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compositionComposition:APREMILAST-20MG
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Prescription Medicine
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Apretas 20 Tablet 4's is used to treat Plaque psoriasis (scaly, itchy, and red patches on the skin), psoriasis arthritis (inflammation in the joints in people with psoriasis), and oral ulcers. It contains Apremilast, which blocks the action of some chemical messengers that are responsible for inflammation related to psoriatic arthritis and psoriasis and thus, lowers the signs and symptoms of these conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

APREMILAST-20MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Apretas 20 Tablet 4's

Apretas 20 Tablet 4's is a prescription medication used to treat moderate to severe plaque psoriasis and active psoriatic arthritis. It is also prescribed to treat painful mouth ulcers associated with Behçet's disease. By targeting specific pathways involved in inflammation, this medication helps clear skin plaques and reduce joint swelling and stiffness from within.

To get the best results, you should take Apretas 20 Tablet 4's consistently every day, typically twice a day after an initial period of gradually increasing the dose. You can take this tablet with or without food, making it easy to fit into your daily routine. Combining your medical treatment with a balanced diet, regular gentle exercise, and proper skin moisturising can significantly improve your therapeutic results.

While taking Apretas 20 Tablet 4's, you might experience mild side effects like nausea, diarrhea, or tension headaches, especially during the first few weeks of starting the treatment. However, if you experience severe diarrhea, significant unexplained weight loss, or changes in your mood such as depression, you must consult your doctor immediately.

Before starting Apretas 20 Tablet 4's, tell your healthcare provider if you have a history of depression, kidney disease, or severe digestive problems. Do not take this medicine if you have a known allergy to any of its ingredients.

Certain medicines, particularly strong seizure medications or tuberculosis treatments, can make Apretas 20 Tablet 4's less effective, which is why sharing your full medication list with your pharmacist is crucial. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, talk to your doctor to weigh the benefits and risks of this treatment.

Uses of Apretas 20 Tablet 4's

Apretas 20 Tablet 4's is used to treat certain long-term inflammatory conditions by reducing excessive immune activity, including:

  • Plaque Psoriasis: Apretas 20 Tablet 4's helps reduce the overproduction of skin cells, leading to a visible reduction in red, scaly patches and plaques.
  • Psoriatic Arthritis: It targets joint inflammation, which helps decrease pain, swelling, and stiffness in the joints.
  • Behçet's Disease: It aids in healing and preventing painful mouth ulcers associated with this chronic inflammatory condition.

Key Benefits

Apretas 20 Tablet 4's offers several important benefits that help control inflammation, relieve symptoms, and improve quality of life, including:

  • Convenient Oral Relief: Unlike many other advanced treatments for psoriasis or psoriatic arthritis that require injections or infusions, Apretas 20 Tablet 4's offers the convenience of a simple oral tablet.
  • Improved Joint Mobility: By calming chronic inflammation, this medication helps you move more freely and comfortably, making daily physical tasks easier to manage.
  • Clearer Skin: Many patients experience a significant clearing of skin plaques, leading to reduced itching, scaling, and physical discomfort.
  • Targeted Inflammation Control: It works specifically on the inflammatory pathways inside your cells, helping to prevent flare-ups before they start.

Directions for Use

  • Take Apretas 20 Tablet 4's with or without food as advised by your doctor.
  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Swallow Apretas 20 Tablet 4's as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Apretas 20 Tablet 4's Works

Apretas 20 Tablet 4's contains apremilast, a phosphodiesterase 4 (PDE4) inhibitor that helps reduce inflammation associated with conditions such as psoriasis and psoriatic arthritis. Apretas 20 Tablet 4's works by blocking the activity of the PDE4 enzyme inside immune cells. This helps restore the balance between inflammatory and anti-inflammatory signals in the body, reducing the production of substances that cause inflammation. As a result, it slows the rapid growth of skin cells and helps calm the overactive immune response that contributes to joint inflammation. Together, these actions help reduce redness, scaling, itching, joint pain, swelling, and stiffness, while improving symptoms of psoriasis and psoriatic arthritis.
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Alcohol

Unsafe

Limit intake of alcohol, as this may increase the risk of serious side effects.

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Pregnancy

Caution

If you are pregnant, inform your doctor before taking Apretas 20 Tablet 4's. Consult your doctor if you become pregnant while taking Apretas 20 Tablet 4's.

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Breast Feeding

Caution

It is not known whether Apretas 20 Tablet 4's may pass into breast milk or not. If you are breastfeeding, inform your doctor before taking Apretas 20 Tablet 4's.

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Driving

Safe if prescribed

Apretas 20 Tablet 4's has no or negligible influence on the ability to drive and use machines.

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Liver

Caution

Apretas 20 Tablet 4's to be taken with caution, especially if you have a history of liver problems. Your doctor may adjust the dose of this medicine based on your condition.

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Kidney

Caution

Apretas 20 Tablet 4's to be taken with caution, especially if you have a history of kidney diseases. Your doctor may adjust the dose of this medicine based on your condition.

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Children

Unsafe

Apretas 20 Tablet 4's is not recommended for use in children and adolescents below 17 years.

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Heart

Consult your doctor

Apretas 20 Tablet 4's can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Safe if prescribed

Apretas 20 Tablet 4's is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Apretas 20 Tablet 4's

If you take too much of this medication, seek immediate medical attention or call your local poison control centre. Bring the medication packaging with you to show the emergency medical team.

Diet & Lifestyle Advise

  • Stay Well Hydrated: Because mild diarrhoea or nausea can occur when you start Apretas 20 Tablet 4's, drink plenty of water and electrolyte-rich fluids throughout the day to prevent dehydration.
  • Protect and Moisturise Your Skin: Apply a thick, fragrance-free emollient to your skin within three minutes of bathing to lock in moisture and support the skin barrier.
  • Engage in Low-Impact Exercise: If you have joint pain, engage in gentle activities like swimming, cycling, or yoga to keep your joints flexible without putting excessive stress on them.
  • Eat an Anti-Inflammatory Diet: Focus on foods rich in omega-3 fatty acids (like salmon and flaxseeds) and colorful vegetables, which can help support your body's natural anti-inflammatory processes.
  • Track Your Mood: Keep a daily journal of your mood and emotional well-being to easily notice any changes, and share these observations with your doctor.
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Have a query?

How Soon It Starts Working

  • The time required for Apretas 20 Tablet 4's to start to work: The time required for Apretas 20 Tablet 4's to show its action is unknown.
  • The time for which the effects of Apretas 20 Tablet 4's last: The duration of action for Apretas 20 Tablet 4's is unknown.

What if you forget to take Apretas 20 Tablet 4's

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular routine. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Apretas 20 Tablet 4's tablets at a controlled room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Monitor Your Weight Regularly: Weigh yourself weekly when starting this treatment and inform your doctor if you experience significant, unexplained weight loss.
  • Prepare for the Starting Phase: Be aware that your doctor will use a starter pack to gradually increase your dose; do not skip this step as it helps prevent severe stomach upset.
  • Report Mood Changes Immediately: Alert a family member or close friend that you are taking this medication so they can help monitor you for signs of depression or mood shifts.
  • Check Your Kidney Health: Ensure your doctor checks your kidney function before starting, as a lower dose may be required if your kidneys do not filter waste efficiently.
  • Review Your Complete Drug List: Tell your doctor about all other medicines you take, as certain liver enzyme-inducing drugs can significantly lower the levels of Apretas 20 Tablet 4's in your blood, making it less effective.

verifiedApollotooltip

Apretas 20 Tablet 4's may interact with certain medicines, which can reduce its effectiveness or require dose adjustments. Inform your doctor about all prescription medicines, over-the-counter products, vitamins, and herbal supplements you are taking, including:

  • Strong CYP3A4 Inducers (such as rifampin, phenytoin, phenobarbital, carbamazepine, or St. John’s wort): These medicines can significantly lower Apretas 20 Tablet 4's levels in the body, reducing its effectiveness.

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verifiedApollotooltip

Apretas 20 Tablet 4's does not have any known significant interactions with food.

  • You can take Apretas 20 Tablet 4's with or without meals.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIPSORIATICS]

FAQs

Apretas 20 Tablet 4's is used to treat plaque psoriasis (scaly, itchy, and red patches on the skin), psoriatic arthritis (inflammation in the joints in people with psoriasis), and oral ulcers caused by Behcet's disease.
Apretas 20 Tablet 4's works by blocking the action of some chemical messengers that are responsible for inflammation.
Yes, Apretas 20 Tablet 4's may cause depression as a side effect. The patient may also have suicidal thoughts. Apretas 20 Tablet 4's should be avoided in people with a history of depression. In case you develop any of these symptoms, Inform your doctor immediately.
Yes, Apretas 20 Tablet 4's may cause a reduction in appetite, which may further lead to weight loss. You should monitor your weight frequently while on treatment with Apretas 20 Tablet 4's. In case of big weight loss, inform your doctor. Your doctor may consider stopping Apretas 20 Tablet 4's.
Rifampicin is an antibiotic. You should not take rifampicin if you are taking Apretas 20 Tablet 4's. Rifampicin interferes with the working of Apretas 20 Tablet 4's by reducing its levels, making it less effective. As a result, you may not see any recovery after taking Apretas 20 Tablet 4's.
As soon as you recall, take the missed dose. If the next dose is approaching, skip the missing dose and resume your regular dosing regimen. Do not duplicate the dose to make up for a missing one.
No, Apretas 20 Tablet 4's is not an immunosuppressant. It belongs to a class of drugs called phosphodiesterase 4 (PDE4) inhibitors which work by blocking the action of PDE4 that is found in inflammatory cells.
Take Apretas 20 Tablet 4's as advised by the doctor. Swallow it as whole with a glass of water. Do not break, crush or chew it.
If you get pregnant during treatment with Apretas 20 Tablet 4's, inform your doctor immediately. You are recommended to avoid pregnancy during treatment with Apretas 20 Tablet 4's as it may harm unborn baby.
Apretas 20 Tablet 4's may cause side effects such as nausea, vomiting, diarrhoea, back pain or weight loss. If these side effects persist or worsen, please consult your doctor.
While there is no direct chemical interaction between alcohol and Apretas 20 Tablet 4's, alcohol can dehydrate you and exacerbate skin inflammation or stomach upset. It is best to limit alcohol intake. Talk to your doctor about what is safe for you.
Hair loss is not a medically recognised or common side effect of Apretas 20 Tablet 4's. If you experience unusual hair thinning or shedding, it may be due to other underlying health factors. Talk to your doctor to determine the cause.
Unlike many biological therapies, Apretas 20 Tablet 4's is a selective oral treatment that targets specific inflammatory pathways rather than suppressing the entire immune system. This means it generally does not carry the same high risk of serious infections. Talk to your doctor for more details.
Unlike some other systemic treatments for psoriasis or arthritis, Apretas 20 Tablet 4's does not typically require routine laboratory monitoring or frequent blood tests. However, your doctor may check your kidney function before starting. Talk to your doctor to plan your monitoring schedule.
There is limited data on the safety of Apretas 20 Tablet 4's during pregnancy. It is generally recommended to discuss family planning with your healthcare provider before starting or while taking this medication. Talk to your doctor about alternative options if you are planning a pregnancy.
Mild nausea and diarrhoea are common when first starting Apretas 20 Tablet 4's but usually improve within a few weeks. If your stomach issues are severe, cause dehydration, or persist beyond the first month, do not stop the medication abruptly. Talk to your doctor for advice on managing these symptoms.
No, you should not crush, chew, or break the Apretas 20 Tablet 4's tablet. The tablets are formulated to release the active medicine safely in your digestive system, and breaking them can interfere with this process. Talk to your doctor or pharmacist if you have difficulty swallowing pills.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - APR0202
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