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Perigard 4 mg Tablet is prescribed alone or in combination with other drugs used to treat high blood pressure and heart failure. It contains Perindopril, which relaxes and widens the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body. In addition to this, it also reduces the physical effects of anxiety. It may cause side effects such as headaches, ankle swelling, slow heart rate, and nausea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Perigard 4 mg Tablet
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Limit fruit intake to two servings a day, choose a low-potassium options like apples and strawberries.
  • Restrict starchy vegetables like potatoes and pumpkin to half a cup daily.
  • Avoid or limit foods like tomato products, high-bran cereals, and salty or sugary snacks.
  • Limit dairy products to 200g of yoghurt or 300ml of milk per day.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

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Drug-Drug Interactions

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Drug-Drug Interactions: Perigard 4 mg Tablet may interact with medication used for heart failure, high blood pressure (nitroglycerin, aliskiren, losartan, valsartan, olmesartan, candesartan, captopril, enalapril), epilepsy and anxiety medications (pregabilin), diuretics (hydrochlorothiazide, furosemide, bumetanide, chlorthalidone, indapamide), NSAIDS (naproxen, ibuprofen, indomethacin, celecoxib), narcotic analgesics (codeine) and medication used for mania and depression (lithium).

Drug-Food Interactions: Avoid intake of high potassium and sodium intake. Including these in your diet might raise your blood potassium level (hyperkalemia). Besides this, do not use salt substitutes or potassium supplements while taking Perigard 4 mg Tablet .

Drug-Disease Interactions: Perigard 4 mg Tablet should not be given to patients with angioedema (swelling), bone marrow suppression, congestive heart failure, hemodialysis (A medical procedure to remove fluid and waste products from the blood and to correct electrolyte imbalances), hyperkalemia (high potassium level), low blood pressure (hypotension), liver disease, and kidney dysfunction.

Drug-Drug Interactions

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How does the drug interact with Perigard 4 mg Tablet:
Combining Aliskiren with Perigard 4 mg Tablet can increase the risk of low blood pressure, high potassium levels, and kidney damage.

How to manage the interaction:
Taking Perigard 4 mg Tablet with Aliskiren is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Perigard 4 mg Tablet:
Taking Azilsartan medoxomil with Perigard 4 mg Tablet can cause low blood pressure, kidney function impairment, or increased potassium levels.

How to manage the interaction:
Although taking Azilsartan medoxomil with Perigard 4 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Consult a doctor if you experience vomiting, weakness, tingling in your hands and feet, or palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Perigard 4 mg Tablet:
Coadministration of Olmesartan medoxomil with Perigard 4 mg Tablet may cause low blood pressure, kidney problems, and may increase potassium levels in the blood.

How to manage the interaction:
Although taking olmesartan medoxomil together with Perigard 4 mg Tablet may lead to an interaction but can be taken if prescribed by the doctor. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
PerindoprilPotassium citrate
Severe
How does the drug interact with Perigard 4 mg Tablet:
Taking Potassium citrate with Perigard 4 mg Tablet can cause hyperkalemia(a high level of the electrolyte potassium in the blood) which can increase the risk of kidney problems and abnormal heart rhythm.

How to manage the interaction:
Taking Perigard 4 mg Tablet with Potassium citrate together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. It is advised to reduce the intake of potassium-rich foods. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Perigard 4 mg Tablet:
Amiloride when taken with Perigard 4 mg Tablet may cause a hyperkalemia (high potassium levels in blood).

How to manage the interaction:
Although taking amiloride and Perigard 4 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor if you experience symptoms including fatigue, disorientation, numbness or tingling, and irregular heartbeats. Do not discontinue any medications without a doctor's advice.
PerindoprilPotassium iodide
Severe
How does the drug interact with Perigard 4 mg Tablet:
Combining Potassium Iodide with Perigard 4 mg Tablet can cause hyperkalemia(high potassium levels in blood) which can increase the risk the risk of kidney problems and abnormal heart rhythm.

How to manage the interaction:
Taking Perigard 4 mg Tablet with Potassium iodide together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat contact your doctor immediately. Do not stop using any medications without a doctor's advice. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Perigard 4 mg Tablet:
Coadministration of Perigard 4 mg Tablet with Valsartan may increase the risk of side effects (low blood pressure, kidney function impairment, and hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Perigard 4 mg Tablet together with Valsartan may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience symptoms such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Perigard 4 mg Tablet:
Coadministration of Losartan with Perigard 4 mg Tablet can increase of kidney problems and irregular heart rhythm.

How to manage the interaction:
Taking Losartan with Perigard 4 mg Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, or irregular heartbeat, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Perigard 4 mg Tablet:
Using Perigard 4 mg Tablet together with piroxicam may reduce the effects of Perigard 4 mg Tablet in lowering blood pressure, they may also increase the risk of kidney problems.

How to manage the interaction:
Co-administration of Piroxicam with Perigard 4 mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, breathing difficulty, muscle pain, and irregular heart rhythm, contact a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Perigard 4 mg Tablet:
Taking Perigard 4 mg Tablet with trimethoprim can cause hyperkalemia(high levels of potassium in blood) which can increase the risk of kidney problems and abnormal heart rhythm.

How to manage the interaction:
Co-administration of Perigard 4 mg Tablet with Trimethoprim can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat contact your doctor immediately. Do not stop using any medications without a doctor's advice. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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PERINDOPRIL-4MGPotassium rich foods
Moderate

Drug-Food Interactions

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PERINDOPRIL-4MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Taking Perigard 4 mg Tablet with potassium-containing foods can increase the risk of hyperkalemia (high potassium levels in the blood). Avoid moderately high or high potassium dietary intake with Perigard 4 mg Tablet, as it can lead to an interaction.

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