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Ano Metrogyl Cream is a combination medicine used in the treatment of anal fissures, anal fistula, and piles (haemorrhoids). This medicine decreases the sensation of pain by blocking the pain signals from the nerves to brain, thereby reduces inflammation (redness and swelling) and promoting better healing. It helps reduce itching, redness and swelling due to piles. Common side effects include rectal pain, burning sensation and redness at the site of application

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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

LIGNOCAINE-4%W/W+METRONIDAZOLE-1%W/W+SUCRALFATE-7%W/W

Manufacturer/Marketer :

Lekar Pharma Ltd

Consume Type :

Rectal

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Ano Metrogyl Cream

Ano Metrogyl Cream is a specialised rectal medication used to relieve the pain, swelling, and discomfort associated with haemorrhoids (piles) and anal fissures. It combines three active therapeutic actions to numb local pain, reduce bacterial growth, and form a physical barrier over damaged tissue to encourage healing. This product is formulated specifically for localised rectal application to target the root of the discomfort directly.

For best results, you should apply Ano Metrogyl Cream consistently and exactly as directed by your doctor, often after a bowel movement to ensure maximum contact with the affected tissue. This medication does not need to be taken with food, but maintaining a fibre-rich diet and drinking plenty of water during your treatment will help soften your stools and reduce strain. Consistent use as prescribed ensures the tissues have a continuous protective environment to heal.

Most patients tolerate Ano Metrogyl Cream very well, but you may experience mild, temporary local side effects like a brief burning sensation, itching, or redness at the application site. These symptoms usually resolve on their own within a few minutes. However, if you experience severe skin irritation, worsening rectal pain, or signs of an allergic reaction, stop using the product and consult your doctor immediately.

Do not use this medicine if you have a known history of allergy to local anaesthetics or any of the other active ingredients. Before starting Ano Metrogyl Cream, tell your doctor if you have severe liver damage, poor blood circulation, or active open wounds in the rectal area that are deep or bleeding excessively. Your doctor will evaluate if this medication is safe for your specific condition.

Although this medicine is applied rectally, some of the metronidazole may be absorbed into the bloodstream. Tell your healthcareprovider about all the medicines you are taking, including other rectal products. It is also best to avoid alcohol during treatment, as metronidazole may cause an unpleasant reaction in some people, including flushing, nausea, vomiting, stomach cramps, and a fast heartbeat. If you are pregnant, breastfeeding, or planning a pregnancy, talk to your doctor or pharmacist before starting this treatment to ensure it is safe for you.

Uses of Ano Metrogyl Cream

Your doctor may prescribe Ano Metrogyl Cream to help manage the following conditions:

  • Anal Fissures: Ano Metrogyl Cream helps by relieving intense pain, reducing localised inflammation, and protecting the delicate torn skin lining the anal canal to promote faster recovery.
  • Haemorrhoids (Piles): This medicine eases local swelling, calms persistent itching, numbs throbbing pain, and prevents bacterial infections in inflamed, swollen veins.

Key Benefits

Ano Metrogyl Cream is used to relieve pain, prevent infection, and promote healing of wounds and anorectal conditions such as anal fissures or post-surgical wounds. It provides symptomatic relief while supporting the natural healing process.

  • Provides Fast Pain Relief: Lignocaine numbs the affected area, helping relieve pain, burning, and discomfort.
  • Helps Prevent Infection: Metronidazole helps control bacterial growth, reducing the risk of infection in the treated area.
  • Promotes Wound Healing: Sucralfate forms a protective barrier over damaged tissues, supporting healing and protecting the wound from further irritation.
  • Reduces Discomfort During Bowel Movements: By relieving pain and protecting the affected area, it helps make bowel movements more comfortable.
  • Supports Tissue Recovery: The combined action of the ingredients helps reduce inflammation, promote tissue repair, and improve overall comfort.
Side effects of Ano Metrogyl Cream 20 gm
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

Directions for Use

  • Adhere to your doctor's guidance regarding the dosage and timing of this medication for optimal effectiveness.
  • Apply a small amount of Ano Metrogyl Cream on the clean and dry affected area of the skin of the anus.
  • Wash your hands before and after using Ano Metrogyl Cream.

How Ano Metrogyl Cream Works

Ano Metrogyl Cream contains lignocaine, metronidazole, and sucralfate. It works through the combined action of three distinct medical agents that target pain, infection, and tissue damage simultaneously. The first active component, lignocaine, is a local anaesthetic. It temporarily blocks pain signals along the nerve pathways in the skin. By numbing the sensitive nerve endings in the anal region, it provides rapid relief from sharp pain and itching. The second active component, metronidazole, is an antibacterial agent. It prevents and treats local bacterial infections in the inflamed tissues. By keeping the wound clean from bacteria, it reduces inflammation and helps prevent complications that can delay recovery. The third active component, sucralfate, is a protective barrier agent. It binds directly to the proteins on the damaged tissue surface. It forms a physical, gel-like coating that shields the raw area from friction and stools, allowing the cells underneath to regenerate and heal safely. Together, these three active components help relieve pain, control infection, and protect damaged tissues to support healing.
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Alcohol

Caution

Interaction of Ano Metrogyl Cream with alcohol is unknown. Please consult a doctor before consuming alcohol while using Ano Metrogyl Cream.

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Pregnancy

Caution

Please consult a doctor if you are pregnant or planning for pregnancy. Ano Metrogyl Cream is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Caution

It is unknown whether Ano Metrogyl Cream is excreted in human milk. Therefore, it is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks.

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Driving

Safe if prescribed

Ano Metrogyl Cream usually does not affect your ability to drive or operate machinery.

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Liver

Caution

If you have any concerns regarding the use of Ano Metrogyl Cream in patients with liver problems, please consult a doctor.

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Kidney

Caution

If you have any concerns regarding the use of Ano Metrogyl Cream in patients with kidney problems, please consult a doctor.

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Children

Caution

Ano Metrogyl Cream should be used in children only if prescribed by a doctor.

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Heart

Caution

Limited information was available regarding the use of Ano Metrogyl Cream in patients with heart problems. Please consult your doctor.

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Geriatrics

Caution

Limited information is available regarding the use of Ano Metrogyl Cream in elderly patients. If you have any concerns about the usage of Ano Metrogyl Cream in geriatrics, please consult your doctor.

What if I have taken an overdose of Ano Metrogyl Cream

Because Ano Metrogyl Cream is applied locally to the rectum, a serious overdose is highly unlikely when used as directed. However, if the medication is accidentally swallowed, or if you experience unusual dizziness or a slow heartbeat, seek immediate medical attention or contact a poison control centre.

Diet & Lifestyle Advise

  • Increase dietary fibre: Eat more whole grains, fruits, vegetables, and beans to soften your stool and make bowel movements easier.
  • Stay hydrated: Drink at least 8 to 10 glasses of water daily to prevent constipation and reduce straining.
  • Avoid straining: Do not strain or hold your breath during bowel movements, as this increases pressure on the rectal veins.
  • Practice sitz baths: Sit in a tub of warm water for 15 to 20 minutes two to three times a day to soothe the area and improve blood flow.
  • Wear loose clothing: Choose breathable cotton underwear to prevent moisture buildup and reduce friction on the irritated tissues.

Health Queries

I have had a fistula for the past 4 to 5 years and I am worried if it can turn into cancer. Is surgery really necessary and what should I do?

Vikas Singh

Vikas Singh

M Pharmacy

A fistula, for many years, usually does not turn into cancer, but it can keep causing infection, discharge, and discomfort if left untreated. It does not heal completely with medicines alone in most cases, so surgery is often the main way to treat it and prevent repeated problems. Early treatment can help avoid complications and improve quality of life. Consult your doctor to assess the condition and decide the most suitable treatment option.

What is a posterior deep fissure, and what are the available treatment options for this condition?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

A posterior deep fissure is a painful tear in the skin at the back of the anus, usually caused by constipation or passing hard stools. It is treated with a high-fibre diet, stool softeners, warm sitz baths, and medicated ointments. Long-standing cases may need a minor surgical procedure.

I am suffering from a fistula in the anal region. How can they be effectively managed?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

An anal fistula usually does not heal on its own and is best treated with a minor surgical procedure to remove or close the tract. Medicines may temporarily control infection, but you should consult a general surgeon for proper evaluation and long-term treatment.

I have developed a small pimple-like swelling just above the anus. Sometimes a thick liquid discharges from it, and at other times it becomes dry. There is no pain, and this has been happening for the past year. What could this be, and what should I do?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

A small pimple-like swelling near the anus that occasionally discharges thick fluid is most commonly suggestive of a fistula-in-ano (an abnormal tract between the anal canal and skin). It may not always be painful, but persistent discharge is a warning sign. It is unlikely to heal completely with ointments alone. You should consult a general surgeon for proper examination. Early treatment helps prevent complications and repeated infection. Avoid squeezing it, maintain good hygiene, and keep the area dry until you see a doctor.

What is the treatment for anal fistula and external piles? Could you please recommend a suitable ointment for these conditions?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

Anal fistula usually requires a minor surgical procedure for permanent treatment, as ointments alone cannot cure it. External piles can often be managed with a fibre-rich diet, sitz baths, and anti-haemorrhoid ointments, but persistent symptoms need a doctor's evaluation.
health query

Have a query?

How Soon It Starts Working

The time required for Ano Metrogyl Cream to start to work: The time required for Ano Metrogyl Cream to show its action is unknown. The time for which the effects of Ano Metrogyl Cream last: The duration of action for Ano Metrogyl Cream is clinically unknown.

What if you forget to take Ano Metrogyl Cream

If you forget to apply a dose, apply it as soon as you remember. If it is almost time for your next scheduled application, skip the missed dose and continue with your regular schedule. Do not apply a double amount to make up for a missed application.

Storage

•Store Ano Metrogyl Cream at room temperature, ideally below 25°C or 30°C as indicated on the product packaging.

Drug Warnings

  • Inspect the Medicine Before Use: Do not use the gel if the tube seal is broken or if the product appears discoloured, separated, or has an unusual odour.
  • Clean the Applicator After Use: Wash the applicator thoroughly with warm water and mild soap after each use to help prevent contamination.
  • For External or Rectal Use Only: Use the medicine only as directed. Do not swallow it or allow it to come into contact with your eyes, nose, or mouth.
  • Use Only for the Prescribed Duration: Do not continue using the medicine for longer than recommended, as prolonged use of local anaesthetics may increase the risk of skin sensitivity or delayed healing.
  • Wear Loose, Breathable Clothing: Avoid tight-fitting or non-breathable clothing that may trap moisture and increase irritation around the affected area.

Drug-Drug Interactions

verifiedApollotooltip

Ano Metrogyl Cream may interact with certain medicines, affecting its effectiveness or increasing the risk of side effects.

  • Heart rhythm medicines: May interact with oral antiarrhythmic drugs if significant amounts of the local anaesthetic are absorbed into the bloodstream.
  • Other topical rectal products: Using other rectal creams, ointments, or suppositories at the same time may interfere with the absorption or protective barrier effect of Ano Metrogyl Cream.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Ano Metrogyl Cream when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANORECTAL PREPARATIONS]

FAQs

Ano Metrogyl Cream is used in the treatment of anal fissures (small tear in the anus lining), fistula (abnormal skin opening near the anus) and piles (inflamed and swollen veins in the rectum).
Ano Metrogyl Cream contains Lignocaine, Metronidazole and Sucralfate. Lignocaine decreases pain sensation by preventing pain signals transmission from nerves to the brain. Metronidazole minimizes the spread of bacterial infection around the anus skin region due to swelling and inflamed veins. Sucralfate is a protectant that works by forming a protective layer over the affected area of skin and prevents pain, irritation or burning sensation in the anus. Thereby promoting healing of anus skin and the formation of new healthy skin.
Ano Metrogyl Cream may cause a burning sensation of the skin at the application site as a temporary side effect. However, if the burning sensation persists or worsens, please consult a doctor. Also, avoid using and consult a doctor if you experience increased irritation or redness.
You are recommended to avoid foods rich in oil content and spicy foods for effective results while taking Ano Metrogyl Cream.
Yes, Ano Metrogyl Cream provides relief from pain caused by an anal fissure. Ano Metrogyl Cream contains lignocaine, a local anaesthetic that decreases pain sensation by causing numbness around the affected area.
Do not stop using Ano Metrogyl Cream without consulting your doctor even if you find symptomatic relief as discontinuing suddenly may worsen the condition. Therefore, complete the full course of Ano Metrogyl Cream as your doctor has prescribed it, and if you experience any difficulty while using Ano Metrogyl Cream, please consult your doctor.
No, Ano Metrogyl Cream should not be used for external wounds. Please consult a doctor so that appropriate medication is prescribed to treat external wounds.
Ano Metrogyl Cream is usually not recommended to use in children as safety has not been studied.
No, using higher dosages of Ano Metrogyl Cream won't make it any more effective. An excessive amount of medication may result in unintended adverse effects.
No, it is not intended to treat burns.
No, don't stop using Ano Metrogyl Cream. Your symptoms may improve before the condition is completely cured, but you should complete the entire course of treatment.
Yes, Ano Metrogyl Cream is a combination medicine used in the treatment of anal fissures, anal fistula, and piles (haemorrhoids) effectively.
Your doctor will advise you how often you need to use Ano Metrogyl Cream based on your medical condition.
Ano Metrogyl Cream is a combination of three drugs, namely: Lignocaine (local anaesthetic), Metronidazole (antibiotic) and Sucralfate (protectant).
Use Ano Metrogyl Cream as prescribed by your doctor. Apply a small amount of Ano Metrogyl Cream on the clean and dry affected area of the skin of the anus. Ano Metrogyl Cream is only for external use. Avoid contact of Ano Metrogyl Cream with nose, mouth or eyes. In case Ano Metrogyl Cream comes in contact with these areas accidentally, rinse with water thoroughly. Wash your hands before and after using Ano Metrogyl Cream.
Sometimes, Ano Metrogyl Cream may cause mild irritation, skin rash, and a tingling or burning sensation at the application site. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
No, you should not use if you are allergic to any components present in it.
Do not apply Ano Metrogyl Cream on cuts, wounds, grazes, raw or blistered skin.
Store in a cool and dry place away from sunlight. Keep Ano Metrogyl Cream out of reach and sight of children.
You should only use Ano Metrogyl Cream during pregnancy if your doctor specifically prescribes it after assessing the benefits and risks. Talk to your doctor before starting this medication.
It is best to avoid alcohol while using this medicine and for at least 48 hours after completing treatment. The metronidazole component may cause an unpleasant reaction with alcohol in some people, leading to flushing, nausea, vomiting, stomach cramps, or a fast heartbeat. Alcohol may also worsen dehydration and constipation, which can aggravate piles and anal fissures.
Ano Metrogyl Cream relieves pain, reduces inflammation, and helps heal damaged tissues, but it may not prevent haemorrhoids from returning if underlying causes like constipation or straining persist. Talk to your doctor about long-term dietary and lifestyle changes to manage your condition.

Disclaimer

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.5938 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.925 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Lidocaine Topical Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Sucralfate Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Williams, LaVonn A. Compounding with sucralfate for the treatment of external wounds. International Journal of Pharmaceutical Compounding. February 2009. [Accessed on 21st June 2022]Check here
  6. Lohsiriwat, Varut and Romyen Jitmungngan. Strategies to Reduce Post-Hemorrhoidectomy Pain: A Systematic Review. Medicina. March 2022. [Accessed on 21st June 2022]Check here
  7. Ocean Pharmaceutical. Anosum cream. lignocaine-cream-6376047.htmlCheck here

Country of origin

India

Manufacturer/Marketer address

Cnergy IT Park, 3rd floor Appa Saheb Marathe Marg, Prabhadevi, Mumbai 400025
Other Info - ANO0067

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