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compositionComposition:CYPROHEPTADINE-2MG
prescription
Prescription Medicine
info
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Apicris 2mg Syrup is used to treat allergy symptoms. It contains Cyproheptadine, which works by blocking the action of histamine, a substance responsible for causing allergic reactions. In some cases, this medicine may cause side effects such as drowsiness, dizziness, constipation, blurred vision, restlessness, dry mouth, nose, or throat. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CYPROHEPTADINE-2MG

Manufacturer/Marketer :

Kris Pharma

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Apicris 2mg Syrup

The oral medicine Apicris 2mg Syrup is used to treat allergy symptoms such as runny nose, sneezing, itchy or watery eyes, and hives. It is also prescribed in certain clinical situations to help stimulate appetite and assist with weight gain. This medication works by blocking natural substances in your body that are responsible for causing allergic reactions and itching.

For the best results, you must take Apicris 2mg Syrup consistently at the regular intervals prescribed by your doctor, which is often two to three times a day. You can take this medicine with or without food, though taking it with a meal or a glass of milk can help prevent a mild upset stomach. To support your recovery and overall well-being, try to drink plenty of fluids and maintain a balanced diet while on this treatment.

While taking Apicris 2mg Syrup, some people may experience mild side effects, most commonly drowsiness or a dry mouth. However, you should stop taking the medicine and consult your doctor immediately if you experience serious side effects like extreme confusion, a very fast heartbeat, or difficulty passing urine.

Talk to your doctor before starting Apicris 2mg Syrup if you have glaucoma, a stomach ulcer, an enlarged prostate, asthma, or high blood pressure. Do not take this if you are currently experiencing an acute asthma attack or have a blockage in your stomach or urinary tract.

This medicine can interact with alcohol and other drugs that cause drowsiness, such as sleep aids or muscle relaxants, making you feel significantly more tired and slow to react. Pregnant women, breastfeeding mothers, and elderly individuals should always consult their doctor before using Apicris 2mg Syrup to ensure it is safe for their specific situation.

Uses of Apicris 2mg Syrup

Apicris 2mg Syrup is used to treat allergy symptoms such as runny nose, sneezing, itchy or watery eyes, and hives. The detailed uses of Apicris 2mg Syrup are as follows:

  • Allergic rhinitis and eye allergies: Apicris 2mg Syrup helps relieve seasonal and year-round allergy symptoms, including sneezing, a runny nose, and itchy, watery eyes.
  • Hives and itchy skin: It treats mild, uncomplicated skin allergies, reducing redness, swelling, and intense itching.
  • Appetite loss: In specific cases, doctors prescribe Apicris 2mg Syrup to help stimulate appetite and support gradual, healthy weight gain.

Key Benefits

Apicris 2mg Syrup helps relieve allergy symptoms by blocking the effects of histamine, the substance responsible for allergic reactions. It also supports appetite stimulation in appropriate patients, helping improve comfort and overall wellbeing.

  • Helps Relieve Allergy Symptoms: By reducing the effects of histamine, Apicris 2mg Syrup helps relieve itching, sneezing, runny nose, watery eyes, and other symptoms of allergic reactions, allowing you to carry out your daily activities more comfortably.
  • Supports Appetite Stimulation: In patients with poor appetite due to certain medical conditions, Apicris 2mg Syrup may help increase appetite, supporting better nutritional intake and overall recovery.
  • Improves Comfort and Sleep: By relieving persistent itching and allergy-related discomfort, Apicris 2mg Syrup helps reduce skin irritation and promotes more restful sleep, contributing to improved quality of life.
Side effects of Apicris 2mg Syrup
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.

Directions for Use

  • Apicris 2mg Syrup can be taken with or without food, as advised by your doctor.
  • It is usually taken 2-3 times a day or as prescribed by your doctor.
  • Swallow Apicris 2mg Syrup as a whole with a glass of water.
  • Do not crush or chew this medication.

How Apicris 2mg Syrup Works

The active ingredient, cyproheptadine, works by blocking histamine, a natural chemical that your body releases during an allergic reaction. When histamine binds to its receptors, it causes swelling, redness, and itching. By blocking these receptors, Apicris 2mg Syrup stops the allergic response at its source. In addition to blocking histamine, this medicine also blocks serotonin, another natural chemical messenger in the brain. Serotonin plays a role in regulating your mood and appetite. By blocking specific serotonin pathways, this medicine helps stimulate the appetite center in the brain, encouraging a healthy desire to eat.
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Alcohol

Unsafe

Avoid consumption of alcohol with Apicris 2mg Syrup as it may increase the risk of adverse effects such as drowsiness, dizziness or difficulty in concentrating. Please consult a doctor before consuming alcohol with Apicris 2mg Syrup.

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Pregnancy

Consult your doctor

Apicris 2mg Syrup is a category B pregnancy drug and is given to pregnant women only if the doctor thinks it is essential. Please consult a doctor if you are pregnant.

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Breast Feeding

Caution

Apicris 2mg Syrup is given to breastfeeding women only if the doctor thinks the benefits outweigh the risks. Please consult a doctor if you are breastfeeding.

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Driving

Caution

Apicris 2mg Syrup may cause drowsiness, dizziness or low blood pressure in elderly people. Therefore, drive only if you are alert and have a clear vision after taking Apicris 2mg Syrup.

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Liver

Caution

Take Apicris 2mg Syrup with caution, especially if you have a history of Liver diseases or conditions. Your doctor may adjust the dose as needed.

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Kidney

Consult your doctor

Take Apicris 2mg Syrup with caution, especially if you have a history of Kidney diseases or conditions. Your doctor may adjust the dose as needed.

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Children

Unsafe

Apicris 2mg Syrup is not recommended for children below 2 years as the safety and effectiveness were not established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Apicris 2mg Syrup. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Unsafe

Apicris 2mg Syrup is not safe for use in elderly patients due to the increased risk of side effects.

What if I have taken an overdose of Apicris 2mg Syrup

If you take too much of this medicine, seek emergency medical help immediately. Symptoms of an overdose can include severe drowsiness, dry mouth, dilated pupils, fever, or extreme excitement and agitation, especially in young children.

Diet & Lifestyle Advise

  • Manage dry mouth: Sip water frequently throughout the day, suck on ice chips, or chew sugar-free gum to keep your mouth moist.
  • Stay safe while drowsy: Avoid driving, riding a bicycle, or operating tools and machinery until you are certain how this medicine affects your alertness.
  • Prevent constipation: Eat fibre-rich foods like fresh fruits, vegetables, and whole grains, and drink plenty of water to keep your digestion regular.
  • Focus on nutrition: If you are taking this medicine to help you gain weight, focus on eating nutrient-dense meals high in healthy proteins and fats rather than high-sugar foods.
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How Soon It Starts Working

The time required for Apicris 2mg Syrup to start to work: Apicris 2mg Syrup ideally shows its action within 15 to 60 minutes after administration. The time for which the effects of Apicris 2mg Syrup last: The effect of Apicris 2mg Syrup lasts for 8 to 12 hours.

What if you forget to take Apicris 2mg Syrup

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose entirely and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Apicris 2mg Syrup tablets and oral liquid at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the medication in its original container, tightly closed, to protect it from direct sunlight, heat, and moisture.

Drug Warnings

  • Always inspect the oral liquid before taking it; do not use the medicine if you notice any unusual cloudiness, floating particles, or changes in colour.
  • Avoid drinking alcohol while taking Apicris 2mg Syrup, as it can dangerously increase drowsiness and dizziness.
  • Take extra care in hot weather, as this medicine can reduce your body's ability to sweat, making you more sensitive to heat stroke.
  • Tell your dentist or surgeon that you are taking this medicine before any scheduled medical or dental procedures.
  • Do not share this medicine with anyone else, even if they have the exact same symptoms as you.

Drug-Drug Interactions

verifiedApollotooltip
  • Sleep medicines and sedatives: May increase the risk of severe drowsiness, slowed breathing, and extreme tiredness when combined with sleep aids, muscle relaxants, or anxiety medications.
  • MAO inhibitors (antidepressants): Taking Apicris 2mg Syrup with or shortly after MAO inhibitors can significantly prolong and intensify the anticholinergic side effects, such as dry mouth, blurred vision, and urinary retention.
CyproheptadinePotassium chloride
Critical
CyproheptadineLinezolid
Critical

Drug-Drug Interactions

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CyproheptadinePotassium chloride
Critical
How does the drug interact with Apicris 2mg Syrup:
Taking Apicris 2mg Syrup with Potassium chloride can increase the risk of stomach ulcers.

How to manage the interaction:
Taking Apicris 2mg Syrup with Potassium chloride is not recommended, as it can lead to an interaction, can be taken if your doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools, consult the doctor immediately. Do not stop any medication without talking to a doctor.
CyproheptadineLinezolid
Critical
How does the drug interact with Apicris 2mg Syrup:
Using linezolid together with Apicris 2mg Syrup may increase side effects of Apicris 2mg Syrup.

How to manage the interaction:
Taking Apicris 2mg Syrup with Linezolid is not recommended, consult a doctor before taking it. Contact a doctor if you experience dizziness, drowsiness, blurred vision, dry mouth, constipation, heat intolerance, flushing, decreased sweating, difficulty urinating, palpitation, rapid heartbeat, confusion, disorientation, and memory problems. Do not stop using any medications without talking to a doctor.
CyproheptadinePotassium citrate
Critical
How does the drug interact with Apicris 2mg Syrup:
Taking Apicris 2mg Syrup and Potassium citrate (in tablet or capsule form) together can increase the risk of stomach ulcers.

How to manage the interaction:
Taking Apicris 2mg Syrup with Potassium citrate is not recommended, as it may lead to an interaction but can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
CyproheptadineProcarbazine
Critical
How does the drug interact with Apicris 2mg Syrup:
Using procarbazine together with Apicris 2mg Syrup may increase side effects.

How to manage the interaction:
Taking Apicris 2mg Syrup with Procarbazine is not recommended, please consult your doctor before taking it. Call a doctor if you experience dizziness, drowsiness, blurred vision, dry mouth, constipation, heat intolerance, flushing, decreased sweating, difficulty urinating, palpitation, rapid heartbeat, confusion, disorientation, and memory problems.
CyproheptadineZonisamide
Severe
How does the drug interact with Apicris 2mg Syrup:
Coadministration of Apicris 2mg Syrup with Zonisamide can lead to increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Apicris 2mg Syrup with Zonisamide together is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience changes in blood pressure, increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
CyproheptadineEsketamine
Severe
How does the drug interact with Apicris 2mg Syrup:
Combining Apicris 2mg Syrup with Esketamine can increase the side effects.

How to manage the interaction:
Although there is a possible interaction between Apicris 2mg Syrup and Esketamine, you can take these medicines together if prescribed by your doctor. If you're having trouble with feeling tired, confused or finding it hard to focus, consult a doctor. Do not stop using any medications without talking to a doctor.
CyproheptadineKetamine
Severe
How does the drug interact with Apicris 2mg Syrup:
Using ketamine together with Apicris 2mg Syrup may increase side effects.

How to manage the interaction:
Although taking Ketamine and Apicris 2mg Syrup together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you feel dizzy, sleepy, confused, have trouble focusing, lazy, or have trouble breathing, make sure to contact your doctor right away. Do not stop using any medications without a doctor's advice.
CyproheptadineSodium oxybate
Severe
How does the drug interact with Apicris 2mg Syrup:
Taking Apicris 2mg Syrup with sodium oxybate can enhance the risk of negative effects.

How to manage the interaction:
Although there is a possible interaction between Apicris 2mg Syrup and Sodium oxybate, you can take these medicines together if prescribed by your doctor. If you notice any symptoms like feeling tired, dizzy, confused or having low blood pressure or difficulty breathing, make sure to contact your doctor right away. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid alcohol entirely, as it severely worsens drowsiness, dizziness, and mental slow-down caused by this medicine.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIALLERGIC]

FAQs

Apicris 2mg Syrup is used to treat symptoms of allergies such as itching, runny nose, sneezing, or watery eyes. It also helps stimulate appetite.
Apicris 2mg Syrup contains Cyproheptadine, an anti-allergic drug that works by blocking the action of histamine, a substance responsible for causing allergic reactions. Thereby, helps to provide relief from symptoms of allergy such as sneezing, running nose, watery eyes, itching, swelling and congestion or stiffness.
Apicris 2mg Syrup may cause dry mouth as a temporary side effect in some people. It is not necessary for everyone taking Apicris 2mg Syrup to experience this side effect. However, to avoid such side effects, drink plenty of water, regularly rinse your mouth, practice good oral hygiene and suck on sugarless candy. However, if the condition persists or worsens, please consult a doctor.
You are not recommended to take Apicris 2mg Syrup with topiramate (anticonvulsant) as co-administration of these two medicines may increase the risk of adverse effects such as reduced sweating, increased body temperature. Heatstroke and hospitalization may occur in a few people, especially in hot weather and during vigorous exercise. However, please consult a doctor before taking Apicris 2mg Syrup with other medicines.
You are recommended to take Apicris 2mg Syrup for as long as your doctor has prescribed it. However, if the symptoms persist or worsen with rash, fever or persistent headache after 1 week of using Apicris 2mg Syrup, please consult your doctor.
Apicris 2mg Syrup may be used to prevent and treat migraine headaches especially in children. Apicris 2mg Syrup reduces the intensity and frequency of headache. However, please consult a doctor before taking Apicris 2mg Syrup.
You are recommended to avoid taking Apicris 2mg Syrup if you have asthma, glaucoma, enlarged prostate, urinary problems, stomach ulcer or blockage. However, if you have any of these conditions, please inform your doctor before taking Apicris 2mg Syrup.
Apicris 2mg Syrup may be used to treat allergic reactions caused by insect bites. Apicris 2mg Syrup blocks the action of histamine, a substance responsible for causing allergic reactions. Thereby, helps to provide relief from allergic symptoms. However, please consult a doctor before using Apicris 2mg Syrup.
Apicris 2mg Syrup should be taken as directed by a healthcare professional. The frequency of administration may vary depending on the specific condition being treated, individual tolerance, and response to therapy. It's essential to follow the prescribed dosage and schedule to ensure safe and effective treatment.
If you forget to take a dose of Apicris 2mg Syrup, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up the dose.
Yes, Apicris 2mg Syrup can cause drowsiness as a common side effect due to its antihistamine properties. This drowsiness can range from mild to severe and may impair cognitive function, reaction time, and motor skills.
Apicris 2mg Syrup should only be used during pregnancy if clearly needed and under the guidance of a healthcare professional. There is limited research on its safety during pregnancy, and it's essential to weigh the potential benefits against the potential risks to the mother and fetus.
Yes, Apicris 2mg Syrup can cause weight gain due to its appetite-stimulating effects, leading to increased food intake. Monitor your weight and consult your doctor if you notice significant changes.
This medicine frequently causes drowsiness and can slow your reaction times. You should avoid driving, operating machinery, or performing tasks that require full mental focus until you know how this medicine affects you. Talk to your doctor if you have concerns.
Yes, you can take Apicris 2mg Syrup with or without food. If you find that the medicine causes mild stomach upset, taking it with a meal or a glass of milk can help prevent this. Talk to your doctor or pharmacist for personalised advice.
Dry mouth is a very common side effect. You can manage this by taking frequent sips of water, chewing sugar-free gum, or sucking on hard sugar-free candies. Talk to your doctor if the dry mouth persists or becomes severe.
Older adults are often more sensitive to the side effects of Apicris 2mg Syrup, such as drowsiness, confusion, dry mouth, constipation, and low blood pressure. Talk to your doctor, as they may decide to prescribe a lower starting dose to ensure safety.
This medicine is used in children, but the correct dose must be carefully calculated by a paediatrician based on the child's age and weight. Never give this medicine to newborns or premature infants. Talk to your doctor before giving Apicris 2mg Syrup to any child.

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Reference

  1. U.S. Food and Drug Administration (FDA). 087056S045Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Cyproheptadine Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. MedlinePlus. Cyproheptadine. [Accessed on 11-Sep-2020]Check here
  4. WebMD. Cyproheptadine. [Accessed on 11-Sep-2020]Check here
  5. Lactmed. Cyproheptadine. [Accessed on 11-Sep-2020]Check here
  6. Bertrand, Valérie et al. Safety of Cyproheptadine, an Orexigenic Drug. Analysis of the French National Pharmacovigilance Data-Base and Systematic Review. National Library of Medicine. (PMC). [Accessed on 18th June 2022]Check here
  7. Najib, Khadijehsadat et al. Beneficial effect of cyproheptadine on body mass index in undernourished children: a randomized controlled trial. National Library of Medicine. (PMC). [Accessed on 18th June 2022]Check here

Country of origin

India
Other Info - AP16087
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