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Premot-N Tablet is used to treat heavy, painful, or irregular periods, premenstrual syndrome (PMS), and endometriosis. Additionally, it may be used in the treatment of breast cancer. It contains Norethisterone, which works by restoring the hormone levels in the body. In some cases, this medicine may cause side effects such as unusual vaginal bleeding or spotting, dizziness, dry mouth, constipation, nausea, and diarrhoea. Let the doctor know if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Premot-N Tablet:
The combined use of Premot-N Tablet and phenobarbital can reduce the blood levels and effects of Premot-N Tablet.

How to manage the interaction:
Although taking phenobarbital and Premot-N Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience any symptoms like abnormal bleeding, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Premot-N Tablet:
Using tranexamic acid together with norethindrone may increase the risk of blood clots.

How to manage the interaction:
Taking Premot-N Tablet with tranexamic acid can lead to an interaction, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg, contact a doctor immediately .Do not discontinue any medications without consulting a doctor.
NorethisteroneEtretinate
Severe
How does the drug interact with Premot-N Tablet:
Using Etretinate and Premot-N Tablet together can cause severe, birth defects. Never use etretinate if you are pregnant. Both a primary and a secondary form of birth control must be used together and for at least 3 years after stopping therapy.

How to manage the interaction:
Although taking Premot-N Tablet and Etretinate together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these signs, make sure to contact your doctor right away. These symptoms may be related to your birth control. Do not stop using any medications without a doctor's advice.
How does the drug interact with Premot-N Tablet:
Taking griseofulvin with Premot-N Tablet may reduce blood levels and the effects of Premot-N Tablet.

How to manage the interaction:
Although there is a possible interaction between Griseofulvin and Premot-N Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience any of these symptoms like unexpected bleeding or abnormal bleeding, it's important to contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Premot-N Tablet:
Coadministration of Premot-N Tablet with Tizanidine can cause drowsiness, confusion, slow heart rate, shallow breathing, feeling light-headed, fainting.

How to manage the interaction:
Taking Premot-N Tablet with Tizanidine together can result in an interaction, but it can be taken if your doctor has advised it. However, if you notice any symptoms, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Premot-N Tablet:
Co-administration of Premot-N Tablet with Bosentan can reduce the blood levels and effects of norethindrone.

How to manage the interaction:
Taking Premot-N Tablet with Bosentan together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Premot-N Tablet:
Coadministration of Phenytoin and Premot-N Tablet may decrease the blood levels of Premot-N Tablet, which may make Premot-N Tablet less effective.

How to manage the interaction:
Although taking Phenytoin and Premot-N Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. If you experience any symptoms, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Premot-N Tablet:
Coadministration of Premot-N Tablet with Dabrafenib can reduce the metabolism and decrease the levels of Premot-N Tablet in the body.

How to manage the interaction:
Taking Premot-N Tablet with Dabrafenib together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of hot flashes, vaginal dryness, or abnormal bleeding, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NorethisteroneBoceprevir
Severe
How does the drug interact with Premot-N Tablet:
Using Boceprevir and Premot-N Tablet together can reduce the blood levels and decrease the effectiveness of norethindrone.

How to manage the interaction:
Combining Boceprevir with Premot-N Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, abnormal bleeding, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
NorethisteroneFosamprenavir
Severe
How does the drug interact with Premot-N Tablet:
Using norethindrone together with fosamprenavir may decrease the effects of fosamprenavir.

How to manage the interaction:
Taking Premot-N Tablet with Fosamprenavir together can result in an interaction, but it can be taken if your doctor has advised it. If you're taking birth control and experiencing any symptoms, it's important to reach out to a doctor right away. They can recommend other options that won't interfere with your medication. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Consuming Grapefruit juice may increase the blood levels of Premot-N Tablet. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Premot-N Tablet dose. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Premot-N Tablet dose.

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