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Adicobal-1500 Injection 2 ml is used to treat nutritional deficiencies and as adjuvant therapy for various medical conditions. It contains methylcobalamin (vitamin B12), niacinamide (nicotinamide), and pyridoxine (vitamin B6). Together, they provide essential nutrients for adequate growth and proper organ functioning. Adicobal-1500 Injection 2 ml may cause side effects such as upset stomach, constipation, diarrhoea, nausea, and injection site reactions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

METHYLCOBALAMIN-1500MCG+NIACINAMIDE-100MG+PYRIDOXINE-100MG

Manufacturer/Marketer :

Adisys Healthcare

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Adicobal-1500 Injection 2 ml

Adicobal-1500 Injection 2 ml is an injectable prescription medicine used to treat peripheral neuropathy and clinical conditions caused by vitamin B6, vitamin B12, and niacin deficiencies. It is especially useful when oral therapy is not feasible, such as in critically ill patients, ICU patients, or people with excessive vomiting. By delivering these vitamins directly into the body, it helps restore depleted nutrient levels more quickly. 

To achieve the best results, you should receive Adicobal-1500 Injection 2 ml exactly as prescribed by your doctor. In severe cases, it may be given daily until symptoms improve and then reduced to maintenance dosing. Because it is administered by injection, food does not affect how it works. This medicine is intended for adult use and is for single use only. 

While using this injection, some people may experience mild side effects such as pain or redness at the injection site, nausea, vomiting, diarrhoea, dizziness, headache, or flushing. Seek medical attention immediately if you develop difficulty breathing, facial swelling, severe rash, or other signs of a serious allergic reaction. Long-term high-dose pyridoxine exposure can also cause peripheral sensory neuropathy, so new tingling or numbness should be reported promptly. 

Do not use this medicine if you are allergic to any of its ingredients. Tell your doctor before treatment if you have hypertension, cardiovascular disease, lung disease, diabetes, liver disease, or a history of bleeding-related problems, because extra caution may be needed in these settings. 

This medicine can interact with several drugs, including metformin, phenytoin, phenobarbital, isoniazid, hydralazine, penicillamine, oral contraceptives, levodopa, carbamazepine, diazepam, and sodium valproate. If you are pregnant, breastfeeding, or an older adult, consult your doctor before starting treatment. Large doses of nicotinamide should be avoided in pregnancy, and caution is advised in nursing mothers.

Uses of Adicobal-1500 Injection 2 ml

Your doctor may prescribe Adicobal-1500 Injection 2 ml to treat the following conditions:

  • Peripheral neuropathy: Helps relieve nerve pain, tingling, numbness, and burning sensations in the hands and feet.
  • Clinical conditions resulting in B6, B12, or niacin deficiencies: Used when these deficiencies need parenteral correction, especially when oral therapy is not feasible.

Key Benefits

By bypassing the digestive tract, Adicobal-1500 Injection 2 ml provides rapid delivery of essential vitamins, which is helpful when absorption is poor or oral treatment cannot be used. This supports faster correction of deficiency states and helps the body recover more reliably than oral supplements in selected patients. 

  • Supports nerve health: Methylcobalamin helps with myelin-related processes and nerve repair, while pyridoxine supports neurotransmitter and amino-acid metabolism.
  • Helps reduce neuropathic symptoms: May help ease numbness, tingling, and burning pain associated with peripheral neuropathy.
  • Supports energy metabolism: Niacinamide helps form NAD, which is important for cellular energy production and neuronal function.
  • Corrects deficiency states: Replenishes depleted B-vitamin stores when dietary intake or oral absorption is inadequate.
Side effects of Adicobal-1500 Injection 2 ml
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the six steps to manage medication-triggered Nervousness:
  • Tell your doctor immediately if you experience symptoms of Nervousness, such as anxiety, jitteriness, or an increased heart rate, after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen to alleviate symptoms of Nervousness. This can include switching to a different medication, reducing the dosage, or temporarily stopping the medication. Your doctor may also recommend alternative techniques like relaxation, mindfulness meditation, or journaling. These techniques can help reduce anxiety and Nervousness.
  • Practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling, to help manage Nervousness.
  • Engage in regular physical activity, such as walking or jogging, to help reduce anxiety and improve mood.
  • Your doctor may advise considering cognitive-behavioural therapy (CBT) or other forms of talk therapy to address underlying anxiety or Nervousness.
  • You should maintain regular follow-up appointments with your doctor to monitor nervousness symptoms, adjust treatment plans as needed, and discuss any concerns or questions.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication, to improve effectiveness.
  • Adicobal-1500 Injection 2 ml will be administered by a healthcare professional.
  • Do not self-administer it.

How Adicobal-1500 Injection 2 ml Works

Adicobal-1500 Injection 2 ml combines three essential vitamins that work together to support nervous system and metabolic health. Methylcobalamin supports methylation reactions involved in myelin formation and nerve regeneration. Pyridoxine is converted in the body to pyridoxal 5’-phosphate, an active coenzyme required for amino-acid, neurotransmitter, and haem-related metabolism. Niacinamide contributes to NAD/NADH production, which is important for cellular energy and neuronal maintenance. Together, these nutrients help restore depleted stores, support nerve repair, and improve metabolic function in patients with deficiency-related symptoms.
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Alcohol

Caution

No interaction was found. However, it is advisable not to take or limit alcohol as a precautionary measure.

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Pregnancy

Caution

Limited data are available on the effect of Adicobal-1500 Injection 2 ml in pregnancy. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Adicobal-1500 Injection 2 ml. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Limited data are available on the effect of Adicobal-1500 Injection 2 ml on breastfeeding. Hence, if you are a nursing mother, inform your doctor before receiving Adicobal-1500 Injection 2 ml. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Safe

Adicobal-1500 Injection 2 ml does not impact your ability to drive or use machinery.

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Liver

Caution

Inform your doctor if you have had any history of liver diseases before taking Adicobal-1500 Injection 2 ml. Your doctor will weigh the benefits and potential risks before prescribing Adicobal-1500 Injection 2 ml.

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Kidney

Caution

Inform your doctor if you have had any history of kidney diseases before taking Adicobal-1500 Injection 2 ml. Your doctor will weigh the benefits and potential risks before prescribing Adicobal-1500 Injection 2 ml.

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Children

Unsafe

There was limited information about the usage of Adicobal-1500 Injection 2 ml in paediatric patients. Please seek medical advice. Only if the benefits exceed the dangers will your doctor prescribe.

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Heart

Caution

Adicobal-1500 Injection 2 ml is generally safe for heart patients and supports nerve and metabolic health. However, it's important to consult your doctor to avoid any interaction with cardiac medications.

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Geriatrics

Caution

Geriatric patients can receive Adicobal-1500 Injection 2 ml, as it's generally safe and supports nerve and metabolic health. However, age-related organ changes may increase sensitivity, so medical supervision is important.

What if I have taken an overdose of Adicobal-1500 Injection 2 ml

An overdose is unlikely when the medicine is administered by a healthcare professional. However, excessive pyridoxine exposure over time can cause sensory neuropathy, and very high nicotinamide doses may cause adverse effects such as nausea, vomiting, or liver-related problems. Seek medical attention if an overdose is suspected or if severe symptoms develop.

Diet & Lifestyle Advise

  • Eat a balanced diet: Include B-vitamin-rich foods such as lean meats, fish, eggs, dairy, whole grains, and leafy green vegetables to support recovery.
  • Limit alcohol intake: Excessive alcohol can worsen vitamin deficiency states and should be avoided or strictly limited.
  • Quit smoking: Smoking can hinder recovery and worsen overall vascular and nerve health.
  • Stay hydrated: Drink enough water each day to support general health while receiving parenteral vitamin therapy.
  • Keep follow-up appointments: Routine monitoring helps your doctor assess treatment response and adjust dosing if needed.
health query

Have a query?

How Soon It Starts Working

The time required for Adicobal-1500 Injection 2 ml to start to work: Adicobal-1500 Injection 2 ml ideally shows its action within 2 hours after administration. The time for which the effects of Adicobal-1500 Injection 2 ml last: The duration of action for Adicobal-1500 Injection 2 ml is unknown.

What if you forget to take Adicobal-1500 Injection 2 ml

If you miss an appointment for your injection, contact your doctor or clinic as soon as possible to reschedule. Do not inject a double dose to make up for a missed one.

Storage

• Store Adicobal-1500 Injection 2 ml at or below 30°C and protect it from light. Keep the ampoule in its original carton, and do not freeze the medicine.

Drug Warnings

  • Inspect the vial before use: Do not use the injection if the liquid is cloudy, discoloured, or contains visible particles.
  • Use only once: The ampoule is for single use only and should be discarded after opening.
  • Rotate injection sites: If injections are given regularly, changing the site can help reduce pain and local irritation.
  • Watch for allergic signs: Seek help promptly if you develop itching, rash, facial swelling, or breathing changes after an injection.
  • Keep up with routine blood tests: Your doctor may monitor your vitamin status and related labs to confirm the treatment is working.

Drug-Drug Interactions

verifiedApollotooltip
  • Metformin: Long-term use may be associated with reduced vitamin B12 levels, so monitoring may be needed.
  • Phenytoin and phenobarbital: Serum concentrations have been reported to decrease with concomitant use of mecobalamin.
  • Isoniazid, hydralazine, penicillamine, and oral contraceptives: May increase pyridoxine requirements.
  • Levodopa: Pyridoxine can reduce its effect unless used with an appropriate decarboxylase inhibitor.
  • Carbamazepine, diazepam, and sodium valproate: Niacinamide may potentiate anticonvulsant action and may decrease carbamazepine clearance.
Mecobalamin + Pyridoxine (vit b6) + NicotinamideAtorvastatin
Severe
Mecobalamin + Pyridoxine (vit b6) + NicotinamideLeflunomide
Severe

Drug-Drug Interactions

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Mecobalamin + Pyridoxine (vit b6) + NicotinamideAtorvastatin
Severe
How does the drug interact with Adicobal-1500 Injection 2 ml:
Coadministration of Nicotinamide with Atorvastatin can increase the risk and severity of side effects like rhabdomyolysis (breakdown of skeletal muscle) or kidney damage.

How to manage the interaction:
Taking Nicotinamide with Atorvastatin together is used with caution as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unexplained muscle pain, muscle stiffness or tenderness, fever, dark-colored urine, or weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + Pyridoxine (vit b6) + NicotinamideLeflunomide
Severe
How does the drug interact with Adicobal-1500 Injection 2 ml:
Coadministration of nicotinamide with leflunomide can increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between nicotinamide and leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Mecobalamin + Pyridoxine (vit b6) + NicotinamideKetoconazole
Severe
How does the drug interact with Adicobal-1500 Injection 2 ml:
Taking Nicotinamide with Ketoconazole can increase the risk or severity of liver injury.

How to manage the interaction:
Taking Nicotinamide with Ketoconazole together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any symptoms of fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + Pyridoxine (vit b6) + NicotinamideMipomersen
Severe
How does the drug interact with Adicobal-1500 Injection 2 ml:
Coadministration of Nicotinamide and Mipomersen can increase the risk of liver damage.

How to manage the interaction:
Co-administration of Nicotinamide with Mipomersen can result in an interaction, but it can be taken if your doctor has advised it. It is important to keep a close eye on any signs of liver problems. If you notice any symptoms like fever, joint pain, or loss of appetite, it's best to call a doctor right away. They can help determine if there is any liver damage and provide the necessary treatment. Do not stop using any medications without a doctor's advice.
Mecobalamin + Pyridoxine (vit b6) + NicotinamideTeriflunomide
Severe
How does the drug interact with Adicobal-1500 Injection 2 ml:
Coadministration of Nicotinamide and Teriflunomide can increase the risk of liver damage.

How to manage the interaction:
Taking Nicotinamide with Teriflunomide together can result in an interaction, but it can be taken if your doctor has advised it. It is important to keep a close eye on any signs of liver problems. If you notice any symptoms like fever, joint pain, or loss of appetite, it's best to call a doctor right away. They can help determine if there is any liver damage or bleeding and provide the necessary treatment. Do not stop using any medications without a doctor's advice.
Mecobalamin + Pyridoxine (vit b6) + NicotinamideRosuvastatin
Severe
How does the drug interact with Adicobal-1500 Injection 2 ml:
Coadministration of Nicotinamide with Rosuvastatin may increase the risk and severity of side effects like rhabdomyolysis (breakdown of skeletal muscle) or kidney damage which can be fatal.

How to manage the interaction:
Taking Nicotinamide with Rosuvastatin together can result in an interaction, but it can be taken if your doctor has advised it. If you notice any symptoms like unexplained muscle pain, muscle stiffness or tenderness, fever, dark-coloured urine, or weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
Mecobalamin + Pyridoxine (vit b6) + NicotinamideLomitapide
Severe
How does the drug interact with Adicobal-1500 Injection 2 ml:
Coadministration of Nicotinamide and Lomitapide can increase the risk of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Nicotinamide and Lomitapide, but it can be taken if prescribed by a doctor. It is important to keep an eye out for any signs of liver damage. If you notice any symptoms like fever, joint pain, or loss of appetite, it's a good idea to contact a doctor right away. They can help determine if there is any liver damage and provide appropriate treatment. Do not discontinue any medications without consulting a doctor.
Mecobalamin + Pyridoxine (vit b6) + NicotinamideLovastatin
Severe
How does the drug interact with Adicobal-1500 Injection 2 ml:
Coadministration of Nicotinamide with Lovastatin can increase the risk and severity of side effects like rhabdomyolysis (breakdown of skeletal muscle) or kidney damage.

How to manage the interaction:
Taking high-dose Nicotinamide with Lovastatin together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unexplained muscle pain, muscle stiffness or tenderness, fever, dark-colored urine, or weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + Pyridoxine (vit b6) + NicotinamideSimvastatin
Severe
How does the drug interact with Adicobal-1500 Injection 2 ml:
Coadministration of Nicotinamide with Simvastatin can increase the risk and severity of side effects like rhabdomyolysis (breakdown of skeletal muscle) or kidney damage.

How to manage the interaction:
Taking Nicotinamide with Simvastatin together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unexplained muscle pain, muscle stiffness or tenderness, fever, dark-colored urine, or weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + Pyridoxine (vit b6) + NicotinamidePitavastatin
Severe
How does the drug interact with Adicobal-1500 Injection 2 ml:
Co-administration of Nicotinamide with Pitavastatin can increase the risk and severity of side effects like rhabdomyolysis (breakdown of skeletal muscle).

How to manage the interaction:
Taking Nicotinamide with Pitavastatin together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unexplained muscle pain, muscle stiffness or tenderness, fever, dark-colored urine, or weakness, contact a doctor immediately. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: No direct food interaction is established, but heavy alcohol use can worsen deficiency states and reduce treatment effectiveness.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[VITAMINS]

FAQs

The frequency of Adicobal-1500 Injection 2 ml injections depends on your nutritional deficiency, medical condition, and your doctor's treatment plan. Your doctor will determine the appropriate dose and schedule, which may vary from person to person. Do not take or receive Adicobal-1500 Injection 2 ml more frequently than prescribed.
Many patients begin to feel an increase in energy levels within a few days, but nerve healing is a gradual process. It may take several weeks of consistent treatment to notice a significant reduction in nerve pain or numbness. Talk to your doctor if you do not notice any improvement after a few weeks.
Yes, this medicine generally does not affect your ability to drive. However, if you experience temporary dizziness or lightheadedness immediately after the injection, wait until you feel fully alert before driving. Talk to your doctor if these symptoms persist.
While the nutrients in this injection are essential, high-dose parenteral vitamins should only be used during pregnancy if clearly needed and prescribed by your obstetrician. Talk to your doctor to determine if this treatment is safe for you and your baby.
An injection delivers the nutrients directly into your bloodstream, completely bypassing the digestive tract. This is highly beneficial for people who have gut absorption issues, severe deficiencies, or conditions that make swallowing oral pills difficult. Talk to your doctor about which form is best for your health needs.
It is highly recommended to avoid or limit alcohol while using this medicine. Alcohol impairs your body’s ability to absorb and utilize these essential nutrients, which can make the treatment much less effective. Talk to your doctor for advice on safe alcohol consumption.
Mild pain, redness, or swelling at the injection site is common and usually goes away within a few hours. Applying a cold compress to the area can help relieve discomfort. Talk to your doctor if the pain worsens, or if you notice signs of infection like pus or warmth around the site.
This medicine is not known to cause weight gain directly. However, as it helps restore your energy levels and normal metabolic function, your appetite may improve, which could lead to healthy weight maintenance if you were previously underweight due to illness. Talk to your doctor if you have concerns about weight changes.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

1472, 11Th Main, 38Th Cross, Near Adiyar Ananda Bavan, 4Th T Block, Jayanagar, Bangalore- 560011
Other Info - ADI0246

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