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compositionComposition:ACICLOVIR-400MG
prescription
Prescription Medicine
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ACR-V 400 Tablet is used to treat viral infections. It contains Aciclovir, which prevents the multiplication of viruses in human cells by acting on their DNA, resulting in decreased viral overload. In some cases, you may experience side effects such as headaches, feeling dizzy, nausea or vomiting, diarrhoea, rash, and skin sensitivity to sunlight. Use protection while having sexual intercourse to avoid the transfer of genital herpes (a sexually transmitted disease) to your partner.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ACICLOVIR-400MG

Manufacturer/Marketer :

East West Pharma India Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About ACR-V 400 Tablet

ACR-V 400 Tablet is an antiviral prescription medicine used to treat infections caused by certain types of viruses. It is commonly prescribed to manage shingles, chickenpox, genital herpes, and cold sores. This medicine helps shorten the duration of the outbreak and eases the associated discomfort.

For the best results, you must take ACR-V 400 Tablet regularly at evenly spaced intervals throughout the day and complete the full prescribed course. You can take this oral medicine with or without food, though taking it with a glass of water is highly recommended. Staying well-hydrated throughout your treatment helps protect your kidneys and supports your recovery.

While taking ACR-V 400 Tablet , you might experience mild side effects like nausea, diarrhea, or headaches. These are usually temporary, but if you experience serious symptoms such as severe dizziness, confusion, or changes in how much you urinate, contact your doctor immediately.

Before starting ACR-V 400 Tablet , tell your doctor if you have kidney problems or a weakened immune system. Do not take this medicine if you have had a severe allergic reaction to the active ingredient or any of the inactive ingredients in the tablet.

Some medicines, especially those that affect your kidneys, can interact with ACR-V 400 Tablet and increase the risk of side effects. If you are pregnant, breastfeeding, or over the age of 65, talk to your doctor or pharmacist to ensure this medicine is safe for you.
 

Uses of ACR-V 400 Tablet

ACR-V 400 Tablet is used to treat infections caused by herpes viruses and helps reduce the severity and duration of symptoms, including:

  • Shingles (Herpes Zoster): Treats the painful rash of shingles, helping blisters heal faster and reducing nerve-related pain.
  • Genital Herpes: Helps active outbreaks heal more quickly and may be used long-term to prevent or reduce the frequency of future outbreaks.
  • Cold Sores (Herpes Labialis): Limits the spread of the virus, reducing healing time and discomfort associated with cold sores around the mouth.
  • Chickenpox (Varicella): When started early, helps lessen the severity of symptoms such as fever, itching, and blister formation.
  • Note on Available Formulations: ACR-V 400 Tablet is available in both oral and topical forms. Oral ACR-V 400 Tablet is generally prescribed for conditions such as shingles, genital herpes, chickenpox, and more extensive herpes infections. Topical ACR-V 400 Tablet cream may be recommended for certain cases of cold sores or localized herpes simplex infections. Your doctor will determine which formulation is most appropriate based on the type, severity, and location of the infection.
     

Key Benefits

ACR-V 400 Tablet offers several important benefits for people affected by herpes virus infections, including:

  • Faster Recovery: Targets the virus directly, helping lesions heal more quickly and allowing a faster return to normal daily activities.
  • Pain Relief: Reduces the intensity and duration of pain, burning, and discomfort associated with viral outbreaks.
  • Fewer Recurrences: When used as suppressive therapy, it can significantly decrease the frequency of recurrent herpes outbreaks.
  • Lower Risk of Transmission: Regular preventive treatment may help reduce the risk of passing the virus to others, particularly in genital herpes.
  • Improved Quality of Life: By controlling symptoms and reducing outbreak frequency, it helps individuals manage their condition with greater confidence and comfort.
     

Directions for Use

To ensure ACR-V 400 Tablet works effectively and safely, follow these usage instructions carefully:

  • Swallow Whole: Take the tablet whole with a full glass of water. Do not crush, chew, or break it unless specifically instructed by your doctor.
  • Take With or Without Food: ACR-V 400 Tablet can be taken with or without meals. Taking it with food may help reduce mild stomach discomfort.
  • Stay Well Hydrated: Drink plenty of fluids throughout the day while taking this medicine to help your kidneys process and eliminate the medication safely.
  • Follow the Prescribed Schedule: Take ACR-V 400 Tablet exactly as directed by your doctor, at the recommended dose and duration.
  • Complete the Full Course: Continue taking the medicine for the entire prescribed period, even if your symptoms improve earlier, to help prevent the infection from returning or worsening.
     

How ACR-V 400 Tablet Works

ACR-V 400 Tablet contains aciclovir, an antiviral medicine used to treat infections caused by certain viruses, including herpes simplex virus and varicella-zoster virus. Aciclovir works by entering virus-infected cells, where it is converted into its active form. Once activated, it interferes with the viral DNA replication process by blocking the enzyme needed for the virus to make copies of its genetic material. By preventing the virus from multiplying, aciclovir helps stop the spread of the infection to healthy cells and limits the progression of the disease. Together, these actions help reduce the severity and duration of viral infections, promote healing of affected tissues, and support the body's natural immune response in controlling the infection.
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Alcohol

Caution

Limit alcohol intake while using ACR-V 400 Tablet to prevent any adverse effects.

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Pregnancy

Caution

ACR-V 400 Tablet is a pregnancy Category B medicine. It is not known whether ACR-V 400 Tablet will affect pregnant women or the fetus or not. Hence, the intake of ACR-V 400 Tablet should be only if prescribed and under medical supervision.

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Breast Feeding

Caution

It is not known whether ACR-V 400 Tablet will pass through the milk in breastfeeding women or not. Hence, ACR-V 400 Tablet should only be taken if prescribed by a doctor and under medical supervision.

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Driving

Caution

ACR-V 400 Tablet can affect alertness and coordination. So, operating machinery which requires concentration should be avoided.

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Liver

Safe if prescribed

ACR-V 400 Tablet is safe if prescribed by a doctor. It is known not to interact with liver functioning.

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Kidney

Caution

ACR-V 400 Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Safe if prescribed

ACR-V 400 Tablet is safe if prescribed by a child specialist.

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Heart

Consult your doctor

ACR-V 400 Tablet can be used in heart patients if prescribed by the physician.

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Geriatrics

Caution

ACR-V 400 Tablet is known to cause side effects like neurotoxicity and nephrotoxicity in elderly patients. Hence, pleae consult you physician.

What if I have taken an overdose of ACR-V 400 Tablet

If you accidentally take too much ACR-V 400 Tablet , seek immediate medical attention or contact a poison control centre. Drinking plenty of water can help minimise kidney issues in case of an accidental overdose.

Diet & Lifestyle Advise

  • Stay Hydrated: Drink plenty of water throughout the day while taking ACR-V 400 Tablet to help your kidneys filter the medication efficiently.
  • Keep Outbreaks Clean and Dry: Gently wash any blisters with mild soap and water, then pat them dry. Avoid picking or scratching the sores to prevent secondary infections.
  • Wear Loose Clothing: If you have shingles or chickenpox, wear loose, soft clothing made of natural fibres like cotton to reduce friction and irritation on your skin.
  • Manage Stress: Stress is a common trigger for herpes outbreaks. Incorporate stress-relief techniques like deep breathing, meditation, or light walking into your daily routine.
     
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How Soon It Starts Working

The time required for ACR-V 400 Tablet to start to work: ACR-V 400 Tablet ideally shows its action within 1.5 to 2 hours after administration.

The time for which the effects of ACR-V 400 Tablet last: The effect of ACR-V 400 Tablet lasts for 9 to 12 hours.

What if you forget to take ACR-V 400 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store ACR-V 400 Tablet at room temperature, ideally between 15°C and 25°C (59°F to 77°F). Keep the tablets in their original packaging to protect them from light and moisture.

Drug Warnings

  • Start Treatment Early: Start taking ACR-V 400 Tablet at the very first sign of an outbreak (such as tingling, itching, or burning) for the most effective results.
  • Stay Well Hydrated: Drink at least 6 to 8 glasses of water daily while taking this medicine to help reduce the risk of kidney-related side effects.
  • Use the Liquid Form Correctly: If you are taking the liquid suspension form of ACR-V 400 Tablet , shake the bottle well before each use and use a proper medical measuring device rather than a household spoon.
  • Prevent the Spread of Infection: Avoid close physical contact, such as kissing or sharing utensils, while you have active cold sores or shingles blisters to help prevent spreading the virus to others.
     

Drug-Drug Interactions

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Drug-Drug Interactions

ACR-V 400 Tablet may interact with certain medications, potentially affecting its safety or effectiveness. Inform your doctor about all medicines, supplements, and herbal products you are taking, including:

  • Kidney-Affecting Medicines: Taking ACR-V 400 Tablet with other medications that may affect kidney function, such as nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or certain diuretics (water pills), may increase the risk of kidney-related side effects.
  • Gout Medications (Probenecid): Probenecid can increase the amount of ACR-V 400 Tablet in the bloodstream, which may raise the likelihood of side effects.


Drug-Disease Interactions

Certain medical conditions may influence how ACR-V 400 Tablet works or increase the risk of side effects. Tell your doctor if you have any of the following:

  • Kidney Disease: Reduced kidney function can cause ACR-V 400 Tablet to accumulate in the body. Your doctor may adjust the dosage and monitor your kidney function during treatment.
  • Nervous System Conditions: Individuals with neurological disorders or a history of nervous system problems may be more susceptible to side effects such as confusion, dizziness, agitation, or changes in mental status.
AciclovirCidofovir
Critical
AciclovirEverolimus
Severe

Drug-Drug Interactions

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AciclovirCidofovir
Critical
How does the drug interact with ACR-V 400 Tablet:
Co-administration of Cidofovir with Acyclovir can increase the risk of kidney problems.

How to manage the interaction:
Taking ACR-V 400 Tablet with Cidofovir is not recommended, please consult your doctor before taking it. You should consult a doctor if you experience vomiting, irregular urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, weakness, and palpitations. Do not stop using any medications without talking to a doctor.
AciclovirEverolimus
Severe
How does the drug interact with ACR-V 400 Tablet:
Coadministration of ACR-V 400 Tablet with Everolimus may increase the risk or severity of kidney injury.

How to manage the interaction:
Taking ACR-V 400 Tablet with Everolimus together can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience vomiting, irregular urination, sudden weight gain or loss, swelling, breathing difficulty, muscle pains, dizziness, or palpitations. Do not discontinue any medications without consulting a doctor.
AciclovirTenofovir alafenamide
Severe
How does the drug interact with ACR-V 400 Tablet:
Coadministration of ACR-V 400 Tablet with Tenofovir alafenamide may increase the risk or severity of kidney injury.

How to manage the interaction:
Taking ACR-V 400 Tablet with tenofovir alafenamide can result in an interaction. However, if the benefits outweigh the risks, your doctor will prescribe them. Contact a doctor immediately if you experience symptoms such as decreased or increased urine output, sudden weight gain or loss, swelling, or shortness of breath. Do not discontinue any medication without consulting your doctor.
AciclovirAmphotericin b
Severe
How does the drug interact with ACR-V 400 Tablet:
Coadministration of ACR-V 400 Tablet with Amphotericin B can increase the risk or severity of kidney disorder.

How to manage the interaction:
Taking ACR-V 400 Tablet with Amphotericin b together can result in an interaction, it can be taken if a doctor has advised it. Consult a doctor if you experience irregular urination, muscle ache, shortness if breath, or palpitations. Do not discontinue any medications without consulting a doctor.
AciclovirTenofovir disoproxil
Severe
How does the drug interact with ACR-V 400 Tablet:
Coadministration of ACR-V 400 Tablet with Tenofovir Disoproxil may increase the risk or severity of kidney disorder.

How to manage the interaction:
Coadministration of ACR-V 400 Tablet with Tenofovir disoproxil can result in an interaction, it can be taken when your doctor has advised it. Contact a doctor immediately if you experience decreased or increased urine output, sudden weight gain or loss, swelling, or shortness of breath. Do not discontinue any medications without consulting a doctor.
AciclovirIodamide
Severe
How does the drug interact with ACR-V 400 Tablet:
Coadministration of Iodamide contrast with ACR-V 400 Tablet may increase the risk or severity of kidney injury.

How to manage the interaction:
Before undergoing any imaging procedure let your doctor know you are on ACR-V 400 Tablet treatment.
AciclovirMetrizamide
Severe
How does the drug interact with ACR-V 400 Tablet:
Coadministration of Metrizamide in contrast with ACR-V 400 Tablet may increase the risk or severity of kidney disorder.

How to manage the interaction:
Before undergoing any imaging procedure, let your doctor know you are on ACR-V 400 Tablet treatment. Look out for signs such as vomiting, increased or decreased urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, or weakness. Consult the doctor immediately.
AciclovirTizanidine
Severe
How does the drug interact with ACR-V 400 Tablet:
Concomitant use of ACR-V 400 Tablet with Tizanidine can increase the risk of developing low blood pressure.

How to manage the interaction:
Coadministration of ACR-V 400 Tablet with Tizanidine can result in an interaction, but it can be taken if your doctor has advised it. Contact a doctor immediately if you experience signs such as dizziness, excessive sweating, or palpitations. Do not discontinue any medications without consulting a doctor.
AciclovirSirolimus
Severe
How does the drug interact with ACR-V 400 Tablet:
Coadministration of ACR-V 400 Tablet with Sirolimus may increase the risk or severity of kidney injury.

How to manage the interaction:
Taking ACR-V 400 Tablet with Sirolimus can result in an interaction, it can be taken if your doctor has advised it. However, if you experience vomiting, a decrease in hunger, irregular urine, weight gain or loss, swelling, difficulty breathing, muscle pain, or weakness, consult a doctor.
AciclovirTacrolimus
Severe
How does the drug interact with ACR-V 400 Tablet:
Co-administration of ACR-V 400 Tablet with tacrolimus may increase the risk or severity of kidney problems.

How to manage the interaction:
Coadministration of ACR-V 400 Tablet with Tacrolimus can result in an interaction, it can be taken if your doctor has advised it. Contact a doctor immediately if you experience signs such as decreased or increased urine output, sudden weight gain or loss, swelling, or shortness of breath. Do not discontinue any medications without first consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIVIRALS]

FAQs

ACR-V 400 Tablet is used to treat viral infections. It plays a vital role in treating cold sores (an inflamed blister in or near the mouth caused by infection with the herpes simplex virus), genital herpes (a common sexually transmitted infection marked by genital pain and sores), and herpes zoster (a viral infection that causes a painful rash). In addition to this, it is also used to treat chickenpox.
ACR-V 400 Tablet works by preventing the multiplication of viruses in human cells. As a result, this stops the proliferation of viruses and produces new viruses, slowly leading to the viral infection clearing up.
No, ACR-V 400 Tablet should not be taken if you have HIV (Human Immuno Deficiency Syndrome). It can increase the risk of Thrombotic Thrombocytopenic Purpura (blood clot formation in small blood vessels).
No, ACR-V 400 Tablet should be taken in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor.
If you miss a dose of ACR-V 400 Tablet , take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.
Do not stop taking ACR-V 400 Tablet without talking to your doctor. If you suddenly stop taking ACR-V 400 Tablet , you may experience confusion, fever, mental state changes, or severe muscle stiffness. Your doctor will probably decrease your dose gradually depending upon your disease condition.
No, ACR-V 400 Tablet is not known to affect contraception (condoms). Also, to avoid transmission of herpes infection as it is a sexually transmitted disease; please use any form of contraception.
Serious side effects of ACR-V 400 Tablet are blood in the urine, chest pain or palpitations, hair loss, kidney problems, low blood pressure, lymph node swelling, seizures, serious skin reactions, and mental health changes such as agitation or aggression, confusion, depression, hallucinations, and psychotic symptoms.
Yes, elderly patients need to be more careful while taking ACR-V 400 Tablet as they might be more sensitive to the side effects of this medicine.
Taking more than the recommended dose of ACR-V 400 Tablet may cause an overdose. The symptoms of overdose include extreme tiredness, seizures (fits), change in the amount of urine, loss of consciousness and agitation. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.
Common side effects of ACR-V 400 Tablet are headaches, feeling dizzy, feeling or being sick (nausea or vomiting), diarrhoea, rash, and skin sensitivity to sunlight. Most of these side effects of ACR-V 400 Tablet are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
ACR-V 400 Tablet should be used during pregnancy or breastfeeding only if prescribed by the doctor. Please consult the doctor if you are pregnant, planning for pregnancy or breastfeeding.
Alcohol may not interfere with the working of ACR-V 400 Tablet . However, limit alcohol intake while using ACR-V 400 Tablet to prevent any adverse effects.
Patients with impaired immunity or having HIV may get resistant to ACR-V 400 Tablet treatment. Inform the doctor if you have HIV or low immunity.
No, hair loss caused due to ACR-V 400 Tablet is not permanent. It stops on discontinuing the medicine.
Yes, you can take ACR-V 400 Tablet with or without food. If you find that it upsets your stomach, taking it with a meal or a snack may help. Talk to your doctor if stomach upset persists.
ACR-V 400 Tablet begins working shortly after you take your first dose to stop the virus from multiplying. However, it may take a few days for you to notice your symptoms improving. Talk to your doctor if your condition does not improve or gets worse.
No, ACR-V 400 Tablet does not cure herpes or shingles. These viruses remain in the body even after treatment, but ACR-V 400 Tablet helps shorten the duration of active outbreaks and relieves pain. Talk to your doctor about long-term management strategies.
There is no direct interaction between alcohol and ACR-V 400 Tablet . However, alcohol can dehydrate your body and weaken your immune system, which may slow your recovery. Talk to your doctor about safe alcohol consumption during treatment.
If your blisters or rash do not improve after completing your full course of ACR-V 400 Tablet , do not take extra doses. Talk to your doctor to evaluate your treatment plan.
Yes, but you must be careful. Because your kidneys process this medicine, your doctor may need to prescribe a lower dose to ensure it does not build up in your body. Talk to your doctor about your kidney health before starting.
While ACR-V 400 Tablet reduces the risk of spreading the virus by treating active outbreaks, it does not completely eliminate the risk of transmission. You should avoid sexual contact during active outbreaks and use barrier protection. Talk to your doctor for more advice.
ACR-V 400 Tablet may be prescribed for children to treat certain viral infections, including chickenpox and herpes virus infections. The dosage is carefully calculated based on the child's age, weight, medical condition, and kidney function. Parents and caregivers should never give ACR-V 400 Tablet to a child without medical advice and should always follow the paediatrician's dosing instructions exactly.
Oral ACR-V 400 Tablet works throughout the body and is commonly used to treat conditions such as shingles, genital herpes, chickenpox, and more severe herpes infections. ACR-V 400 Tablet cream is applied directly to affected skin areas and may be used for certain cold sores or localised herpes simplex infections. Your doctor will recommend the most suitable formulation based on your condition and symptoms.

Disclaimer

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.4334 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Health Service (NHS). Aciclovir - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Electronic Medicines Compendium (EMC). Pil.9273 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Aciclovir 800 mg Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 11 July 2025]Check here
  5. Aciclovir 800 mg Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 11 July 2025]Check here
  6. Drugbank.Acyclovir.Drugbank[Accessed on 11July 2025]Check here
  7. Taylor M, Gerriets V. Acyclovir. [Updated 2023 May 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; [Accessed on 11 July 2025]Check here

Country of origin

India

Manufacturer/Marketer address

6, Nandalal Bose Sarani,Kolkata -700071.
Other Info - ACR0091
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