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Plagerine 75 Tablet is used for the prevention of heart attack or stroke in people at high risk of heart disease. It contains Clopidogrel, which helps in preventing the formation of harmful blood clots (plaque) in your veins. It makes your blood flow easily through your veins, making it less likely to form a serious blood clot. So, it helps prevent blood clots if you have an increased risk of having severe chest pain (unstable angina or heart attack), stroke, or peripheral arterial disease (heart problem due to narrowed blood vessels). In some cases, you may experience side effects such as nosebleeds, heavier periods, bleeding gums, easy bruising, diarrhoea, stomach pain, indigestion, or heartburn. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-Drug Interactions: Plagerine 75 Tablet may have interaction with other anticoagulants (e.g. warfarin, aspirin, rivaroxaban, apixaban), pain killers (e.g. ibuprofen), antidepressants (e.g. citalopram), and indigestion medicine/proton pump inhibitors (e.g. omeprazole).

Drug-Food Interactions: Plagerine 75 Tablet may interact with Ginkgo biloba and St John’s wort plant (used as an antidepressant) and increase the risk of bleeding.

Drug-Disease Interactions: Plagerine 75 Tablet should not be given to the people with stomach ulcers, brain haemorrhage (bleeding in your brain), haemophilia (a bleeding disorder), and liver or kidney problems.

Drug-Drug Interactions

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How does the drug interact with Plagerine 75 mg Tablet:
When Selexipag and Plagerine 75 mg Tablet are taken together, the body's ability to break down Selexipag may be reduced.

How to manage the interaction:
Taking Plagerine 75 mg Tablet with Selexipag is not recommended, please consult your doctor before taking it. They can be taken if prescribed by your doctor.
How does the drug interact with Plagerine 75 mg Tablet:
Taking Plagerine 75 mg Tablet together with mifepristone increases the risk of vaginal bleeding in women.

How to manage the interaction:
Although taking Plagerine 75 mg Tablet with mifepristone is not recommended, that would certainly result in interaction, it can be taken if a doctor prescribes it. If you experience prolonged and heavy bleeding, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Plagerine 75 mg Tablet:
Co-administration of Cangrelor with Plagerine 75 mg Tablet and reduce its effectiveness if used at the same time.

How to manage the interaction:
Although taking Plagerine 75 mg Tablet with cangrelor can result in an interaction, they can be taken together if prescribed by a doctor. Plagerine 75 mg Tablet should be taken after the Cangrelor infusion is complete. Do not stop taking any medication without consulting a doctor.
How does the drug interact with Plagerine 75 mg Tablet:
Coadministration of Plagerine 75 mg Tablet and Apixaban may raise the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Plagerine 75 mg Tablet and Apixaban, it can be taken if prescribed by a doctor. However, consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), bruising, dizziness, lightheadedness, or headache. Do not discontinue any medications without consulting a doctor
How does the drug interact with Plagerine 75 mg Tablet:
Coadministration of Plagerine 75 mg Tablet with modafinil can reduce the effectiveness of Plagerine 75 mg Tablet.

How to manage the interaction:
Although taking Plagerine 75 mg Tablet with Modafinil may possibly result in interaction, but it can be taken together if prescribed by a doctor. Do not stop using any medications without talking to your doctor.
ClopidogrelProtamine
Severe
How does the drug interact with Plagerine 75 mg Tablet:
Taking Protamine with Plagerine 75 mg Tablet can increase the risk of bleeding.

How to manage the interaction:
Taking Protamine with Plagerine 75 mg Tablet together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
How does the drug interact with Plagerine 75 mg Tablet:
Taking Plagerine 75 mg Tablet with Rabeprazole can reduce the effectiveness of Plagerine 75 mg Tablet.

How to manage the interaction:
Taking Plagerine 75 mg Tablet and Rabeprazole together possibly has an interaction, but you can take these medications together if a doctor has advised it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Plagerine 75 mg Tablet:
The use of ramucirumab together with Plagerine 75 mg Tablet may raise the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Plagerine 75 mg Tablet and Ramucirumab, you can take these medicines together if prescribed by your doctor. If you notice these signs, contact your doctor immediately - feeling dizzy or lightheaded, dark or bloody stools, coughing, intense headaches, or weakness. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Plagerine 75 mg Tablet:
Taking Pioglitazone with Plagerine 75 mg Tablet can increases the blood levels of Pioglitazone, when these medicines are taken together, you may experience hypoglycemia (low blood sugar).

How to manage the interaction:
Taking Plagerine 75 mg Tablet together with Pioglitazone may lead to interaction, but it can be taken if prescribed by your doctor. Consult a doctor immediately if you experience headache, dizziness, drowsiness, nervousness, weakness, shaking, or sweating. Do not discontinue any medication without consulting the doctor.
How does the drug interact with Plagerine 75 mg Tablet:
Taking fluvoxamine can lower the levels of Plagerine 75 mg Tablet in the blood, which can result in a decreased effectiveness of Plagerine 75 mg Tablet.

How to manage the interaction:
Taking Plagerine 75 mg Tablet and Fluvoxamine together possibly has an interaction, but you can take these medications together if your doctor has advised it. However, if you experience shortness of breath, dizziness, loss of balance, or trouble walking, consult your doctor immediately. Do not discontinue any medication without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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