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compositionComposition:TRETINOIN-10MG
prescription
Prescription Medicine
info
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Atranza Capsule belongs to a class of drugs called retinoids which is used in the treatment of acne. This medicine works by inhibiting the acne-causing microbes and unblocks pores. Common side effects include dryness of skin, redness, skin irritation, pain or skin flaking.

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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

TRETINOIN-10MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Atranza Capsule

Atranza Capsule is a prescription medicine used to treat a specific type of blood and bone marrow cancer called acute promyelocytic leukaemia (APL). It works by helping immature, abnormal blood cells grow and develop into normal, healthy cells. It is usually given as part of a combination treatment plan with other anti-cancer medicines, such as arsenic trioxide or chemotherapy, depending on your condition. Your oncologist will decide the most appropriate treatment regimen.

To get the best results, you must take this medicine consistently every day exactly as directed by your doctor. Treatment with Atranza Capsule is usually given in planned phases, such as induction and consolidation therapy. Your doctor will determine how long each phase of treatment should continue. It is highly recommended to take these capsules with a meal or a fat-rich snack to help your body absorb the medicine properly. Eating a balanced diet and staying well-hydrated are also important daily habits during your treatment.

While taking Atranza Capsule, you may experience common side effects like dry skin, dry mouth, headaches, or mild bone pain. However, you must contact your healthcare provider immediately if you experience severe symptoms like breathing difficulties, sudden weight gain, or vision changes. Talk to your doctor or pharmacist if you notice any unusual changes in your health.

Before starting this medicine, tell your doctor if you have liver disease, high cholesterol, or kidney problems. You must not take this medicine if you are pregnant or planning to become pregnant, as it can cause severe harm to an unborn baby.

This medicine can interact with alcohol, which can increase your risk of liver damage, and with certain other medications like tetracycline antibiotics or vitamin A supplements, which can cause dangerous pressure build-up in the brain. If you are breastfeeding or are an older adult, you must talk to your doctor to understand the specific risks and monitoring required for your age group.

Uses of Atranza Capsule

Atranza Capsule may be used to help manage the following condition:

  • Acute Promyelocytic Leukaemia (APL): Atranza Capsule helps by forcing abnormal, immature white blood cells in your bone marrow to mature into normal, functioning blood cells, which helps bring the cancer into remission.

Key Benefits

Atranza Capsule offers critical benefits for individuals fighting a specific type of blood cancer by targeting the root cause of abnormal cell growth.

  • Achieving Remission: By prompting leukaemia cells to mature and die off naturally, this medicine helps clear abnormal cells from your blood and bone marrow, paving the way for complete remission.
  • Reducing Bleeding Risks: APL often causes severe bleeding problems. As Atranza Capsule helps normalise your blood counts, it reduces the risk of dangerous bleeding and bruising, helping you feel physically stronger and safer.
Side effects of Atranza Capsule
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Directions for Use

  • Atranza Capsule can be taken with meals to reduce any potential stomach upset and to improve absorption.
  • It is advised to take Atranza Capsule twice daily; however, follow your doctor’s recommendation regarding the dosage and duration.
  • Swallow the medicine as a whole with water.
  • Do not break, crush, or chew it.

How Atranza Capsule Works

Atranza Capsule works by targeting the specific genetic change inside cancer cells that prevents them from developing properly. In acute promyelocytic leukaemia, immature white blood cells accumulate because they are stuck in an early stage of development. Atranza Capsule acts as a signal that encourages these immature cancerous cells to resume their normal development cycle. As the cells mature, they function like normal white blood cells and eventually die naturally, allowing the bone marrow to produce healthy blood cells again.
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Alcohol

Caution

Interaction of alcohol with Atranza Capsule is unknown. Please consult a doctor before consuming alcohol while using Atranza Capsule.

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Pregnancy

Unsafe

Atranza Capsule is Category C pregnancy drug and is considered unsafe for pregnant women as it may harm the unborn baby.

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Breast Feeding

Unsafe

Atranza Capsule is excreted into breast milk and may harm the baby. Therefore, you are recommended to avoid breastfeeding while taking Atranza Capsule.

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Driving

Caution

Atranza Capsule may cause dizziness or severe headache. Therefore, drive only if you alert after taking Atranza Capsule.

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Liver

Caution

Take Atranza Capsule with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Atranza Capsule with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Atranza Capsule should be given to children only in doses advised by the doctor.

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Heart

Consult your doctor

Please consult your doctor before using Atranza Capsule if you have pre-existing heart problems. Your doctor will prescribe Atranza Capsule if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Atranza Capsule to geriatric patients. Your doctor will prescribe Atranza Capsule if the benefits outweigh the risks.

What if I have taken an overdose of Atranza Capsule

If you take more than your prescribed dose, seek emergency medical care or contact a poison control centre immediately. An overdose can cause severe headaches, facial flushing, dry lips, abdominal pain, or dizziness.

Diet & Lifestyle Advise

  • Avoid Vitamin A Supplements: Do not take multivitamins or supplements containing vitamin A unless your doctor specifically recommends them, as they can increase the risk of serious side effects.
  • Keep Your Skin Well Moisturised: Apply a fragrance-free moisturiser and lip balm regularly to help relieve dry skin and cracked lips caused by the treatment.
  • Take with Food: Take Atranza Capsule with a meal. Including healthy fats, such as avocado, nuts, nut butter, olive oil, or full-fat dairy products (unless your doctor has advised otherwise), may help your body absorb the medicine more effectively.
  • Stay Hydrated: Drink plenty of water and other fluids throughout the day, unless your doctor has advised you to limit your fluid intake.
  • Protect Yourself from the Sun: Atranza Capsule can make your skin more sensitive to sunlight. Wear protective clothing, use a broad-spectrum sunscreen with SPF 30 or higher, and avoid excessive sun exposure whenever possible.
health query

Have a query?

How Soon It Starts Working

The time required for Atranza Capsule to start to work: The time required for Atranza Capsule to show its action is unknown. The time for which the effects of Atranza Capsule last: The duration of action for Atranza Capsule is unknown.

What if you forget to take Atranza Capsule

If you miss a dose, take it as soon as you remember if it is within a few hours of your scheduled time. However, if it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one. Talk to your doctor or pharmacist if you are unsure.

Storage

• Store Atranza Capsule capsules at room temperature, ideally between 68°F and 77°F (20°C to 25°C).

Drug Warnings

  • Strict Birth Control: You must use two highly effective forms of birth control simultaneously while taking this medicine and for at least one month after stopping, as it causes severe birth defects.
  • Pregnancy Testing: A negative pregnancy test is required before starting Atranza Capsule. Continue using effective contraception exactly as advised by your doctor throughout treatment and for the recommended period after stopping the medicine.
  • Check Your Lab Results: Attend all scheduled blood tests. Your doctor will need to monitor your liver function, cholesterol levels, and blood counts regularly.
  • Watch for Differentiation Syndrome: Monitor yourself daily for fever, shortness of breath, or sudden weight gain, and report these symptoms immediately. This is a life-threatening but treatable reaction that is usually managed promptly with corticosteroids and other supportive treatment under medical supervision.
  • Do Not Donate Blood: Do not donate blood while taking this medicine and for at least one month after your final dose to prevent exposing pregnant women to the drug.
  • Inspect Your Capsules: Before taking your dose, inspect the capsules. Do not take them if they are soft, leaking, cracked, or discoloured.

Drug-Drug Interactions

verifiedApollotooltip

  • Tetracycline antibiotics: May increase the risk of high pressure in the brain, leading to severe headaches and vision changes.
  • Vitamin A supplements: Can lead to toxic levels of Vitamin A in your system, worsening side effects.
  • Certain antifungals (like ketoconazole): May raise the levels of Atranza Capsule in your blood, increasing the risk of side effects.
  • Amiodarone: May increase the risk of liver damage when combined with this medicine.
TretinoinDoxycycline
Critical
TretinoinMinocycline
Critical

Drug-Drug Interactions

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TretinoinDoxycycline
Critical
How does the drug interact with Atranza Capsule:
Coadministration of Atranza Capsule with Doxycycline can increase the risk of side effects like vision problems.

How to manage the interaction:
Taking Atranza Capsule with Doxycycline is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden headache, nausea, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
TretinoinMinocycline
Critical
How does the drug interact with Atranza Capsule:
Co-administration of Atranza Capsule with Minocycline can increase the risk of side effects like pseudotumor cerebri (increased pressure in the brain)

How to manage the interaction:
Taking Atranza Capsule with Minocycline is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TretinoinOxytetracycline
Critical
How does the drug interact with Atranza Capsule:
Co-administration of Atranza Capsule with Oxytetracycline can increase the risk of pseudotumor cerebri (caused by increased pressure in the brain).

How to manage the interaction:
Taking Oxytetracycline with Atranza Capsule is not recommended as it can be taken if prescribed by a doctor. However, if you experience headaches, nausea, vomiting, and vision problems contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TretinoinDemeclocycline
Critical
How does the drug interact with Atranza Capsule:
Combining Atranza Capsule with Demeclocycline can increase the risk of side effects like pseudotumor cerebri (increased pressure in the brain)

How to manage the interaction:
Taking Atranza Capsule with Demeclocycline is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden headache, nausea, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
TretinoinTetracycline
Critical
How does the drug interact with Atranza Capsule:
Coadministration of Atranza Capsule with Tetracycline can increase the risk of pseudotumor cerebri(caused by increased pressure in the brain).

How to manage the interaction:
Taking Atranza Capsule with Tetracycline is not recommended, but can be taken together if prescribed by a doctor. However, if you experience headache, nausea, vomiting, and visual disturbances contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
TretinoinVoriconazole
Severe
How does the drug interact with Atranza Capsule:
Using Atranza Capsule together with Voriconazole may increase the blood levels of Atranza Capsule.

How to manage the interaction:
Taking Atranza Capsule with Voriconazole together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience headache, visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TretinoinLeflunomide
Severe
How does the drug interact with Atranza Capsule:
Co-administration of leflunomide and Atranza Capsule can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Atranza Capsule and leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TretinoinAcitretin
Severe
How does the drug interact with Atranza Capsule:
Coadministration of Acitretin with Atranza Capsule may increase the risk or severity of hypervitaminosis A (too much vitamin A in the body), increased pressure in the brain, and injury of the liver, pancreas, or digestive tract.

How to manage the interaction:
Although there is a possible interaction between Acitretin and Atranza Capsule, you can take these medicines together if prescribed by your doctor. However, if you notice early signs and symptoms of hypervitaminosis A such as inflammation or bleeding of the gums or lips, dry, scaly, itchy, or red skin, hair loss, headache, dizziness, and nausea, contact a doctor immediately. Avoid or limit the consumption of additional vitamin A while taking these medications. Do not discontinue any medication without consulting a doctor.
TretinoinAprotinin
Severe
How does the drug interact with Atranza Capsule:
Co-administration of Aprotinin and Atranza Capsule may increase the risk of blood clots.

How to manage the interaction:
Co-administration of Atranza Capsule with Aprotinin can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - chest pain, coughing up blood, sudden loss of vision, pain, redness, or swelling in your arm or leg - contact your doctor right away. Do not stop using any medications without a doctor's advice.
TretinoinTranexamic acid
Severe
How does the drug interact with Atranza Capsule:
Co-administration of Atranza Capsule with tranexamic acid may increase the risk of blood clots.

How to manage the interaction:
Taking Atranza Capsule with tranexamic acid is not recommended due to its increased effects, however, it can be taken only if your doctor has advised it. If you experience symptoms such as chest pain, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: May increase the risk of liver damage and raise cholesterol levels when consumed during treatment.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[RETINOIDS]

FAQs

Atranza Capsule belongs to a class of drugs called retinoids (similar to vitamin A). Atranza Capsule is used to treat acute promyelocytic leukaemia (a type of blood problem).
Atranza Capsule works by reducing the excessive production of abnormal blood cells and stimulates the growth of normal, mature cells in blood and bone marrow. Thus, helps in the treatment of acute promyelocytic leukaemia.
You are recommended to avoid pregnancy while taking Atranza Capsule and for 1 month after stopping treatment with Atranza Capsule as it may cause the birth of the deformed baby. Therefore, you are advised to use effective contraceptive measures while taking Atranza Capsule and for 1 month after stopping treatment with Atranza Capsule to prevent pregnancy. Also, women using Atranza Capsule should take a pregnancy test every month and if you become pregnant while taking Atranza Capsule, inform your doctor immediately.
Atranza Capsule may cause dizziness as a temporary side effect. Therefore, drive only if you are alert after taking Atranza Capsule.
You are not recommended to take low-dose progestogens (mini pill) with Atranza Capsule as their effectiveness may be reduced. However, discuss with your doctor if you have any concerns regarding this so that a different oral contraceptive may be prescribed.
Atranza Capsule may cause painful swelling in the leg in a few patients. If you experience painful swelling in your leg, difficulty breathing or sudden chest pain while taking Atranza Capsule, please inform your doctor immediately as these might be signs of a blood clot.
The duration of your treatment depends on your specific treatment plan, how well you respond, and your lab results. Your doctor will decide exactly when it is safe to stop. Talk to your doctor.
It is highly recommended to avoid alcohol while taking this medicine. Alcohol can increase your risk of liver damage and worsen high cholesterol levels caused by the treatment. Talk to your doctor.
Regular blood tests are crucial to monitor your liver function, blood cell counts, and cholesterol levels. This helps your doctor ensure the medicine is working safely and effectively. Talk to your doctor.
This is a serious, life-threatening reaction that can occur during leukaemia treatment. Symptoms include fever, breathing difficulties, cough, and sudden weight gain. If you notice any of these, contact your medical team immediately. Talk to your doctor.
You should avoid multivitamins or any supplements containing Vitamin A, as this can cause a dangerous buildup of the vitamin in your body and severe side effects. Always check labels before taking any new supplement. Talk to your doctor.
Yes, very dry skin, cracked lips, and dry eyes are very common side effects of this medication. Using a heavy moisturiser, lip balm, and lubricating eye drops regularly can help manage these symptoms. Talk to your doctor.
No, you must not donate blood while taking this medicine and for at least one month after your final dose. This prevents the drug from accidentally being given to a pregnant woman. Talk to your doctor.

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Manufacturer/Marketer address

50Th K.M. Stone, Nh-1, Murthal, Sonepat
Other Info - AT86036
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