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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Atropine Sulphate Injection 1 ml is used to treat bradycardia (decreased heart rate). It contains Atropine, which restores normal heartbeat during cardiac arrest. It is also used to reduce saliva, mucus, or other secretions in the respiratory tract during surgery. It is further used as an antidote to treat organophosphate insecticide, nerve gas or mushroom poisonings.
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Composition :

ATROPINE-0.6MG

Manufacturer/Marketer :

Harson Laboratories

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Atropine Sulphate Injection 1 ml

Atropine Sulphate Injection 1 ml is used to treat bradycardia (decreased heart rate). It restores normal heartbeat during cardiac arrest. It is also used to reduce saliva, mucus, or other secretions in the respiratory tract during surgery. It is further used as an antidote to treat organophosphate insecticide, nerve gas or mushroom poisonings.

Atropine Sulphate Injection 1 ml contains Atropine, which belongs to the class of muscarinic antagonists or parasympatholytics. It works by blocking the activity of acetylcholine (chemical messenger). As a result, this helps to bring back the blood pressure within the normal range and relaxes the heart. Hence, it treats symptomatic bradycardia and prevents sudden falls in blood pressure.

Atropine Sulphate Injection 1 ml may cause some common side effects like constipation, bloating, stomach pain, nausea, vomiting, dry eyes, blurred vision, dry mouth, fast/pounding heartbeat, flushing (sudden warmth, redness, or tingly feeling), confusion, headache, dizziness, drowsiness, and thirst. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects are persistent, please reach out to your doctor.

Inform your doctor if you are allergic to Atropine Sulphate Injection 1 ml or any of its ingredients. Before using Atropine Sulphate Injection 1 ml, inform your doctor if you have any medical history, including asthma, glaucoma (elevated pressure in the eye), heart rhythm disorder, liver/kidney diseases, enlarged prostate, stomach diseases or myasthenia gravis (muscle weakness). Atropine Sulphate Injection 1 ml may cause blurred vision, dizziness and drowsiness; hence, do not drive or operate machinery until you feel better. Pregnant and breastfeeding women should consult their doctor before using Atropine Sulphate Injection 1 ml. This medicine will be prescribed by a doctor for children depending on the child's age and body weight.

Uses of Atropine Sulphate Injection 1 ml

Treatment of Bradycardia (slow heart rate), an organophosphate insecticide, nerve gas, and mushroom poisoning reduces saliva and mucus secretions in the airway during surgery.

Directions for Use

It will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Atropine Sulphate Injection 1 ml contains Atropine, which is an anticholinergic agent, antisialagogue (that inhibits the flow of saliva), and an antidote. It is used to treat bradycardia (slow heart rate). It also restores a normal heartbeat in cardiac arrest or failure patients. It is used as a preoperative medication before anaesthesia to inhibit salivation and excessive secretions of the respiratory tract. It also acts as an antidote to insecticide, nerve gas, and mushroom poisoning. In combination with other medicines, Atropine Sulphate Injection 1 ml is used to reverse the muscle relaxant effect during surgery.

How Atropine Sulphate Injection 1 ml Works

Atropine Sulphate Injection 1 ml contains Atropine, which belongs to the class of muscarinic antagonists or parasympatholytics. It works by blocking the activity of acetylcholine (chemical messenger). As a result, this helps to bring back the blood pressure within the normal range and relaxes the heart. Hence, it treats symptomatic bradycardia and prevents sudden falls in blood pressure.

Storage

Store in a cool and dry place away from sunlight
Side effects of Atropine Sulphate Injection 1 ml
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Drink enough water throughout the day.
  • Avoid alcohol and caffeine.
  • Take a bath or cool shower frequently.
  • Wear loose-fitted light-coloured clothing.
  • Use a hat to protect yourself from sunlight.
  • Avoid heavy activity or strenuous exercise in hot environments.
  • Consult the doctor if you notice significant decrease in sweating.
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.

What if I have taken an overdose of Atropine Sulphate Injection 1 ml

The overdose of Atropine Sulphate Injection 1 ml is unlikely as it is administered by a doctor. However, in case of overdose, patients may experience very fast heart beat, quick breathing, fever, restlessness, confusion, hallucinations or loss of co-ordination. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Before using Atropine Sulphate Injection 1 ml, inform your doctor if you have any medical history, including asthma, glaucoma, heart rhythm disorder, liver/kidney diseases, enlarged prostate, stomach diseases or myasthenia gravis (muscle weakness). Atropine Sulphate Injection 1 ml may cause blurred vision, dizziness and drowsiness, hence do not drive or operate machinery until you feel better. Pregnant and breastfeeding women should consult their doctor before using Atropine Sulphate Injection 1 ml. Alcohol consumption may worsen the side effect of Atropine Sulphate Injection 1 ml like dizziness and drowsiness. It is better to avoid alcohol while you are being treated with Atropine Sulphate Injection 1 ml. This medicine will be prescribed by a doctor for children depending on the child's age and body weight.

Drug-Drug Interactions

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AtropineSecretin
Severe
AtropineHydromorphone
Severe

Drug-Drug Interactions

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AtropineSecretin
Severe
How does the drug interact with Atropine Sulphate Injection 1 ml Sulphate Injection 1 ml:
When Secretin human is used with Atropine Sulphate Injection 1 ml, the therapeutic efficacy of Secretin human can be decrease.

How to manage the interaction:
Although there is a possible interaction between Atropine Sulphate Injection 1 ml and Secretin, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
AtropineHydromorphone
Severe
How does the drug interact with Atropine Sulphate Injection 1 ml Sulphate Injection 1 ml:
Using Hydromorphone together with Atropine Sulphate Injection 1 ml may increase the risk and/or severity of some side effects (dizziness, drowsiness, confusion, difficulty concentrating, difficulty urinating, dry mouth, abdominal cramping, and constipation).

How to manage the interaction:
Although taking Hydromorphone and Atropine Sulphate Injection 1 ml together can cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact a doctor right away: trouble peeing, feeling dizzy or sleepy, feeling confused or having trouble focusing, dry mouth, constipation, or feeling less mentally sharp. Do not discontinue any medications without consulting a doctor.
AtropinePotassium citrate
Severe
How does the drug interact with Atropine Sulphate Injection 1 ml Sulphate Injection 1 ml:
Taking potassium citrate oral tablets or capsules with Atropine Sulphate Injection 1 ml may increase the irritating effects of potassium on stomach and upper intestine.

How to manage the interaction:
Taking Atropine Sulphate Injection 1 ml with potassium citrate together can result in an interaction, it can be taken if a doctor has advised it. However, if you happen to experience severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, and/or black, tarry stools, consult the doctor. Do not discontinue any medications without consulting a doctor.
AtropineZonisamide
Severe
How does the drug interact with Atropine Sulphate Injection 1 ml Sulphate Injection 1 ml:
Coadministration of Atropine Sulphate Injection 1 ml and Zonisamide can cause increased body temperature and decreased sweating.

How to manage the interaction:
Although taking Atropine Sulphate Injection 1 ml and Zonisamide together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, or lightheadedness, or if you have reduced sweating or a fever, consult a doctor immediately. Avoid tasks that need mental attention, such as driving or operating dangerous machinery. Do not discontinue any medications without consulting a doctor.
AtropineSolifenacin
Severe
How does the drug interact with Atropine Sulphate Injection 1 ml Sulphate Injection 1 ml:
When Atropine Sulphate Injection 1 ml is used with solifenacin may cause side effects (drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems).

How to manage the interaction:
Co- administration of Atropine Sulphate Injection 1 ml with solifenacin can lead to an interaction, it can be taken if a doctor has advised it. However, if you experience drowsiness, blurred vision, dry mouth, heat intolerance, flushing, reduced sweating, trouble urinating, abdominal cramps, constipation, irregular heartbeat, disorientation, and memory issues, consult the doctor. Avoid tasks that need mental attention, such as driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
AtropineTopiramate
Severe
How does the drug interact with Atropine Sulphate Injection 1 ml Sulphate Injection 1 ml:
When Atropine Sulphate Injection 1 ml and Topiramate are taken together it can cause increased body temperature and decreased sweating.

How to manage the interaction:
Although taking Atropine Sulphate Injection 1 ml and topiramate together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, or lightheadedness, or if you have reduced sweating or a fever, consult a doctor immediately. Avoid tasks that need mental attention, such as driving or operating dangerous machinery. Do not discontinue any medications without consulting a doctor.
AtropinePotassium chloride
Severe
How does the drug interact with Atropine Sulphate Injection 1 ml Sulphate Injection 1 ml:
Co-administration of Atropine Sulphate Injection 1 ml with Potassium chloride oral tablets or capsules can increase the risk of stomach ulcers, bleeding, and other gastrointestinal injury.

How to manage the interaction:
There may be a possibility of interaction between Atropine Sulphate Injection 1 ml and Potassium chloride, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact the doctor right away: severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting(especially with blood), decreased hunger, dark, tarry stools. Do not discontinue any medications without a doctor's advice.
AtropinePramlintide
Severe
How does the drug interact with Atropine Sulphate Injection 1 ml Sulphate Injection 1 ml:
Coadministration of Pramlintide with Atropine Sulphate Injection 1 ml can increase the risk of reduced movement in the digestive system.

How to manage the interaction:
Taking Atropine Sulphate Injection 1 ml with Pramlintide together can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
AtropineUmeclidinium bromide
Severe
How does the drug interact with Atropine Sulphate Injection 1 ml Sulphate Injection 1 ml:
Using Atropine Sulphate Injection 1 ml together with umeclidinium may increase side effects (drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, rapid heartbeat, confusion, memory problems, and glaucoma - an eye disease that causes vision loss in one or both eyes).

How to manage the interaction:
Although taking Atropine Sulphate Injection 1 ml and Umeclidinium bromide together can cause an interaction, it can be taken if a doctor has suggested it. If you experience drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, rapid heartbeat, confusion, memory problems, and glaucoma - an eye disease that causes vision loss in one or both eyes. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Keep your cholesterol and triglyceride levels under control.

  • Eat at regular intervals and maintain a healthy diet that includes fresh fruits and vegetables

  • Limit alcohol intake since it raises blood pressure and increases the risk of heart diseases

  • Keep a check on your weight and exercise regularly to keep your heart healthy.

  • Your doctor also guides you on noticing and managing the early symptoms of detecting heart diseases. 

Habit Forming

No

Therapeutic Class

ANTICHOLINERGICS

Atropine Sulphate Injection 1 ml Substitute

Substitutes safety advice
  • Atropine Sulphate-1Ml Inj

    by AYUR

    4.56per tablet
  • Atropine Injection10 ml

    by Others

    15.12per tablet
  • Atrotas Injection 1ml

    by AYUR

    4.05per tablet
  • Rathi Atropine Sulphate 0.6 mg Injection 1 ml

    by Others

    3.52per tablet
  • Atropcot 0.6 mg Injection 1 ml

    by Others

    5.10per tablet
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Alcohol

Caution

Alcohol consumption may worsen the side effect of this medicine like dizziness and drowsiness. It is better to avoid alcohol while you are being treated with Atropine Sulphate Injection 1 ml.

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Pregnancy

Caution

Please inform your doctor if you are pregnant or planning pregnancy. Your doctor will prescribe Atropine Sulphate Injection 1 ml only if the benefits outweigh the risk.

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Breast Feeding

Caution

Please inform your doctor if you are breastfeeding. Your doctor will prescribe Atropine Sulphate Injection 1 ml only if the benefits outweigh the risk.

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Driving

Caution

Atropine Sulphate Injection 1 ml may cause side effects like dizziness and drowsiness that could affect your driving ability. Do not drive or operate machinery in such cases. Drive only when you are mentally alert.

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Liver

Caution

Inform your doctor if you have any history of liver diseases or hepatic impairment before receiving Atropine Sulphate Injection 1 ml.

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Kidney

Caution

Inform your doctor if you have any history of kidney diseases/impairment before receiving Atropine Sulphate Injection 1 ml.

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Children

Caution

Please consult your doctor. Your doctor will decide the dose depending on the age and condition of your child.

FAQs

Atropine Sulphate Injection 1 ml belongs to a class of drugs known as 'anticholinergics', used to treat bradycardia (decreased heart rate). It restores normal heartbeat during cardiac arrest. It is also used to reduce saliva, mucus, or other secretions in the respiratory tract during surgery. It is further used as an antidote to treat organophosphate insecticide, nerve gas or mushroom poisonings.

Atropine Sulphate Injection 1 ml contains Atropine, which is used to treat bradycardia (slow heart rate). It works by blocking the activity of acetylcholine (chemical messenger). As a result, this helps to bring back the blood pressure within the normal range and relaxes the heart.

Dry mouth could be a side-effect of Atropine Sulphate Injection 1 ml. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent mouth drying.

Atropine may decrease sweating and make you more prone to heat stroke. Hence, it is advised to avoid becoming overheated or dehydrated during any physical activity and in hot weather.

Atropine is contraindicated in allergic reactions, urinary difficulties, elevated pressure in the eye (glaucoma), and stomach-related disorders like achalasia of the oesophagus, a blockage in the intestine (paralytic ileus) or acute form of colonic distension (toxic megacolon).

Country of origin

INDIA

Manufacturer/Marketer address

12, R. C. Patel Industrial Estate, Akota, Baroda - 390 020., INDIA
Other Info - ATR0008

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