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compositionComposition:L ASPARAGINASE-10000IU
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Prescription Medicine
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L-Ginase 10000 IU Injection is used to treat acute lymphoblastic leukaemia. It contains L Asparaginase which works by lowering asparagine levels in the body, which is necessary for the survival of cancer cells. Thus, it stops the cancer cells from dividing and growing. If you are pregnant or planning pregnancy, please inform your doctor before receiving L-Ginase 10000 IU Injection. You are recommended to use effective contraceptive methods before and for at least 3 months after treatment to prevent pregnancy.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

L ASPARAGINASE-10000IU

Manufacturer/Marketer :

Getwell Life Sciences India Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About L-Ginase 10000 IU Injection

L-Ginase 10000 IU Injection belongs to the class of medicines called antineoplastic (anticancer) agents used in the treatment of acute lymphoblastic leukaemia (a type of blood and bone marrow cancer). Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer. It is a type of blood cancer which causes excessive production of lymphocytes (a type of white blood cells) by the bone marrow.

L-Ginase 10000 IU Injection contains L Asparaginase which works by lowering asparagine levels in the body, which is necessary for the survival of cancer cells. Thus, L-Ginase 10000 IU Injection stops the cancer cells from dividing and growing. 

L-Ginase 10000 IU Injection will be administered by a healthcare professional; do not self-administer. Sometimes, L-Ginase 10000 IU Injection may cause common side effects such as nausea, weight loss, generalised pain or muscle pain, infections or a decrease in normal blood content. Most of these side effects of L-Ginase 10000 IU Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to L asparaginase or other medicines, please tell your doctor. You are recommended to avoid breastfeeding during treatment with L-Ginase 10000 IU Injection as there may be a risk to the feeding child. If you are pregnant or planning pregnancy, please inform your doctor before receiving L-Ginase 10000 IU Injection. Also, you are recommended to use effective contraceptive methods before and for at least 3 months after treatment with L-Ginase 10000 IU Injection to prevent pregnancy. L-Ginase 10000 IU Injection is given to children in doses as advised by the doctor, depending on the age. Avoid driving after receiving L-Ginase 10000 IU Injection as it may cause drowsiness or dizziness.

Uses of L-Ginase 10000 IU Injection

L-Ginase 10000 IU Injection is used to treat acute lymphoblastic leukaemia. The detailed uses of L-Ginase 10000 IU Injection are as follows:

  • Acute lymphoblastic leukaemia (ALL): L-Ginase 10000 IU Injection helps treat this rapid-growing blood cancer by cutting off the supply of an essential nutrient that leukaemia cells need to survive and multiply.
  • Other specific blood disorders: Under expert clinical guidelines, L-Ginase 10000 IU Injection may be used in combination regimens to help control other rare blood-related cancers.

 

Key Benefits

L-Ginase 10000 IU Injection helps treat certain types of cancer by targeting abnormal cancer cells and slowing or stopping their growth. It is often used as part of combination chemotherapy to improve overall treatment effectiveness and support disease control.

  • Helps Control Cancer Growth: By targeting cancer cells, L-Ginase 10000 IU Injection helps slow disease progression and supports the goal of achieving remission in appropriate cancers.
  • Enhances Combination Cancer Therapy: When used with other chemotherapy medicines, L-Ginase 10000 IU Injection can improve the effectiveness of the overall treatment plan and help achieve better treatment outcomes.
  • Supports Bone Marrow Recovery: By reducing the number of abnormal cancer cells, L-Ginase 10000 IU Injection helps allow healthy bone marrow to recover and resume the production of normal blood cells, supporting overall blood health during treatment.
     
Side effects of L-Ginase 10000 IU Injection
  • If you experience or encounter any severe allergic reaction, stop using medication and consult the doctor right away.
  • Tell your doctor about the allergic reaction, including the medication taken and any symptoms experienced.
  • Your doctor will evaluate the severity of the reaction and determine the best course of action.
  • To ensure a full recovery, follow your doctor's advice, attend scheduled follow-up appointments, and undergo recommended tests to monitor progress and adjust treatment as needed.
Managing Medication-Related Skin Allergies: A Step-by-Step Guide
  • If you experience signs of skin allergies such as redness, itching, or irritation after taking medication, contact your doctor right away.
  • To alleviate skin allergy symptoms, your doctor may change your medication regimen or offer tailored medication management advice.
  • Your doctor may recommend or prescribe drugs to relieve discomfort.
  • Cool compresses or calamine lotion can help relieve redness and itching on the afflicted skin area.
  • Staying hydrated by consuming plenty of water can help relieve discomfort.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Managing Medication-Triggered Pancreatitis: A Step-by-Step Guide:
  • If you take medication and get severe stomach pain, feel nauseous, vomit, or have a fever, get emergency medical help right away. This could be a sign of pancreatitis, an inflammation of the pancreas.
  • Your doctor may alter your treatment plan, provide supportive therapy, or prescribe alternative medications to manage the reaction. They will also perform regular tests to monitor your progress and adjust your treatment as needed.
  • Follow your doctor's advice, including dietary recommendations and lifestyle changes, and avoid triggers like alcohol and fatty foods.
  • Monitor your condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • Inform your physician if you notice redness, heat, swelling, or pus since these are infection signs.
  • Your physician can prescribe medication to reduce symptoms and promote healing.
  • Do not scratch to prevent irritation and infection.
  • Clean and dry the area to prevent infection.
  • Apply heat or cold packs to reduce pain and swelling.
  • Massage the area lightly to promote blood flow and reduce swelling.
  • Inform your physician if you notice signs of infection such as redness, swelling, or pus to prevent complications.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • L-Ginase 10000 IU Injection will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How L-Ginase 10000 IU Injection Works

L-Ginase 10000 IU Injection contains L-asparaginase works by targeting a specific amino acid in your bloodstream that cancer cells rely on to grow. Healthy cells are able to manufacture this building block on their own, but leukaemia cells cannot make it and must absorb it from your blood. When this injection enters your body, it quickly breaks down this amino acid, removing it from your blood supply. Deprived of this vital nutrient, the leukaemia cells are starved, stopping them from multiplying and causing them to die. Since your healthy cells can still produce their own supply of this amino acid, they are largely spared from this starving effect.
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Alcohol

Caution

Avoid or limit alcohol consumption while on treatment with L-Ginase 10000 IU Injection as it may worsen your condition.

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Pregnancy

Consult your doctor

Limited data available on the effect of L-Ginase 10000 IU Injection on pregnant women. Hence, if you are pregnant, or planning pregnancy, inform your doctor before receiving L-Ginase 10000 IU Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Unsafe

You are recommended to avoid breastfeeding during treatment with L-Ginase 10000 IU Injection as there may be a risk to the child.

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Driving

Caution

L-Ginase 10000 IU Injection may cause drowsiness or dizziness. If you experience any such side effects, avoid driving or operating machinery.

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Liver

Caution

If you have pre-existing or a history of liver disease, inform your doctor before receiving L-Ginase 10000 IU Injection. Your doctor may recommend regular tests to monitor liver function while receiving L-Ginase 10000 IU Injection.

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Kidney

Caution

If you have pre-existing or a history of kidney disease, inform your doctor before receiving L-Ginase 10000 IU Injection. Your doctor may recommend regular tests to monitor kidney function while receiving L-Ginase 10000 IU Injection.

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Children

Caution

The dosage for children is recommended based on their age, body weight and condition of the child.

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Heart

Caution

Inform your doctor before receiving L-Ginase 10000 IU Injection if you have a pre-existing or a history of heart disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available about the use of L-Ginase 10000 IU Injection in geriatric patients. Please consult your physician.

What if I have taken an overdose of L-Ginase 10000 IU Injection

Because this medication is injected by healthcare professionals in a controlled clinical environment, an accidental overdose is highly unlikely. However, if you suspect an error or experience severe symptoms like extreme dizziness, breathing issues, or confusion after an injection, notify your medical team immediately.

Diet & Lifestyle Advise

  • Drink plenty of fluids: Make sure to drink at least 8 to 10 glasses of water daily to help your kidneys clear the breakdown products of cancer cells and prevent dehydration.
  • Eat frequent, light meals: To manage nausea and maintain your strength, eat five or six small, bland meals throughout the day instead of three large ones.
  • Avoid raw or undercooked foods: Since your immune system may be weakened during treatment, stick to thoroughly cooked meals and wash fresh fruits and vegetables carefully to prevent infections.
  • Track your blood sugar levels: If your doctor advises, monitor your blood glucose levels at home, as this treatment can temporarily raise blood sugar.
  • Get adequate rest: Your body needs energy to recover from chemotherapy. Prioritize sleep and allow yourself to rest whenever you feel tired.
     
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Have a query?

How Soon It Starts Working

The time required for L-Ginase 10000 IU Injection to start to work: The onset time of L-Ginase 10000 IU Injection has not been clinically established. The time for which the effects of L-Ginase 10000 IU Injection last: The duration of L-Ginase 10000 IU Injection’s effect is clinically not established.

What if you forget to take L-Ginase 10000 IU Injection

If you miss an appointment for your injection, contact your healthcare provider or oncology clinic immediately to reschedule. Keeping your treatment on a strict schedule is vital to ensuring the medicine works as effectively as possible.

Storage

• L-Ginase 10000 IU Injection is generally stored and managed by your healthcare provider at the clinic or hospital.
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Stay for observation: Plan to remain at the clinic for at least an hour after your injection so your healthcare team can monitor you closely for any immediate allergic reactions.
  • Rotate injection sites: If you receive this medicine as an injection into a muscle, make sure your nurse rotates the injection site each time to minimise localised pain and swelling.
  • Check the vial: If you are handling the medicine, always inspect the liquid inside the vial. It should be clear and colourless; do not use it if you notice any cloudiness, discolouration, or floating particles.
  • Avoid live vaccines: Do not receive any live vaccines (such as the measles, mumps, or oral polio vaccines) during your treatment, as your immune system will be less able to fight off the weakened virus.
  • Complete all blood tests: Attend every scheduled blood test appointment so your doctor can check your liver function, pancreas health, blood clotting time, and blood sugar levels regularly.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners (like warfarin or heparin): Using these medicines together with L-Ginase 10000 IU Injection can significantly increase your risk of severe bleeding or bruising.
  • Corticosteroids (such as prednisone or dexamethasone): Combining these drugs may increase the risk of developing high blood sugar levels or temporary diabetes.
  • Methotrexate: Taking this chemotherapy drug at the same time as L-Ginase 10000 IU Injection can alter how both medications work, sometimes reducing their overall effectiveness if not spaced correctly by your oncologist.
     
AsparaginaseNatalizumab
Severe
AsparaginaseLeflunomide
Severe

Drug-Drug Interactions

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AsparaginaseNatalizumab
Severe
How does the drug interact with L-Ginase 10000 IU Injection:
Taking L-Ginase 10000 IU Injection with Natalizumab together can increase the risk of developing serious infections.

How to manage the interaction:
Taking L-Ginase 10000 IU Injection with Natalizumab together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, discomfort or burning when you urinate, progressive weakness on one side of the body, clumsiness of limbs, disturbance of vision, confusion, or changes in thinking, memory, and personality, consult a doctor. Do not stop using any medications without talking to a doctor.
AsparaginaseLeflunomide
Severe
How does the drug interact with L-Ginase 10000 IU Injection:
Taking L-Ginase 10000 IU Injection with leflunomide may raise the risk of severe infections, and liver problems.

How to manage the interaction:
Although there is an interaction between L-Ginase 10000 IU Injection and leflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
AsparaginaseTeriflunomide
Severe
How does the drug interact with L-Ginase 10000 IU Injection:
The use of L-Ginase 10000 IU Injection in conjunction with teriflunomide may raise the risk of severe infections, liver problems.

How to manage the interaction:
Co-administration of L-Ginase 10000 IU Injection with Teriflunomide can result in an interaction, but it can be taken if a doctor has advised it. However, If you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, consult the doctor. Do not stop using any medications without talking to a doctor.
AsparaginaseMipomersen
Severe
How does the drug interact with L-Ginase 10000 IU Injection:
Coadministration of L-Ginase 10000 IU Injection and Mipomersen may increase the risk of liver problems.

How to manage the interaction:
Although taking L-Ginase 10000 IU Injection and Mipomersen together can evidently cause an interaction, it can be taken if your doctor has suggested it. Call a doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes. Do not stop using any medications without talking to a doctor.
AsparaginaseThalidomide
Severe
How does the drug interact with L-Ginase 10000 IU Injection:
Taking thalidomide together with L-Ginase 10000 IU Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and L-Ginase 10000 IU Injection together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
AsparaginaseLomitapide
Severe
How does the drug interact with L-Ginase 10000 IU Injection:
Coadministration of L-Ginase 10000 IU Injection and Lopitamide may increase the risk of liver issues.

How to manage the interaction:
Taking L-Ginase 10000 IU Injection with Lomitapide together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AsparaginaseBexarotene
Severe
How does the drug interact with L-Ginase 10000 IU Injection:
The use of L-Ginase 10000 IU Injection with bexarotene may raise the risk of inflammation of the pancreas.

How to manage the interaction:
Co-administration of L-Ginase 10000 IU Injection with Bexarotene can result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor if you have symptoms such as persistent nausea, vomiting, abdominal soreness, and upper abdominal pain, especially if it worsens after eating or extends to the back. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid consuming alcohol during your treatment, as it can worsen liver stress and increase the risk of liver damage when combined with this medication.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

L-Ginase 10000 IU Injection is used to treat Acute lymphoblastic leukaemia.
L-Ginase 10000 IU Injection contains L Asparaginase, an anticancer agent that works by lowering asparagine levels in the body, which is necessary for the survival of cancer cells. Thus, L-Ginase 10000 IU Injection stops the cancer cells from dividing and growing.
Contact your doctor immediately if you notice signs of infection, severe allergic reactions, unusual bleeding, significant swelling, dizziness, or any unknown symptoms.
While liver damage is rare, severe liver impairment can occur with L-Ginase 10000 IU Injection. Liver function should be carefully monitored before and throughout treatment, and if significant liver issues arise, treatment should be discontinued, with immediate medical consultation.
Nausea and extreme tiredness may be side effects of L-Ginase 10000 IU Injection, but responses vary. You are recommended to consult your healthcare provider to confirm if these symptoms are related or if another cause is involved.
To get relief from diarrhoea while on L-Ginase 10000 IU Injection, ensure proper hydration, eat a mild diet, and avoid irritant foods. If symptoms persist or worsen, consult your doctor for potential treatment adjustments or additional medicines.
If you observe changes in your skin after receiving L-Ginase 10000 IU Injection, you are recommended to contact your doctor. They can evaluate whether the changes are due to L-Ginase 10000 IU Injection and advise the necessary course of action. Do not take any other medicine unless advised by a doctor.
Yes, you should inform your doctor about the swelling and frequent muscle cramps, as these could be side effects or signs of an underlying issue. Your doctor can assess the situation and make any necessary adjustments to your treatment to prevent further complications.
You can generally maintain your regular diet unless advised by your doctor. However, you are recommended to stay hydrated by drinking water regularly, and eating small, simple meals throughout the day instead of large ones, to help prevent nausea and vomiting.
L-Ginase 10000 IU Injection causes side effects such as nausea, vomiting, weight loss, muscle pain, loss of appetite, headache, lack of energy, drowsiness, and stomach pain. Most of these are temporary and do not require any medical attention, as they will gradually reduce over time. Please, contact a doctor if these persist for longer durations.
L-Ginase 10000 IU Injection is given as an injection into a large muscle or as a slow infusion directly into a vein. This procedure is always performed by a trained healthcare professional in a clinic or hospital. Talk to your doctor to understand your specific treatment schedule.
You should avoid getting any live vaccines during your treatment, as your immune system may be too weak to handle them safely. Always discuss any planned vaccinations with your healthcare team first. Talk to your doctor or pharmacist for guidance on safe vaccines.
On its own, this medication is not highly linked to hair loss, but because it is almost always prescribed alongside other strong chemotherapy drugs, you may experience hair loss as part of your overall treatment. Talk to your doctor to learn what to expect.
If you develop severe, constant pain in your upper stomach that radiates to your back, seek emergency medical care immediately, as this can be a sign of a serious pancreas condition called pancreatitis. Talk to your doctor right away if this occurs.
This injection can temporarily reduce your pancreas's ability to produce insulin, which may lead to high blood sugar levels. Your healthcare team will monitor your blood sugar closely during treatment. Talk to your doctor if you experience extreme thirst, dry mouth, or frequent urination.
It is highly recommended to avoid alcohol during your treatment, as both alcohol and this medication can strain your liver, and combining them raises your risk of liver damage. Talk to your doctor or pharmacist if you need help managing this.
No, this medication can be harmful to an unborn baby and is generally not recommended during pregnancy or while breastfeeding. You must use effective birth control during treatment and for a period after your final dose. Talk to your doctor to discuss your options.
Because allergic reactions are a recognised risk, you will typically be asked to stay at the clinic for at least one hour after your injection so healthcare professionals can monitor you. Talk to your doctor or clinic nurse if you have any questions about your appointment timing.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

464, Udyog Vihar, Phase-V Sector 19, Gurugram Haryana 122016
Other Info - LGI0006
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