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  3. Amitril 25 Tablet 10's

Amitril 25 Tablet 10's, Pack of 10 TABLETS
Amitril 25 Tablet 10's, Pack of 10 TABLETS
Amitril 25 Tablet 10's, Pack of 10 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Amitril 25 Tablet is used to treat depression, neuropathic pain, chronic tension-type headaches, and migraine in adults. Additionally, it is also used to treat bedwetting at night in children aged 6 years and above. It contains Amitriptyline, which works by affecting certain chemical messengers (serotonin and norepinephrine) in the brain, which communicate between brain cells, thereby helping to regulate mood and prevent depression. Additionally, it reduces the transmission of pain signals, thereby providing relief from neuropathic pain. In some cases, you may experience certain common side effects such as sleepiness, drowsiness, headache, irregular heartbeat, dry mouth, constipation, nausea, weight gain, slurred or slow speech, and a congested nose. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

AMITRIPTYLINE-25MG

Manufacturer/Marketer :

Sigma Laboratories Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Amitril 25 Tablet

Amitril 25 Tablet is used to treat depression, neuropathic pain, chronic tension-type headaches, and migraine in adults. Additionally, Amitril 25 Tablet is also used to treat bedwetting at night in children aged 6 years and above. Depression is a mood disorder that affects a person's daily life, characterised by feelings of sadness, loss, or anger.

Amitriptyline is contained in Amitril 25 Tablet , which works by affecting certain chemical messengers (serotonin and norepinephrine) in the brain, which communicate between brain cells, thereby helping to regulate mood and prevent depression. Besides this, Amitril 25 Tablet also affects the transmission of pain signals, thereby providing relief from neuropathic pain.

You are advised to take Amitril 25 Tablet for as long as your doctor has prescribed it for you, depending on your medical condition and response to the treatment. In some cases, you may experience certain common side effects such as sleepiness, drowsiness, headache, irregular heartbeat, dry mouth, constipation, nausea, weight gain, slurred or slow speech, and a congested nose. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Amitril 25 Tablet for as long as your doctor has prescribed. Consult your doctor if you are pregnant or breastfeeding. Amitril 25 Tablet may cause drowsiness, sleepiness and dizziness; do not drive unless you are alert. Amitril 25 Tablet can be given to children over 6 years old if prescribed by the doctor for bedwetting. Amitril 25 Tablet should not be given to children for treating depression or neuropathic pain. Avoid consuming alcohol along with Amitril 25 Tablet as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Amitril 25 Tablet

Amitril 25 Tablet is used for the treatment of depression, neuropathic pain, chronic tension-type headaches, and migraine. The detailed uses of Amitril 25 Tablet are as follows:
•Depression Treatment: Amitril 25 Tablet is used to treat major depressive disorder by balancing neurotransmitters in the brain, which helps improve mood and relieve depression symptoms.
•Chronic Pain Management: Amitril 25 Tablet is used to manage chronic pain, particularly neuropathic pain conditions such as fibromyalgia and diabetic neuropathy, by changing how the brain processes pain signals.
•Migraine Prophylaxis: Amitril 25 Tablet is prescribed as a preventive treatment for migraines, helping to stabilise mood and reduce headache frequency, making it easier to manage migraine symptoms.

Directions for Use

  • Amitril 25 Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Swallow Amitril 25 Tablet as a whole with a glass of water.
  • Do not break, crush or chew it.

Medicinal Benefits

Amitril 25 Tablet belongs to a group of medicines called tricyclic antidepressants. Amitril 25 Tablet is used to treat depression, neuropathic pain, chronic tension-type headaches, and migraine in adults. Amitril 25 Tablet is also used to treat bedwetting at night in children aged 6 years and above. Amitril 25 Tablet works by affecting certain chemical messengers (serotonin and/or norepinephrine) in the brain, which communicate between brain cells, thereby helping in regulating mood and treating depression. Amitril 25 Tablet prevents the transmission of pain signals, thereby providing relief from neuropathic pain.

How Amitril 25 Tablet Works

Amitriptyline is contained in Amitril 25 Tablet , which works by affecting certain chemical messengers (serotonin and norepinephrine) in the brain, which communicate between brain cells, thereby helping to regulate mood and prevent depression. Besides this, Amitril 25 Tablet also affects the transmission of pain signals, thereby providing relief from neuropathic pain.

Storage

Store in a cool and dry place away from sunlight
Side effects of Amitril 25 Tablet
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Try to practice deep breathing exercises or repeat calming words or phrases.
  • Seek for medical help if aggression occurs frequently, as it can worsen gradually if not attended.
  • You can also try listening to music or relaxing or writing a journal to express the feeling that aggravates to find a solution.
  • Consume controlled amounts of salt to raise sodium levels.
  • Eat fresh fruits like apples, berries, oranges, mangoes, and bananas.
  • Include fresh vegetables like broccoli, sweet potatoes, beets, okra, spinach, peppers, carrots, and edamame.
  • Choose frozen vegetables without added butter or sauce.
  • Drink electrolyte beverages like sports drinks or electrolyte solutions to replenish sodium and other electrolytes.
  • Avoid excessive salt intake, but allow for controlled increases as needed.
  • Monitor and manage underlying health conditions that may contribute to hyponatremia.
  • Quit smoking as smoking impairs erectile function by significantly damaging blood vessels.
  • Maintain a healthy weight as overweight can cause erectile dysfunction.
  • Exercise regularly as physical activity enhances blood flow and overall health, benefiting erectile function.
  • Consume a healthy diet loaded with whole grains, fruits and vegetables.
  • Limit alcohol consumption as excessive alcohol intake can impair erectile function.
  • Manage stress by practicing techniques such as yoga, relaxation exercises or meditation.
  • In case erectile dysfunction is due to psychological factors, consider couple counselling or sex therapy to address relationship and anxiety issues.
  • Openly discuss your concerns with your partner.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

What if I have taken an overdose of Amitril 25 Tablet

Do not take more than the prescribed dose of Amitril 25 Tablet as it may cause an overdose. The symptoms of overdose include irregular heartbeat, seizures (fits), confusion, coma, hallucinations, drowsiness, or fever. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Amitril 25 Tablet if you are allergic to any of its components, if you recently had a heart attack, or heart problems, are taking other antidepressants like isocarboxazid, phenelzine, selegiline, tranylcypromine or have taken them in the last 14 days, have severe liver disease or if you have taken moclobemide (used to treat depression and social anxiety). Inform your doctor before taking Amitril 25 Tablet if you have heart rhythm problems or hypotension. Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Do not take Amitril 25 Tablet if you are pregnant or breastfeeding unless prescribed. Amitril 25 Tablet causes drowsiness and dizziness; do not drive unless you are alert. Amitril 25 Tablet can be given to children above 6 years if prescribed by the doctor for treating bedwetting. Amitril 25 Tablet should not be given to children for treating depression or neuropathic pain. Avoid consuming alcohol along with Amitril 25 Tablet as it could lead to increased drowsiness and dizziness. Rise slowly from a sitting or lying position, as Amitril 25 Tablet may experience orthostatic hypotension (a sudden drop in blood pressure that can lead to dizziness upon standing).

Drug-Drug Interactions

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AmitriptylineCisapride
Critical
AmitriptylineIsocarboxazid
Critical

Drug-Drug Interactions

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AmitriptylineCisapride
Critical
How does the drug interact with Amitril 25 Tablet:
Coadministration of Amitril 25 Tablet and Cisapride may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitril 25 Tablet with Cisapride may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
AmitriptylineIsocarboxazid
Critical
How does the drug interact with Amitril 25 Tablet:
Combining Isocarboxazid with Amitril 25 Tablet can increase the risk of serotonin syndrome (increase serotonin hormone).

How to manage the interaction:
Although using Isocarboxazid and Amitril 25 Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Amitril 25 Tablet. Do not discontinue any medications without consulting a doctor.
AmitriptylinePimozide
Critical
How does the drug interact with Amitril 25 Tablet:
Combining Amitril 25 Tablet and Pimozide may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitril 25 Tablet with Pimozide may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
AmitriptylinePotassium chloride
Critical
How does the drug interact with Amitril 25 Tablet:
The combination of Amitril 25 Tablet and Potassium chloride may cause stomach and upper intestinal discomfort. (Only applicable to an oral preparation)

How to manage the interaction:
Although co-administration of Amitril 25 Tablet and Potassium chloride is not recommended as it can possibly lead to an interaction, they can be taken if prescribed by a doctor. If you experience severe stomach pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (in particular with blood), decreased hunger, and black stools while taking these medications, consult a doctor immediately. Do not discontinue any medications without talking to a doctor.
AmitriptylineLinezolid
Critical
How does the drug interact with Amitril 25 Tablet:
Taking Linezolid with Amitril 25 Tablet can increase the risk of serotonin syndrome (increased serotonin hormone).

How to manage the interaction:
Although using Linezolid and Amitril 25 Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Amitril 25 Tablet. Do not discontinue any medications without consulting a doctor.
AmitriptylineThioridazine
Critical
How does the drug interact with Amitril 25 Tablet:
Amitril 25 Tablet and Thioridazine can enhance each other's effects when used together.

How to manage the interaction:
Although using Amitril 25 Tablet and Thioridazine together can cause an interaction, they can be used if prescribed by a doctor. If you have extreme sleepiness, confusion, anxiety, vomiting, vision problems, feeling hot or cold, sweating, muscle stiffness, fainting, fits, or coma, seek medical help. Do not discontinue any medications without consulting a doctor.
AmitriptylineMethylene blue
Critical
How does the drug interact with Amitril 25 Tablet:
Combining Methylene blue with Amitril 25 Tablet can increase the risk of serotonin syndrome (increased serotonin hormone).

How to manage the interaction:
Although using Methylene blue and Amitril 25 Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Amitril 25 Tablet. Do not discontinue any medications without consulting a doctor.
AmitriptylineTranylcypromine
Critical
How does the drug interact with Amitril 25 Tablet:
Taking Tranylcypromine with Amitril 25 Tablet can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although using Tranylcypromine and Amitril 25 Tablet together is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, consult a doctor if you have symptoms such as confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
AmitriptylineHalofantrine
Critical
How does the drug interact with Amitril 25 Tablet:
Combining Amitril 25 Tablet and Halofantrine may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitril 25 Tablet with Halofantrine may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
AmitriptylineFurazolidone
Critical
How does the drug interact with Amitril 25 Tablet:
Combining Furazolidone with Amitril 25 Tablet can increase the risk of serotonin syndrome(increased serotonin hormone).

How to manage the interaction:
Although using Furazolidone and Amitril 25 Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Amitril 25 Tablet. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintaining a healthy diet and exercising regularly helps improve overall health and boosts self-esteem.
  • Regularly attend therapy sessions.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Include foods rich in omega-3 fatty acids, such as fish, nuts, fresh fruits, vegetables, and olive oil.
  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in the proper maintenance of neurotransmitters. 
  • Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges and pears.
  • Exercising helps in the production of the body’s natural antidepressants. It also helps relieve stress, improve mood, boost self-esteem, and promote restful sleep.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

PSYCHOTHERAPEUTICS

Amitril 25 Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Amitril 25 Tablet as it may cause an increased sedative effect.

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Pregnancy

Caution

Avoid taking Amitril 25 Tablet if you are pregnant unless prescribed by a doctor. Please consult your doctor if you have any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Amitril 25 Tablet ; your doctor will decide whether breastfeeding mothers can take Amitril 25 Tablet or not.

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Driving

Unsafe

Amitril 25 Tablet causes sleepiness, dizziness and drowsiness. Do not drive or operate machinery if you experience these symptoms.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Caution

Amitril 25 Tablet can be given to children above 6 years if prescribed by the doctor for treating bedwetting. Amitril 25 Tablet should not be given to children for treating depression or neuropathic pain.

Have a query?

FAQs

Amitril 25 Tablet is used to treat depression, neuropathic pain, chronic tension-type headaches, and migraine in adults. Additionally, it is also used to treat bedwetting in children aged 6 years and above at night.

Amitril 25 Tablet works by affecting certain chemical messengers (serotonin and/or norepinephrine) in the brain, which communicate between brain cells, thereby helping regulate mood and treating depression.

Amitril 25 Tablet prevents the transmission of pain signals, thereby providing relief from neuropathic pain.

Amitril 25 Tablet causes sleepiness, drowsiness, and dizziness. Do not drive or operate machinery if you are experiencing these symptoms.

Amitril 25 Tablet causes weight gain due to increased appetite. Eat a healthy diet and exercise regularly to maintain a healthy weight.

Do not discontinue Amitril 25 Tablet without consulting your doctor, as it could lead to recurring symptoms. To treat your condition effectually, continue taking Amitril 25 Tablet for as long as prescribed. Do not hesitate to consult your doctor if you experience any difficulties while taking Amitril 25 Tablet .

Amitril 25 Tablet may cause decreased sex drive, problems with erection and orgasm. Consult your doctor if you have any concerns regarding this.

Dry mouth may be a side effect of Amitril 25 Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum or candy may help stimulate saliva and thereby prevent mouth dryness.

Yes, orthostatic hypotension could be a side-effect of Amitril 25 Tablet . Orthostatic hypotension is a sudden drop in blood pressure that occurs when standing, leading to dizziness. If you experience this, do not try to stand up suddenly or start walking; instead, lie down and get up slowly only when you feel better. People taking Amitril 25 Tablet are advised to regularly monitor their blood pressure levels to avoid such unpleasant events.

You might notice improvement within a few weeks. Still, it typically takes 4 to 6 weeks for the full effects of amitriptyline to be experienced. Avoid stopping the medication after 1 or 2 weeks, even if you don't feel immediate benefits. Allow at least 6 weeks for the medication to take full effect.

Amitril 25 Tablet is used to treat bedwetting at night in children aged 6 years and above. It should be given to children only if prescribed by the doctor.

Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.

Before using this medication, inform your doctor about your medical history, including any ongoing medications, to avoid potential interactions and minimise side effects.

Amitril 25 Tablet is one of many medications used to treat depression. Incorporating lifestyle changes can maximise its benefits and speed up recovery. Maintaining an active lifestyle and adhering to a healthy diet can significantly impact the rate of recovery from depression.

Always follow your doctor's advice on how to take your medication. Be aware of potential side effects and avoid taking more than the prescribed dosage. Never stop taking medication without consulting your doctor. Always inform your doctor about all other medications you're taking, including over-the-counter drugs and supplements.

It's necessary to understand that suicidal thoughts can be a side effect of a few antidepressants, including amitriptyline, especially when starting the medicine. However, it is equally crucial to understand that depression can lead to suicidal thoughts. If you are considering self-harm, please seek treatment right now.

Yes, Amitril 25 Tablet may cause difficulty peeing in certain cases. If it happens, try to relax when you pee. Do not try to force the flow of urine. If you still cannot go, try again later. Talk to your doctor urgently if you cannot pee at all.

Taking more than the recommended dosage does not provide additional pain relief and can increase the risk of adverse effects.

Taking Amitril 25 Tablet in pregnancy would not usually require extra monitoring of your baby. Your doctor can explain how taking Amitril 25 Tablet can help you and how it might affect you. They will also help you choose the best treatment for you and your baby.

You might notice improvement within a few weeks. Still, it typically takes 4 to 6 weeks for the full effects of amitriptyline to be experienced. Allow at least 6 weeks for the medication to take full effect.

You might notice improvement within a few weeks. Still, it typically takes 4 to 6 weeks to experience the full effects of amitriptyline. Allow at least 6 weeks for the medication to work fully.

Amitril 25 Tablet is occasionally used to help individuals sleep better. It can make you feel very sleepy, especially when you first start taking it. For the first few days of therapy, it is advised to avoid driving, cycling, and using machinery or tools until you understand how this medicine affects you.

Country of origin

INDIA

Manufacturer/Marketer address

Sigma House, 43 S Wadala, Wadala West, Wadala, Mumbai, Maharashtra 400031
Other Info - AMI0064

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jun 30, 2025 | 11:17 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.10849.pdf
  2. https://medlineplus.gov/druginfo/meds/a682388.html
  3. https://www.drugs.com/amitriptyline.html
  4. https://www.nhs.uk/medicines/amitriptyline-for-pain/
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