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compositionComposition:AMITRIPTYLINE-12.5MG+CHLORDIAZEPOXIDE-5MG
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Prescription Medicine
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ACULIP TABLET is used to treat moderate to severe depression associated with moderate to severe anxiety. It contains Amitriptyline and Chlordiazepoxide, which works by affecting certain chemical messengers in the brain that communicate between brain cells, thereby regulating mood and treating depression. Also, it helps suppress the excessive and abnormal activity of the nerve cells in the brain. In some cases, you may experience common side effects such as dizziness, drowsiness, dry mouth, constipation, blurred vision and bloating. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

AMITRIPTYLINE-12.5MG+CHLORDIAZEPOXIDE-5MG

Manufacturer/Marketer :

Shine Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About ACULIP TABLET

ACULIP TABLET is a combination oral medication prescribed to treat moderate to severe depression that occurs alongside moderate to severe anxiety. It combines two active components that work together to balance chemicals in the brain, helping to improve mood and reduce feelings of tension. This medicine is designed to address both emotional and physical symptoms of these co-occurring conditions.

For the best results, you should take ACULIP TABLET consistently at the same time every day, exactly as directed by your doctor. It can be taken with or without food, though taking it with food may help prevent an upset stomach. Incorporating supportive habits, such as keeping a regular sleep schedule, practising gentle physical activity, and avoiding excess caffeine, can also help maximise the benefits of this treatment.

While taking ACULIP TABLET , some people may experience mild side effects like drowsiness, dry mouth, or constipation. These are usually manageable, but you must contact your doctor immediately if you notice serious symptoms such as severe mood changes, confusion, difficulty urinating, or thoughts of self-harm.

Do not take this if you are recovering from a recent heart attack, have severe liver damage, or have closed-angle glaucoma. Before starting this medication, tell your doctor if you have a history of urinary blockage, thyroid problems, seizures, or a history of substance abuse, as this medicine may not be safe for you.

This medicine can interact with other substances, including alcohol, sleeping pills, and certain pain relievers, which can cause severe drowsiness or dangerously slow breathing. Smoking can also reduce how well this medicine works in your body. If you are pregnant, breastfeeding, or an elderly individual, consult your doctor before using ACULIP TABLET , as special precautions or lower doses are often necessary.

Uses of ACULIP TABLET

ACULIP TABLET is used to treat moderate to severe depression that occurs alongside moderate to severe anxiety. The detailed uses of ACULIP TABLET are as follows:

  • Depression associated with moderate to severe anxiety: ACULIP TABLET helps raise mood levels while simultaneously easing persistent worry, nervousness, and physical tension.
  • Anxiety-induced sleep difficulties: By calming active brain signals, it helps patients who struggle to fall asleep or stay asleep due to racing thoughts and depression.

Key Benefits

ACULIP TABLET helps manage symptoms of depression and anxiety by improving mood and reducing anxiety-related symptoms. By addressing both emotional and physical symptoms, it supports better daily functioning and overall wellbeing.

  • Helps Improve Mood and Reduce Anxiety: By balancing brain chemicals involved in mood regulation, ACULIP TABLET helps relieve symptoms of depression while reducing feelings of anxiety, nervousness, and tension.
  • Supports Better Sleep and Relaxation: By calming the nervous system, ACULIP TABLET helps improve sleep quality and promotes physical relaxation, allowing you to feel more rested and refreshed.
  • Improves Daily Functioning and Quality of Life: By reducing emotional distress and supporting better sleep, ACULIP TABLET helps improve concentration, energy levels, and the ability to carry out everyday activities with greater confidence and comfort.
Side effects of Aculip Tablet
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Try to practice deep breathing exercises or repeat calming words or phrases.
  • Seek for medical help if aggression occurs frequently, as it can worsen gradually if not attended.
  • You can also try listening to music or relaxing or writing a journal to express the feeling that aggravates to find a solution.
  • Consume controlled amounts of salt to raise sodium levels.
  • Eat fresh fruits like apples, berries, oranges, mangoes, and bananas.
  • Include fresh vegetables like broccoli, sweet potatoes, beets, okra, spinach, peppers, carrots, and edamame.
  • Choose frozen vegetables without added butter or sauce.
  • Drink electrolyte beverages like sports drinks or electrolyte solutions to replenish sodium and other electrolytes.
  • Avoid excessive salt intake, but allow for controlled increases as needed.
  • Monitor and manage underlying health conditions that may contribute to hyponatremia.
  • Quit smoking as smoking impairs erectile function by significantly damaging blood vessels.
  • Maintain a healthy weight as overweight can cause erectile dysfunction.
  • Exercise regularly as physical activity enhances blood flow and overall health, benefiting erectile function.
  • Consume a healthy diet loaded with whole grains, fruits and vegetables.
  • Limit alcohol consumption as excessive alcohol intake can impair erectile function.
  • Manage stress by practicing techniques such as yoga, relaxation exercises or meditation.
  • In case erectile dysfunction is due to psychological factors, consider couple counselling or sex therapy to address relationship and anxiety issues.
  • Openly discuss your concerns with your partner.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • Take ACULIP TABLET with or without food or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with glass of water.
  • Do not crush, break, or chew it.

How ACULIP TABLET Works

ACULIP TABLET works through the combined action of its two active components in the central nervous system. The first component, amitriptyline, is an antidepressant that increases the levels of natural chemical messengers, specifically serotonin and norepinephrine, in the brain. This action helps to correct chemical imbalances, thereby improving mood, relieving sadness, and restoring interest in daily activities. The second component, chlordiazepoxide, is a calming agent belonging to the benzodiazepine class. It enhances the effects of a natural calming chemical in the brain known as GABA. By boosting GABA activity, this component slows down excessive nerve activity, which quickly reduces feelings of panic, muscle tension, and severe anxiety. Together, these two actions provide a balanced approach to managing complex emotional symptoms.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking ACULIP TABLET as it may cause increased sleepiness and dizziness.

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Pregnancy

Unsafe

Avoid taking ACULIP TABLET if you are pregnant unless prescribed by a doctor as it may cause birth defects.

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Breast Feeding

Caution

Consult your doctor before taking ACULIP TABLET ; your doctor will decide whether ACULIP TABLET can be taken by breastfeeding mothers or not.

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Driving

Unsafe

ACULIP TABLET may cause sleepiness, dizziness and might impair thinking and motor skills. Do not drive or operate machinery if you experience these symptoms.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

ACULIP TABLET should not be given to children as safety and effectiveness have not been established.

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Heart

Unsafe

This medicine is contraindicated in cardiac patients due to its adverse effects.

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Geriatrics

Caution

ACULIP TABLET should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using ACULIP TABLET .

What if I have taken an overdose of ACULIP TABLET

If you suspect an overdose, seek immediate emergency medical attention. Symptoms of an overdose may include extreme drowsiness, confusion, slow reflexes, shallow breathing, or loss of consciousness.

Diet & Lifestyle Advise

  • Drink plenty of water throughout the day and eat foods high in fibre, such as whole grains, fruits, and vegetables, to help prevent constipation.
  • To ease dry mouth, suck on sugar-free hard candies, chew sugar-free gum, or take frequent sips of water.
  • Avoid drinking alcohol entirely, as it can dangerously increase the sedative effects of this medicine, causing severe drowsiness and coordination problems.
  • Stand up slowly from a sitting or lying position to give your body time to adjust, which helps prevent dizziness and accidental falls.
  • Maintain a quiet, dark, and consistent sleep environment to support the medicine's natural calming action on your sleep cycle.
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Have a query?

How Soon It Starts Working

The time required for ACULIP TABLET to start to work: The time required for ACULIP TABLET to show its action is unknown. The time for which the effects of ACULIP TABLET last: The duration of action for ACULIP TABLET is unknown.

What if you forget to take ACULIP TABLET

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a forgotten one.

Storage

•Store ACULIP TABLET tablets at controlled room temperature, ideally between 20°C to 25°C (68°F to 77°F). •Keep the medication in its original container, tightly closed, to protect it from direct light and moisture. Do not store it in bathroom cabinets.

Drug Warnings

  • Do not drive, operate machinery, or perform dangerous tasks until you know exactly how ACULIP TABLET affects your alertness.
  • Never stop taking this medication suddenly, as doing so can trigger uncomfortable withdrawal symptoms such as nausea, headaches, sweating, and increased anxiety; your doctor will help you by gradually increasing dose reductions when it is time to stop.
  • Avoid smoking while taking this medication, as tobacco smoke can speed up how your body processes the medicine, making it less effective.
  • Be vigilant about mental health changes, and ask a family member or close friend to help monitor your behaviour for any signs of worsening depression or suicidal thoughts, especially during the first few weeks of treatment.
  • Never share this medication with anyone else, even if they have similar symptoms, as it can be habit-forming and requires strict medical supervision.

Drug-Drug Interactions

verifiedApollotooltip
  • Monoamine Oxidase Inhibitors (MAOIs): Do not take this medicine within 14 days of using an MAOI antidepressant, as this can lead to high blood pressure, severe seizures, or a life-threatening chemical reaction in the brain.
  • Central Nervous System Depressants: Taking this medicine alongside opioids, sleeping pills, muscle relaxants, or strong antihistamines can cause severe drowsiness, slow breathing, and even coma.
  • Blood Pressure Medications: May alter the effectiveness of certain drugs used to manage blood pressure, requiring close monitoring by your doctor.
Chlordiazepoxide + AmitriptylineZiprasidone
Critical
Chlordiazepoxide + AmitriptylineProcarbazine
Critical

Drug-Drug Interactions

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Chlordiazepoxide + AmitriptylineZiprasidone
Critical
How does the drug interact with Aculip Tablet:
Taking Amitriptyline and Ziprasidone may increase the risk of irregular heartbeat.

How to manage the interaction:
Although there is a interaction between Amitriptyline with Ziprasidone is not recommended, but it can be taken together if prescribed by your doctor. However, consult your doctor immediately if you experience sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats . Do not discontinue any medication without consulting a doctor.
Chlordiazepoxide + AmitriptylineProcarbazine
Critical
How does the drug interact with Aculip Tablet:
Using Amitriptyline together with Procarbazine can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Procarbazine and Amitriptyline together is not recommended as it may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
Chlordiazepoxide + AmitriptylineThioridazine
Critical
How does the drug interact with Aculip Tablet:
Amitriptyline and Thioridazine can enhance each other's effects when used together.

How to manage the interaction:
Although using Amitriptyline and Thioridazine together is not recommended as it can cause an interaction, they can be used if prescribed by a doctor. If you have extreme sleepiness, confusion, anxiety, vomiting, vision problems, feeling hot or cold, sweating, muscle stiffness, fainting, fits, or coma, seek medical help. Do not discontinue any medications without consulting a doctor.
Chlordiazepoxide + AmitriptylineTranylcypromine
Critical
How does the drug interact with Aculip Tablet:
Taking Tranylcypromine with Amitriptyline can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although using Tranylcypromine and Amitriptyline together is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, consult a doctor if you have symptoms such as confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
Chlordiazepoxide + AmitriptylineHalofantrine
Critical
How does the drug interact with Aculip Tablet:
Combining Amitriptyline and Halofantrine may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitriptyline with Halofantrine is not recommended as it may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
Chlordiazepoxide + AmitriptylineBepridil
Critical
How does the drug interact with Aculip Tablet:
Combining Amitriptyline and Bepridil may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitriptyline with Bepridil is not recommended as it may result in an interaction, it can be used if a doctor recommends it. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
Chlordiazepoxide + AmitriptylineSaquinavir
Critical
How does the drug interact with Aculip Tablet:
Combining Amitriptyline and Saquinavir may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitriptyline with Saquinavir is not recommended as it may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
Chlordiazepoxide + AmitriptylineDronedarone
Critical
How does the drug interact with Aculip Tablet:
Combining Amitriptyline and Dronedarone may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitriptyline with Dronedarone is not recommended as it may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
Chlordiazepoxide + AmitriptylineFurazolidone
Critical
How does the drug interact with Aculip Tablet:
Combining Furazolidone with Amitriptyline can increase the risk of serotonin syndrome(increased serotonin hormone).

How to manage the interaction:
Although using Furazolidone and Amitriptyline together is not recommended as it may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
Chlordiazepoxide + AmitriptylinePimozide
Critical
How does the drug interact with Aculip Tablet:
Combining Amitriptyline and Pimozide may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitriptyline with Pimozide is not recommended as it may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and Grapefruit Juice: Grapefruit can slow down how your liver processes the calming component of this medicine, increasing its levels in your blood and raising the risk of severe side effects.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

Yes

Therapeutic Class

[PSYCHOTHERAPEUTICS]

FAQs

ACULIP TABLET is used to treat moderate to severe depression associated with moderate to severe anxiety.
ACULIP TABLET contains Amitriptyline and Chlordiazepoxide. Amitriptyline works by affecting certain chemical messengers (serotonin and/or norepinephrine) in the brain, which communicate between brain cells, thereby regulating mood and treating depression. Chlordiazepoxide works by increasing the action of a chemical messenger called GABA. This helps suppress the excessive and abnormal activity of the nerve cells in the brain.
ACULIP TABLET may cause weight gain due to increased appetite. Eat a healthy diet and exercise regularly to maintain a healthy weight.
Do not discontinue ACULIP TABLET without consulting your doctor, as it could cause withdrawal symptoms. To treat your condition effectually, continue taking ACULIP TABLET for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking ACULIP TABLET .
Dry mouth could be a side-effect of ACULIP TABLET . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Constipation might occur as a side-effect of ACULIP TABLET . Drink plenty of fluids and eat fibre-rich food if you experience constipation. Consult your doctor if you experience severe constipation.
ACULIP TABLET may cause side effects like dizziness and tiredness in some people. Consult the doctor if the condition persists or if you experience severe dizziness or tiredness.
Painkillers should be taken with ACULIP TABLET only if advised by the doctor. However, opioid-based analgesics should not be taken with ACULIP TABLET as it may cause drowsiness and breathing problems. Always check with the doctor before taking painkillers or other medicines along with ACULIP TABLET .
ACULIP TABLET may cause suicidal thoughts/behaviour; therefore, monitor the person taking ACULIP TABLET for any changes in mood/behaviour and report to the doctor if you notice any unusual behaviour.
Store ACULIP TABLET at room temperature, protected from light and moisture. Keep it out of sight and reach of children.
Yes, ACULIP TABLET may cause sleepiness. Do not drive or operate machinery unless you know how the medicine affects you.
ACULIP TABLET may cause sexual problems like decreased sexual desire, inability to reach an orgasm and erectile dysfunction in men. Discuss with the doctor if you experience sexual problems during treatment with ACULIP TABLET .
ACULIP TABLET may change the colour of urine to green or blue. It is generally harmless and resolves once the medicine is stopped. However, consult the doctor if you have any concerns regarding this.
The active ingredients of ACULIP TABLET are Amitriptyline (tricyclic anti-depressant) and Chlordiazepoxide (benzodiazepine anxiolytic). It is used to treat moderate to severe depression associated with moderate to severe anxiety.
ACULIP TABLET can be taken with or without food as advised by the doctor. Swallow ACULIP TABLET as a whole with a glass of water; do not chew or crush it.
Yes, ACULIP TABLET is safe if taken in the dose and duration prescribed by the doctor. It should not be taken for longer durations as it may cause physical dependence.
Though ACULIP TABLET may help you sleep better by improving your mood, it should not be used for sleep-related issues. Talk to the doctor if you have sleep-related problems.
ACULIP TABLET may not be beneficial for heart health as it may cause QT prolongation (a condition that affects heart rhythm) in some people. Before starting treatment with ACULIP TABLET discuss you’re your doctor if you have heart rhythm problems.
Side effects of ACULIP TABLET include dizziness, drowsiness, dry mouth, constipation, blurred vision and bloating. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
No, you must avoid alcohol. Alcohol severely increases the sedative effects of ACULIP TABLET , which can lead to extreme drowsiness, breathing difficulties, and impaired coordination. Talk to your doctor if you have concerns about avoiding alcohol.
Yes. Since ACULIP TABLET contains Chlordiazepoxide, a benzodiazepine, prolonged or inappropriate use may lead to physical and psychological dependence. Take it only as prescribed by your doctor and do not stop it suddenly without medical advice.
Consult your doctor before taking ACULIP TABLET if you are pregnant, planning to become pregnant, or breastfeeding. Amitriptyline and Chlordiazepoxide may not be suitable during pregnancy or breastfeeding, as they can affect the baby. Your doctor will weigh the benefits and potential risks before recommending treatment.
Drowsiness is common, especially when starting the medicine. Your doctor may suggest taking your dose at bedtime to help manage daytime sleepiness. Talk to your doctor before changing your schedule.
Some patients may experience changes in appetite or metabolic changes that lead to weight gain. Maintaining a balanced diet and regular exercise can help manage this. Talk to your doctor if you notice sudden weight changes.
Yes. ACULIP TABLET can interact with several over-the-counter medicines, particularly antihistamines, sleep aids, cough and cold medicines, and other products that cause drowsiness. These combinations may increase dizziness, sleepiness, and other side effects. Always check with your doctor or pharmacist before taking any new over-the-counter medicine.

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Country of origin

INDIA

Manufacturer/Marketer address

308-310 Dwarkesh Complex, Sun Pharma Road, Po:Atladra, Vadodara-390 012., Gujarat, India.
Other Info - ACU0026

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