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compositionComposition:SODIUM VALPROATE-300MG
prescription
Prescription Medicine
info
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Avol-300 CR Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache). It helps reduce mood swings and improve impulsive behaviour.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

SODIUM VALPROATE-300MG

Manufacturer/Marketer :

Elikem Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Avol-300 CR Tablet

Avol-300 CR Tablet is an oral prescription medicine used to treat different types of seizures in epilepsy. It is also prescribed to manage manic episodes associated with bipolar disorder and to prevent migraine headaches in adults. This medicine works by calming overactive nerves in the brain to help you stay balanced and seizure-free.

For Avol-300 CR Tablet to work effectively, you must take it consistently every day at the same times. It is usually taken once or twice a day, and taking it with or after food can help prevent stomach upset. Making simple lifestyle adjustments, such as getting enough sleep, managing daily stress, and eating regular meals, can also support your treatment and improve your overall results.

While taking Avol-300 CR Tablet , you might experience mild side effects like drowsiness, nausea, or temporary hair thinning. However, you must contact your doctor immediately if you notice serious symptoms such as severe upper stomach pain, unexplained bruising, or yellowing of your skin and eyes.

Do not take this if you have active liver disease or a family history of severe liver problems. Before starting Avol-300 CR Tablet , tell your doctor if you have kidney problems, urea cycle disorders, or mitochondrial disease. It is especially important to discuss your medical history because this medicine should not be taken during pregnancy unless there is no other treatment option.

This medicine can interact with alcohol, which can make you feel extremely sleepy and increase the risk of seizures, so it is best to avoid drinking while on this treatment. You should also consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, or if you are an older adult, as your body may handle the medication differently.
 

Uses of Avol-300 CR Tablet

Avol-300 CR Tablet is used to treat different types of seizures in epilepsy. The detailed uses of Avol-300 CR Tablet are as follows:

  • Epilepsy (Seizures): Avol-300 CR Tablet helps control and prevent various kinds of seizures, including generalised and partial seizures, by stabilising the electrical activity in the brain.
  • Bipolar Disorder (Manic Episodes): Avol-300 CR Tablet manages periods of extreme excitement, high energy, or irritability by helping to restore the balance of certain natural chemicals in your brain.
  • Migraine Prevention: Avol-300 CR Tablet helps by reducing how often you get severe migraine headaches, though it is not used to treat a migraine attack that has already started.
     

Key Benefits

Avol-300 CR Tablet helps manage certain neurological conditions by stabilising electrical activity in the brain. Depending on the condition being treated, it helps control seizures, stabilise mood, or reduce the frequency of migraine attacks, supporting a better quality of life.

  • Helps Control Seizures: By reducing abnormal electrical activity in the brain, Avol-300 CR Tablet helps decrease the frequency of seizures, allowing you to carry out daily activities with greater safety and confidence.
  • Supports Mood Stability: For individuals with bipolar disorder, Avol-300 CR Tablet helps reduce extreme mood swings and prevent manic episodes, promoting greater emotional stability and improved daily functioning.
  • Helps Prevent Migraine Attacks: When used for migraine prevention, Avol-300 CR Tablet helps reduce the frequency of migraine episodes, allowing you to spend more time enjoying your daily activities with fewer interruptions from headaches.
     
Side effects of Avol-300 Cr Tab
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Get help from a health care professional.
  • Manage your feelings and things that trigger them.
  • Fuel your body with good food like fruits, veggies, and whole grains.
  • Find calm through activities like meditation or yoga.
  • Work on changing negative patterns and thoughts.
  • Focus on being healthy overall, not just how you look.

Directions for Use

  • Avol-300 CR Tablet can be taken with or without food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Avol-300 CR Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Avol-300 CR Tablet Works

Avol-300 CR Tablet contains sodium valproate, which helps to look at the chemistry of the brain. Your brain relies on electrical signals and chemical messengers to function. Sometimes, overactive electrical signals can cause a seizure or trigger a migraine. Avol-300 CR Tablet works by increasing the levels of a natural calming chemical in your brain called gamma-aminobutyric acid (GABA). By boosting GABA, Avol-300 CR Tablet helps block the excessive and rapid electrical signals that cause brain cells to overreact. This balancing effect calms brain activity, which helps prevent the onset of seizures, reduces the frequency of migraines, and stabilises fluctuating moods.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Avol-300 CR Tablet as it may cause increased dizziness and sleepiness.

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Pregnancy

Unsafe

Avol-300 CR Tablet belongs to pregnancy category D. Avoid taking Avol-300 CR Tablet if you are pregnant as it could lead to serious birth defects.

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Breast Feeding

Consult your doctor

Avol-300 CR Tablet may pass into breastmilk. Consult your doctor before taking Avol-300 CR Tablet if you are breastfeeding.

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Driving

Unsafe

Avol-300 CR Tablet causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

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Liver

Unsafe

Avol-300 CR Tablet should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Consult your doctor

Avol-300 CR Tablet can be given to children if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight.

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Heart

Consult your doctor

It is unknown whether Avol-300 CR Tablet is safe for use in cardiac patients or not. Please consult your physician.

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Geriatrics

Caution

Avol-300 CR Tablet should be given with caution in elderly patients due to age-related side effects. Seek medical advice before using Avol-300 CR Tablet .

What if I have taken an overdose of Avol-300 CR Tablet

In case of an accidental overdose, seek immediate emergency medical attention right away. Symptoms of an overdose can include extreme drowsiness, confusion, shallow breathing, or loss of consciousness.

Diet & Lifestyle Advise

  • Maintain a consistent sleep routine: Lack of sleep is a well-known trigger for both seizures and migraines. Aim for 7 to 8 hours of quality sleep every night.
  • Avoid alcohol completely: Alcohol can increase the sedative effects of Avol-300 CR Tablet , making you extremely dizzy or sleepy, and it can also lower your seizure threshold.
  • Eat regular meals: Skipping meals can trigger migraines or affect your metabolic balance. Eating consistent, balanced meals helps maintain steady energy levels.
  • Keep a health diary: Track your daily doses, any seizures or migraine attacks, and any mild side effects you notice. This record is highly valuable for your doctor during check-ups.
  • Stay adequately hydrated: Drinking enough water throughout the day supports overall brain health and can help reduce the frequency of headaches.
     
health query

Have a query?

How Soon It Starts Working

  • The time required for Avol-300 CR Tablet to start to work: Avol-300 CR Tablet ideally shows its action within 2 hours after administration.
  • The time for which the effects of Avol-300 CR Tablet last: The effect of Avol-300 CR Tablet lasts for 24 hours.

What if you forget to take Avol-300 CR Tablet

If you miss a dose of Avol-300 CR Tablet , take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, talk to your doctor or pharmacist.

Storage

• Store Avol-300 CR Tablet tablets, capsules, or oral solutions at room temperature, ideally between 15°C and 30°C (59°F to 86°F).

Drug Warnings

  • Use highly effective birth control: This medication carries a high risk of causing severe birth defects. If you are of childbearing age, discuss safe, reliable contraception options with your doctor.
  • Do not stop treatment abruptly: Stopping Avol-300 CR Tablet suddenly can cause severe, continuous seizures that can be dangerous. Always consult your doctor before making any changes.
  • Avoid driving or operating machinery: This medicine can make you feel sleepy or dizzy, especially when you first start taking it. Do not perform tasks requiring full alertness until you know how it affects you.
  • Monitor your mood: Pay close attention to any sudden changes in your mental health. Report any signs of depression, anxiety, or unusual thoughts to your doctor immediately.
  • Get regular blood tests: Your doctor will need to perform periodic blood tests to monitor your liver function, platelet counts, and the level of medicine in your body. Keep all your medical appointments.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Aspirin: Taking aspirin with Avol-300 CR Tablet can increase the level of this medicine in your blood, raising the risk of side effects.
  • Other seizure medications: Medicines like carbamazepine, phenytoin, or phenobarbital can speed up how your body processes Avol-300 CR Tablet , while taking it with lamotrigine can increase lamotrigine levels to unsafe amounts.
  • Blood thinners: Combining this medicine with blood thinners like warfarin can increase your risk of bleeding or bruising.
     
Sodium ValproateSodium phenylbutyrate
Critical
Sodium ValproateBuprenorphine
Severe

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with Avol-300 Cr Tab:
Combining Sodium phenylbutyrate and Avol-300 Cr Tab can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Avol-300 Cr Tab is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateBuprenorphine
Severe
How does the drug interact with Avol-300 Cr Tab:
Using buprenorphine together with Avol-300 Cr Tab may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Avol-300 Cr Tab can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateMeropenem
Severe
How does the drug interact with Avol-300 Cr Tab:
Co-administration of Meropenam and Avol-300 Cr Tab together can reduce the effect of Avol-300 Cr Tab.

How to manage the interaction:
Co-administration of Meropenam and Avol-300 Cr Tab can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateLithium
Severe
How does the drug interact with Avol-300 Cr Tab:
Co-administration of Lithium with Avol-300 Cr Tab can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Avol-300 Cr Tab can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
Sodium ValproateKetamine
Severe
How does the drug interact with Avol-300 Cr Tab:
Co-administration of Ketamine and Avol-300 Cr Tab can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Avol-300 Cr Tab can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.
Sodium ValproateTeriflunomide
Severe
How does the drug interact with Avol-300 Cr Tab:
Co-administration of Teriflunomide and Avol-300 Cr Tab can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Avol-300 Cr Tab can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateVorinostat
Severe
How does the drug interact with Avol-300 Cr Tab:
Co-administration of Vorinostat with Avol-300 Cr Tab can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Avol-300 Cr Tab can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateErtapenem
Severe
How does the drug interact with Avol-300 Cr Tab:
The combined use of Ertapenem and Avol-300 Cr Tab can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Avol-300 Cr Tab can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.
Sodium ValproateDoripenem
Severe
How does the drug interact with Avol-300 Cr Tab:
Co-administration of Avol-300 Cr Tab with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Avol-300 Cr Tab can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateLeflunomide
Severe
How does the drug interact with Avol-300 Cr Tab:
Co-administration of Leflunomide and Avol-300 Cr Tab can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Avol-300 Cr Tab can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Drinking alcohol while taking this medicine can cause severe drowsiness, impair coordination, and increase the risk of seizures.

 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Avol-300 CR Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache).
Avol-300 CR Tablet decreases the excessive and abnormal nerve activity in the brain. It balances the brain's chemical messenger and prevents overactivity of the brain, thereby controlling seizure episodes.
Avol-300 CR Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps in blocking the nerve transmission across the brain and provides a calming effect.
Avol-300 CR Tablet limits the transmission of nerve pain, thereby preventing migraine headaches. Migraines are a neurological condition characterised by intense headaches.
Do not discontinue Avol-300 CR Tablet without consulting your doctor. To treat your condition effectively, continue taking Avol-300 CR Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Avol-300 CR Tablet ; your doctor will reduce the dose gradually to avoid worsening of seizures.
Birth-control pills like oestrogen-containing products may affect the way Avol-300 CR Tablet works. It is better to consult the doctor if you are using birth control pills to avoid pregnancy.
Avol-300 CR Tablet might cause fertility issues in both men and women. However, it can be reversible upon discontinuation of Avol-300 CR Tablet . In rare cases, Avol-300 CR Tablet can be a contributing factor in male infertility.
Limit caffeine intake, avoid smoking and mouthwashes containing alcohol, drink water regularly, and chew sugar-free gum/candy might prevent dry mouth.
Avol-300 CR Tablet may change the results of liver enzymes, urine and blood tests. Inform the person doing the tests that you are taking Avol-300 CR Tablet .
Store Avol-300 CR Tablet at room temperature, in a dry place. Keep out of sight and reach of children.
Avol-300 CR Tablet may cause side effects like stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Yes, Avol-300 CR Tablet causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.
No, taking higher than the recommended dose of Avol-300 CR Tablet will not be more effective and may cause unpleasant side effects. Do not take more than the prescribed dose of Avol-300 CR Tablet as it may cause an overdose.
No, you should avoid drinking alcohol while taking this medicine. Alcohol can increase the sleepiness and dizziness caused by Avol-300 CR Tablet and may also increase your risk of having a seizure. Talk to your doctor.
You must contact your doctor immediately before planning a pregnancy or as soon as you discover you are pregnant. This medicine carries a high risk of causing physical and developmental birth defects. Your doctor will help you evaluate alternative treatments. Talk to your doctor.
Yes, weight gain is a common side effect for some people taking this medicine. Managing your diet and staying physically active can help, but you should not make drastic changes without medical advice. Talk to your doctor.
No, you should never stop taking this medicine on your own. Stopping it suddenly can cause your seizures to return more frequently or become more severe. If you need to stop, your doctor will guide you on how to reduce your dose safely. Talk to your doctor.
Your doctor needs to check your blood regularly to monitor your liver health, check your blood platelet counts, and ensure the level of medicine in your body is within a safe and effective range. Talk to your doctor.
Some people experience temporary thinning or loss of hair while taking this medicine. In most cases, the hair grows back once the treatment is stopped or adjusted, though it may grow back with a slightly different texture. Talk to your doctor.
You can take this medicine with or without food. However, taking it with or immediately after a meal can help reduce common stomach upsets, such as nausea or indigestion. Talk to your doctor.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.1500 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Health Service (NHS). Sodium Valproate - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Valproate Sodium Intravenous Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Valproic acid [Package Leaflet]. 2023. [Accessed on 06 Apr. 2024]Check here
  5. Valproate sodium [Prescribing Information]. 2013. [Accessed on 18 Sep. 2024]Check here
  6. Rahman M, Awosika AO, Nguyen H Valproic Acid. [Updated 2024 Mar 19]. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024Check here
  7. Valproic Acid: MedlinePlus Drug InformationMedlinePlus. Sulfasalazine [Internet]. U.S. National Library of Medicine; 2025 [Accessed on 10 Mar 2025]Check here

Country of origin

India
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