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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Regestrone 5 mg Tablet is used to treat heavy, painful, or irregular periods, premenstrual syndrome (PMS), and endometriosis. Additionally, it may be used in the treatment of breast cancer. It contains Norethisterone, which works by restoring the hormone levels in the body. In some cases, this medicine may cause side effects such as unusual vaginal bleeding or spotting, dizziness, dry mouth, constipation, nausea, and diarrhoea. Let the doctor know if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Drug-Drug Interactions

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NorethisteroneAmprenavir
Severe

Drug-Drug Interactions

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How does the drug interact with Regestrone 5 mg Tablet:
Coadministration of Regestrone 5 mg Tablet with Rifabutin can reduce the blood levels and effects of norethindrone.This increases the risk of severe bleeding and unintended pregnancy.

How to manage the interaction:
Taking Regestrone 5 mg Tablet with Rifabutin together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of abnormal bleeding, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NorethisteroneAmprenavir
Severe
How does the drug interact with Regestrone 5 mg Tablet:
Coadministration of Amprenavir and Regestrone 5 mg Tablet together may reduce amprenavir effects.

How to manage the interaction:
Combining Amprenavir with Regestrone 5 mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
NorethisteroneBoceprevir
Severe
How does the drug interact with Regestrone 5 mg Tablet:
Using Boceprevir and Regestrone 5 mg Tablet together can reduce the blood levels and decrease the effectiveness of norethindrone.

How to manage the interaction:
Combining Boceprevir with Regestrone 5 mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, abnormal bleeding, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Regestrone 5 mg Tablet:
Using tranexamic acid together with norethindrone may increase the risk of blood clots.

How to manage the interaction:
Taking Regestrone 5 mg Tablet with tranexamic acid can lead to an interaction, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg, contact a doctor immediately .Do not discontinue any medications without consulting a doctor.
How does the drug interact with Regestrone 5 mg Tablet:
Coadministration of Regestrone 5 mg Tablet and primidone can reduce the blood levels and effects of Regestrone 5 mg Tablet and increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Regestrone 5 mg Tablet and Primidone, they can be taken together if prescribed by a doctor. However, if you experience abnormal bleeding, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Regestrone 5 mg Tablet:
Eslicarbazepine may reduce the effects of Regestrone 5 mg Tablet and its blood levels.

How to manage the interaction:
Although taking Eslicarbazepine and Regestrone 5 mg Tablet results in an interaction, they can be taken together if prescribed by your doctor. Do not stop using any medications without consulting a doctor.
NorethisteroneEtretinate
Severe
How does the drug interact with Regestrone 5 mg Tablet:
Using Etretinate and Regestrone 5 mg Tablet together can cause severe, birth defects. Never use etretinate if you are pregnant. Both a primary and a secondary form of birth control must be used together and for at least 3 years after stopping therapy.

How to manage the interaction:
Although taking Regestrone 5 mg Tablet and Etretinate together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these signs, make sure to contact your doctor right away. These symptoms may be related to your birth control. Do not stop using any medications without a doctor's advice.
NorethisteroneRifapentine
Severe
How does the drug interact with Regestrone 5 mg Tablet:
Combining Rifapentine and norethindrone reduces the blood levels and effects of norethindrone and increases the risk of bleeding and unintended pregnancy.

How to manage the interaction:
Although there is a possible interaction between Regestrone 5 mg Tablet and Rifapentine, you can take these medicines together if prescribed by your doctor. If you're having any of these symptoms like unexpected bleeding, abnormal bleeding, it's important to reach out to a doctor right away. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Regestrone 5 mg Tablet:
Using Felbamate and Regestrone 5 mg Tablet together can reduce the blood levels and effects of norethindrone.

How to manage the interaction:
There may be a possibility of interaction between Regestrone 5 mg Tablet and Felbamate, but it can be taken if prescribed by a doctor. If you notice any unusual symptoms like changes in your menstrual cycle, excessive bleeding, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Regestrone 5 mg Tablet:
Coadministration of Acitretin with Regestrone 5 mg Tablet may interfere with the contraceptive effect of Regestrone 5 mg Tablet.

How to manage the interaction:
Acitretin and Regestrone 5 mg Tablet should be used together only if prescribed by your doctor. Use of at least two methods of effective contraception is mandatory during acitretin therapy and for at least 3 years after stopping therapy.

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Consuming Grapefruit juice may increase the blood levels of Regestrone 5 mg Tablet. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Regestrone 5 mg Tablet dose. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Regestrone 5 mg Tablet dose.

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