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compositionComposition:APREPITANT-125MG+APREPITANT-80MG
prescriptionPrescription Medicine
Aprelief Kit 125/80Mg Capsule

Aprelief Kit 125/80Mg Capsule is used to prevent nausea and vomiting caused by chemotherapy (anti-cancer medicines) in adults and adolescents aged 12 years and above. It contains Aprepitant, which blocks a chemical that produces vomiting by acting on the neurological system. Thus, it helps prevent nausea and vomiting.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

APREPITANT-125MG+APREPITANT-80MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

Aprelief Kit 125/80Mg Capsule belongs to a class of drugs called anti-emetics. It is used to prevent nausea and vomiting caused by chemotherapy (anti-cancer medicines) in adults and adolescents aged 12 years and above. Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

Aprelief Kit 125/80Mg Capsule contains Aprepitant. Aprepitant blocks a chemical that produces vomiting by acting on the neurological system. Thus, it helps prevent nausea and vomiting.

Take Aprelief Kit 125/80Mg Capsule as prescribed. You are recommended to take Aprelief Kit 125/80Mg Capsule for as long as your doctor has advised it. In some cases, Aprelief Kit 125/80Mg Capsule may cause common side effects such as headache, constipation, loss of appetite, tiredness, indigestion, and hiccups. Most of these side effects do not require medical attention and gradually resolve over time. However, inform your doctor if the side effects persist or worsen.

Please tell your doctor if you are allergic to Aprelief Kit 125/80Mg Capsule or any other medicines. Aprelief Kit 125/80Mg Capsule is not recommended for children below 12 years of age. If you are pregnant or breastfeeding, please inform your doctor before taking Aprelief Kit 125/80Mg Capsule. Avoid driving or operating machinery if you feel dizzy or sleepy after taking Aprelief Kit 125/80Mg Capsule. If you are taking other prescription or non-prescription medicines, inform your doctor before taking Aprelief Kit 125/80Mg Capsule.

Uses of Aprelief Kit 125/80Mg Capsule

Aprelief Kit 125/80Mg Capsule is used in the treatment of Chemotherapy-induced nausea and vomiting. The detailed uses of Aprelief Kit 125/80Mg Capsule are as follows:

  • Chemotherapy-induced nausea and vomiting (CINV) prevention:Aprelief Kit 125/80Mg Capsule helps to prevent nausea and vomiting caused by chemotherapy, which improves patient comfort and quality of life.
  • Postoperative nausea and vomiting (PONV) prevention:Aprelief Kit 125/80Mg Capsule can also be used to prevent nausea and vomiting after surgery, which reduces recovery time and complications.

Key Benefits

Aprelief Kit 125/80Mg Capsule contains Aprepitant, an anti-emetic (a drug used to treat nausea and vomiting) that works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps to prevent nausea and vomiting caused by anti-cancer medicines in adults and adolescents from the age of 12 years.

Side effects of Aprelief Kit 125/80Mg Capsule
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If you have excess nerve pain and numbness, soak in Epsom salt and warm water. This can help ease the pain and associated discomfort.
  • Use compression socks and make sure to rest for a while to get relief from pain.
  • Avoid smoking and intake of alcohol or fluids that aggravate the pain.
  • Massage your feet or affected area often to get relief from pain. Take the medication prescribed by your doctor without fail.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Hiccups can be controlled if you can hold your breath for a short time.
  • Drink plenty of warm fluids and gargle with salt water.
  • Swallow some sugar as it can give relief to some extent.
  • You can try to pull your knees up to your chest and lean forward, which helps relieve hiccups.
  • Try to breathe in a paper bag for a while, but don't keep the paper over your head.

Directions for Use

  • Aprelief Kit 125/80Mg Capsule can be taken with or without food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Aprelief Kit 125/80Mg Capsule as a whole with a glass of water.
  • Do not crush, break, or chew it.
Aprelief Kit 125/80Mg Capsule contains Aprepitant, which blocks a chemical that produces vomiting by acting on the neurological system. Thus, it helps prevent nausea and vomiting.
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Alcohol

Caution

The interaction of alcohol with Aprelief Kit 125/80Mg Capsule is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before taking Aprelief Kit 125/80Mg Capsule. Your doctor may prescribe this medicine only if clearly needed.

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Breast Feeding

Consult your doctor

It is unknown whether Aprepitant is excreted in breast milk. Hence, if you are a nursing mother, inform your doctor before taking Aprelief Kit 125/80Mg Capsule.

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Driving

Caution

Aprelief Kit 125/80Mg Capsule may cause dizziness or drowsiness in some people. Hence, do not drive or operate machinery if you feel dizzy or drowsy after taking Aprelief Kit 125/80Mg Capsule.

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Liver

Consult your doctor

If you have liver disease, inform your doctor before taking Aprelief Kit 125/80Mg Capsule. Your doctor may monitor your liver condition.

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Kidney

Consult your doctor

If you have kidney problems, inform your doctor before taking Aprelief Kit 125/80Mg Capsule.

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Children

Unsafe

Aprelief Kit 125/80Mg Capsule is not recommended for children below 12 years of age.

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Heart

Safe if prescribed

Aprelief Kit 125/80Mg Capsule is generally considered safe, but it’s still important to proceed with medical guidance.

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Geriatrics

Safe if prescribed

Aprelief Kit 125/80Mg Capsule is generally safe for geriatric individuals. Please consult your doctor if you have any concerns.

Since Aprelief Kit 125/80Mg Capsule is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Diet & Lifestyle Advise

  • Eat a healthy and low-fat diet that includes lots of fruits and vegetables, lean meats, skinless poultry, nuts, fish, whole grains, and plant-based oils, especially in small portions, as it will be easy for digestion.
  • Avoid eating over-sweet food and include more salty food, especially if you have been vomiting.
  • Increase the intake of fluids. Drink a small amount of water after small intervals to stay hydrated.
  • Avoid taking greasy or oily foods, as these foods trigger nausea and vomiting.
  • If the smell of food makes you feel sick (vomit), do not cook food, as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Have a query?

Drug Warnings

Please tell your doctor if you are allergic to Aprelief Kit 125/80Mg Capsule or any other medicines. Aprelief Kit 125/80Mg Capsule is not recommended for children below 12 years of age. If you are pregnant or breastfeeding, please inform your doctor before taking Aprelief Kit 125/80Mg Capsule. Avoid driving or operating machinery if you feel dizzy or sleepy after taking Aprelief Kit 125/80Mg Capsule. If you are taking any other prescription or non-prescription medicines, inform your doctor before taking Aprelief Kit 125/80Mg Capsule.

Drug-Drug Interactions

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AprepitantPimozide
Critical
AprepitantFlibanserin
Critical

Drug-Drug Interactions

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AprepitantPimozide
Critical
How does the drug interact with Aprelief Kit 125/80Mg Capsule:
Using pimozide together with Aprelief Kit 125/80Mg Capsule may significantly increase the blood levels of pimozide. High blood levels of pimozide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Aprelief Kit 125/80Mg Capsule and Pimozide together is not recommended; as it can lead to an interaction, you can take them if your doctor advises you to. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, get immediate medical help. Do not discontinue any medications without consulting a doctor.
AprepitantFlibanserin
Critical
How does the drug interact with Aprelief Kit 125/80Mg Capsule:
Using flibanserin together with Aprelief Kit 125/80Mg Capsule can significantly increase the blood levels of flibanserin.

How to manage the interaction:
Taking Flibanserin and Aprelief Kit 125/80Mg Capsule together is not recommended as it can lead to an interaction; they can be taken if prescribed by a doctor. Consult a doctor if you develop any symptoms, such as extreme sleepiness or low blood pressure, that cause dizziness, lightheadedness, or fainting. To reduce the chance of these side effects, use Flibanserin at bedtime. Do not discontinue any medications without consulting a doctor.
AprepitantAstemizole
Critical
How does the drug interact with Aprelief Kit 125/80Mg Capsule:
Co-administration with Aprelief Kit 125/80Mg Capsule and Astemizole may increase the blood levels of Astemizole.

How to manage the interaction:
Although taking Aprelief Kit 125/80Mg Capsule and Astemizole together is not recommended as it can lead to an interaction, it is safe if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor. Astemizole should not be combined with any other medications without a doctor's advice.
AprepitantTerfenadine
Critical
How does the drug interact with Aprelief Kit 125/80Mg Capsule:
Co-administration with Aprelief Kit 125/80Mg Capsule and Terfenadine may increase the blood levels of Terfenadine and leads to irregular heartbeat.

How to manage the interaction:
Taking Aprelief Kit 125/80Mg Capsule and Terfenadine together is not recommended as it can lead to an interaction. It is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantLomitapide
Critical
How does the drug interact with Aprelief Kit 125/80Mg Capsule:
Lomitapide blood levels can be significantly increased by combining it with Aprelief Kit 125/80Mg Capsule.

How to manage the interaction:
Although using Lomitapide and Aprelief Kit 125/80Mg Capsule together may cause an interaction, they can be taken if advised by a doctor. Consult a doctor if you have any of the following symptoms: diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, liver problems causing fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, dark colored urine, light-colored stools, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AprepitantEliglustat
Critical
How does the drug interact with Aprelief Kit 125/80Mg Capsule:
Aprelief Kit 125/80Mg Capsule combined with Eliglustat can considerably raise blood levels of Eliglustat. This raises the possibility of cardiac adverse effects such as abnormal heart rhythm, heart block, and cardiac arrest.

How to manage the interaction:
Taking Aprelief Kit 125/80Mg Capsule and Eliglustat together is not recommended as it can lead to an interaction; they can be consumed if prescribed by a doctor. Consult a doctor if you have symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, weak heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AprepitantCisapride
Critical
How does the drug interact with Aprelief Kit 125/80Mg Capsule:
Co-administration with Aprelief Kit 125/80Mg Capsule and Cisapride may cause irregular heart rhythm.

How to manage the interaction:
Although taking Aprelief Kit 125/80Mg Capsule and Cisapride together is not recommended as it can lead to an interaction, it is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantCobimetinib
Severe
How does the drug interact with Aprelief Kit 125/80Mg Capsule:
Co-administration of Aprelief Kit 125/80Mg Capsule with Cobimetinib may result in a rise in Cobimetinib blood levels.

How to manage the interaction:
Although taking Aprelief Kit 125/80Mg Capsule with cobimetinib may cause an interaction, it is safe to do so if advised by your doctor. Consult a doctor if you have nausea, vomiting, diarrhea, mouth sores, bleeding, heart issues, rash, sensitivity to light, eye difficulties, or muscle damage. Do not discontinue any medications without consulting a doctor.
AprepitantAcalabrutinib
Severe
How does the drug interact with Aprelief Kit 125/80Mg Capsule:
Coadministration of Aprelief Kit 125/80Mg Capsule can significantly increase the blood levels of Acalabrutinib.

How to manage the interaction:
Although there is an interaction between Aprelief Kit 125/80Mg Capsule and acalabrutinib, it can be taken if prescribed by a doctor. A doctor should be consulted if you experience any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in the phlegm, red or irritated skin, body sores, and discomfort when urinating. Without consulting a doctor, never stop taking medicines.
AprepitantFentanyl
Severe
How does the drug interact with Aprelief Kit 125/80Mg Capsule:
Coadministration of fentanyl and Aprelief Kit 125/80Mg Capsule may significantly increase the blood levels and effects of fentanyl.

How to manage the interaction:
Although co-administration of Aprelief Kit 125/80Mg Capsule and Fentanyl can lead to an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, excessive drowsiness, or difficulty breathing. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

No
[ANTIEMETICS]

FAQs

Aprelief Kit 125/80Mg Capsule is used to treat Chemotherapy-induced nausea and vomiting.

Aprelief Kit 125/80Mg Capsule contains Aprepitant, an anti-emetic (a drug used to treat nausea and vomiting) that works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps to prevent nausea and vomiting caused by anti-cancer medicines in adults and adolescents from the age of 12 years.

You are not recommended to take erythromycin with Aprelief Kit 125/80Mg Capsule as it may increase the blood levels and effects of Aprelief Kit 125/80Mg Capsule. Contact your doctor if your condition changes or you experience side effects such as diarrhoea, constipation, nausea, or loss of appetite. However, please consult your doctor before taking other medicines with Aprelief Kit 125/80Mg Capsule.

You are advised not to take hormonal birth control medicines such as birth control pills, implants, skin patches, and certain Intrauterine devices (IUDs) as they may not work properly when taken together with Aprelief Kit 125/80Mg Capsule. Therefore, you are recommended to use another or additional non-hormonal form of birth control method during treatment with Aprelief Kit 125/80Mg Capsule and for up to 2 months after using Aprelief Kit 125/80Mg Capsule.

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
India
Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.
Other Info - APR0026

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