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  3. Afinitor 5 mg Tablet 10's

Afinitor 5 mg Tablet 10's, Pack of 10 TABLETS
Afinitor 5 mg Tablet 10's, Pack of 10 TABLETS
Afinitor 5 mg Tablet 10's, Pack of 10 TABLETS
Afinitor 5 mg Tablet 10's, Pack of 10 TABLETS
Afinitor 5 mg Tablet 10's, Pack of 10 TABLETS
Afinitor 5 mg Tablet 10's, Pack of 10 TABLETS
Afinitor 5 mg Tablet 10's, Pack of 10 TABLETS
Afinitor 5 mg Tablet 10's, Pack of 10 TABLETS
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Afinitor 5 mg Tablet is used to treat cancer and to prevent organ rejection. It contains Everolimus which works by stopping cancer cells from reproducing and decreasing the activity of the immune system. In some cases, this medicine may cause side effects such as weakness, infection, cough, diarrhoea, fever, and fatigue. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

EVEROLIMUS-5MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Afinitor 5 mg Tablet

Afinitor 5 mg Tablet belongs to the group of medicine called ‘anti-cancer’. It is primarily used to treat breast cancer, pancreatic cancer, lung cancer and kidney cancer. Breast cancer is a type of cancer that develops in breast cells stimulated by the female sex hormone known as estrogen. Pancreatic cancer is described as a cancerous growth in the pancreas which normally begins in the cells that generate the juices that help break down food and the hormones which help in controlling blood sugar levels. Lung cancer is the uncontrolled growth of abnormal cells in one or both lungs. 

Afinitor 5 mg Tablet contains 'Everolimus' which belongs to the group of medicines known as 'kinase inhibitors'. It works by decreases the activity of the immune system of the body and prevents rejection of the transplanted organ. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells.

Take Afinitor 5 mg Tablet as prescribed by your doctor. You are advised to take Afinitor 5 mg Tablet for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience weakness, infection, sinus inflammation, cough, diarrhea, fever, fatigue, otitis media (infection of the ear), stomatitis (Inflammation of the mouth) and upper respiratory tract infection. Most of these side effects of Afinitor 5 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

To treat your condition effectually, continue taking Afinitor 5 mg Tablet for as long as your doctor has prescribed. If you are known to be allergic to Afinitor 5 mg Tablet or any other medicines, please tell your doctor. Do not take Afinitor 5 mg Tablet if you are pregnant or planning for pregnancy as Afinitor 5 mg Tablet may harm the unborn baby. Afinitor 5 mg Tablet should not be taken by breastfeeding mothers as it may cause harm to the newborn baby. Afinitor 5 mg Tablet causes tiredness, thus, it is advisable not to drive unless you are alert. Elderly people are more sensitive to medicine so they may adjust the dosage according to their condition.

Uses of Afinitor 5 mg Tablet

Treatment of Breast cancer, pancreatic cancer, lung cancer and kidney cancer.

Directions for Use

Take Afinitor 5 mg Tablet with or without food as advised by the doctor. Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Afinitor 5 mg Tablet is indicated to the patients dealing with breast cancer, pancreatic cancer, lung cancer, kidney cancer and stomach/ intestinal cancer. Cancer of this type tends to spread quickly in other parts of the body. Afinitor 5 mg Tablet travels through the bloodstream and effectively destroys cancerous cells and other parts of the body. It works by decreases the activity of the immune system of the body and prevents rejection of the transplanted organ. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells. Besides this, it is also effective in people with genetic disorders to treat some types of tumors in the brain or kidney.

How Afinitor 5 mg Tablet Works

Afinitor 5 mg Tablet contains 'Everolimus' which belongs to the group of medicines known as 'kinase inhibitors'. It works by decreases the activity of the immune system of the body and prevents rejection of the transplanted organ. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells.

Storage

Store in a cool and dry place away from sunlight
Side effects of Afinitor 5 mg Tablet
  • Eat more plant based foods like vegetables, fruits and whole grains.
  • Reduce intake of foods containing high fat such as dairy, oil and red meat.
  • Exercise for at least 30 minutes 5 days a week.
  • Aim for weight loss and maintain healthy weight.
  • Quit smoking.
  • Control blood sugar and blood pressure.
  • Stay hydrated by taking fluids like water, juices and soups etc.
  • Eat fruits and vegetables which contain vitamins.
  • Take iron rich food like dry fruits, green leafy vegetables and sea food etc.
  • Reduce intake of milk, cheese, yogurt, soy, chocolate, ice cream, Grapes, Popcorn, canned salmon, pomegranate.
  • Regular exercise like walking, jogging is helpful.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Get plenty of rest and avoid activities that tire you out to allow your body fight the infection.
  • Drink lots of fluids to help loosen mucus in the lungs.
  • Use over-the-counter medications like paracetamol or ibuprofen to manage fever.
  • Use a humidifier as it helps soothe irritated airways.
  • Do not make changes to your medication schedule or take over-the-counter medicines without consulting your doctor.
  • Eat a healthy balanced diet.
  • Reduce stress with relaxation techniques such as yoga or meditation.
  • Keep track of your menstrual cycle any irregularities.
  • Have regular check ups to exclude other health problems.
  • Exercise but do not exercise to the extent of overheating.
  • Hydrate well, eat well (particularly iron and vitamins).
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
Managing Medication-Triggered Epistaxis (Nosebleed): A Step-by-Step Guide:
  • If you experience nosebleeds or unusual bleeding after taking medication, seek medical attention right away and schedule an appointment to discuss your symptoms with your doctor.
  • Your doctor may adjust your treatment plan by changing the dosage, switching to a different medication, or stopping the medication.
  • If your doctor advises, take steps to manage bleeding and promote healing, such as applying pressure, using saline nasal sprays, or applying a cold compress, using humidifiers, avoiding blowing or picking your nose, and applying petroleum jelly to the nostrils.
  • Schedule follow-up appointments with your doctor to monitor progress, adjust treatment plans, and prevent future episodes.

What if I have taken an overdose of Afinitor 5 mg Tablet

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

If you are known to be allergic to Afinitor 5 mg Tablet or any other medicines, please tell your doctor. Afinitor 5 mg Tablet should not be taken in the conditions like liver disease, diabetes and high level of cholesterol. Do not take Afinitor 5 mg Tablet if you have recent surgery, infection and hepatitis B. Afinitor 5 mg Tablet may weaken your immune system, inform your doctor before taking Afinitor 5 mg Tablet . Afinitor 5 mg Tablet may also impair your kidney function. Therefore, monitor your kidney function regularly while taking Afinitor 5 mg Tablet . Afinitor 5 mg Tablet may cause cough, fever and shortness of breathing, thereby inform your doctor while taking your Afinitor 5 mg Tablet . Afinitor 5 mg Tablet may cause skin cancer, if you observe night sweating, weight loss, or change in color and size of the mole inform your doctor. Do not take Afinitor 5 mg Tablet if you are pregnant or planning for pregnancy as Afinitor 5 mg Tablet may harm the unborn baby. Afinitor 5 mg Tablet should not be taken by breastfeeding mothers as it may cause harm to the newborn baby. Afinitor 5 mg Tablet causes tiredness, thus, it is advisable not to drive unless you are alert. Elderly people are more sensitive to medicine so they may adjust the dosage according to their condition.

Drug-Drug Interactions

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EverolimusKetorolac
Severe
EverolimusNeomycin
Severe

Drug-Drug Interactions

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EverolimusKetorolac
Severe
How does the drug interact with Afinitor 5 mg Tablet:
Coadministration of Afinitor 5 mg Tablet with ketorolac may increase the risk of kidney problems.

How to manage the interaction:
Although taking Ketorolac and Afinitor 5 mg Tablet together can result in an interaction, but it can be taken if a doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, swelling, breathing difficulty, pain, weakness, tiredness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without consulting a doctor.
EverolimusNeomycin
Severe
How does the drug interact with Afinitor 5 mg Tablet:
Afinitor 5 mg Tablet can cause kidney issues, and taking it with Neomycin, can enhance the risk.

How to manage the interaction:
Although taking Afinitor 5 mg Tablet and Neomycin together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not stop using any medications without talking to a doctor.
EverolimusNelfinavir
Severe
How does the drug interact with Afinitor 5 mg Tablet:
Taking Afinitor 5 mg Tablet with nelfinavir can considerably raise blood levels of Afinitor 5 mg Tablet, increasing the risk of serious side effects (pneumonitis - lung inflammation, infection, mouth ulcers, anemia, or bleeding).

How to manage the interaction:
Although taking Afinitor 5 mg Tablet and Nelfinavir together can cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without a doctor's advice.
EverolimusZafirlukast
Severe
How does the drug interact with Afinitor 5 mg Tablet:
When Afinitor 5 mg Tablet is taken with Zafirlukast, the amount of Afinitor 5 mg Tablet in the blood can go up.

How to manage the interaction:
Co-administration of Zafirlukast with Afinitor 5 mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
EverolimusBaricitinib
Severe
How does the drug interact with Afinitor 5 mg Tablet:
Coadministration of baricitinib and Afinitor 5 mg Tablet can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Afinitor 5 mg Tablet if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
EverolimusGriseofulvin
Severe
How does the drug interact with Afinitor 5 mg Tablet:
When Afinitor 5 mg Tablet is taken with Griseofulvin, it may decrease the blood levels of Afinitor 5 mg Tablet, which may make Afinitor 5 mg Tablet less effective in treating the condition.

How to manage the interaction:
There may be a possibility of interaction between Afinitor 5 mg Tablet and Griseofulvin, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
EverolimusAmprenavir
Severe
How does the drug interact with Afinitor 5 mg Tablet:
Taking Afinitor 5 mg Tablet with Amprenavir can considerably raise blood levels of Afinitor 5 mg Tablet, increasing the risk of serious side effects (pneumonitis - lung inflammation, infection, mouth ulcers, anemia, or bleeding).

How to manage the interaction:
Taking Afinitor 5 mg Tablet with Amprenavir together can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
EverolimusMifepristone
Severe
How does the drug interact with Afinitor 5 mg Tablet:
Co-administration of Afinitor 5 mg Tablet with mifepristone may significantly increase the risk of side effects.

How to manage the interaction:
Taking Afinitor 5 mg Tablet with mifepristone together can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
EverolimusLetermovir
Severe
How does the drug interact with Afinitor 5 mg Tablet:
Taking Afinitor 5 mg Tablet with letermovir can considerably raise blood levels of Afinitor 5 mg Tablet, increasing the risk of serious side effects (pneumonitis - lung inflammation, infection, mouth ulcers, anemia, or bleeding).

How to manage the interaction:
Although taking Afinitor 5 mg Tablet and Letermovir together can cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without a doctor's advice.
EverolimusColistin
Severe
How does the drug interact with Afinitor 5 mg Tablet:
Coadministration of Colistin with Afinitor 5 mg Tablet can increase the risk of developing kidney problems.

How to manage the interaction:
Although there is a possible interaction between Colistin and Afinitor 5 mg Tablet, it can be taken if prescribed by a doctor. However, if you experience vomiting, irregular urination, sudden weight gain or loss, swelling, shortness of breath, or weakness, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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EVEROLIMUS-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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EVEROLIMUS-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Taking Afinitor 5 mg Tablet with grapefruit juice can raise blood levels and enhance the effects of Afinitor 5 mg Tablet. Since the co-administration of Afinitor 5 mg Tablet along with grapefruit juice can lead to an interaction, You should not consume grapefruit juice or eat grapefruits while taking Afinitor 5 mg Tablet.

Diet & Lifestyle Advise

  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yogurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep, rest well.
  • Performing yoga and other relaxation techniques may also improve physical and mental health and may reduce your stress levels.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Afinitor 5 mg Tablet Substitute

Substitutes safety advice

  • Evermil 5 Tablet 10's

    by AYUR

    ₹463.30per tablet

  • Rolimus 5 Tablet

    by AYUR

    ₹601.63per tablet

  • Everbliss 5mg Tablet

    by Others

    ₹487.73per tablet

  • EVERTOR 5MG TABLET

    by Others

    ₹1621.77per tablet

  • Everbliss 5 Tablet 10's

    by Others

    ₹594.75per tablet

Product Substitutes

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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Afinitor 5 mg Tablet to avoid unpleasant side-effects.

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Pregnancy

Unsafe

Afinitor 5 mg Tablet is belonging to pregnancy C category. It is not safe in pregnancy as it may causes harm to the unborn baby. Do not conceive a baby while taking Afinitor 5 mg Tablet .

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Breast Feeding

Unsafe

Afinitor 5 mg Tablet should not be taken by breastfeeding mothers as it may harm to the new-born baby.

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Driving

Caution

Afinitor 5 mg Tablet may cause tiredness (fatigue), do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Afinitor 5 mg Tablet should be taken with caution in patients dealing with liver disease. The doctor may adjust the dose according to the medical condition of the patient.

bannner image

Kidney

Caution

Afinitor 5 mg Tablet is likely unsafe in patients with severe kidney disease as it may cause kidney failure which can be dangerous, use Afinitor 5 mg Tablet only when prescribed by a doctor.

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Children

Unsafe

Afinitor 5 mg Tablet is not recommended for children below 18 years as the safety and effectiveness were not established.

Have a query?

FAQs

Afinitor 5 mg Tablet is used to treat breast cancer, pancreatic cancer, lung cancer and kidney cancer.

Afinitor 5 mg Tablet is an anticancer medicine. It belongs to a group of medicines known as a kinase inhibitor. It works by lowering the blood supply to the tumor, which reduces the growth and spread of cancer cells.

There is no specific duration of treatment with Afinitor 5 mg Tablet . Afinitor 5 mg Tablet is continued till benefit is seen or undesirable toxicity or side effects occur.

You should prevent grapefruit or grapefruit juice while taking Afinitor 5 mg Tablet . This is because taking them together may rise the levels of Afinitor 5 mg Tablet in your blood to toxic levels. Avoid the use of live vaccinations and any probable contact with people who have received live vaccinations.

Afinitor 5 mg Tablet can lead to serious side effects that consist of severe allergic reactions, angioedema (painless swelling under the skin) and kidney failure which can be dangerous and can lead to death. It is possible that you may develop an infection or problems associated to lungs like breathing problems.

It usually takes three to six months for most types of lung cancer to double their size. It will take a long time for lung cancer to reach a size that could be diagnosed in X-Ray.

Afinitor 5 mg Tablet contains Everolimus, which belongs to the group of medicines known as kinase inhibitors.

Regular monitoring is essential when using Afinitor 5 mg Tablet . Your doctor may check your blood tests, blood sugar, blood pressure, and kidney function. They may also adjust your dose based on your response to treatment or any side effects that occur. It's essential to report any changes or concerns to your doctor to ensure safe and effective treatment.

While taking Afinitor 5 mg Tablet , avoiding certain things is essential to ensure your safety. Avoid consuming grapefruit juice and products and St. John's Wort, as they can interact with the medication. Certain antibiotics, antifungals, and medications can also interact with Everolimus, so consult your doctor before taking any new medications. Additionally, consult your doctor before receiving any vaccinations and avoid high-risk activities that may increase the risk of infections and bleeding. It's also important to avoid getting pregnant or fathering a child while taking Everolimus, as well as breastfeeding. Finally, limit your sun exposure to avoid increasing the risk of skin cancer. Always consult your doctor or pharmacist for a comprehensive list of medications and activities to avoid while taking Everolimus.

Before using any medication, including Afinitor 5 mg Tablet , you should know its purpose, usage, safety profile, precautions, and limitations.

Afinitor 5 mg Tablet is administered orally in the form of a tablet. Take Everolimus with or without food, as advised by your doctor. Swallow the tablet whole with water; do not crush, break, or chew it. Note: It's important to follow your doctor's instructions and take Afinitor 5 mg Tablet exactly as prescribed

By regularly monitoring your progress through brain scans and other evaluations, your doctor can determine if Afinitor 5 mg Tablet is effectively shrinking your brain tumor.

Afinitor 5 mg Tablet is indeed considered a cytotoxic medication, but it's a targeted therapy that specifically targets cancer cells and inhibits their growth. It's not a traditional chemotherapy medication, but it can still have side effects and be harmful to healthy cells to some extent. If you have any concerns or questions, please consult your doctor or healthcare team to discuss potential risks and benefits and manage any side effects.

Common side effects of Afinitor 5 mg Tablet may include weakness, infection, sinus inflammation, cough, diarrhoea, fever, fatigue, otitis media (infection of the ear), stomatitis (Inflammation of the mouth) and upper respiratory tract infection. Most of these side effects of Afinitor 5 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - AFI0013

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:48 PM IST

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Reference

  1. https://www.drugs.com/mtm/everolimus.html
  2. https://www.medicines.org.uk/emc/files/pil.11084.pdf
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