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  3. Atacurium 25 mg Injection 2.5 ml

Atacurium 25 mg Injection 2.5 ml, Pack of 1 Injection
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Composition :

ATRACURIUM-25MG

Manufacturer/Marketer :

Themis Chemicals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Atacurium 25 mg Injection

Atacurium 25 mg Injection belongs to the group of medicines called skeletal muscle relaxants used to reduce and relieve muscle spasms (excessive tension in the muscles) occurring during surgery in intensive care. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms.

Atacurium 25 mg Injection contains ‘Atracurium’ that works by blocking the action of acetylcholine on skeletal muscles. Thus, stop sending a pain signal to the brain, relieving muscle stiffness or muscle spasm along with pain and surgery. Atacurium 25 mg Injection is used during surgery.  It is also used during general anaesthesia to ease tracheal intubation (a tube into the windpipe) and controlled ventilation.

Atacurium 25 mg Injection is given by the healthcare professional during surgery.  In some cases, you may experience tachycardia (rapid heartbeat), temporary hypotension (low blood pressure), wheezing, bronchospasm (asthma-like symptoms), skin flushing, and urticaria (nettle rash). Most of these side effects of Atacurium 25 mg Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Before receiving Atacurium 25 mg Injection inform your doctor if you have had myasthenia gravis or Eaton-Lambert syndrome,  severe electrolyte disorder, asthma-like symptoms (a history of allergy, asthma or bronchospasm), burns and lack of adequate circulatory filling (hypovolaemia), pregnant or breastfeeding mother. Your doctor will prescribe Atacurium 25 mg Injection only if the benefits outweigh the risks. Atacurium 25 mg Injection is not recommended in neonates (children under the age of one month). Atacurium 25 mg Injection is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees Celsius else its efficiency might get lost. Do not store in the freezer or the fridge.

Uses of Atacurium 25 mg Injection

Treatment of Muscle contraction during surgery.

Directions for Use

• Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.• Atacurium 25 mg Injection will be administered by a healthcare professional.• Do not self-administer.

Medicinal Benefits

Atacurium 25 mg Injection belongs to the group of medicines called muscle relaxants used to reduce and relieve muscle contraction (excessive tension in the muscles) during surgery, other procedures, and in intensive care. It is also used to calm muscles while on a breathing machine, during general anaesthesia to ease tracheal intubation (a tube into the windpipe), and controlled ventilation. It works by blocking the action of acetylcholine on skeletal muscles. Also, stop sending a pain signal to the brain, relieving muscle stiffness or muscle spasm along with pain and surgery. An experienced doctor must give Atacurium 25 mg Injection under carefully controlled conditions. It is used during procedures that require that the patient is fully anaesthetized (unconscious) or heavily sedated.

How Atacurium 25 mg Injection Works

Atacurium 25 mg Injection contains ‘Atracurium’ that works by blocking the action of acetylcholine on skeletal muscles. Thus, stop sending a pain signal to the brain, relieving muscle stiffness or muscle spasm along with pain and surgery.

Storage

Store in a cool and dry place away from sunlight
Side effects of Atacurium 25 mg Injection 2.5 ml
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.
  • Injection site reaction can include numbness or redness.
  • Get a physical examination, follow your doctor's instructions, if it worsens or gets swollen.
  • Apply cold compress for pain relief.
  • Practice good hygiene and keep the injection site away from heat and pressure.
  • Avoid scratching the affected area.
  • Wear loose clothing to reduce irritation.
  • Keep the affected area moisturized with a gentle moisturiser.
  • To alleviate the reaction, remove the irritant by immediately stopping contact and washing the area with mild soap and cool water.
  • Apply a cool, wet compress to reduce inflammation and itching.
  • Consult a doctor if your skin reaction is severe, widespread, or accompanied by swelling, blistering, or breathing difficulties.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.

What if I have taken an overdose of Atacurium 25 mg Injection

The overdose of Atacurium 25 mg Injection is unlikely as it is administered by a doctor. However, if you suspect any adverse reactions or unusual symptoms while on treatment with Atacurium 25 mg Injection , please inform your doctor immediately.

Drug Warnings

Before you receive Atacurium 25 mg Injection , tell your doctor if you have a disease that affects the muscles and nervous control (neuromuscular disease such as myasthenia gravis or Eaton-Lambert syndrome (muscle disorder)), a severe electrolyte disorder, cancer spread widely from a primary source (carcinomatosis), a sensitivity to histamine, asthma-like symptoms (a history of allergy, asthma or bronchospasm), burns, lack of adequate circulatory filling (hypovolaemia). Atacurium 25 mg Injection should not be given to pregnant women unless prescribed. If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking Atacurium 25 mg Injection . Mothers should stop breastfeeding for 24 hours after receiving Atacurium 25 mg Injection . Atacurium 25 mg Injection is not recommended in neonates (children under the age of one month) as safety and effectiveness in pediatric patients below the age of 1 month have not been established. Atacurium 25 mg Injection some formulations containing benzyl alcohol. In neonates, benzyl alcohol has been associated with an increased incidence of neurological and other complications, sometimes fatal.

Drug-Drug Interactions

verifiedApollotooltip
AtracuriumClindamycin
Severe
AtracuriumColistin
Severe

Drug-Drug Interactions

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AtracuriumClindamycin
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Co-administration of Clindamycin with Atacurium 25 mg Injection 2.5 ml can increase the risk of muscle weakness.

How to manage the interaction:
Taking Clindamycin with Atacurium 25 mg Injection 2.5 ml together can possibly result in an interaction, but it can be taken if a doctor has advised it. "Clindamycin can affect the muscles and nerves in your body. When used with other medications that also affect the muscles and nerves, it can cause a serious problem called neuromuscular blockade. If you have trouble breathing or can't breathe at all, please call your doctor right away." Do not stop using any medications without a doctor's advice.
AtracuriumColistin
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Coadministration of Atacurium 25 mg Injection 2.5 ml with Colistin can increase the risk of Atacurium 25 mg Injection 2.5 ml side effects.

How to manage the interaction:
Although there is a possible interaction between Colistin and Atacurium 25 mg Injection 2.5 ml, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, slurred speech, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.
AtracuriumStreptomycin
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Co-administration of Streptomycin with Atacurium 25 mg Injection 2.5 ml may increase the risk or severity of side effects.

How to manage the interaction:
Co-administration of Streptomycin with Atacurium 25 mg Injection 2.5 ml can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
AtracuriumTobramycin
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Using Atacurium 25 mg Injection 2.5 ml with Tobramycin can increase the risk of respiratory depression (breathing disorder).

How to manage the interaction:
Although there is a interaction between Tobramycin and Atacurium 25 mg Injection 2.5 ml, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to your doctor.
AtracuriumFentanyl
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Combining Atacurium 25 mg Injection 2.5 ml with Fentanyl can increase the risk of irregular heart rhythm and low blood pressure.

How to manage the interaction:
There may be a possibility of interaction between Atacurium 25 mg Injection 2.5 ml and Fentanyl, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
AtracuriumBotulinum toxin
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Coadministration of Botulinum toxin with Atacurium 25 mg Injection 2.5 ml may increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Botulinum toxin and Atacurium 25 mg Injection 2.5 ml, it can be taken if prescribed by a doctor. However, contact a doctor immediately if you experience excessive muscle weakness or trouble breathing, swallowing, or speaking. Do not discontinue any medications without consulting a doctor.
AtracuriumPolymyxin b
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Co-administration of Polymyxin B with Atacurium 25 mg Injection 2.5 ml may cause serious breathing problems

How to manage the interaction:
There may be a possibility of interaction between Polymyxin b and Atacurium 25 mg Injection 2.5 ml, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without a doctor's advice.
AtracuriumDoxycycline
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Co-administration of Atacurium 25 mg Injection 2.5 ml with doxycycline may increase the risk of breathing problems.

How to manage the interaction:
Although there is an interaction between Atacurium 25 mg Injection 2.5 ml and Doxycycline, bit it can be taken together if prescribed by your doctor. Do not stop using any medications without first talking to your doctor.
AtracuriumAmikacin
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Co-administration of Amikacin with Atacurium 25 mg Injection 2.5 ml can increase the risk of developing breathing difficulties.

How to manage the interaction:
Taking Atacurium 25 mg Injection 2.5 ml with Amikacin together can result in an interaction, but it can be taken if your doctor has advised it. Consult your doctor if you experience shortness of breath, palpitations, chest discomfort, or dizziness. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid freezing and hot temperatures.

  • Avoid wearing tight-fitting clothes. Instead, wear loose garments.

  • Rest well, and get plenty of sleep.

  • To avoid developing pressure sores, change your position every two hours.

  • Hot or cold therapy can help treat muscle spasms. Apply an ice pack or hot pack on the muscle for 15-20minutes.

  • Stay hydrated, and drink plenty of water.

Habit Forming

No

Therapeutic Class

MUSCLE RELAXANTS/SKELETAL MUSCLE RELAXANTS

Atacurium 25 mg Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Avoid consumption of alcohol after taking Atacurium 25 mg Injection as it may increase the risk of side effects.

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Pregnancy

Caution

If you are pregnant, inform your doctor before receiving Atacurium 25 mg Injection ; Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are breastfeeding, inform your doctor before receiving Atacurium 25 mg Injection ; Your doctor will prescribe only if the benefits outweigh the risks.

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Driving

Caution

Atacurium 25 mg Injection causes sleepiness and drowsiness. So, avoid driving or operating heavy machinery after taking this medicine.

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Liver

Caution

Atacurium 25 mg Injection should be used with caution in patients with liver diseases. Your doctor may adjust the dose of Atacurium 25 mg Injection before prescribing.

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Kidney

Caution

Atacurium 25 mg Injection should be used with caution in patients with kidney diseases. Your doctor may adjust the dose of Atacurium 25 mg Injection before prescribing.

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Children

Caution

Atacurium 25 mg Injection use is not recommended in neonates (children under the age of one month). Your doctor will decide the dose of Atacurium 25 mg Injection based on age and condition of your child.

Have a query?

FAQs

Atacurium 25 mg Injection is used to reduce and relieve muscle spasms (excessive tension in the muscles) occurring during surgery in intensive care.

Atacurium 25 mg Injection contains 'Atracurium' that relaxes the muscles by blocking the impulses from the nerves. It is used for skeletal muscle relaxation during surgery.

Atacurium 25 mg Injection causes sleepiness and drowsiness. So, drive only if you are alert and omit driving or operating machinery if you feel sleepy or drowsy.

Atacurium 25 mg Injection is safe and effective when administered to patients with severe heart disease. However, rapid administration of large doses may occasionally produce transient hypotension in patients with heart problems. Please consult your doctor. Your doctor will prescribe only if the benefits outweigh the risks.

Do not use Atacurium 25 mg Injection have had myasthenia gravis or Eaton-Lambert syndrome, severe electrolyte disorder, asthma-like symptoms (a history of allergy, asthma or bronchospasm), burns, and lack of adequate circulatory filling (hypovolaemia), pregnant or breastfeeding mother. Avoid driving or performing hazardous tasks until you know how Atacurium 25 mg Injection will affect you, and your reactions could be impaired.

Atacurium 25 mg Injection is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees Celsius else its efficiency might get lost. Do not store in the freezer or the fridge.

Atacurium 25 mg Injection is given by IV injection administered by a healthcare professional under carefully controlled conditions. Do not self-administer Atacurium 25 mg Injection .

The common side effects of the Atacurium 25 mg Injection are tachycardia (rapid heartbeat), temporary hypotension (low blood pressure), wheezing, bronchospasm (asthma-like symptoms), skin flushing, and urticaria (nettle rash). However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.

Country of origin

INDIA

Manufacturer/Marketer address

11/12, Udyog Nagar, S. V. Road, Goregaon (W), Mumbai- 400104.
Other Info - ATA0031

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Keep Refrigerated. Do not freeze.Prepaid payment required.

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:45 AM IST

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Reference

  1. https://www.drugs.com/monograph/atracurium.html
  2. https://www.medicines.org.uk/emc/files/pil.6297.pdf

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