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compositionComposition:PENICILLAMINE-250MG
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Prescription Medicine
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Aaramine-250mg Tablet is used to treat rheumatoid arthritis, Wilson's disease, cystinuria, and lead poisoning. It helps remove excess copper from the body and prevent organ damage.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PENICILLAMINE-250MG

Manufacturer/Marketer :

RR Biotech

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Aaramine-250mg Tablet

Aaramine-250mg Tablet is an oral prescription medication used to manage excess copper levels in the body, prevent certain types of kidney stones, and treat severe active rheumatoid arthritis. It acts as a binding agent that helps clear heavy metals from your bloodstream and tissues. Doctors typically prescribe it when other standard treatments have not provided sufficient relief.

To ensure this medication works effectively, you must take it consistently every single day exactly as prescribed by your healthcare provider. For proper absorption, take this medicine on an empty stomach, at least one hour before or two hours after a meal. Making specific dietary adjustments, such as drinking large amounts of water or avoiding copper-rich foods, can significantly improve your treatment outcomes.

While taking Aaramine-250mg Tablet , you may experience some common side effects such as temporary changes in your sense of taste, mild nausea, or soft stools. However, you must contact your doctor immediately if you experience more serious symptoms, such as unexplained bruising, severe skin rashes, or swelling in your face and ankles.

Before starting this treatment, tell your doctor if you have a history of kidney disease, liver damage, or blood disorders. Do not take this if you have severe kidney impairment, are breastfeeding, or have previously developed bone marrow disorders while using this medication.

This medicine can interact with iron supplements, zinc, and antacids, which block your body from absorbing it. You should also avoid drinking alcohol as it can increase stomach irritation and place extra stress on your organs. If you are pregnant, planning a pregnancy, or are an elderly patient, discuss the unique safety risks with your doctor before taking this medicine.

Uses of Aaramine-250mg Tablet

Aaramine-250mg Tablet used in the treatment of Wilson's disease, cystinuria, and rheumatoid arthritis. The detailed uses of Aaramine-250mg Tablet are as follows:

  • Wilson's disease: Aaramine-250mg Tablet helps by binding to excess copper in your tissues and blood, allowing your kidneys to safely flush it out through your urine.
  • Cystinuria (cystine kidney stones): This medicine binds with cystine in the kidneys to make it highly soluble, which prevents it from forming painful stones in your urinary tract.
  • Severe active rheumatoid arthritis: It helps reduce severe joint swelling, stiffness, and pain by calming down the overactive parts of your immune system that attack your joints.

Key Benefits

Aaramine-250mg Tablet helps treat conditions caused by excess copper, certain types of kidney stones, and severe rheumatoid arthritis.
The following are the key benefits of this medication:

  • Helps remove excess copper from the body in people with copper overload.
  • Reduces the risk of damage to organs caused by copper buildup.
  • Helps prevent certain types of recurrent kidney stones.
  • Improves joint pain, swelling, and stiffness in severe rheumatoid arthritis.
  • Supports better movement and makes daily activities more comfortable.
  • Promotes long-term health by helping prevent disease-related complications.
Side effects of Aaramine-250 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Regularly brush and floss your teeth.
  • Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
  • Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
  • Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
  • Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.
  • Increased protein levels indicate the body is dehydrated and when blood plasma is concentrated.
  • Consume water and stay hydrated. Talk to your doctor and take an oral rehydrating salt (ORS).
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding hydration.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.

Directions for Use

  • Aaramine-250mg Tablet should be taken 1 hour before or 2 hours after a meal. Avoid drinking milk while taking Aaramine-250mg Tablet .
  • Your doctor will determine the dosage and timing of this medication based on your medical condition. Typically, it is taken 3-4 times daily.
  • Swallow Aaramine-250mg Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Aaramine-250mg Tablet Works

Aaramine-250mg Tablet belongs to a group of medications known as chelating agents. When you take it, the medicine circulates through your body and acts like a magnet, chemically binding to excess heavy metals, specifically copper. Once bound, these metals become water-soluble, allowing your kidneys to filter them out of your bloodstream and expel them through your urine. To prevent kidney stones, the medicine works by combining with an amino acid called cystine. Normally, cystine does not dissolve well in urine and clumps together to form hard stones. By binding with cystine, Aaramine-250mg Tablet converts it into a highly soluble compound that dissolves easily and passes out of your body without forming stones. In severe rheumatoid arthritis, the exact way the medicine works is not fully understood, but it is known to suppress certain overactive immune cells. By lowering the activity of your immune system, it stops the chronic inflammatory response that continuously attacks and damages your joint tissues.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Aaramine-250mg Tablet . It could lead to increased dizziness and drowsiness.

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Pregnancy

Unsafe

Aaramine-250mg Tablet is a pregnancy category D drug. It is not recommended to take Aaramine-250mg Tablet while you are pregnant. Aaramine-250mg Tablet may cause serious birth defects.

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Breast Feeding

Unsafe

Aaramine-250mg Tablet should not be used in breastfeeding mothers as Aaramine-250mg Tablet passes into breast milk.

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Driving

Caution

Aaramine-250mg Tablet may cause dizziness, drowsiness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Unsafe

Aaramine-250mg Tablet is not recommended for the liver patients.

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Kidney

Caution

Aaramine-250mg Tablet should be used with caution in patients with kidney diseases. Dose adjustments may be necessary.

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Children

Consult your doctor

Aaramine-250mg Tablet should be used in children under the care of the doctor. The dose may depend on the weight and age of the child.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Aaramine-250mg Tablet . Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Caution

Aaramine-250mg Tablet should be used with extreme caution in elderly patients due to an increased risk of adverse effects.

What if I have taken an overdose of Aaramine-250mg Tablet

If you take more than your prescribed dose, seek immediate emergency medical attention or contact a poison control centre right away. Do not wait for symptoms of toxicity to appear.

Diet & Lifestyle Advise

  • For Wilson's disease: Strictly limit your intake of copper-rich foods, such as chocolate, mushrooms, nuts, shellfish, liver, and organic meats. If your home has copper pipes, have your tap water tested for copper levels.
  • For Cystinuria: Drink plenty of water throughout the day and night. Aim to drink enough fluids to produce at least 3 litres of urine daily, including drinking a large glass of water right before going to bed.
  • Monitor your vitamins: This medicine can deplete your body's levels of Vitamin B6. Talk to your doctor about whether you should take a daily Vitamin B6 supplement.
  • Avoid mineral supplements close to your dose: Do not take mineral-rich daily multivitamins, zinc, or iron within 2 hours of your medication.
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Have a query?

How Soon It Starts Working

  • The time required for Aaramine-250mg Tablet to start to work: Aaramine-250mg Tablet ideally shows its action within 30 to 90 minutes after administration
  • The time for which the effects of Aaramine-250mg Tablet last: The duration of action for Aaramine-250mg Tablet is clinically unknown.

What if you forget to take Aaramine-250mg Tablet

If you miss a dose, take it as soon as you remember, provided it is on an empty stomach. If it is almost time for your next scheduled dose, skip the missed dose and return to your normal schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Aaramine-250mg Tablet at controlled room temperature, between 20°C and 25°C (68°F to 77°F). •Keep the container tightly closed to protect the medication from moisture and direct light.

Drug Warnings

  • Attend regular blood tests: Keep all your scheduled blood and urine test appointments. These help your doctor monitor your kidney health and blood cell counts during treatment.
  • Check your medicine before use: Inspect the capsules or tablets before taking them. Do not use them if they are damp, discoloured, or damaged.
  • Tell your healthcare providers: Inform your doctor, dentist, or surgeon that you are taking Aaramine-250mg Tablet before any procedure. This medicine may slow down wound healing.
  • Protect your skin from the sun: Wear protective clothing and use sunscreen when outdoors. This medicine can make your skin more sensitive and fragile.
  • Watch for skin rashes: Check your skin for any new rash, especially during the first few weeks of treatment or after a dose increase. Contact your doctor immediately if you notice a rash.

Drug-Drug Interactions

verifiedApollotooltip
  • Iron and Zinc supplements: These minerals bind to Aaramine-250mg Tablet in your stomach, stopping your body from absorbing the medicine and making it much less effective.
  • Antacids (e.g., Magnesium hydroxide, Aluminium hydroxide, Calcium carbonate): Antacids can block the absorption of Aaramine-250mg Tablet when taken at the same time.
  • Gold therapy or antimalarials (e.g., Auranofin, Chloroquine): Using these medicines alongside Aaramine-250mg Tablet significantly increases your risk of developing severe kidney and blood disorders.
  • Medicines used to treat heart failure (e.g., Digoxin): This medicine can lower the levels of digoxin in your blood, potentially reducing its effectiveness for heart conditions.
PenicillamineSodium aurothiomalate
Severe
PenicillamineLeflunomide
Severe

Drug-Drug Interactions

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PenicillamineSodium aurothiomalate
Severe
How does the drug interact with Aaramine-250 Tablet:
Using Aaramine-250 Tablet together with sodium aurothiomalate can increase the severity of adverse effects of Aaramine-250 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Sodium aurothiomalate and Aaramine-250 Tablet, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to your doctor.
PenicillamineLeflunomide
Severe
How does the drug interact with Aaramine-250 Tablet:
Using Aaramine-250 Tablet with leflunomide can increase the risk of low blood levels.

How to manage the interaction:
There may be a possibility of interaction between Leflunomide and Aaramine-250 Tablet, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
PenicillamineCladribine
Severe
How does the drug interact with Aaramine-250 Tablet:
Taking cladribine with Aaramine-250 Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladribine with Aaramine-250 Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
PenicillamineDeferiprone
Severe
How does the drug interact with Aaramine-250 Tablet:
Deferiprone when taken with Aaramine-250 Tablet can cause an increased risk of low blood levels.

How to manage the interaction:
Co-administration of Aaramine-250 Tablet with Deferiprone can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
PenicillamineIoversol
Severe
How does the drug interact with Aaramine-250 Tablet:
Using ioversol together with Aaramine-250 Tablet can cause an increased risk of kidney problems.

How to manage the interaction:
Although there is a drug interaction between Aaramine-250 Tablet and ioversol, they can be taken together if advised by the doctor. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm consult your doctor immediately. Do not discontinue medications without consulting a doctor.
PenicillamineClozapine
Severe
How does the drug interact with Aaramine-250 Tablet:
Taking Aaramine-250 Tablet with Clozapine can increase the risk of low blood levels.

How to manage the interaction:
Taking Aaramine-250 Tablet with Clozapine together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
PenicillamineIodamide
Severe
How does the drug interact with Aaramine-250 Tablet:
Using iodamide together with Aaramine-250 Tablet can cause an increased risk of kidney problems.

How to manage the interaction:
Although there is a drug interaction between Aaramine-250 Tablet and iodamide, they can be taken together if advised by the doctor. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm consult your doctor immediately. Do not discontinue medications without consulting a doctor.
PenicillamineMetrizamide
Severe
How does the drug interact with Aaramine-250 Tablet:
Taking Aaramine-250 Tablet together with metrizamide can cause severe kidney problems.

How to manage the interaction:
Although taking Aaramine-250 Tablet and Metrizamide together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
PenicillamineTenofovir disoproxil
Severe
How does the drug interact with Aaramine-250 Tablet:
Coadministration of Tenofovir disoproxil with Aaramine-250 Tablet can increase the risk of developing kidney problems.

How to manage the interaction:
Taking Tenofovir disoproxil with Aaramine-250 Tablet can possibly result in an interaction, it can be taken when your doctor has advised it. However, if you experience vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, shortness of breath, muscle cramps, dizziness, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
PenicillamineTenofovir alafenamide
Severe
How does the drug interact with Aaramine-250 Tablet:
Taking Aaramine-250 Tablet and tenofovir alafenamide can increase the risk of kidney problems.

How to manage the interaction:
Taking Aaramine-250 Tablet and Tenofovir alafenamide together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Food and Milk: Taking this medicine with meals, snacks, or dairy products severely limits how much medicine enters your system. Always take it on an empty stomach.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CHELATING AGENTS]

FAQs

No. Aaramine-250mg Tablet should generally not be used during pregnancy because it can cause serious harm to an unborn baby, including birth defects or miscarriage. It should also not be used while breastfeeding. If you are pregnant, planning to become pregnant, or breastfeeding, speak with your doctor immediately. Your doctor will discuss the risks and benefits of treatment and advise you on appropriate contraception during treatment and for the recommended period after stopping the medicine.
No. Food and dairy products greatly reduce how much of this medicine your body can absorb. You must take Aaramine-250mg Tablet on an empty stomach, either 1 hour before breakfast or 2 hours after you finish eating. Talk to your doctor or pharmacist if you struggle with this schedule.
This medication can sometimes cause serious side effects affecting your kidneys and your blood cells. Regular blood and urine tests allow your doctor to monitor your health closely and ensure the medicine is working safely. Talk to your doctor to learn more.
You can take multivitamins, but you must space them out. Multivitamins containing iron, zinc, or calcium can bind to the medication in your stomach and stop it from working. Always separate them by at least 2 hours. Talk to your doctor or pharmacist for advice on a safe schedule.
A temporary loss or change in your sense of taste is a very common side effect of this medicine. However, this side effect is usually temporary and typically improves on its own within a few months, even while you continue your treatment. Talk to your doctor if this affects your nutrition.
It is highly recommended that you avoid alcohol while taking this medicine. Alcohol can increase stomach irritation and add extra stress to your liver, which may already be working harder due to your underlying health condition. Talk to your doctor for personalised advice.
Aaramine-250mg Tablet can increase your body's excretion of Vitamin B6, which can occasionally lead to a deficiency and cause nerve issues. Your doctor may prescribe a daily Vitamin B6 supplement to prevent this. Talk to your doctor before starting any new supplement.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

Nh 21 A, Dattowal, Nalagarh Dist Solan, Himachal Pradesh-174101
Other Info - AAR0019
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