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compositionComposition:AMITRIPTYLINE-25MG
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Prescription Medicine
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AMITRIPTYLINE-25MG

Manufacturer/Marketer :

Sigma Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Amitril 25 Tablet

Amitril 25 Tablet is an oral prescription medication primarily used to treat depression and help elevate mood. Doctors also prescribe this medicine to help prevent migraine headaches and manage certain types of long-term nerve pain. It belongs to a class of medicines known as tricyclic antidepressants, which work by balancing natural chemicals in the brain.

For the best results, you should take Amitril 25 Tablet consistently every day, exactly as prescribed by your doctor, even if you begin to feel better. You can take this medication with or without food, though taking it with food may help prevent an upset stomach. Combining this treatment with regular sleep patterns, gentle exercise, and stress-reduction techniques can significantly support your overall recovery.

Some people may experience mild side effects when starting Amitril 25 Tablet , such as drowsiness, dry mouth, or mild constipation. While these issues often improve as your body adjusts, you must contact your healthcare provider immediately if you experience serious symptoms like a fast or irregular heartbeat, severe dizziness, or unusual changes in your mood.

Do not take this if you have recently had a heart attack or are currently taking certain medications for depression known as monoamine oxidase inhibitors (MAOIs). Talk to your doctor before starting Amitril 25 Tablet if you have a history of heart disease, liver damage, glaucoma, seizures, or difficulty urinating.

Drinking alcohol while taking Amitril 25 Tablet can cause extreme drowsiness and increase the risk of dangerous breathing difficulties, so it should be avoided. You should also talk to your doctor or pharmacist if you are pregnant, breastfeeding, or are an elderly individual, as you may be more sensitive to the effects of this medicine.

Uses of Amitril 25 Tablet

Amitril 25 Tablet is used to treat depression. The detailed uses of Amitril 25 Tablet are as follows:

  • Depression: Amitril 25 Tablet helps elevate mood, reduce anxiety, and improve daily energy levels by balancing chemical messengers in the brain.
  • Neuropathic pain: It relieves chronic nerve pain, such as burning or tingling sensations caused by nerve damage, by altering how your body processes pain signals.
  • Migraine prevention: Taken daily, it reduces the frequency and severity of migraine attacks, though it is not used to treat a migraine headache that has already started.
  • Fibromyalgia: It can help improve sleep quality and reduce widespread muscle pain and tenderness associated with this condition.
     

Key Benefits

Amitril 25 Tablet helps manage multiple conditions by influencing certain chemical messengers in the brain. By improving mood, reducing nerve-related pain, and helping prevent migraine attacks, it supports overall well-being and enhances day-to-day functioning. This medicine offers several key benefits:

  • Supports Improved Mood and Emotional Well-Being: Amitril 25 Tablet helps restore the balance of important brain chemicals involved in mood regulation. This can lead to gradual improvements in feelings of sadness, anxiety, and emotional distress, while also supporting better sleep quality, energy levels, and overall mental well-being.
  • Provides Relief from Nerve Pain: By reducing abnormal pain signals sent by damaged or irritated nerves, Amitril 25 Tablet helps relieve persistent nerve-related pain. This can make everyday activities more comfortable, improve mobility, and support a better quality of life.
  • Helps Prevent Migraine Attacks: Amitril 25 Tablet can help reduce the frequency and severity of migraine episodes when taken regularly as prescribed. By preventing migraine attacks before they occur, it helps minimise disruptions to daily activities and allows for a more active and productive lifestyle.
     
Side effects of Amitril 25 Tablet
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Try to practice deep breathing exercises or repeat calming words or phrases.
  • Seek for medical help if aggression occurs frequently, as it can worsen gradually if not attended.
  • You can also try listening to music or relaxing or writing a journal to express the feeling that aggravates to find a solution.
  • Consume controlled amounts of salt to raise sodium levels.
  • Eat fresh fruits like apples, berries, oranges, mangoes, and bananas.
  • Include fresh vegetables like broccoli, sweet potatoes, beets, okra, spinach, peppers, carrots, and edamame.
  • Choose frozen vegetables without added butter or sauce.
  • Drink electrolyte beverages like sports drinks or electrolyte solutions to replenish sodium and other electrolytes.
  • Avoid excessive salt intake, but allow for controlled increases as needed.
  • Monitor and manage underlying health conditions that may contribute to hyponatremia.
  • Quit smoking as smoking impairs erectile function by significantly damaging blood vessels.
  • Maintain a healthy weight as overweight can cause erectile dysfunction.
  • Exercise regularly as physical activity enhances blood flow and overall health, benefiting erectile function.
  • Consume a healthy diet loaded with whole grains, fruits and vegetables.
  • Limit alcohol consumption as excessive alcohol intake can impair erectile function.
  • Manage stress by practicing techniques such as yoga, relaxation exercises or meditation.
  • In case erectile dysfunction is due to psychological factors, consider couple counselling or sex therapy to address relationship and anxiety issues.
  • Openly discuss your concerns with your partner.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

To get the full benefit of Amitril 25 Tablet and minimise side effects, follow these simple guidelines:

  • Take Amitril 25 Tablet oral tablets by mouth, typically once daily, often at bedtime to help manage drowsiness.
  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can affect how the medicine is released into your body.
  • You can take this medicine with or without food, but keeping your choice consistent each day is recommended.
  • Always follow your doctor's exact instructions regarding how and when to take Amitril 25 Tablet , and do not stop taking it suddenly without consulting them first.

 

How Amitril 25 Tablet Works

Amitril 25 Tablet works by increasing the levels of certain natural chemical messengers in the brain, specifically serotonin and norepinephrine. These chemicals are responsible for regulating your mood and blocking pain signals sent along your nerves. By preventing the brain from reabsorbing these chemicals too quickly, Amitril 25 Tablet prolongs their active presence. This helps stabilise your emotional state and reduces the transmission of chronic pain signals to the brain, providing comfort over time.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Amitril 25 Tablet as it may cause an increased sedative effect.

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Pregnancy

Consult your doctor

Avoid taking Amitril 25 Tablet if you are pregnant unless prescribed by a doctor. Please consult your doctor if you have any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor before taking Amitril 25 Tablet ; your doctor will decide whether breastfeeding mothers can take Amitril 25 Tablet or not.

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Driving

Unsafe

Amitril 25 Tablet causes sleepiness, dizziness and drowsiness. Do not drive or operate machinery if you experience these symptoms.

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Liver

Consult your doctor

Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Amitril 25 Tablet can be given to children above 6 years if prescribed by the doctor for treating bedwetting. Amitril 25 Tablet should not be given to children for treating depression or neuropathic pain.

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Heart

Caution

Extreme caution should be exercised in cardiac patients while taking Amitril 25 Tablet . The patient should be closely monitored for any changes.

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Geriatrics

Consult your doctor

Please consult a doctor before giving Amitril 25 Tablet to geriatric patients. Your doctor will prescribe Amitril 25 Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Amitril 25 Tablet

Do not take more than the prescribed dose of Amitril 25 Tablet as it may cause an overdose. The symptoms of overdose include irregular heartbeat, seizures (fits), confusion, coma, hallucinations, drowsiness, or fever. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Sip water frequently, chew sugar-free gum, or suck on hard sugar-free candies to relieve dry mouth caused by this medication.
  • Increase your daily intake of dietary fiber and drink plenty of water to help prevent or manage constipation, which is a common side effect.
  • Stand up slowly from sitting or lying positions to minimize the risk of dizziness or fainting due to sudden drops in blood pressure.
  • Protect your skin from the sun by wearing sunscreen and protective clothing, as Amitril 25 Tablet can make your skin more sensitive to sunlight.
  • Avoid driving or operating machinery until you know how Amitril 25 Tablet affects your alertness, especially during the first few weeks of treatment.

 

Have a query?

How Soon It Starts Working

  • The time required for Amitril 25 Tablet to start to work: Amitril 25 Tablet ideally shows its action within 4 to 6 weeks after administration.
  • The time for which the effects of Amitril 25 Tablet last: The effect of Amitril 25 Tablet lasts for 5 days.

What if you forget to take Amitril 25 Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue your regular schedule. Do not take a double dose.

Storage

•Store Amitril 25 Tablet oral tablets at room temperature, ideally between 20°C to 25°C (68°F to 77°F). • Keep the tablets in their original container, tightly closed, to protect them from direct light and moisture.

Drug Warnings

  • Never stop taking Amitril 25 Tablet suddenly, as doing so can trigger withdrawal symptoms like nausea, headache, and general weakness; always consult your doctor for a plan to gradually reduce your dose.
  • It may take several weeks of consistent daily use before you notice the full benefits of this medicine on your mood or pain levels.
  • Closely monitor your mood and behaviour, especially when first starting this medication, and report any sudden feelings of sadness, anxiety, or suicidal thoughts to a healthcare professional immediately.
  • Inform any surgeon, dentist, or doctor treating you that you are taking Amitril 25 Tablet before undergoing any medical procedures or tests, as it can interact with anaesthetics.

 

Drug-Drug Interactions

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Drug-Drug Interactions

  • Taking Amitril 25 Tablet alongside monoamine oxidase inhibitors (MAOIs) can cause dangerously high blood pressure and severe brain chemistry imbalances; avoid using them within 14 days of each other.
  • Combining this medication with other drugs that cause drowsiness, such as sleep medicines, muscle relaxants, or opioid pain relievers, can lead to severe sleepiness and slow breathing.
  • Using Amitril 25 Tablet with drugs that affect your heart rhythm, such as certain antiarrhythmics or antipsychotics, can increase the risk of serious irregular heartbeats.

Drug-Food Interactions

  • Avoiding alcohol is highly recommended, as it can dangerously intensify the drowsy and sedative effects of this medication.
  • Grapefruit juice may interfere with how your body processes Amitril 25 Tablet , potentially increasing the level of the drug in your bloodstream and raising the risk of side effects.

Drug-Disease Interactions

  • Heart conditions: May worsen arrhythmias, prolong the QT interval, or cause complications in individuals with a history of recent heart attacks.
  • Glaucoma: May increase pressure inside the eye, which can worsen narrow-angle glaucoma.
  • Seizure disorders: Can lower the seizure threshold, making seizures more likely to occur in individuals with epilepsy.
  • Urinary retention: Can worsen difficulties with urination, particularly in men with an enlarged prostate gland.
     

Drug-Drug Interactions

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How does the drug interact with Amitril 25 Tablet:
Amitril 25 Tablet and Thioridazine can enhance each other's effects when used together.

How to manage the interaction:
Although using Amitril 25 Tablet and Thioridazine together can cause an interaction, they can be used if prescribed by a doctor. If you have extreme sleepiness, confusion, anxiety, vomiting, vision problems, feeling hot or cold, sweating, muscle stiffness, fainting, fits, or coma, seek medical help. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Amitril 25 Tablet:
Combining Amitril 25 Tablet and Pimozide may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitril 25 Tablet with Pimozide may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Amitril 25 Tablet:
Taking Amitril 25 Tablet and Ziprasidone may increase the risk of irregular heartbeat.

How to manage the interaction:
Although there is a interaction between Amitril 25 Tablet with Ziprasidone, but it can be taken together if prescribed by your doctor. However, consult your doctor immediately if you experience sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats . Do not discontinue any medication without consulting a doctor.
AmitriptylineHalofantrine
Critical
How does the drug interact with Amitril 25 Tablet:
Combining Amitril 25 Tablet and Halofantrine may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitril 25 Tablet with Halofantrine may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Amitril 25 Tablet:
Combining Amitril 25 Tablet and Sparfloxacin may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitril 25 Tablet with Sparfloxacin may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor. Note: Sparfloxacin is no longer available in the market. Grepafloxacin should not be combined with any other medications.
How does the drug interact with Amitril 25 Tablet:
Using Amitril 25 Tablet together with Safinamide can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Safinamide and Amitril 25 Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Amitril 25 Tablet. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Amitril 25 Tablet:
Co-administration of Amitril 25 Tablet together with Selegiline can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is a mood stabilizer).

How to manage the interaction:
Although using Selegiline and Amitril 25 Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Amitril 25 Tablet. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Amitril 25 Tablet:
Using Amitril 25 Tablet together with Rasagiline can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Rasagiline and Amitril 25 Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Inform a doctor if you have recently taken Amitril 25 Tablet. Do not discontinue any medications without consulting a doctor.
AmitriptylineMesoridazine
Critical
How does the drug interact with Amitril 25 Tablet:
Coadministration of Amitril 25 Tablet and Mesoridazine may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitril 25 Tablet with Mesoridazine may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
Critical
How does the drug interact with Amitril 25 Tablet:
Combining Amitril 25 Tablet and Bepridil may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitril 25 Tablet with Bepridil may result in an interaction, it can be used if a doctor recommends it. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Amitril 25 Tablet is used to treat depression, neuropathic pain, chronic tension-type headaches, and migraine in adults. Additionally, it is also used to treat bedwetting in children aged 6 years and above at night.

Amitril 25 Tablet works by affecting certain chemical messengers (serotonin and/or norepinephrine) in the brain, which communicate between brain cells, thereby helping regulate mood and treating depression.

Amitril 25 Tablet prevents the transmission of pain signals, thereby providing relief from neuropathic pain.

Amitril 25 Tablet causes sleepiness, drowsiness, and dizziness. Do not drive or operate machinery if you are experiencing these symptoms.

Amitril 25 Tablet causes weight gain due to increased appetite. Eat a healthy diet and exercise regularly to maintain a healthy weight.

Amitril 25 Tablet may cause decreased sex drive, problems with erection and orgasm. Consult your doctor if you have any concerns regarding this.

You might notice improvement within a few weeks. Still, it typically takes 4 to 6 weeks for the full effects of amitriptyline to be experienced. Avoid stopping the medication after 1 or 2 weeks, even if you don't feel immediate benefits. Allow at least 6 weeks for the medication to take full effect.

Amitril 25 Tablet is used to treat bedwetting in children aged 6 years and older. It should be given to children only if prescribed by the doctor.

Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.

Amitril 25 Tablet is one of many medications used to treat depression. Incorporating lifestyle changes can maximise its benefits and speed up recovery. Maintaining an active lifestyle and adhering to a healthy diet can significantly impact the rate of recovery from depression.

Always take Amitril 25 Tablet exactly as prescribed. Do not exceed the recommended dose or stop treatment without consulting your doctor. Inform your doctor about your medical history and all medicines or supplements you are taking to avoid interactions and minimise side effects. Be aware of possible side effects and seek medical advice if you have concerns.

It's necessary to understand that suicidal thoughts can be a side effect of a few antidepressants, including amitriptyline, especially when starting the medicine. However, it is equally crucial to understand that depression can lead to suicidal thoughts. If you are considering self-harm, please seek treatment right now.

Yes, Amitril 25 Tablet may cause difficulty peeing in certain cases. If it happens, try to relax when you pee. Do not try to force the flow of urine. If you still cannot go, try again later. Talk to your doctor urgently if you cannot pee at all.

Taking more than the recommended dosage does not provide additional pain relief and can increase the risk of adverse effects.

You may notice some improvement within 1 to 2 weeks of starting Amitril 25 Tablet . However, the full benefits for depression, neuropathic pain, headaches, or migraine prevention may take 4 to 6 weeks of regular use. Do not stop taking the medicine if you do not feel better immediately. Continue taking it as prescribed and consult your doctor if your symptoms do not improve.

Amitril 25 Tablet is occasionally used to help individuals sleep better. It can make you feel very sleepy, especially when you first start taking it. For the first few days of therapy, it is advised to avoid driving, cycling, and using machinery or tools until you understand how this medicine affects you.

You should avoid alcohol while taking Amitril 25 Tablet , as it can significantly increase drowsiness, impair your coordination, and increase the risk of serious side effects like breathing difficulties. Talk to your doctor.

Yes, Amitril 25 Tablet can cause an increase in appetite and weight gain in some individuals. Maintaining a balanced diet and exercising regularly can help manage this side effect. Talk to your doctor.

Amitril 25 Tablet should only be used during pregnancy if your doctor determines that the benefits outweigh the potential risks. Use during late pregnancy may occasionally affect the newborn or cause temporary withdrawal symptoms after birth. Discuss the risks and benefits with your doctor before taking this medicine during pregnancy.

Because Amitril 25 Tablet commonly causes drowsiness and sleepiness, taking your daily dose at night can help you sleep better and prevent you from feeling overly tired during daytime hours. Talk to your doctor.

Do not stop taking Amitril 25 Tablet without consulting your doctor, even if you feel better. Stopping suddenly may cause withdrawal symptoms such as headache, nausea, irritability, or sleep disturbances, and your symptoms may return. Your doctor will advise you on how to reduce the dose gradually and safely.

Yes, dry mouth is a common side effect of Amitril 25 Tablet . You can help manage it by drinking water regularly, chewing sugar-free gum, sucking on sugar-free candies or ice chips, limiting caffeine intake, avoiding smoking, and avoiding alcohol-containing mouthwashes. Consult your doctor if the symptom becomes troublesome.

Yes, Amitril 25 Tablet can affect blood pressure and may cause orthostatic hypotension, a sudden drop in blood pressure when standing up. This can make you feel dizzy or lightheaded. Rise slowly from sitting or lying positions and consult your doctor if symptoms persist or worsen.

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Country of origin

INDIA

Manufacturer/Marketer address

Sigma House, 43 S Wadala, Wadala West, Wadala, Mumbai, Maharashtra 400031
Other Info - AMI0064
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