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Acmesod 8.4 %w/v Injection 25 ml is used to treat Metabolic acidosis, severe diarrhoea, drug intoxication, and poisoning. It contains Sodium bicarbonate, an electrolyte replenisher and systemic alkaliser that reduces the acid in the blood. It also helps reduce the amount of acid in the body after a heart attack in patients who have too much potassium in their blood or too much acid.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Questus Pharma Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Acmesod 8.4 %w/v Injection 25 ml

Acmesod 8.4 %w/v Injection 25 ml is a sterile injection used to treat metabolic acidosis, a serious medical condition where there is too much acid in the body fluids. It is also given to make the urine less acidic, which helps the body eliminate certain toxins and protects the kidneys during intensive medical therapies. This sterile solution plays a vital role in restoring the normal acid-base balance of your blood in critical care situations.

Since this medication is given as an intravenous injection or slow drip, the frequency and consistency of its use are entirely determined by your doctor based on continuous laboratory monitoring. It is injected directly into your bloodstream, meaning it does not interact with food in your stomach. While receiving this therapy, making temporary lifestyle adjustments like monitoring your fluid and salt intake can significantly support your treatment results.

While undergoing treatment, some people may experience mild side effects like slight swelling or redness at the injection site. However, you must inform your healthcare provider immediately if you experience serious side effects, such as muscle twitching, severe weakness, or breathing difficulties. Your medical team will monitor you closely to manage and prevent these risks.

Talk to your doctor before starting this medicine if you have a history of heart failure, high blood pressure, kidney disease, or low calcium levels. Do not take this medicine if you have severe metabolic alkalosis (a condition in which your blood becomes too alkaline, meaning it does not contain enough acid) or extremely low calcium levels.

This injection can interact with certain medications like corticosteroids, lithium, or aspirin, which may alter their effects or increase fluid retention. If you are pregnant, breastfeeding, or an elderly individual, consult your doctor to ensure this treatment is safe and appropriate for your specific health needs.

Uses of Acmesod 8.4 %w/v Injection 25 ml

Acmesod 8.4 %w/v Injection 25 ml is used in the treatment of metabolic acidosis, severe diarrhoea, drug intoxication, and poisoning. The detailed uses of Acmesod 8.4 %w/v Injection 25 ml are as follows:

  • Metabolic Acidosis: Helps restore the normal acid-base balance in the blood when it becomes too acidic due to severe kidney disease, uncontrolled diabetes, or circulatory shock.
  • Severe Diarrhea: Replaces lost bicarbonate ions and fluids to correct acidity and dehydration caused by severe fluid loss.
  • Certain Drug Poisonings: Helps the kidneys clear certain acidic toxins (like aspirin or phenobarbital) faster by making the urine more alkaline.
  • Urine alkalinization (making the urine less acidic): Helps prevent certain kidney stones and protects the kidneys during some chemotherapy treatments.

Key Benefits

  • This medication rapidly corrects life-threatening blood acidity, helping to restore normal organ function and reduce distressing symptoms like extreme fatigue, rapid breathing, and confusion.
  • By making the urine less acidic, it protects the kidneys from severe damage caused by toxic substances or cellular breakdown products during intensive medical treatments.
  • It promotes faster recovery in critical care situations by maintaining a stable chemical environment in the body, allowing other treatments and natural healing processes to work effectively.

Directions for Use

  • The timing and frequency of Acmesod 8.4 %w/v Injection 25 ml will be determined by your doctor, based on your medical condition and response to treatment.
  • Acmesod 8.4 %w/v Injection 25 ml will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Acmesod 8.4 %w/v Injection 25 ml Works

Acmesod 8.4 %w/v Injection 25 ml helps reduce excess acid in your blood when your body is unable to maintain a normal acid balance. After it is injected into a vein, it acts like a natural neutralizer, reducing the extra acid and restoring the body's normal chemical balance. This helps important organs such as the heart, kidneys, and brain work properly. It can also make the urine less acidic, helping the kidneys remove certain medicines and harmful substances from the body more easily.
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Alcohol

Consult your doctor

It is unknown if alcohol affects Acmesod 8.4 %w/v Injection 25 ml. Please consult your doctor.

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Pregnancy

Consult your doctor

Acmesod 8.4 %w/v Injection 25 ml belongs to pregnancy category C. Please inform your doctor if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Inform your doctor if you are breastfeeding; your doctor will prescribe only if the benefits outweigh the risks.

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Driving

Caution

It is not known if Acmesod 8.4 %w/v Injection 25 ml affects your ability to drive. however, drive or operate machinery only if you are alert.

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Liver

Consult your doctor

Inform your doctor if you have a liver impairment or any concerns before receiving Acmesod 8.4 %w/v Injection 25 ml.

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Kidney

Consult your doctor

Inform your doctor if you have kidney impairment or any concerns. Acmesod 8.4 %w/v Injection 25 ml is not recommended if you have conditions like kidney failure or kidney stones.

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Children

Consult your doctor

Please consult your doctor if you have any concerns regarding the usage of Acmesod 8.4 %w/v Injection 25 ml in children. Rapid injection (10 mL/min) of hypertonic Sodium bicarbonate injection solutions in children below two years may cause hypernatremia (high sodium levels), a decrease in cerebrospinal fluid pressure and possible intracranial haemorrhage.

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Heart

Consult your doctor

Inform your doctor if you have heart disease before using Acmesod 8.4 %w/v Injection 25 ml. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Acmesod 8.4 %w/v Injection 25 ml should be used in the elderly only when recommended by a doctor. If you have any concerns about using Acmesod 8.4 %w/v Injection 25 ml for geriatrics, please consult a doctor.

What if I have taken an overdose of Acmesod 8.4 %w/v Injection 25 ml

If you suspect an overdose (which can cause symptoms like muscle twitching, severe headache, dizziness, or breathing difficulties), seek immediate medical attention or contact an emergency room right away.

Diet & Lifestyle Advise

  • Monitor sodium intake: Because this medicine contains a significant amount of sodium, your doctor may advise you to limit salt in your diet to prevent fluid retention and high blood pressure.
  • Stay well-hydrated: Drink plenty of water as directed by your healthcare provider to help your kidneys process the medication and maintain healthy fluid balance.
  • Follow potassium advice: This treatment can alter your potassium levels. Eat potassium-rich foods (like bananas or leafy greens) or limit them only if specifically instructed by your doctor based on your blood tests.
  • Avoid heavy mineral supplements: Unless approved by your healthcare provider, avoid taking large doses of calcium or other mineral supplements, as they can interact with the therapy and cause unwanted deposits in the body.
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How Soon It Starts Working

  • The time required for Acmesod 8.4 %w/v Injection 25 ml to start to work: The peak effect of Acmesod 8.4 %w/v Injection 25 ml can be observed within 5 to 10 minutes of IV administration.
  • The time for which the effects of Acmesod 8.4 %w/v Injection 25 ml last: Acmesod 8.4 %w/v Injection 25 ml effect can last for 1 to 2 hours of IV administration.

What if you forget to take Acmesod 8.4 %w/v Injection 25 ml

Because this medication is usually given by a healthcare professional in a clinical setting, a missed dose is unlikely. If you are receiving this treatment at home and miss a scheduled dose, contact your doctor or healthcare provider immediately for instructions. Do not double the dose to catch up.

Storage

• Store Acmesod 8.4 %w/v Injection 25 ml injection vials or infusion bags at controlled room temperature, ideally between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the solution: Always check the vial or bag before use; the liquid must be completely clear and colorless. Do not inject if you see cloudiness, crystals, or floating particles.
  • Check the injection site: Monitor the area where the needle enters your vein. If you notice any redness, swelling, burning, or leakage of fluid, stop the infusion immediately and inform your medical team.
  • Do not mix with other medications: Do not mix Acmesod 8.4 %w/v Injection 25 ml with other drugs in the same IV line or syringe unless explicitly directed by a pharmacist or doctor, as it can cause other medications to clump or lose their effectiveness.
  • Keep up with regular blood tests: Your doctor may order blood tests, including arterial blood gas (ABG) tests (blood tests that measure the acid, carbon dioxide, and oxygen levels in your blood) and electrolyte tests. These help make sure the medicine is working properly and that your dose is adjusted safely.
  • Practice safe needle disposal: If injecting at home, place all used needles, syringes, and sharp objects in a puncture-resistant sharps container immediately after use. Never reuse needles.

Drug-Drug Interactions

verifiedApollotooltip
  • May decrease the clearance of basic drugs (like quinidine or amphetamines), increasing their levels and side effects in the body.
  • May increase the clearance of acidic drugs (like aspirin or lithium), potentially reducing their effectiveness.
  • May increase the risk of sodium retention and swelling when combined with corticosteroids.

Drug-Drug Interactions

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How does the drug interact with Acmesod 8.4 %w/v Injection 25 ml:
Taking Acmesod 8.4 %w/v Injection 25 ml with Gefitinib together can reduce the levels and treatment outcomes of Gefitinib.

How to manage the interaction:
Although taking Gefitinib and Acmesod 8.4 %w/v Injection 25 ml together can cause an interaction, it can be taken if a doctor has suggested it. Contact your doctor if your symptoms do not improve. Do not stop using any medications without talking to a doctor.
How does the drug interact with Acmesod 8.4 %w/v Injection 25 ml:
Co-administration of Acmesod 8.4 %w/v Injection 25 ml and Dolutegravir reduces the levels of Dolutegravir, resulting in reduced effectiveness.

How to manage the interaction:
Although taking Dolutegravir and Acmesod 8.4 %w/v Injection 25 ml together can result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience symptoms like fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, and pain or burning during urination, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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  • No clinically significant food interactions are known with Acmesod 8.4 %w/v Injection 25 ml when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Acmesod 8.4 %w/v Injection 25 ml is used to treat Metabolic acidosis, severe diarrhoea, drug intoxication, and poisoning.
Acmesod 8.4 %w/v Injection 25 ml acts as an electrolyte replenisher and systemic alkaliser. It reduces the acid in the blood.
Acmesod 8.4 %w/v Injection 25 ml is used to treat metabolic acidosis caused due to diabetes, hepatitis, starvation, shock, cardiac arrest, renal insufficiency, severe dehydration, severe primary lactic acidosis, Addison's disease or administration of acidic drugs. Metabolic acidosis is an electrolyte disorder characterised by an acid-base imbalance in the body.
Acmesod 8.4 %w/v Injection 25 ml is indicated in severe diarrhoea, which is often accompanied by a significant loss of bicarbonate. Acmesod 8.4 %w/v Injection 25 ml helps by compensating for the lost bicarbonate ions.
Acmesod 8.4 %w/v Injection 25 ml is indicated for treating certain drug intoxication, such as barbiturates (in cases where barbiturate-protein complex dissociation is desired). Acmesod 8.4 %w/v Injection 25 ml may also be used to treat patients who have taken too many tricyclic antidepressants only after other resuscitation methods have been attempted.
Acmesod 8.4 %w/v Injection 25 ml is used in poisoning by methyl alcohol or salicylates and in haemolytic reactions that require the alkalinisation of urine to lower the nephrotoxicity of haemoglobin and its by-products.
This medication is injected directly into a vein (intravenously) as a slow injection or a continuous infusion. It is usually administered by a trained healthcare professional in a hospital or clinic. Talk to your doctor if you have questions about your administration schedule.
You must use this medication with extreme caution if you have high blood pressure. Because it contains sodium, it can cause your body to hold onto extra fluid, which may raise your blood pressure further. Talk to your doctor before starting this treatment if you have hypertension.
Do not use the medication if it looks cloudy, contains visible particles, or if the container is leaking. A cloudy solution indicates contamination or chemical changes that make it unsafe to inject. Talk to your doctor or pharmacist to get a replacement vial.
This medication should only be used during pregnancy or breastfeeding if clearly needed and prescribed by a physician. Your doctor will weigh the benefits against any potential risks to you and your baby. Talk to your doctor if you are pregnant or planning to breastfeed.
When given intravenously, this medication works almost immediately to neutralize excess acid in the bloodstream. However, the time it takes to fully resolve your symptoms depends on the underlying cause of your condition. Talk to your doctor for specific expectations regarding your recovery.
While rare, a severe allergic reaction can occur. Signs include hives, skin rash, itching, swelling of the face, lips, tongue, or throat, and severe dizziness or trouble breathing. If you experience any of these symptoms, seek emergency medical help immediately. Talk to your doctor if you have a history of allergies to similar treatments.
Some medications can interact with this injection, changing how they work or increasing the risk of side effects. It is vital to share a complete list of all prescription drugs, over-the-counter medicines, and herbal supplements you are taking with your healthcare team. Talk to your doctor or pharmacist to ensure there are no unsafe interactions.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

No 3-3, 40, E Marredpally, Mamidpalli, Malkajgiri, Secunderabad, Telangana 500026
Other Info - ACM0075
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