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Plagerine 75 Tablet is used for the prevention of heart attack or stroke in people at high risk of heart disease. It contains Clopidogrel, which helps in preventing the formation of harmful blood clots (plaque) in your veins. It makes your blood flow easily through your veins, making it less likely to form a serious blood clot. So, it helps prevent blood clots if you have an increased risk of having severe chest pain (unstable angina or heart attack), stroke, or peripheral arterial disease (heart problem due to narrowed blood vessels). In some cases, you may experience side effects such as nosebleeds, heavier periods, bleeding gums, easy bruising, diarrhoea, stomach pain, indigestion, or heartburn. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-Drug Interactions: Plagerine 75 Tablet may have interaction with other anticoagulants (e.g. warfarin, aspirin, rivaroxaban, apixaban), pain killers (e.g. ibuprofen), antidepressants (e.g. citalopram), and indigestion medicine/proton pump inhibitors (e.g. omeprazole).

Drug-Food Interactions: Plagerine 75 Tablet may interact with Ginkgo biloba and St John’s wort plant (used as an antidepressant) and increase the risk of bleeding.

Drug-Disease Interactions: Plagerine 75 Tablet should not be given to the people with stomach ulcers, brain haemorrhage (bleeding in your brain), haemophilia (a bleeding disorder), and liver or kidney problems.

Drug-Drug Interactions

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How does the drug interact with Plagerine 75 mg Tablet:
Taking Plagerine 75 mg Tablet together with mifepristone increases the risk of vaginal bleeding in women.

How to manage the interaction:
Although taking Plagerine 75 mg Tablet with mifepristone is not recommended, that would certainly result in interaction, it can be taken if a doctor prescribes it. If you experience prolonged and heavy bleeding, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Plagerine 75 mg Tablet:
When Selexipag and Plagerine 75 mg Tablet are taken together, the body's ability to break down Selexipag may be reduced.

How to manage the interaction:
Taking Plagerine 75 mg Tablet with Selexipag is not recommended, please consult your doctor before taking it. They can be taken if prescribed by your doctor.
How does the drug interact with Plagerine 75 mg Tablet:
Coadministration of Plagerine 75 mg Tablet with Rivaroxaban increases the risk of severe bleeding due to the additive effect.

How to manage the interaction:
Although taking Plagerine 75 mg Tablet with Rivaroxaban may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience any unusual bleeding or have other signs of bleeding like feeling dizzy or lightheaded, red or black, sticky stools, coughing up or vomiting blood that looks like coffee grounds, or having a severe headache consult your doctor immediately. Do not discontinue any medication without consulting your doctor.
How does the drug interact with Plagerine 75 mg Tablet:
Coadministration of Plagerine 75 mg Tablet with Esomeprazole may reduce the effectiveness of Plagerine 75 mg Tablet.

How to manage the interaction:
Taking Plagerine 75 mg Tablet and esomeprazole together possibly has an interaction, but you can take these medications together if your doctor has advised it. Do not stop using any medications without talking to your doctor.
How does the drug interact with Plagerine 75 mg Tablet:
Taking Pioglitazone with Plagerine 75 mg Tablet can increases the blood levels of Pioglitazone, when these medicines are taken together, you may experience hypoglycemia (low blood sugar).

How to manage the interaction:
Taking Plagerine 75 mg Tablet together with Pioglitazone may lead to interaction, but it can be taken if prescribed by your doctor. Consult a doctor immediately if you experience headache, dizziness, drowsiness, nervousness, weakness, shaking, or sweating. Do not discontinue any medication without consulting the doctor.
How does the drug interact with Plagerine 75 mg Tablet:
Using dalteparin together with Plagerine 75 mg Tablet may increase the risk of bleeding.

How to manage the interaction:
There may be a possible interaction between Plagerine 75 mg Tablet and Dalteparin, but they can be taken together if prescribed by your doctor. However, If you experience any unusual bleeding or have other signs of bleeding like feeling dizzy or lightheaded, red or black, sticky stools, or having a headache consult your doctor without any delay. Do not discontinue any medication without consulting your doctor.
ClopidogrelTipranavir
Severe
How does the drug interact with Plagerine 75 mg Tablet:
Taking Tipranavir with Plagerine 75 mg Tablet can make the blood-thinning effects of Plagerine 75 mg Tablet stronger.

How to manage the interaction:
Although there is a possible interaction between Plagerine 75 mg Tablet and Tipranavir, you can take these medicines together if prescribed by your doctor. If you notice any bleeding, severe headaches, weakness, or black stools, contact your doctor right away. Do not stop using any medications without talking to your doctor.
How does the drug interact with Plagerine 75 mg Tablet:
Taking Plagerine 75 mg Tablet with acalabrutinib may increase the risk of bleeding.

How to manage the interaction:
There could be a possible interaction between Plagerine 75 mg Tablet and Acalabrutinib, but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding or have other signs of bleeding, like feeling dizzy or lightheaded, red or black, sticky stools, or severe headaches. Do not discontinue any medication without consulting your doctor.
How does the drug interact with Plagerine 75 mg Tablet:
Taking Plagerine 75 mg Tablet with Dabigatran may increase the risk of bleeding.

How to manage the interaction:
Although there may be an interaction between Plagerine 75 mg Tablet and Apixaban, they can be taken together if advised by your doctor. However, consult your doctor immediately if you experience any unusual bleeding, dizziness or lightheadedness, red or black, sticky stools, or headaches. Do not discontinue any medication without consulting your doctor.
How does the drug interact with Plagerine 75 mg Tablet:
Taking deferasirox together with Plagerine 75 mg Tablet may increase the risk of gastrointestinal ulcers and bleeding.

How to manage the interaction:
Although taking Plagerine 75 mg Tablet together with Deferasirox has a possibility of interaction, it can be taken if prescribed by your doctor. However, if you experience abdominal pain, bloating, dizziness, lightheadedness, red or black, tarry stools oe headache. Do not discontinue any medication without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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