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  3. Arganat 250Mg/2.5Ml Inf

Arganat 250Mg/2.5Ml Inf, Pack of 1 Injection
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Composition :

ARGATROBAN-250MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Arganat 250Mg/2.5Ml Inf

Arganat 250Mg/2.5Ml Inf belongs to the anticoagulant medication class known as a direct thrombin inhibitor. It is used to manage heparin-induced thrombocytopenia (HIT), a rare, life-threatening complication of heparin therapy. Besides this, it works as an anticoagulant in adult patients with or at risk for HIT undergoing percutaneous coronary intervention (PCI).

Arganat 250Mg/2.5Ml Inf contains 'Argatroban,' which is a direct thrombin inhibitor. It works by reversibly binding to thrombin, a substance in the blood that causes blood clotting. This prevents the formation of harmful clots in the body.

Arganat 250Mg/2.5Ml Inf is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. The most common side effects in HIT patients were dyspnea, hypotension, fever, diarrhoea, sepsis, and cardiac arrest. The most common side effects in PCI patients were chest pain, hypotension, back pain, nausea, vomiting and headache. These side effects may vary individually. Most of these side effects do not require medical attention and will resolve gradually. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before taking the Arganat 250Mg/2.5Ml Inf, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. Arganat 250Mg/2.5Ml Inf is not recommended during pregnancy unless indicated by the doctor. Discontinue nursing or drug, taking into account the importance of the drug to the mother. It is recommended not to consume any alcoholic beverages to rule out any possibility of side effects. Safety and effectiveness have not been established in the paediatric population.

Uses of Arganat 250Mg/2.5Ml Inf

Arganat 250Mg/2.5Ml Inf is used in the treatment of Heparin-Induced Thrombocytopenia (HIT). The detailed uses of Arganat 250Mg/2.5Ml Inf are as follows:<br/>• Heparin-Induced Thrombocytopenia (HIT) Treatment: Arganat 250Mg/2.5Ml Inf provides anticoagulation, preventing further clot formation and managing thrombotic risk in HIT patients.<br/> • Anticoagulation management in percutaneous coronary intervention (PCI): Arganat 250Mg/2.5Ml Inf serves as an anticoagulant during PCI in HIT patients or those at risk, ensuring procedural safety.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.• Arganat 250Mg/2.5Ml Inf will be administered by the doctor or healthcare professional in a medical setting.• Do not self-administer.

Medicinal Benefits

Arganat 250Mg/2.5Ml Inf contains 'Argatroban,' which is a direct thrombin inhibitor. It works by reversibly binding to thrombin, a substance in the blood that causes blood clotting. This prevents the formation of harmful clots in the body.

How Arganat 250Mg/2.5Ml Inf Works

Arganat 250Mg/2.5Ml Inf contains 'Argatroban,' which is a direct thrombin inhibitor. It works by reversibly binding to thrombin, a substance in the blood that causes blood clotting. This prevents the formation of harmful clots in the body.

Storage

Store in a cool and dry place away from sunlight
Side effects of Arganat 250Mg/2.5Ml Inf
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

What if I have taken an overdose of Arganat 250Mg/2.5Ml Inf

Since Arganat 250Mg/2.5Ml Inf is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly. Overdose of Arganat 250Mg/2.5Ml Inf may cause Excessive anticoagulation, with or without bleeding.

Drug Warnings

Inform your doctor about all of your health problems (especially active bleeding), allergic reactions (food or medicine sensitivities), and drugs you are using (especially Thrombolytic agents such as Urokinase) before taking the Arganat 250Mg/2.5Ml Inf. When pregnant, Arganat 250Mg/2.5Ml Inf should not be used unless specifically advised by a physician. So, inform your doctor if you are pregnant or planning to. Discontinue nursing or medicine, taking into account the importance of the drug to the mother. Do not consume any other medications while on therapy unless prescribed by the doctor.

Drug-Drug Interactions

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ArgatrobanCefdinir
Severe
ArgatrobanDalteparin
Severe

Drug-Drug Interactions

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ArgatrobanCefdinir
Severe
How does the drug interact with Arganat 250Mg/2.5Ml Inf:
Taking cefdinir with Arganat 250Mg/2.5Ml Inf may lead to increase in the effects of Arganat 250Mg/2.5Ml Inf.

How to manage the interaction:
Although taking Cefdinir and Arganat 250Mg/2.5Ml Inf together can evidently cause an interaction, but it can be taken if prescribed by a doctor. In case you experience any side effects like chest tightness, shortness of breath, swelling of legs, or palpitations, consult a doctor. Do not stop using any medications without first talking to your doctor.
ArgatrobanDalteparin
Severe
How does the drug interact with Arganat 250Mg/2.5Ml Inf:
Combining Arganat 250Mg/2.5Ml Inf with Dalteparin can increase the risk of bleeding.

How to manage the interaction:
Although taking Dalteparin with Arganat 250Mg/2.5Ml Inf may possibly lead to an interaction, they can be taken if a doctor prescribes it. Consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.
ArgatrobanApixaban
Severe
How does the drug interact with Arganat 250Mg/2.5Ml Inf:
Coadministration of Arganat 250Mg/2.5Ml Inf and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Arganat 250Mg/2.5Ml Inf and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ArgatrobanClopidogrel
Severe
How does the drug interact with Arganat 250Mg/2.5Ml Inf:
Taking clopidogrel together with Arganat 250Mg/2.5Ml Inf can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between clopidogrel and Apixaban, they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding or have other signs of bleeding, like feeling dizzy or lightheaded, red or black, sticky stools, or severe headaches. Do not discontinue any medications without consulting your doctor.
ArgatrobanDabigatran etexilate
Severe
How does the drug interact with Arganat 250Mg/2.5Ml Inf:
Taking Dabigatran etexilate with Arganat 250Mg/2.5Ml Inf can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Arganat 250Mg/2.5Ml Inf together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
ArgatrobanFondaparinux
Severe
How does the drug interact with Arganat 250Mg/2.5Ml Inf:
Taking Arganat 250Mg/2.5Ml Inf with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between fondaparinux and Arganat 250Mg/2.5Ml Inf, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting. Do not discontinue any medications without consulting a doctor.
ArgatrobanPrasugrel
Severe
How does the drug interact with Arganat 250Mg/2.5Ml Inf:
Co-administration of Prasugrel with Arganat 250Mg/2.5Ml Inf can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Prasugrel with Arganat 250Mg/2.5Ml Inf can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Consume a well-balanced and healthy diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.
  • Keep your weight under control with a BMI of 19.5-24.9.
  • Exercise on a regular basis to keep your body and mind healthy.
  • Avoid chronic stress.
  • Smoking and consuming alcohol should be avoided.
  • To reduce the risk of bleeding, avoid activities such as contact sports and the use of sharp objects such as nail cutters and razors.

Habit Forming

No

Therapeutic Class

ANTICOAGULANT/ANTITHROMBOTIC
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Alcohol

Caution

Do not consume alcohol while on treatment with Arganat 250Mg/2.5Ml Inf as it may lead to unpleasant side effects.

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Pregnancy

Caution

Arganat 250Mg/2.5Ml Inf should not be used in pregnancy unless clearly necessary. If you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Arganat 250Mg/2.5Ml Inf.

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Breast Feeding

Unsafe

Breastfeeding must be avoided during treatment with Arganat 250Mg/2.5Ml Inf. Discuss with your doctor if you have any concerns.

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Driving

Caution

Avoid driving or operating machinery while you are on treatment with this medicine.

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Liver

Caution

Please inform your doctor if you have liver conditions before receiving Arganat 250Mg/2.5Ml Inf. Your doctor may adjust the dose or prescribe a suitable alternative depending on your medical condition.

bannner image

Kidney

Caution

Please inform your doctor if you have liver conditions before receiving Arganat 250Mg/2.5Ml Inf. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

It is not recommended for children as the safety and effectiveness have not been established.

Have a query?

FAQs

Arganat 250Mg/2.5Ml Inf is used to treat Heparin-Induced thrombocytopenia (HIT).

Arganat 250Mg/2.5Ml Inf contains Argatroban, which is a direct thrombin inhibitor. It works by reversibly binding to thrombin, a substance in the blood that causes blood clotting. This prevents the formation of harmful clots in the body.

The clinical assessment and laboratory data are used to diagnose HIT. Primary laboratory diagnostics for HIT include immunologic assays such as an enzyme-linked immunosorbent assay (ELISA) and functional platelet-activation assays such as the serotonin release assay (SRA).

When a person with haemophilia takes the blood-thinning treatment, their body develops antibodies against it, resulting in heparin-induced thrombocytopenia.

Heparin-induced thrombocytopenia (HIT) is triggered by antibodies that recognise complexes between platelet factor 4 (PF4) and heparin or glycosaminoglycan side chains.

No, it is advisable not to drink alcohol while taking Arganat 250Mg/2.5Ml Inf. Drinking alcohol during treatment may cause unpleasant side effects.

Arganat 250Mg/2.5Ml Inf usually starts working within a short time. However, the exact timeline for improvement varies depending on individual factors and the condition being treated. Follow your doctor's advice to have better results.

People with certain health issues like bleeding, very high blood pressure, and liver problems should not take Arganat 250Mg/2.5Ml Inf. Those who are allergic to Arganat 250Mg/2.5Ml Inf should also avoid it. Pregnant or breastfeeding women should consult their doctor before using this medication.

Using Arganat 250Mg/2.5Ml Inf may increase the risk of bleeding as it prevents blood clots by inhibiting thrombin. Especially people who have specific health issues or taking other medicines (like antiplatelet agents, thrombolytics, and other anticoagulants..etc) may lead to increased bleeding risk. Hence, it is always advised to inform if you have any existing medical conditions or are taking other medications to your doctor before taking Arganat 250Mg/2.5Ml Inf.

Arganat 250Mg/2.5Ml Inf generally does not involve hair loss. However, some individuals may experience hair loss due to other health issues or medicines they are taking. If you are having concerns about your hair loss please discuss it with your doctor.

Arganat 250Mg/2.5Ml Inf can impact the liver, especially for individuals with pre-existing liver conditions. Since it's metabolized in the liver, compromised (decreased) liver function can lead to toxicity. Inform your doctor about liver issues, they will adjust the dose or undergo closer monitoring.

Store Arganat 250Mg/2.5Ml Inf in its original container at room temperature, away from light and freezing. Keep it out of the reach of children.

The common side effects of Arganat 250Mg/2.5Ml Inf may occur in some individuals are dyspnea, hypotension, fever, diarrhea, and headache. Most of them resolve independently but consult your doctor if they persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - ARG0081

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:21 PM IST

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Reference

  1. https://www.pfizermedicalinformation.com/en-us/search/hcp-medication/mecha/61371/657316?ok=ARGATROBAN%20mecha
  2. https://labeling.pfizer.com/ShowLabeling.aspx?format=PDF&amp;id=4601
  3. https://www.ncbi.nlm.nih.gov/books/NBK555971/#:~:text=Argatroban%20is%20a%20medication%20used,a%20class%20of%20anticoagulant%20drugs.
  4. https://www.drugs.com/drug-interactions/argatroban.html

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