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compositionComposition:MEFENAMIC ACID-250MG+TRANEXAMIC ACID-500MG
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Prescription Medicine
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Amnic TR 500mg/250mg Tablet is used to treat dysmenorrhea (period pain) and menorrhagia (heavy menstrual bleeding). Additionally, it is used to treat severe blood loss, swelling in various body parts, fever, inflammation, and migraine headaches. It contains two medicines, namely Tranexamic acid and Mefenamic acid. It may cause common side effects such as nausea, vomiting, diarrhoea, indigestion, heartburn, and headache.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

MEFENAMIC ACID-250MG+TRANEXAMIC ACID-500MG

Manufacturer/Marketer :

Ambit Bio Medix

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Amnic TR 500mg/250mg Tablet

Amnic TR 500mg/250mg Tablet is a combination medicine used to treat heavy menstrual bleeding accompanied by painful period cramps. It helps manage excessive blood loss and relieves pelvic pain during your menstrual cycle. Amnic TR 500mg/250mg Tablet is specifically prescribed for temporary use during your period days and is not meant for long-term daily consumption.

You should take Amnic TR 500mg/250mg Tablet only during your menstrual period, exactly as advised by your doctor. It is highly recommended to take Amnic TR 500mg/250mg Tablet with food or immediately after a meal to protect your stomach lining from irritation. Making simple lifestyle adjustments, such as staying well-hydrated and using a heating pad on your lower abdomen, can also support your recovery during treatment.

While taking Amnic TR 500mg/250mg Tablet, some people may experience mild side effects such as nausea, heartburn, or temporary digestive upset. If you experience any severe symptoms, such as sudden changes in your vision, severe calf pain, or difficulty breathing, stop taking the medication and consult your doctor immediately.

Before starting Amnic TR 500mg/250mg Tablet, you must talk to your doctor if you have a history of kidney problems, asthma, or stomach ulcers. Do not take this if you have active blood clots, a history of deep vein thrombosis, or a known allergy to aspirin or other pain-relieving medicines.

Amnic TR 500mg/250mg Tablet can interact with oral contraceptives, blood thinners, and alcohol, which may increase your risk of bleeding or blood clots. If you are pregnant, planning a pregnancy, or breastfeeding, consult your healthcare provider before taking this medication to ensure it is safe for you.

Uses of Amnic TR 500mg/250mg Tablet

Amnic TR 500mg/250mg Tablet is used in the treatment of dysmenorrhea (period pain) and menorrhagia (heavy menstrual bleeding). The detailed uses of Amnic TR 500mg/250mg Tablet are as follows:

  • Menstrual cramps and pain (dysmenorrhea): Amnic TR 500mg/250mg Tablet relieves painful lower abdominal cramps and discomfort that often accompany heavy periods.
  • Heavy menstrual bleeding (menorrhagia): Amnic TR 500mg/250mg Tablet helps reduce the excessive volume of blood loss during your period, making your cycle more manageable.

Key Benefits

Amnic TR 500mg/250mg Tablet helps manage heavy menstrual bleeding and associated menstrual pain, improving comfort and supporting normal daily activities. By reducing excessive blood loss and relieving cramps, it helps make menstrual cycles more manageable.
Benefits may include:
• Helps reduce heavy menstrual bleeding.
• Relieves menstrual cramps and pelvic pain.
• Supports greater comfort during menstrual periods.
• Helps reduce fatigue and weakness associated with excessive blood loss.
• May help lower the risk of iron deficiency related to heavy menstrual bleeding.
• Improves ability to carry out daily activities with fewer menstrual-related disruptions.
 

Side effects of Amnic TR 500mg/250mg Tablet
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
  • Stay hydrated to promote healthy digestion and general well-being.
  • Nonsteroidal anti-inflammatory medications (NSAIDs) have the potential to make worse ulcers by irritating the stomach lining.
  • Avoiding or consuming alcohol is advised because it can irritate the stomach lining and slow down the healing process.
  • limit intake of hot foods, caffeine, and acidic foods such as citrus and tomatoes, as they can worsen the ulcer.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.

Directions for Use

Please read these instructions carefully before taking your medication:

  • Swallow the Amnic TR 500mg/250mg Tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can affect how the medicine is absorbed.
  • Always take Amnic TR 500mg/250mg Tablet with or after food to minimize the risk of stomach upset.
  • Only take this medication on the days you are actively bleeding or experiencing severe pain during your period. Do not take it on non-period days.
  • Always follow your doctor's exact instructions regarding how many days to take this medication.

 

How Amnic TR 500mg/250mg Tablet Works

Amnic TR 500mg/250mg Tablet contains Tranexamic Acid and Mefenamic Acid. • Tranexamic Acid: It helps reduce excessive menstrual bleeding by preventing blood clots from breaking down too quickly. This helps control blood loss during periods. • Mefenamic Acid: It helps relieve menstrual pain, cramps, and inflammation by reducing the substances in the body that cause pain and uterine contractions.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Amnic TR 500mg/250mg Tablet as it may cause increased drowsiness. It can also increase the risk of stomach bleeding.

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Pregnancy

Consult your doctor

Please consult your doctor if you are pregnant or if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor before taking Amnic TR 500mg/250mg Tablet if you are breastfeeding, your doctor will decide if Amnic TR 500mg/250mg Tablet can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Amnic TR 500mg/250mg Tablet may cause drowsiness and dizziness. Do not drive or operate machinery unless you are alert.

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Liver

Consult your doctor

Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Amnic TR 500mg/250mg Tablet should not be given to children as the safety and effectiveness were not established.

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Heart

Unsafe

This medicine is not recommended in cardiac patients due to its adverse effects. However, if prescribed extreme caution should be exercised.

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Geriatrics

Caution

Amnic TR 500mg/250mg Tablet can be given in elderly patients with caution and only if prescribed by the doctor.

What if I have taken an overdose of Amnic TR 500mg/250mg Tablet

If you accidentally take more than the prescribed dose of Amnic TR 500mg/250mg Tablet, seek immediate medical attention or contact a local poison control centre. Symptoms of an overdose may include severe nausea, vomiting, severe headache, confusion, or stomach pain.

Diet & Lifestyle Advise

Eat iron-rich foods: Incorporate spinach, red meat, beans, and fortified cereals into your diet to help rebuild iron levels lost during heavy bleeding.

  • Stay hydrated: Drink plenty of water to maintain blood volume and reduce the fatigue associated with heavy periods.
  • Apply gentle heat: Use a warm compress or heating pad on your lower back or abdomen to help soothe muscle cramping.
  • Limit caffeine and alcohol: Reducing these substances can help prevent dehydration and minimize stomach irritation while taking this medication.
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How Soon It Starts Working

  • The time required for Amnic TR 500mg/250mg Tablet to start to work: The time required for Amnic TR 500mg/250mg Tablet to show its action is unknown.
  • The time for which the effects of Amnic TR 500mg/250mg Tablet last: The duration of action for Amnic TR 500mg/250mg Tablet is unknown.

What if you forget to take Amnic TR 500mg/250mg Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Take the medicine with food: Always take Amnic TR 500mg/250mg Tablet with a meal or snack to help reduce stomach irritation and lower the risk of stomach ulcers.
  • Use only for the prescribed duration: Do not take Amnic TR 500mg/250mg Tablet for longer or more frequently than recommended by your doctor.
  • Monitor for vision changes: Stop taking the medicine and seek medical advice immediately if you notice any unusual changes in your vision, including blurred vision or changes in color perception.
  • Avoid taking other pain relievers without medical advice: Do not use other NSAID pain medicines, such as ibuprofen or naproxen, while taking Amnic TR 500mg/250mg Tablet unless specifically approved by your doctor, as this may increase the risk of side effects.
  • Watch for signs of stomach bleeding: Contact your healthcare provider immediately if you notice dark, black, tarry, or sticky stools, as this may indicate gastrointestinal bleeding.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Birth control pills and other estrogen-containing medicines: Taking these alongside Amnic TR 500mg/250mg Tablet may increase the risk of developing blood clots.
  • Blood thinners (e.g., warfarin, heparin): Combining these with Amnic TR 500mg/250mg Tablet may increase the risk of bleeding and may affect the effectiveness of either treatment.
  • Other nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., aspirin, ibuprofen): Taking these medicines alongside Amnic TR 500mg/250mg Tablet may increase the risk of stomach irritation, ulcers, and bleeding
Mefenamic acid + Tranexamic acidMedroxyprogesterone
Critical
Mefenamic acid + Tranexamic acidEtonogestrel
Critical

Drug-Drug Interactions

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Mefenamic acid + Tranexamic acidMedroxyprogesterone
Critical
How does the drug interact with Amnic TR 500mg/250mg Tablet:
Taking medroxyprogesterone acetate with tranexamic acid may increase the risk of blood clots.

How to manage the interaction:
Taking Medroxyprogesterone with Tranexamic acid is not recommended but can be taken if prescribed by a doctor. Consult your doctor immediately if you experience chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg. Do not stop using any medications without talking to a doctor.
Mefenamic acid + Tranexamic acidEtonogestrel
Critical
How does the drug interact with Amnic TR 500mg/250mg Tablet:
Co-administration of tranexamic acid with etonogestrel may cause blood clots.

How to manage the interaction:
Taking Tranexamic acid with Etonogestrel is not recommended, as it can lead to an interaction, it can be taken if prescribed by the doctor. However, If you experience chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult a doctor immediately.
Mefenamic acid + Tranexamic acidKetorolac
Critical
How does the drug interact with Amnic TR 500mg/250mg Tablet:
Coadministration of Mefenamic acid with Ketorolac can increase the risk or severity of inflammation, bleeding, and ulceration.

How to manage the interaction:
Taking Mefenamic acid with Ketorolac together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acid + Tranexamic acidNorethisterone
Critical
How does the drug interact with Amnic TR 500mg/250mg Tablet:
Taking tranexamic acid together with norethindrone may increase the risk of blood clots.

How to manage the interaction:
Although there is an interaction between norethisterone and tranexamic acid, they can be taken together if prescribed by a doctor. However, If you experience chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Mefenamic acid + Tranexamic acidEthinylestradiol
Critical
How does the drug interact with Amnic TR 500mg/250mg Tablet:
Taking Ethinylestradiol with Amnic TR 500mg/250mg Tablet acid may increase the risk of blood clots.

How to manage the interaction:
Although there is an interaction between Amnic TR 500mg/250mg Tablet and ethinylestradiol, it can be taken if a doctor has prescribed it. However, if you experience chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acid + Tranexamic acidMeloxicam
Critical
How does the drug interact with Amnic TR 500mg/250mg Tablet:
Co-administration of mefenamic acid with meloxicam can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Mefenamic acid with Meloxicam together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking a doctor.
Mefenamic acid + Tranexamic acidLevonorgestrel
Critical
How does the drug interact with Amnic TR 500mg/250mg Tablet:
Taking levonorgestrel with tranexamic acid may increase the risk of blood clot.

How to manage the interaction:
Taking Tranexamic acid with Levonorgestrel may lead to an interaction, it can be taken together if prescribed by the doctor. However, if you experience chest pain, shortness of breath, coughing up blood, blood in the urine, redness, or swelling in your arm or leg, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acid + Tranexamic acidDrospirenone
Critical
How does the drug interact with Amnic TR 500mg/250mg Tablet:
Taking drospirenone with Amnic TR 500mg/250mg Tablet may increase the risk of blood clots.

How to manage the interaction:
Taking Amnic TR 500mg/250mg Tablet with drospirenone is not recommended, as it can lead to an interaction, but can be taken if prescribed by the doctor. However, if you experience chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult your doctor immediately.
Mefenamic acid + Tranexamic acidTretinoin
Severe
How does the drug interact with Amnic TR 500mg/250mg Tablet:
Co-administration of tretinoin with tranexamic acid may increase the risk of blood clots.

How to manage the interaction:
Although there is an interaction between tretinoin and tranexamic, they can be taken together if prescribed by a doctor. However, If you experience chest pain, difficulty breathing, coughing up blood, and numbness or weakness on one side of the body, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Mefenamic acid + Tranexamic acidTacrolimus
Severe
How does the drug interact with Amnic TR 500mg/250mg Tablet:
Coadministration of mefenamic acid with tacrolimus can increase the risk of kidney problems.

How to manage the interaction:
Although there is an interaction between mefenamic acid and tacrolimus, they can be taken together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid consuming alcohol while taking Amnic TR 500mg/250mg Tablet, as it can increase the risk of stomach irritation, ulcers, and bleeding.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIFIBRINOLYTIC AGENTS]

FAQs

Amnic TR 500mg/250mg Tablet is used to treat dysmenorrhea (period pain) and menorrhagia (heavy menstrual bleeding). Besides this, it is also used to treat severe blood loss, swelling in various body parts, fever, inflammation, and migraine headache.
Amnic TR 500mg/250mg Tablet contains Tranexamic acid and Mefenamic acid. Tranexamic acid helps the body's natural blood clot process by preventing the breakdown of fibrin, this stops fibrinolysis, a process that stops blood clot formation. Mefenamic acid works by blocking the effect of chemical messengers that cause pain.
Diarrhea might be a side-effect of Amnic TR 500mg/250mg Tablet. Drink enough fluids and eat non-spicy food if you experience diarrhea. Consult your doctor if you experience severe diarrhea or if you find blood in stools.
Amnic TR 500mg/250mg Tablet should not be taken for longer durations unless prescribed by the doctor. Amnic TR 500mg/250mg Tablet is usually prescribed for a few days at the time of heavy bleeding and cramps.
Amnic TR 500mg/250mg Tablet is used to treat dysmenorrhea (period pain), pain due to heavy bleeding during periods, and menstrual cramps. Take Amnic TR 500mg/250mg Tablet only as prescribed and do not overdose.
Consult your doctor before taking contraceptive pills along with Amnic TR 500mg/250mg Tablet. When taken together, there is an increased risk of deep vein thrombosis (blood clot in the deep vein, usually in the legs).
Amnic TR 500mg/250mg Tablet contains mefenamic acid, an NSAID which might increase the risk of cardiovascular thrombotic events, myocardial infarction, and stroke. Therefore, avoid taking Amnic TR 500mg/250mg Tablet if you have heart-related problems unless prescribed by the doctor.
Amnic TR 500mg/250mg Tablet typically starts to show its effects within 1-2 hours of taking it, and it helps to reduce heavy menstrual bleeding by improving blood clotting but does not stop bleeding. However, the exact duration for bleeding to stop can vary from one person to other.
Yes, Amnic TR 500mg/250mg Tablet can cause acidity. If you experience heartburn and indigestion, it's advisable to take Amnic TR 500mg/250mg Tablet with food to minimize discomfort. If the symptoms persist, please consult your doctor.
Yes, Amnic TR 500mg/250mg Tablet is safe if you take as per the dose and duration prescribed by your doctor. However, it's important to be aware of potential side effects and contraindications. Always consult your doctor before starting any new medication to ensure it is safe for you, especially if you have pre-existing conditions or are taking other medications.
Always follow your doctor's instructions regarding dosage and duration. Usually it is prescribed for a short duration. Do not exceed the prescribed duration. As overuse can lead to side effects and other health issues.
Amnic TR 500mg/250mg Tablet is a combination of two drugs, tranexamic acid (anti-fibrinolytic) and mefenamic acid (NSAID).
Yes, do not take Amnic TR 500mg/250mg Tablet if you are allergic to any of its contents or if you have severe heart failure. Inform your doctor if you have/had deep vein thrombosis, pulmonary embolism (block a blood vessel in the lungs), coagulopathy (formation of blood clots), epilepsy, irregular periods, heart, kidney, or liver problems. Consult your doctor if you are pregnant or breastfeeding. Do not take any other NSAIDs for pain relief along with Amnic TR 500mg/250mg Tablet unless prescribed.
Store Amnic TR 500mg/250mg Tablet at a temperature not exceeding 25°C. Protect it from light and moisture. Keep out of reach of children.
Yes, you can take Amnic TR 500mg/250mg Tablet with food. It is often recommended to take it after a meal to avoid stomach upset or other gastrointestinal side effects.
Please consult your doctor if you are pregnant. Your doctor will prescribes Amnic TR 500mg/250mg Tablet only if the benefits outweigh the risks.
The common side effects of Amnic TR 500mg/250mg Tablet are nausea, vomiting, diarrhea, indigestion, heartburn, and headache. If any of these side effects persist or worsen, please consult your doctor.
You are recommended to consult your doctor before taking other medicines with Amnic TR 500mg/250mg Tablet to avoid possible interactions.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. National Health Service (NHS). Tranexamic Acid - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 015034S040Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Mefenamic Acid Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Mefenamic acid. 2005. [Accessed on 10 Apr. 2019]Check here
  5. Rivopharm UK Ltd. Electronic medicines Compendium (EMC)Tranexamic Acid 500 mg film-coated tablets. [Revised on June 2018] [Accessed on 24th May 2022]Check here
  6. CDSCO [Internet]. Cdscoonline.gov.in. 2021 [Accessed on 22 November 2021]Check here
  7. Clinical Reference Document. [Accessed on 02 Jun. 2026]Check here

Country of origin

India
Other Info - AM41259
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