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Aquagest 50 Injection 2.237 ml is used in the treatment of dysfunctional uterine bleeding threatened abortion, and amenorrhoea. It is also used in the maintenance of early pregnancy. This medicine contains progesterone, a female hormone which helps increase the progesterone levels in the body. Common side effects include injection site reactions, rash or any other allergy, changes in the breast, darkening of facial skin, scalp hair loss, coarsening of hair in abnormal regions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PROGESTERONE-50MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Aquagest 50 Injection 2.237 ml

Aquagest 50 Injection 2.237 ml is an injectable hormone helper prescribed to treat irregular or missed menstrual periods and abnormal uterine bleeding caused by a lack of natural hormones. It is also commonly used to support early pregnancy in women undergoing fertility treatments. This injection helps prepare and maintain the lining of the uterus so that a fertilized egg can implant and grow.

You will typically receive this injection once a day or on specific days of your menstrual cycle, depending on your treatment plan. Since it is given as an injection, your food intake does not affect how the medicine is absorbed, but maintaining a consistent schedule is highly important for its effectiveness. Making simple lifestyle adjustments, such as managing stress levels and maintaining a stable sleep routine, can support your body's hormonal balance during treatment.

While using this medication, you may experience mild side effects like breast tenderness, headache, or temporary pain at the injection site. However, if you experience severe symptoms such as sudden shortness of breath, severe leg swelling, or vision changes, you must contact your doctor immediately.

Do not take this if you have a history of blood clots, severe liver damage, breast or genital tract cancers, or unusual vaginal bleeding that a doctor has not evaluated. It is crucial to discuss your complete medical history with your doctor before starting therapy, especially if you have asthma, epilepsy, migraine headaches, or heart problems.

This injection can interact with certain medications, including those that affect liver enzymes, so you must share your full medication list with your healthcare provider. You should also avoid smoking and limit alcohol consumption while on this therapy, as they can increase your risk of blood clots. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider to ensure this treatment is safe and appropriate for your specific needs.

Uses of Aquagest 50 Injection 2.237 ml

Aquagest 50 Injection 2.237 ml is used to correct Aquagest 50 Injection 2.237 ml deficiency, regulate menstrual cycles, and support pregnancy during fertility treatment.

  • Treating absence of menstrual periods (amenorrhea): It helps restore a regular menstrual cycle in women who have stopped having periods due to low hormone levels.
  • Managing abnormal uterine bleeding: It regulates the monthly shedding of the uterine lining to control unusual or heavy bleeding caused by hormonal imbalances.
  • Supporting assisted reproductive technology (ART): It helps prepare the womb and supports early pregnancy during fertility procedures like in vitro fertilization (IVF).

Key Benefits

Aquagest 50 Injection 2.237 ml helps restore hormonal balance, support healthy uterine function, and improve the chances of a successful pregnancy during fertility treatment.

  • Restores regular menstrual cycles: Helps regulate the menstrual cycle by correcting Aquagest 50 Injection 2.237 ml deficiency, making periods more predictable.
  • Controls abnormal uterine bleeding: Supports normal shedding of the uterine lining, helping reduce heavy, prolonged, or irregular menstrual bleeding.
  • Supports fertility treatment: Prepares the uterine lining for embryo implantation and helps maintain a favourable environment during the early stages of pregnancy.
  • Protects the uterine lining: Prevents excessive thickening of the endometrium caused by hormonal imbalance, supporting long-term uterine health.
Side effects of Aquagest 50 Injection 2.237 ml
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • The doctor or healthcare professional will administer Aquagest 50 Injection 2.237 ml.
  • Aquagest 50 Injection 2.237 ml is intended for use by women only.
  • Do not self-administer.

How Aquagest 50 Injection 2.237 ml Works

Aquagest 50 Injection 2.237 ml contains progesterone, a naturally occurring female hormone that helps regulate the menstrual cycle and supports pregnancy. Aquagest 50 Injection 2.237 ml works by acting on the lining of the uterus (endometrium), changing it from a growing phase to a receptive phase. This prepares the uterus to receive and support a fertilised egg if pregnancy occurs. If pregnancy does not occur, Aquagest 50 Injection 2.237 ml helps the uterine lining shed normally, resulting in a regular menstrual period. Aquagest 50 Injection 2.237 ml also helps maintain the uterine lining during early pregnancy, creating a suitable environment for the developing embryo and supporting the continuation of pregnancy. Together, these actions help regulate the menstrual cycle, prepare the uterus for pregnancy, and support early pregnancy when required.
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Alcohol

Consult your doctor

It is not known if alcohol affects Aquagest 50 Injection 2.237 ml. In case of any concerns, discuss them with the doctor. However, it is advisable not to take or limit alcohol as a precautionary measure.

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Pregnancy

Consult your doctor

Aquagest 50 Injection 2.237 ml is used in pregnancy conditions like threatened abortion, luteal phase support, and maintenance of pregnancy. Your doctor will weigh the benefits to outweigh the risks before prescribing this medicine.

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Breast Feeding

Consult your doctor

Let your doctor know if you are a nursing mother before receiving Aquagest 50 Injection 2.237 ml; your doctor will decide whether Aquagest 50 Injection 2.237 ml can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Avoid driving or operating machinery if you experience drowsiness after receiving this injection.

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Liver

Consult your doctor

Inform your doctor before receiving the Aquagest 50 Injection 2.237 ml if you have a history of or ongoing liver disease.

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Kidney

Consult your doctor

Inform your doctor before receiving the Aquagest 50 Injection 2.237 ml if you have renal insufficiency or kidney problems. This medicine is excreted through urine, and if you have kidney problems, it may worsen your condition. Your doctor will adjust the dose of this medicine if required based on your condition.

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Children

Unsafe

Aquagest 50 Injection 2.237 ml is not recommended for use in children.

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Heart

Caution

Aquagest 50 Injection 2.237 ml should be used with caution in people with heart conditions, as it may increase the risk of heart attack, stroke, or blood clots when combined with estrogen therapy. Always consult your doctor to evaluate the risks and determine if it's safe for your specific cardiac profile.

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Geriatrics

Caution

Geriatric patients can receive Aquagest 50 Injection 2.237 ml, but it may be more sensitive to side effects like blood clots, fluid retention, or changes in mood. It's important to use it under close medical supervision with individualized dosing.

What if I have taken an overdose of Aquagest 50 Injection 2.237 ml

In case of an accidental overdose or if you suspect you have received too much of this medication, seek immediate emergency medical attention or contact a poison control centre. Symptoms of an overdose may include severe dizziness, nausea, or sleepiness.

Diet & Lifestyle Advise

  • Focus on bone health: Since hormone levels can affect bone density, ensure your diet includes adequate calcium and vitamin D through foods like leafy greens, dairy or fortified plant milks, and fish.
  • Stay hydrated: Drink plenty of water daily to help manage mild fluid retention and bloating that can occur with hormone therapy.
  • Eat balanced meals: Focus on whole foods, including lean proteins, healthy fats (like avocados and nuts), and complex carbohydrates to support overall metabolic and hormonal health.
  • Incorporate gentle exercise: Engage in regular, low-impact physical activities like walking, swimming, or yoga to help manage stress, improve circulation, and reduce the risk of blood clots.
  • Manage stress: Practice relaxation techniques such as deep breathing, meditation, or light stretching, as high stress levels can further disrupt your body's natural hormone levels.
health query

Have a query?

How Soon It Starts Working

The time required for Aquagest 50 Injection 2.237 ml to start to work: The onset time of Aquagest 50 Injection 2.237 ml has not been clinically established. 

The time for which the effects of Aquagest 50 Injection 2.237 ml last: The duration of Aquagest 50 Injection 2.237 ml’s effect is clinically not established.

What if you forget to take Aquagest 50 Injection 2.237 ml

If you miss a dose, contact your doctor or pharmacist immediately for instructions. Do not double the dose to make up for a missed one, as this can disrupt your hormonal balance.

Storage

• Store Aquagest 50 Injection 2.237 ml vials or pre-filled syringes at controlled room temperature, ideally between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the solution: Always look closely at the vial before drawing up your dose; the liquid should be clear or pale yellow and free of any floating particles.
  • Rotate injection sites: Never inject into the exact same spot twice in a row; keeping a simple log of where you inject can help prevent painful skin lumps or tissue damage.
  • Practise strict needle safety: Use a sterile needle and syringe for every single injection, and never share injection equipment with anyone else to avoid serious infections.
  • Watch for signs of blood clots: Be vigilant for sudden leg pain, warmth, redness, or unexplained shortness of breath, as hormone injections can slightly increase the risk of blood clots.
  • Avoid heavy machinery: If this injection makes you feel drowsy, dizzy, or lightheaded, avoid driving or operating tools until you know how the medicine affects you.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Aquagest 50 Injection 2.237 ml:

  •  Liver enzyme inducers (such as rifampin or carbamazepine): May speed up how your body processes this medicine, which can lower its effectiveness.
  • Ketoconazole: May slow down the breakdown of this medication in your liver, potentially raising its levels in your body and increasing the risk of side effects.
ProgesteroneEdoxaban
Severe

Drug-Drug Interactions

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ProgesteroneEdoxaban
Severe
How does the drug interact with Aquagest 50 Injection 2.237 ml:
When Aquagest 50 Injection 2.237 ml is taken with Edoxaban, may increase the blood levels of Edoxaban which increases the risk of serious bleeding complications.

How to manage the interaction:
Although taking Aquagest 50 Injection 2.237 ml and edoxaban together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness, you should consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Aquagest 50 Injection 2.237 ml:
Co-administration of Aquagest 50 Injection 2.237 ml with Morphine may increase the blood levels and side effects of Morphine.

How to manage the interaction:
Co-administration of Morphine with Aquagest 50 Injection 2.237 ml can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.
ProgesteroneVenetoclax
Severe
How does the drug interact with Aquagest 50 Injection 2.237 ml:
Co-administration of Aquagest 50 Injection 2.237 ml with Venetoclax may increase the blood levels of Venetoclax which increases the risk of side effects.

How to manage the interaction:
Although taking Aquagest 50 Injection 2.237 ml and Venetoclax together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any symptoms such as fatigue, nausea, vomiting, diarrhea, and infections, it is advised to consult a doctor. Without consulting a doctor, never stop taking any drugs.

Drug-Food Interactions

verifiedApollotooltip

The following food-related information should be considered while using Aquagest 50 Injection 2.237 ml:

  • There are no specific food interactions established with this injectable medication, but maintaining a balanced diet supports your overall hormonal health.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[HORMONES]

FAQs

Aquagest 50 Injection 2.237 ml is used to treat various medical conditions, including early pregnancy maintenance, dysfunctional uterine bleeding, and threatened abortion. Besides this, it can also be used for the progesterone withdrawal test in the endocrinal evaluation of secondary amenorrhoea (paused or missed periods) to judge oestrogen priming.
Aquagest 50 Injection 2.237 ml contains progesterone; it works by increasing levels of the hormone progesterone in your body.
The most prevalent negative effect of using Aquagest 50 Injection 2.237 ml is the darkening of the facial skin. Please report to the doctor immediately if you notice any significant or rapid changes.
Using Aquagest 50 Injection 2.237 ml is contraindicated in people with cancers such as breast or genital organs. So, inform your doctor if you have cancer in your breasts or genital organs.
Aquagest 50 Injection 2.237 ml is contraindicated in people allergic to progesterone or people diagnosed with porphyria (a disorder in the formation of red blood pigment), cancers in breasts or genital organs, or a blocked blood vessel, vaginal infections, and/or people with missed abortion.
Hair loss is the most prevalent negative effect of utilizing Aquagest 50 Injection 2.237 ml. If you notice any significant or abnormal hair loss, please immediately report it to the doctor.
Yes, you can inject Aquagest 50 Injection 2.237 ml at home, but only after receiving thorough training from your healthcare provider. Your doctor or nurse will teach you how to prepare the dose, inject it safely, and dispose of the needles properly. If you ever feel unsure about the process, talk to your doctor or pharmacist before administering your next dose.
Mild pain, redness, or a small lump at the injection site is common. You can help prevent this by rotating your injection sites daily and applying a warm compress gently to the area after injecting, if your doctor approves. If the pain worsens, or if you notice signs of infection like pus, intense warmth, or spreading redness, talk to your doctor immediately.
No, Aquagest 50 Injection 2.237 ml is not a contraceptive and will not prevent pregnancy. In fact, it is often prescribed to support early pregnancy in women undergoing fertility treatments. If you are not trying to conceive, talk to your doctor about appropriate and safe birth control options while using this medication.
It is highly recommended to limit or avoid alcohol while using Aquagest 50 Injection 2.237 ml. Alcohol can worsen side effects like dizziness and drowsiness, and it can also interfere with your liver's ability to process the medication. Talk to your doctor or pharmacist if you have questions about alcohol use.
Some women experience mild weight changes or bloating while taking Aquagest 50 Injection 2.237 ml, which is often due to temporary fluid retention rather than an increase in body fat. If you notice rapid weight gain, severe swelling in your hands or feet, or if the weight gain concerns you, talk to your doctor.
This medicine can pass into breast milk, and its effects on a nursing infant are not fully established. Therefore, you should always consult your healthcare provider before using this injection if you are currently breastfeeding or planning to breastfeed. Talk to your doctor to weigh the risks and benefits.
The most important factor is consistency. You should take your Aquagest 50 Injection 2.237 ml injection at the exact same time every day to maintain stable hormone levels in your body. Discuss with your doctor or pharmacist to determine the most convenient daily schedule for you.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - AQU0495
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