°F to 77°F) •Keep the tablets in their original packaging to protect them from moisture and direct light.

Drug Warnings

  • Inspect your tablet before taking it; do not use it if the packaging is damaged or the tablet looks broken.
  • Do not take this medication if you are pregnant, as it can cause serious harm to an unborn baby. Use reliable, non-hormonal birth control during treatment.
  • This medication can cause dizziness or fatigue; avoid driving or operating heavy machinery until you know how it affects you.
  • Be sure to attend all scheduled medical appointments so your doctor can monitor your bone density and cholesterol levels.
     

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions

  • Oestrogen-containing therapies: Medicines like birth control pills, oestrogen creams, or hormone replacement therapies can reverse the effects of Macova-5 Tablet 10's and should be avoided.
  • Tamoxifen: Taking this medication alongside tamoxifen can lower the level of Macova-5 Tablet 10's in your body, making it less effective.

Drug-Disease Interactions

  • Osteoporosis: This medicine lowers oestrogen levels, which can accelerate bone thinning and increase your risk of fractures.
  • Liver Disease: If you have moderate to severe liver damage, your body may process this medication more slowly, requiring closer monitoring by your doctor.

 

LetrozoleDiethylstilbestrol
Severe
LetrozoleCitalopram
Severe

Drug-Drug Interactions

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LetrozoleDiethylstilbestrol
Severe
How does the drug interact with Macova-5 Tablet:
Co-administration of Macova-5 Tablet may have an effect when used with Diethylstilbestrol, making it less effective in treating your disease.

How to manage the interaction:
Although taking Macova-5 Tablet and diethylstilbestrol together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
LetrozoleCitalopram
Severe
How does the drug interact with Macova-5 Tablet:
Co-administration of Macova-5 Tablet and Citalopram may raise the risk of a serious irregular heartbeat.

How to manage the interaction:
Although taking Macova-5 Tablet and Citalopram together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, rapid heartbeat, you should consult a doctor. Do not discontinue any medications without a doctor's advice.
LetrozoleDesogestrel
Severe
How does the drug interact with Macova-5 Tablet:
Co-administration of Desogestrel together with Macova-5 Tablet may decrease the effects of Macova-5 Tablet.

How to manage the interaction:
Although taking Macova-5 Tablet and Desogestrel together can result in an interaction, it can be taken if a doctor has prescribed it. Without consulting a doctor, never stop taking any medications.
LetrozoleConjugated Estrogens
Severe
How does the drug interact with Macova-5 Tablet:
Coadministration of Conjugated estrogens with Macova-5 Tablet may reduce the effect of Macova-5 Tablet.

How to manage the interaction:
Although taking Conjugated estrogen and Macova-5 Tablet together can result in an interaction, it can be taken together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
LetrozoleEstramustine
Severe
How does the drug interact with Macova-5 Tablet:
when taken together Macova-5 Tablet's function could be blocked by estramustine, which would reduce its ability to effectively treat your illness.

How to manage the interaction:
Although taking Macova-5 Tablet and estramustine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
LetrozoleEstrone
Severe
How does the drug interact with Macova-5 Tablet:
When taken together Macova-5 Tablet's function could be blocked by estrone, which would reduce its ability to effectively treat your illness.

How to manage the interaction:
Although taking Macova-5 Tablet and estrone together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
LetrozoleEstradiol
Severe
How does the drug interact with Macova-5 Tablet:
Macova-5 Tablet may have a negative effect when used with Estradiol, making it less effective in treating your disease.

How to manage the interaction:
Although taking Macova-5 Tablet and estradiol together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
LetrozoleThalidomide
Severe
How does the drug interact with Macova-5 Tablet:
Coadministration of thalidomide and Macova-5 Tablet may increase the risk of blood clots.

How to manage the interaction:
Although taking Macova-5 Tablet and thalidomide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience symptoms such as chest pain, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, consult a doctor. Do not discontinue any medications without a doctor's advice.
LetrozoleEthinylestradiol
Severe
How does the drug interact with Macova-5 Tablet:
When taken together ethinyl estradiol may interfere with Macova-5 Tablet's activity and make it less effective in treating the condition.

How to manage the interaction:
Although taking Macova-5 Tablet and ethinylestradiol together can result in an interaction, it can be taken if a doctor has prescribed it. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

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Country of origin

India

Manufacturer/Marketer address

Nand Vihar Colony, Narmada Road, Rau Tehsil ,Indore,Madhya Pradesh,453331
Other Info - MAC0521
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