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compositionComposition:DIVALPROEX SODIUM-250MG
prescription
Prescription Medicine
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Adival ER 250 Tablet is used to treat epilepsy, seizures or fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and to prevent migraine. It contains Divalproex sodium, which decreases the brain's excessive and abnormal nerve activity, thereby helping to control seizures. It helps block the nerve transmission across the brain and provides a calming effect. Thereby, helps treat bipolar disorder. In some cases, it may cause common side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DIVALPROEX SODIUM-250MG

Manufacturer/Marketer :

Lotus Life Sciences

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Adival ER 250 Tablet

name is a prescription medication primarily used to control and prevent various types of seizures. It is also prescribed to treat manic episodes associated with bipolar disorder and to prevent migraine headaches in adults. By balancing certain natural chemicals in the brain, it helps manage these neurological and mood-related conditions effectively.

To achieve the best results, you must take Adival ER 250 Tablet consistently at the exact same times every day as directed by your doctor. You can take this medication with or without food, though taking it with meals can help prevent stomach upset. Incorporating stable daily routines, such as managing stress, maintaining a regular sleep schedule, and avoiding alcohol, can significantly support your treatment progress.

While taking Adival ER 250 Tablet , some people may experience mild side effects, such as nausea, sleepiness, or mild dizziness. However, you must contact your doctor immediately if you experience serious symptoms, such as severe upper stomach pain, yellowing of your skin or eyes, or unusual changes in your mood or behaviour.

Before starting Adival ER 250 Tablet , tell your doctor if you have a history of liver problems, pancreas issues, or genetic metabolic disorders. Do not take this medication if you have active liver disease, a mitochondrial disorder, or if you are pregnant, as it can cause serious harm to an unborn baby. Talk to your doctor to find out if this medicine is safe for your specific health history.

This medication can interact with other prescription drugs, alcohol, and certain lifestyle habits, which may change how the medicine works or increase side effects. For example, drinking alcohol while taking this medicine can cause extreme sleepiness and increase the risk of liver issues. If you are pregnant, breastfeeding, or an older adult, consult your doctor or pharmacist to discuss safer treatment options.

Uses of Adival ER 250 Tablet

Adival ER 250 Tablet is used to control and prevent various types of seizures. The detailed uses of Adival ER 250 Tablet are as follows:

  • Epilepsy and Seizures: Adival ER 250 Tablet helps reduce the frequency and intensity of seizures by calming overactive electrical activity in the brain.
  • Bipolar Mania: Adival ER 250 Tablet treats periods of extreme highs, irritability, or excitement by balancing chemical signals in the brain to help stabilise your mood.
  • Migraine Prevention: Adival ER 250 Tablet reduces the number of migraine attacks you experience when taken daily, helping prevent severe head pain before it starts.

Key Benefits

Adival ER 250 Tablet helps manage certain neurological conditions by stabilising electrical activity in the brain. Depending on the condition being treated, it helps control seizures, stabilise mood, or reduce the frequency of migraine attacks, supporting better daily functioning and quality of life.

  • Helps Control Seizures: By reducing abnormal electrical activity in the brain, Adival ER 250 Tablet helps decrease the frequency of seizures, allowing you to carry out daily activities with greater safety and confidence.
  • Supports Mood Stability: For individuals with bipolar disorder, Adival ER 250 Tablet helps reduce mood swings and prevent manic episodes, promoting a more balanced emotional state and improving day-to-day functioning.
  • Helps Prevent Migraine Attacks: When used for migraine prevention, Adival ER 250 Tablet helps reduce the frequency of migraine episodes, allowing you to enjoy your daily activities with fewer painful interruptions and less reliance on rescue pain medicines.

Directions for Use

  • Adival ER 250 Tablet can be taken with or without food, or as advised by the doctor.
  • It is usually taken once daily; however, your doctor may adjust the dose and frequency based on your medical condition.
  • Swallow Adival ER 250 Tablet as a whole with a glass of water.
  • Do not crush, chew, break, or open it.

How Adival ER 250 Tablet Works

Inside the brain, nerve cells communicate using electrical and chemical signals. Sometimes, these signals become hyperactive or unbalanced, leading to seizures, mood swings, or migraines. Adival ER 250 Tablet works by increasing the activity of a natural chemical messenger in the brain called gamma-aminobutyric acid (GABA). GABA acts as a natural brake system, calming down overactive nerve cells and restoring balance. This soothing effect prevents the sudden electrical rushes that cause seizures and helps stabilise your overall brain activity.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Adival ER 250 Tablet , as it may cause increased dizziness.

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Pregnancy

Unsafe

Adival ER 250 Tablet belongs to pregnancy category D. Avoid taking Adival ER 250 Tablet if you are pregnant, as it could lead to serious birth defects. Consult your doctor for further advice.

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Breast Feeding

Consult your doctor

Adival ER 250 Tablet may pass into breastmilk. Consult your doctor before taking Adival ER 250 Tablet if you are breastfeeding.

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Driving

Unsafe

Adival ER 250 Tablet causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery until you are mentally alert.

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Liver

Unsafe

Adival ER 250 Tablet should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns regarding this. Dose adjustment may be needed in patients with kidney impairment.

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Children

Caution

Adival ER 250 Tablet can be given to children if prescribed by the doctor. The doctor will adjust the dose depending on the child's body weight. Care should be taken in children below 2 years as they are at a higher risk of liver toxicity.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Caution

Adival ER 250 Tablet can be given in elderly patients with extreme caution due to the serious adverse effects.

What if I have taken an overdose of Adival ER 250 Tablet

If you take too much of this medication, seek immediate emergency medical care or contact your local poison control centre. Symptoms of an overdose may include extreme sleepiness, shallow breathing, weak muscles, or a slow heartbeat.

Diet & Lifestyle Advise

  • Keep a consistent sleep schedule of 7 to 8 hours per night, as sleep deprivation is a known trigger for seizures, manic episodes, and migraines.
  • Stay properly hydrated throughout the day, as dehydration can worsen side effects like dizziness and headaches.
  • Avoid alcohol entirely while taking this medication, as it severely interacts with Adival ER 250 Tablet to cause extreme sleepiness and increases the risk of liver complications.
  • Maintain a detailed symptom diary to track the frequency of your seizures, mood changes, or migraine triggers, and share this information during your medical check-ups.
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How Soon It Starts Working

  • The time required for Adival ER 250 Tablet to start to work: The time required for Adival ER 250 Tablet to show its action is unknown.
  • The time for which the effects of Adival ER 250 Tablet last: The duration of action for Adival ER 250 Tablet is unknown.

What if you forget to take Adival ER 250 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your normal routine. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you frequently miss doses.

Storage

•Store Adival ER 250 Tablet at room temperature, ideally between 68°F and 77°F (20°C to 25°C). •Keep the medication in its original container with the lid tightly closed to protect it from moisture and direct light.

Drug Warnings

  • Do not stop taking Adival ER 250 Tablet suddenly, even if you feel completely fine, as abrupt discontinuation can trigger severe, continuous seizures.
  • If you are of childbearing age, use a highly effective form of birth control while taking this medicine to prevent unplanned pregnancies due to the risk of severe birth defects.
  • Check your body regularly for any unusual bruising, purple spots, or bleeding from the gums, and notify your doctor immediately if they occur.
  • Avoid driving, riding a bicycle, or operating machinery until you are certain how this medicine affects your alertness and coordination.
  • Keep a medical ID card in your wallet or wear an emergency alert bracelet to notify medical personnel that you are taking this medication in an emergency.

Drug-Drug Interactions

verifiedApollotooltip
  • Aspirin: Taking aspirin can increase the amount of Adival ER 250 Tablet in your blood, which may raise your risk of experiencing harmful side effects.
  • Other seizure medications (such as phenytoin, carbamazepine, or phenobarbital): These drugs can change how your body processes Adival ER 250 Tablet , which may require your doctor to adjust your doses.
  • Blood thinners (such as warfarin): Combining these with Adival ER 250 Tablet can increase your risk of bleeding or bruising.
Sodium ValproateSodium phenylbutyrate
Critical
Sodium ValproateLithium
Severe

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with Adival ER 250 Tablet:
Combining Sodium phenylbutyrate and Adival ER 250 Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Adival ER 250 Tablet is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateLithium
Severe
How does the drug interact with Adival ER 250 Tablet:
Co-administration of Lithium with Adival ER 250 Tablet can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Adival ER 250 Tablet can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
Sodium ValproateMeropenem
Severe
How does the drug interact with Adival ER 250 Tablet:
Co-administration of Meropenam and Adival ER 250 Tablet together can reduce the effect of Adival ER 250 Tablet.

How to manage the interaction:
Co-administration of Meropenam and Adival ER 250 Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateDoripenem
Severe
How does the drug interact with Adival ER 250 Tablet:
Co-administration of Adival ER 250 Tablet with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Adival ER 250 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateVorinostat
Severe
How does the drug interact with Adival ER 250 Tablet:
Co-administration of Vorinostat with Adival ER 250 Tablet can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Adival ER 250 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateBuprenorphine
Severe
How does the drug interact with Adival ER 250 Tablet:
Using buprenorphine together with Adival ER 250 Tablet may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Adival ER 250 Tablet can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateErtapenem
Severe
How does the drug interact with Adival ER 250 Tablet:
The combined use of Ertapenem and Adival ER 250 Tablet can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Adival ER 250 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.
Sodium ValproateTeriflunomide
Severe
How does the drug interact with Adival ER 250 Tablet:
Co-administration of Teriflunomide and Adival ER 250 Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Adival ER 250 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateLeflunomide
Severe
How does the drug interact with Adival ER 250 Tablet:
Co-administration of Leflunomide and Adival ER 250 Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Adival ER 250 Tablet can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateKetamine
Severe
How does the drug interact with Adival ER 250 Tablet:
Co-administration of Ketamine and Adival ER 250 Tablet can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Adival ER 250 Tablet can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Drinking alcohol can cause severe drowsiness and dizziness and significantly increases the risk of developing liver damage.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Adival ER 250 Tablet belongs to a group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, Adival ER 250 Tablet is also used to treat manic episodes associated with bipolar disorder and to prevent migraine.
Adival ER 250 Tablet contains 'Divalproex sodium', which decreases the brain's excessive and abnormal nerve activity, thereby helping to control seizures. Adival ER 250 Tablet increases the amount of a chemical substance called GABA, which helps block the nerve transmission across the brain and provides a calming effect. Thereby, it helps treat bipolar disorder.
Adival ER 250 Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, which helps in blocking the nerve transmission across the brain and provides a calming effect.
Adival ER 250 Tablet limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition characterised by intense headaches.
Do not discontinue Adival ER 250 Tablet without consulting your doctor. To treat your condition effectively, continue taking Adival ER 250 Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Adival ER 250 Tablet . Your doctor will reduce the dose gradually to avoid worsening of seizures.
Adival ER 250 Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.
Use an effective method of contraception during the treatment with Adival ER 250 Tablet . Avoid getting pregnant while taking Adival ER 250 Tablet as it could lead to serious birth defects. Do not stop taking Adival ER 250 Tablet and consult your doctor immediately if you become pregnant.
Adival ER 250 Tablet may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking Adival ER 250 Tablet .
Topiramate (anticonvulsant) should not be taken along with Adival ER 250 Tablet as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.
It is crucial to consult with your doctor before discontinuing Adival ER 250 Tablet . Abruptly stopping this medication can lead to severe consequences, mainly if it's prescribed to treat conditions like epilepsy.
Adival ER 250 Tablet is also used to treat mood disorders. It treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block nerve transmission across the brain and provides a calming effect.
Adival ER 250 Tablet can indeed make you sleepy. This is a common side effect of the medication. If you're experiencing excessive drowsiness, please consult your doctor.
Yes, Adival ER 250 Tablet can cause hair loss as a side effect. While this isn't a common side effect, it can occur in some people. If you notice significant hair loss while taking Adival ER 250 Tablet , it's essential to consult with your doctor.
Yes, Adival ER 250 Tablet can potentially damage your liver. While this is a rare side effect, being aware of the risk is essential. Signs of liver damage may include yellowing of the skin or eyes or jaundice, dark urine, abdominal pain, light-coloured stools, nausea and vomiting. If you experience any of these symptoms while taking Adival ER 250 Tablet , seeking medical attention is crucial.
Avoid consumption of alcohol while taking Adival ER 250 Tablet , as it may cause increased dizziness.
If you experience abdominal pain, nausea, and anorexia while taking Adival ER 250 Tablet , it's essential to contact your doctor immediately. These symptoms can be signs of a severe side effect, such as liver damage.
An overdose of Adival ER 250 Tablet can be a severe medical emergency. The symptoms of an overdose may include heart block, excess sleepiness, and deep coma. If you or someone you know has taken an overdose of Adival ER 250 Tablet , please seek immediate medical attention.
Yes, temporary hair thinning or loss can occur in some people taking Adival ER 250 Tablet . This effect is usually temporary and reversible once the medication is stopped or adjusted, but you should never stop taking it on your own. Talk to your doctor or pharmacist if you notice significant hair changes.
Your doctor will order regular blood tests to check the level of the medicine in your body, monitor your liver health, and measure your blood clotting cells (platelets). This helps ensure the medicine is working safely and effectively. Talk to your doctor about your testing schedule.
Yes, you can take Adival ER 250 Tablet with food. In fact, taking it during or immediately after a meal is highly recommended if you experience nausea or stomach upset. Talk to your doctor or pharmacist if stomach discomfort persists.
Yes, drowsiness and dizziness are common side effects of Adival ER 250 Tablet , especially when you first start taking it or when your dose is increased. Avoid driving or operating machinery until you know how it affects you. Talk to your doctor if the sleepiness interferes with your daily life.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one and return to your regular schedule; do not double the dose. Talk to your doctor or pharmacist if you frequently miss doses.
Moderate amounts of caffeine from coffee or tea are generally fine, but excessive caffeine can trigger migraines or affect your sleep patterns, which may interfere with your treatment goals. Talk to your doctor or pharmacist for personalised dietary advice.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 018723S037Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. DailyMed Database. Fdadrugxsl.Cfm Clinical Monograph. Bethesda, MD: National Library of Medicine; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Divalproex Sodium Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Sodium valproate: medicine to treat epilepsy and bipolar disorder [Internet]. nhs.uk. 2025 [Accessed on 10 April 2025]Check here
  5. CDSCO [Internet]. Cdscoonline.gov.in. 2025 [Accessed on 10 April 2025]Check here
  6. Depakote Formulations. [Accessed on 02 Jun. 2026]Check here
  7. Sanofi India — Pharmaceutical Products. Sanofi.com [Internet]. [Accessed on 2026 Jan 1]Check here

Country of origin

INDIA

Manufacturer/Marketer address

105, Hare Krishna Complex, B/H City Gold Cinema, Ashram Road, Ahmedabad- 380 009, Gujarat (INDIA).
Other Info - ADI0082

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