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  3. Aquagest 50 Injection 2.237 ml

Aquagest 50 Injection 2.237 ml, Pack of 1
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Aquagest 50 Injection 2.237 ml is used in the treatment of dysfunctional uterine bleeding threatened abortion, and amenorrhoea. It is also used in the maintenance of early pregnancy. This medicine contains progesterone, a female hormone which helps increase the progesterone levels in the body. Common side effects include injection site reactions, rash or any other allergy, changes in the breast, darkening of facial skin, scalp hair loss, coarsening of hair in abnormal regions.

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Composition :

PROGESTERONE-50MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Aquagest 50 Injection 2.237 ml

Aquagest 50 Injection 2.237 ml is used to treat various conditions like early pregnancy maintenance, dysfunctional uterine bleeding, and threatened abortion. Besides this, it can also be used for the progesterone withdrawal test in the endocrinal evaluation of secondary amenorrhoea (paused or missed periods)

Aquagest 50 Injection 2.237 ml contains progesterone, which works by increasing levels of the progesterone hormone in your body.

In some cases, you may experience injection site reactions, changes in the breast, darkening of facial skin, scalp hair loss, nausea, fever, and sleep disturbances. Most of these side effects do not require medical attention and resolve over time. However, if the side effects persist, please consult your doctor.

Aquagest 50 Injection 2.237 ml will be administered by a healthcare professional; do not self-administer. This medicine is intended for use in female (women) patients only. Hence not recommended for use in men.

Let your doctor know if you are allergic to any component of Aquagest 50 Injection 2.237 ml. Inform your doctor if you have a blood clot caused by swollen veins (thrombophlebitis), a blocked blood vessel (thromboembolic disorder), a stroke, a suspected vaginal infection, the use of any other vaginal application products, or any ongoing medical conditions such as cancer of the breasts or genital organs. Also inform your doctor if you are pregnant, planning for pregnancy or breastfeeding before receiving this medicine.

Uses of Aquagest 50 Injection 2.237 ml

Aquagest 50 Injection 2.237 ml is used in the maintenance of early pregnancy and treatment of dysfunctional uterine bleeding, threatened abortion, and amenorrhea. The detailed uses of Aquagest 50 Injection 2.237 ml are as follows: <br/>

  • Menstrual Cycle Regulation: Aquagest 50 Injection 2.237 ml helps to regulate irregular menstrual cycles, treating conditions like amenorrhea by stabilizing hormonal imbalances and promoting a regular menstrual cycle.<br/>
  • Treatment of Abnormal Uterine Bleeding: By controlling hormone levels and possibly lowering excessive bleeding during menstruation, Aquagest 50 Injection 2.237 ml can help manage abnormal uterine bleeding.<br/>
  • Luteal Phase Support: Aquagest 50 Injection 2.237 ml is prescribed to support the luteal phase during assisted reproductive technologies like in vitro fertilization (IVF), increasing the chances of pregnancy.<br/>
     

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use. • The doctor or healthcare professional will administer Aquagest 50 Injection 2.237 ml. • Aquagest 50 Injection 2.237 ml is intended for use by women only. • Do not self-administer.

Medicinal Benefits

  • Aquagest 50 Injection 2.237 ml is used to maintain early pregnancy in cases of documented history of repeated miscarriages due to luteal phase defect
  • This medicine is also used as an adjunct to successful infertility treatment with techniques such as in vitro fertilisation (IVF) or gamete intra-fallopian transfer (GIFT) to facilitate uterine implantation of the fertilised ovum.
  • In cases of secondary amenorrhoea (paused or missed periods), it can also be used as a progesterone withdrawal test to assess oestrogen priming.
  • Furthermore, it can treat threatening abortions and dysfunctional uterine haemorrhages.

How Aquagest 50 Injection 2.237 ml Works

Aquagest 50 Injection 2.237 ml contains progesterone; it works by increasing levels of the progesterone hormone in your body.

Storage

• Store in a cool and dry place away from sunlight.• Keep out of sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Aquagest 50 Injection 2.237 ml
  • Regular activity including cardio and weightlifting can help in weight loss and breast tissue reduction.
  • Limit alcohol intake to lower your chances of gynecomastia and hormonal changes.
  • Eat a balanced diet and avoid foods high in estrogen-like compounds.
  • Follow your doctor's instructions take medication consistently to reduce breast enlargement and do not stop taking medication on your own.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Mood swings can be managed but cannot be controlled. Therefore, spending time in nature can help you feel light and improve your mood.
  • Practice meditation, deep breathing and do regular exercise that can positively affect your mood. Also helps in processing the situation before responding to it.
  • Food has direct impact on mood. Therefore, eat foods that are less processed and reduce sugar intake.
  • Consult your doctor if the mood swings are uncontrollable or unmanageable.
  • Always wear loose-fitting clothes suitable for your activity during hot flashes.
  • Include a diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water and stay hydrated.
  • Stay calm and lower your anxiety by practising yoga or meditation.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Use hot or cold packs on your breasts to help alleviate discomfort.
  • Choose a supportive, well-fitting bra, preferably one that has been professionally fitted.
  • Practice relaxation techniques to manage stress and anxiety that may accompany severe breast pain.
  • Limit or avoid caffeine consumption.
  • Eat a low-fat diet and focus on foods rich in complex carbohydrates.
  • Rubbing evening primrose oil on your breasts may help balance fatty acids in the cells and reduce pain.
  • Keep track of when your breast pain occurs and any other symptoms to determine if the pain is regular or not.
  • Vitamin E supplements may help reduce pain for women who experience pain linked to their menstrual cycle.
  • Over-the-counter pain relievers like acetaminophen or ibuprofen can provide relief, but be sure to consult your doctor for the correct dosage, as prolonged use may cause side effects.
  • Talk to your doctor to determine the underlying cause of bleeding between periods and discuss appropriate treatment options.
  • To avoid infection, use sanitary items and change them frequently as part of proper hygiene.
  • Engage in moderate exercise, like walking, cycling, or swimming, to help regulate your menstrual cycle.
  • To lower the chance of hormonal imbalances and intermenstrual bleeding, maintain a healthy weight.
  • Apply a warm compress to the lower abdomen to ease cramps.
  • Seek medical attention if you experience heavy or prolonged bleeding between periods.

What if I have taken an overdose of Aquagest 50 Injection 2.237 ml

Aquagest 50 Injection 2.237 ml is administered by a health care professional in a hospital setting. Hence, the chances of overdose are less. Seek immediate medical attention if you experience any of the following symptoms: difficulty speaking, pain, swelling, or warmth in the groin or calf, shortness of breath or rapid breathing, sudden or severe headaches, sudden dizziness or fainting, unusual sweating, or pain in the chest, jaw, or left arm.

Drug Warnings

  • Please tell your doctor if you are allergic to Aquagest 50 Injection 2.237 ml or any other medicines.
  • Inform your doctor if you are diagnosed with porphyria (a disorder in the formation of red blood pigment), cancers in breasts or genital organs, a blocked blood vessel, vaginal infections, and missed abortion.
  • If you are pregnant, planning for pregnancy or breastfeeding, please consult a doctor before taking Aquagest 50 Injection 2.237 ml.
  • Aquagest 50 Injection 2.237 ml is not recommended for children below 18 years of age.
  • This medicine is intended for use in female (women) patients only. Hence not recommended for use in men.

Drug-Drug Interactions

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ProgesteroneEdoxaban
Severe
ProgesteroneMorphine
Severe

Drug-Drug Interactions

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ProgesteroneEdoxaban
Severe
How does the drug interact with Aquagest 50 Injection 2.237 ml:
When Aquagest 50 Injection 2.237 ml is taken with Edoxaban, may increase the blood levels of Edoxaban which increases the risk of serious bleeding complications.

How to manage the interaction:
Although taking Aquagest 50 Injection 2.237 ml and edoxaban together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness, you should consult a doctor. Do not discontinue any medications without a doctor's advice.
ProgesteroneMorphine
Severe
How does the drug interact with Aquagest 50 Injection 2.237 ml:
Co-administration of Aquagest 50 Injection 2.237 ml with Morphine may increase the blood levels and side effects of Morphine.

How to manage the interaction:
Co-administration of Morphine with Aquagest 50 Injection 2.237 ml can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.
ProgesteroneVenetoclax
Severe
How does the drug interact with Aquagest 50 Injection 2.237 ml:
Co-administration of Aquagest 50 Injection 2.237 ml with Venetoclax may increase the blood levels of Venetoclax which increases the risk of side effects.

How to manage the interaction:
Although taking Aquagest 50 Injection 2.237 ml and Venetoclax together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any symptoms such as fatigue, nausea, vomiting, diarrhea, and infections, it is advised to consult a doctor. Without consulting a doctor, never stop taking any drugs.
ProgesteroneTirzepatide
Moderate
How does the drug interact with Aquagest 50 Injection 2.237 ml:
Aquagest 50 Injection 2.237 ml may interfere with blood glucose control and reduce the effectiveness of tirzepatide and other diabetic medications.

How to manage the interaction:
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor. Monitor your blood sugar levels closely.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise and physical activity to minimize hot flushes and improve sleep. Aerobics, yoga, and activities like tai chi may help relax the body and mind.
  • Try to wear loose clothes before going to bed and sleep in a cool, well-ventilated room. Doing this can prevent symptoms of hot flushes and night sweats. Sleep at least for 8 hours.
  • Avoid or limit intake of caffeine-containing beverages, alcohol, and spicy food, as these are known triggering agents for hot flushes.
  • Try to be stress-free to improve your mood swings due to hormonal fluctuations.
  • Quit smoking as it will help to reduce hot flushes and your risk of developing chronic conditions like heart disease, stroke, and cancer.

Habit Forming

No

Therapeutic Class

HORMONES

Aquagest 50 Injection 2.237 ml Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

It is not known if alcohol affects Aquagest 50 Injection 2.237 ml. In case of any concerns, discuss them with the doctor. However, it is advisable not to take or limit alcohol as a precautionary measure.

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Pregnancy

Consult your doctor

Aquagest 50 Injection 2.237 ml is used in pregnancy conditions like threatened abortion, luteal phase support, and maintenance of pregnancy. Your doctor will weigh the benefits to outweigh the risks before prescribing this medicine.

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Breast Feeding

Consult your doctor

Let your doctor know if you are a nursing mother before receiving Aquagest 50 Injection 2.237 ml; your doctor will decide whether Aquagest 50 Injection 2.237 ml can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Avoid driving or operating machinery if you experience drowsiness after receiving this injection.

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Liver

Consult your doctor

Inform your doctor before receiving the Aquagest 50 Injection 2.237 ml if you have a history of or ongoing liver disease.

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Kidney

Consult your doctor

Inform your doctor before receiving the Aquagest 50 Injection 2.237 ml if you have renal insufficiency or kidney problems. This medicine is excreted through urine, and if you have kidney problems, it may worsen your condition. Your doctor will adjust the dose of this medicine if required based on your condition.

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Children

Unsafe

Aquagest 50 Injection 2.237 ml is not recommended for use in children.

Have a query?

FAQs

Aquagest 50 Injection 2.237 ml is used to treat various medical conditions, including early pregnancy maintenance, dysfunctional uterine bleeding, and threatened abortion. Besides this, it can also be used for the progesterone withdrawal test in the endocrinal evaluation of secondary amenorrhoea (paused or missed periods) to judge oestrogen priming.

Aquagest 50 Injection 2.237 ml contains progesterone; it works by increasing levels of the hormone progesterone in your body.

The most prevalent negative effect of using Aquagest 50 Injection 2.237 ml is the darkening of the facial skin. Please report to the doctor immediately if you notice any significant or rapid changes.

Using Aquagest 50 Injection 2.237 ml is contraindicated in people with cancers such as breast or genital organs. So, inform your doctor if you have cancer in your breasts or genital organs.

Aquagest 50 Injection 2.237 ml is contraindicated in people allergic to progesterone or people diagnosed with porphyria (a disorder in the formation of red blood pigment), cancers in breasts or genital organs, or a blocked blood vessel, vaginal infections, and/or people with missed abortion.

Hair loss is the most prevalent negative effect of utilizing Aquagest 50 Injection 2.237 ml. If you notice any significant or abnormal hair loss, please immediately report it to the doctor.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - AQU0495

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 23, 2025 | 2:11 PM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/017362s104lbl.pdf
  2. https://www.drugs.com/cdi/progesterone-injection.html
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