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  3. Aspezex 10000 Injection 1's

Aspezex 10000 Injection 1's, Pack of 1 Injection
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Composition :

L ASPARAGINASE-10000IU

Manufacturer/Marketer :

Halsted Pharma Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Aspezex 10000 Injection

Aspezex 10000 Injection belongs to the class of medicines called antineoplastic (anticancer) agents used in the treatment of acute lymphoblastic leukaemia (a type of blood and bone marrow cancer). Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer. It is a type of blood cancer which causes excessive production of lymphocytes (a type of white blood cells) by the bone marrow.

Aspezex 10000 Injection contains L Asparaginase which works by lowering asparagine levels in the body, which is necessary for the survival of cancer cells. Thus, Aspezex 10000 Injection stops the cancer cells from dividing and growing. 

Aspezex 10000 Injection will be administered by a healthcare professional; do not self-administer. Sometimes, Aspezex 10000 Injection may cause common side effects such as nausea, weight loss, generalised pain or muscle pain, infections or a decrease in normal blood content. Most of these side effects of Aspezex 10000 Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to L asparaginase or other medicines, please tell your doctor. You are recommended to avoid breastfeeding during treatment with Aspezex 10000 Injection as there may be a risk to the feeding child. If you are pregnant or planning pregnancy, please inform your doctor before receiving Aspezex 10000 Injection. Also, you are recommended to use effective contraceptive methods before and for at least 3 months after treatment with Aspezex 10000 Injection to prevent pregnancy. Aspezex 10000 Injection is given to children in doses as advised by the doctor, depending on the age. Avoid driving after receiving Aspezex 10000 Injection as it may cause drowsiness or dizziness.

Uses of Aspezex 10000 Injection

Aspezex 10000 Injection is used to treat acute lymphoblastic leukaemia (ALL). The detailed uses of Aspezex 10000 Injection are as follows:<br/>• Treats acute lymphoblastic leukaemia: Aspezex 10000 Injection helps manage this type of blood and bone marrow cancer by targeting cancer cells.<br/>• Stops cancer cell growth: Aspezex 10000 Injection reduces the levels of asparagine needed by cancer cells to grow, thereby preventing their multiplication.<br/>• Supports chemotherapy regimens: Aspezex 10000 Injection is often used as part of combination therapy to improve treatment outcomes in acute lymphoblastic leukaemia (ALL).<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.• Aspezex 10000 Injection will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

Aspezex 10000 Injection contains L Asparaginase, an anticancer agent used in the treatment of acute lymphoblastic leukaemia (a type of blood and bone marrow cancer). It lowers the levels of asparagine in the body, which is necessary for the survival of cancer cells. Thus, Aspezex 10000 Injection stops the cancer cells from dividing and growing. 

How Aspezex 10000 Injection Works

Aspezex 10000 Injection contains L Asparaginase which works by lowering asparagine levels in the body, which is necessary for the survival of cancer cells. Thus, Aspezex 10000 Injection stops the cancer cells from dividing and growing.

Storage

Store in a cool and dry place away from sunlight
Side effects of Aspezex 10000 Injection
  • If you experience or encounter any severe allergic reaction, stop using medication and consult the doctor right away.
  • Tell your doctor about the allergic reaction, including the medication taken and any symptoms experienced.
  • Your doctor will evaluate the severity of the reaction and determine the best course of action.
  • To ensure a full recovery, follow your doctor's advice, attend scheduled follow-up appointments, and undergo recommended tests to monitor progress and adjust treatment as needed.
Managing Medication-Related Skin Allergies: A Step-by-Step Guide
  • If you experience signs of skin allergies such as redness, itching, or irritation after taking medication, contact your doctor right away.
  • To alleviate skin allergy symptoms, your doctor may change your medication regimen or offer tailored medication management advice.
  • Your doctor may recommend or prescribe drugs to relieve discomfort.
  • Cool compresses or calamine lotion can help relieve redness and itching on the afflicted skin area.
  • Staying hydrated by consuming plenty of water can help relieve discomfort.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Managing Medication-Triggered Pancreatitis: A Step-by-Step Guide:
  • If you take medication and get severe stomach pain, feel nauseous, vomit, or have a fever, get emergency medical help right away. This could be a sign of pancreatitis, an inflammation of the pancreas.
  • Your doctor may alter your treatment plan, provide supportive therapy, or prescribe alternative medications to manage the reaction. They will also perform regular tests to monitor your progress and adjust your treatment as needed.
  • Follow your doctor's advice, including dietary recommendations and lifestyle changes, and avoid triggers like alcohol and fatty foods.
  • Monitor your condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • Inform your physician if you notice redness, heat, swelling, or pus since these are infection signs.
  • Your physician can prescribe medication to reduce symptoms and promote healing.
  • Do not scratch to prevent irritation and infection.
  • Clean and dry the area to prevent infection.
  • Apply heat or cold packs to reduce pain and swelling.
  • Massage the area lightly to promote blood flow and reduce swelling.
  • Inform your physician if you notice signs of infection such as redness, swelling, or pus to prevent complications.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

What if I have taken an overdose of Aspezex 10000 Injection

Since Aspezex 10000 Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

If you are allergic to L asparaginase or any other medicines, please tell your doctor. You are recommended to avoid breastfeeding during treatment with Aspezex 10000 Injection as there may be a risk to the feeding child. If you are pregnant or planning for pregnancy, please inform your doctor before receiving Aspezex 10000 Injection. Also, you are recommended to use effective contraceptive methods before and for at least three months after treatment with Aspezex 10000 Injection to prevent pregnancy. Aspezex 10000 Injection is given to children in doses as advised by the doctor, depending on the age. Avoid driving after receiving Aspezex 10000 Injection if you experience drowsiness or dizziness. Aspezex 10000 Injection may increase the risk of infections. Therefore, consult your doctor if you notice any signs of infection and avoid contact with people having viral infections. If you experience any significant bleeding during treatment with Aspezex 10000 Injection, inform your doctor immediately, as Aspezex 10000 Injection may affect your body’s ability to prevent excessive bleeding. 

Drug-Drug Interactions

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AsparaginaseLeflunomide
Severe
AsparaginaseLomitapide
Severe

Drug-Drug Interactions

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AsparaginaseLeflunomide
Severe
How does the drug interact with Aspezex 10000 Injection:
Taking Aspezex 10000 Injection with leflunomide may raise the risk of severe infections, and liver problems.

How to manage the interaction:
Although there is an interaction between Aspezex 10000 Injection and leflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
AsparaginaseLomitapide
Severe
How does the drug interact with Aspezex 10000 Injection:
Coadministration of Aspezex 10000 Injection and Lopitamide may increase the risk of liver issues.

How to manage the interaction:
Taking Aspezex 10000 Injection with Lomitapide together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AsparaginaseThalidomide
Severe
How does the drug interact with Aspezex 10000 Injection:
Taking thalidomide together with Aspezex 10000 Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Aspezex 10000 Injection together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
AsparaginaseTeriflunomide
Severe
How does the drug interact with Aspezex 10000 Injection:
The use of Aspezex 10000 Injection in conjunction with teriflunomide may raise the risk of severe infections, liver problems.

How to manage the interaction:
Co-administration of Aspezex 10000 Injection with Teriflunomide can result in an interaction, but it can be taken if a doctor has advised it. However, If you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, consult the doctor. Do not stop using any medications without talking to a doctor.
AsparaginaseBexarotene
Severe
How does the drug interact with Aspezex 10000 Injection:
The use of Aspezex 10000 Injection with bexarotene may raise the risk of inflammation of the pancreas.

How to manage the interaction:
Co-administration of Aspezex 10000 Injection with Bexarotene can result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor if you have symptoms such as persistent nausea, vomiting, abdominal soreness, and upper abdominal pain, especially if it worsens after eating or extends to the back. Do not stop using any medications without talking to a doctor.
AsparaginaseNatalizumab
Severe
How does the drug interact with Aspezex 10000 Injection:
Taking Aspezex 10000 Injection with Natalizumab together can increase the risk of developing serious infections.

How to manage the interaction:
Taking Aspezex 10000 Injection with Natalizumab together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, discomfort or burning when you urinate, progressive weakness on one side of the body, clumsiness of limbs, disturbance of vision, confusion, or changes in thinking, memory, and personality, consult a doctor. Do not stop using any medications without talking to a doctor.
AsparaginaseMipomersen
Severe
How does the drug interact with Aspezex 10000 Injection:
Coadministration of Aspezex 10000 Injection and Mipomersen may increase the risk of liver problems.

How to manage the interaction:
Although taking Aspezex 10000 Injection and Mipomersen together can evidently cause an interaction, it can be taken if your doctor has suggested it. Call a doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes. Do not stop using any medications without talking to a doctor.
AsparaginaseDalteparin
Moderate
How does the drug interact with Aspezex 10000 Injection:
Using dalteparin with Aspezex 10000 Injection may increase your risk of blood clots or bleeding.

How to manage the interaction:
Although taking Desogestrel and Fosamprenavir together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fast heartbeat, anxiety, constipation, cough, dark urine, diarrhea, dizziness, lightheadedness, fainting, fever, hives or welts, itching skin or rash call your doctor right away. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
  • Drink plenty of water daily during treatment with Aspezex 10000 Injection, as some cancer therapies may cause dehydration.
  • Exercise regularly and maintain a healthy body weight.
  • Regularly wash your hands and avoid contact with people having infections.
  • Quit smoking.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Aspezex 10000 Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Avoid or limit alcohol consumption while on treatment with Aspezex 10000 Injection as it may worsen your condition.

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Pregnancy

Consult your doctor

Limited data available on the effect of Aspezex 10000 Injection on pregnant women. Hence, if you are pregnant, or planning pregnancy, inform your doctor before receiving Aspezex 10000 Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Unsafe

You are recommended to avoid breastfeeding during treatment with Aspezex 10000 Injection as there may be a risk to the child.

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Driving

Caution

Aspezex 10000 Injection may cause drowsiness or dizziness. If you experience any such side effects, avoid driving or operating machinery.

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Liver

Caution

If you have pre-existing or a history of liver disease, inform your doctor before receiving Aspezex 10000 Injection. Your doctor may recommend regular tests to monitor liver function while receiving Aspezex 10000 Injection.

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Kidney

Caution

If you have pre-existing or a history of kidney disease, inform your doctor before receiving Aspezex 10000 Injection. Your doctor may recommend regular tests to monitor kidney function while receiving Aspezex 10000 Injection.

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Children

Caution

The dosage for children is recommended based on their age, body weight and condition of the child.

Have a query?

FAQs

Aspezex 10000 Injection is used to treat Acute lymphoblastic leukaemia.

Aspezex 10000 Injection contains L Asparaginase, an anticancer agent that works by lowering asparagine levels in the body, which is necessary for the survival of cancer cells. Thus, Aspezex 10000 Injection stops the cancer cells from dividing and growing.

Aspezex 10000 Injection may increase blood sugar levels. This can be controlled by receiving insulin. However, if you notice any symptoms such as increased thirst, dry mouth, frequent urination, tiredness, or blurred vision, please inform your doctor, as these might be symptoms of high blood sugar levels.

Aspezex 10000 Injection may cause stomach pain in some patients. You are advised to inform your doctor immediately if you have stomach pain, as it may be a sign of pancreatitis (inflammation of the pancreas).

Contact your doctor immediately if you notice signs of infection, severe allergic reactions, unusual bleeding, significant swelling, dizziness, or any unknown symptoms.

While liver damage is rare, severe liver impairment can occur with Aspezex 10000 Injection. Liver function should be carefully monitored before and throughout treatment, and if significant liver issues arise, treatment should be discontinued, with immediate medical consultation.

Nausea and extreme tiredness may be side effects of Aspezex 10000 Injection, but responses vary. You are recommended to consult your healthcare provider to confirm if these symptoms are related or if another cause is involved.

To get relief from diarrhoea while on Aspezex 10000 Injection, ensure proper hydration, eat a mild diet, and avoid irritant foods. If symptoms persist or worsen, consult your doctor for potential treatment adjustments or additional medicines.

If you observe changes in your skin after receiving Aspezex 10000 Injection, you are recommended to contact your doctor. They can evaluate whether the changes are due to Aspezex 10000 Injection and advise the necessary course of action. Do not take any other medicine unless advised by a doctor.

Yes, you should inform your doctor about the swelling and frequent muscle cramps, as these could be side effects or signs of an underlying issue. Your doctor can assess the situation and make any necessary adjustments to your treatment to prevent further complications.

You can generally maintain your regular diet unless advised by your doctor. However, you are recommended to stay hydrated by drinking water regularly, and eating small, simple meals throughout the day instead of large ones, to help prevent nausea and vomiting.

During your treatment with Aspezex 10000 Injection, avoid breastfeeding as there may be risks to feeding the child. Prevent driving a vehicle if you are feeling drowsy or dizzy. Avoid contact with those who have viral infections. Limit caffeine, fatty, spicy, or overly sweet foods to prevent nausea and avoid alcohol intake and smoking. Consult a doctor if you have any concerns or if any signs of infection occur.

Aspezex 10000 Injection causes side effects such as nausea, vomiting, weight loss, muscle pain, loss of appetite, headache, lack of energy, drowsiness, and stomach pain. Most of these are temporary and do not require any medical attention, as they will gradually reduce over time. Please, contact a doctor if these persist for longer durations.

Country of origin

India
Other Info - ASP0110

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:23 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.12340.pdf
  2. https://www.ema.europa.eu/en/documents/product-information/spectrila-epar-product-information_en.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/aspamer080102LB.pdf
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/101063s5169lbl.pdf

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