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Azashine 100 mg Injection is used to treat Myelodysplastic syndrome, chronic myelomonocytic leukaemia, and acute myeloid leukaemia. It contains Azacitidine, a nucleoside metabolic inhibitor which works by preventing cancer cells from growing. It incorporates into the genetic material of the cells and interferes with the production of new DNA and RNA. This helps correct problems with the maturation and growth of young blood cells in the bone marrow, which causes myelodysplastic disorders.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AZACITIDINE-100MG

Manufacturer/Marketer :

Hetero Drugs Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Azashine 100 mg Injection

Azashine 100 mg Injection is a prescription anticancer medicine used to treat certain blood and bone marrow disorders, including myelodysplastic syndromes (MDS), chronic myelomonocytic leukaemia (CMML), and some types of acute myeloid leukaemia (AML). It works by slowing the growth of abnormal bone marrow cells and helping restore the production of healthy blood cells, which can improve blood counts and reduce disease progression.

This medicine is administered as an injection by a trained healthcare professional, either under the skin (subcutaneously) or into a vein (intravenously). Treatment is usually given in repeated cycles consisting of several consecutive treatment days followed by a rest period. It is important to attend every scheduled appointment and complete each treatment cycle exactly as prescribed, even if you begin to feel better.

During treatment, your doctor will perform regular blood tests to monitor your red blood cells, white blood cells, platelets, and kidney and liver function. Because Azashine 100 mg Injection temporarily lowers blood cell counts, you may become more susceptible to infections, bleeding, or anaemia. Contact your doctor immediately if you develop a fever, chills, unusual bruising or bleeding, severe fatigue, persistent shortness of breath, or any other signs of infection.

Before starting treatment, tell your doctor if you have kidney disease, liver disease, heart disease, or a history of severe infections. This medicine should not be used if you are allergic to azacitidine or mannitol, or if you have advanced malignant liver tumours.

Azashine 100 mg Injection can interact with other medicines that suppress the immune system or affect blood clotting, increasing the risk of infections or bleeding. Avoid receiving live vaccines during treatment unless your doctor specifically recommends them. This medicine may harm an unborn baby, so effective contraception is recommended during treatment and for some time after the last dose. Breastfeeding should be avoided throughout treatment and for at least one week after the final dose. Older adults generally tolerate this medicine well but may require closer monitoring of kidney function and blood counts.

Uses of Azashine 100 mg Injection

Your doctor may prescribe this medicine to help manage the following conditions:

  • Myelodysplastic Syndromes (MDS): Azashine 100 mg Injection helps improve the production of healthy blood cells by reducing the growth of abnormal bone marrow cells. This can lessen symptoms of anaemia, reduce the need for blood transfusions, and slow disease progression.
  • Acute Myeloid Leukaemia (AML): In selected adults who are not suitable for intensive chemotherapy, this medicine slows the growth of abnormal leukaemia cells and helps control the disease while supporting the production of healthier blood cells.
  • Chronic Myelomonocytic Leukaemia (CMML): Azashine 100 mg Injection helps regulate the abnormal production of blood-forming cells in the bone marrow, improving blood counts and helping manage symptoms associated with this condition.

Key Benefits

When taken as prescribed, Azashine 100 mg Injection offers several important benefits in the treatment of certain blood cancers and bone marrow disorders.

  • Improves healthy blood cell production: By reducing the growth of abnormal bone marrow cells, this medicine allows healthier red blood cells, white blood cells, and platelets to develop, helping improve overall blood function.
  • Reduces the need for blood transfusions: Many patients experience improved blood counts during treatment, decreasing their dependence on repeated red blood cell or platelet transfusions.
  • Helps lower the risk of complications: By improving blood cell production, Azashine 100 mg Injection may reduce symptoms such as severe fatigue from anaemia, frequent infections caused by low white blood cell counts, and excessive bruising or bleeding due to low platelet levels.
  • Slows disease progression: Regular treatment helps control the growth of abnormal bone marrow cells, delaying disease progression and helping maintain a better quality of life for many patients.
Side effects of Azashine 100 mg Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Azashine 100 mg Injection will be administered by a nurse or doctor.
  • Do not self-administer.

How Azashine 100 mg Injection Works

Azashine 100 mg Injection contains azacitidine, a hypomethylating agent that helps treat certain blood and bone marrow disorders by slowing the growth of abnormal cells and restoring healthier blood cell production. After administration, azacitidine enters rapidly dividing abnormal bone marrow cells, where it becomes incorporated into their DNA and RNA. It blocks the activity of an enzyme called DNA methyltransferase (DNMT), reducing abnormal DNA methylation. This allows important genes that regulate normal cell growth and maturation to become active again. As a result, abnormal blood-forming cells grow more slowly or die, while healthier bone marrow cells are able to mature and produce functional red blood cells, white blood cells, and platelets. At higher doses, azacitidine also has direct cytotoxic effects on rapidly dividing abnormal cells, further helping control the disease.
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Alcohol

Consult your doctor

It is not known if alcohol affects Azashine 100 mg Injection. Please consult your doctor.

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Pregnancy

Unsafe

Azacitidine belongs to pregnancy category D. Azashine 100 mg Injection should not be used during pregnancy as it may harm the baby. Consult the doctor immediately if you become pregnant during treatment with Azashine 100 mg Injection.

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Breast Feeding

Unsafe

It is unknown if Azacitidine passes into breast milk. Breastfeeding is not recommended during treatment with Azashine 100 mg Injection.

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Driving

Caution

Azashine 100 mg Injection may cause dizziness and tiredness. Avoid driving or operating machinery if you experience any side effects that might lessen your ability to do so.

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Liver

Caution

If you have a history of liver disease, inform your doctor before receiving Azashine 100 mg Injection. This medicine should be used with caution in patients with severe pre-existing liver impairment.

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Kidney

Caution

If you have a history of kidney disease, inform your doctor before receiving Azashine 100 mg Injection. Monitoring patients with kidney impairment is advised.

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Children

Unsafe

Azashine 100 mg Injection is not recommended for children below 18 years as safety and effectiveness have not been established.

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Heart

Consult your doctor

Please consult your doctor before receiving Azashine 100 mg Injection if you have pre-existing heart problems. Your doctor will prescribe Azashine 100 mg Injection if the benefits outweigh the risks.

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Geriatrics

Safe if prescribed

Azashine 100 mg Injection is generally considered safe when used under medical supervision in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of Azashine 100 mg Injection

An overdose is unlikely because this medicine is prepared and administered by trained healthcare professionals. However, if an overdose is suspected, you will be monitored closely and treated for any complications. Seek immediate medical attention if severe or unusual symptoms develop after receiving your treatment.

Diet & Lifestyle Advise

The following lifestyle measures can help support your treatment and reduce the risk of complications while receiving Azashine 100 mg Injection:

  • Reduce your risk of infections: Wash your hands frequently, avoid close contact with people who are sick, and wear a mask in crowded places if advised by your healthcare provider, as your immune system may be weakened during treatment.
  • Choose safe, nutritious foods: Eat a balanced diet rich in protein, fruits, vegetables, and whole grains to support recovery. Wash fresh produce thoroughly and avoid raw or undercooked meat, seafood, eggs, and unpasteurised dairy products to reduce the risk of foodborne infections.
  • Stay well-hydrated: Drink plenty of water and other healthy fluids unless your doctor has advised you to limit fluid intake. Good hydration helps support kidney function and your overall health during treatment.
  • Prevent bleeding and injuries: Use a soft toothbrush, shave with an electric razor, and avoid activities that may cause cuts or bruises if your platelet count is low.
  • Balance activity with rest: Light physical activity, such as walking, may help reduce fatigue, but listen to your body and get enough rest throughout your treatment.
  • Attend all follow-up appointments: Regular blood tests and medical reviews are essential to monitor your blood counts, organ function, and response to treatment.
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How Soon It Starts Working

The time required for Azashine 100 mg Injection to start to work: The time required for Azashine 100 mg Injection to show its action is not clinically established. The time for which the effects of Azashine 100 mg Injection last: The effect of Azashine 100 mg Injection lasts for 24 hours.

What if you forget to take Azashine 100 mg Injection

Because this medicine is administered by a healthcare professional, missing a dose is uncommon. If you miss a scheduled treatment appointment, contact your doctor or treatment centre as soon as possible to arrange another appointment. Do not attempt to alter your treatment schedule without medical advice.

Storage

•Storage and handling of Azashine 100 mg Injection are managed by healthcare professionals.

Drug Warnings

  • Keep all treatment appointments: Completing every treatment cycle on schedule helps achieve the best possible response. Do not skip or delay your appointments without consulting your doctor.
  • Monitor your blood counts regularly: Blood tests before each treatment cycle help your doctor check your blood cell counts, kidney function, and liver function. Your dose may be delayed or adjusted depending on the results.
  • Report signs of infection immediately: Contact your doctor if you develop a fever (38°C/100.4°F or higher), chills, persistent sore throat, cough, or any other signs of infection, as this medicine can lower your white blood cell count.
  • Watch for unusual bleeding or bruising: Seek medical attention if you notice prolonged bleeding, frequent nosebleeds, blood in your urine or stools, or unusual bruising, as your platelet count may become low during treatment.
  • Tell your healthcare provider before any surgery or dental procedure: This medicine may increase your risk of bleeding and infection, so your healthcare team should know you are receiving azacitidine.
  • Avoid live vaccines during treatment: Live vaccines may increase your risk of infection while your immune system is weakened. Consult your doctor before receiving any vaccination.
  • Pregnancy warning: Both men and women should use effective contraception during treatment and for the recommended period after the last dose because this medicine can harm an unborn baby. Do not breastfeed during treatment and for at least one week after your final dose.
  • When to seek urgent medical care: Seek immediate medical attention if you develop severe shortness of breath, chest pain, swelling of the face or throat, severe allergic reactions, or yellowing of the skin or eyes.

Drug-Drug Interactions

verifiedApollotooltip
  • Other bone marrow-suppressing medicines: Combining Azashine 100 mg Injection with chemotherapy medicines or other drugs that reduce blood cell production may increase the risk of severe infections, anaemia, and bleeding.
  • Immunosuppressants: Medicines that weaken the immune system, such as corticosteroids or certain medicines used after organ transplantation, may further increase your risk of infection.
  • Anticoagulants and antiplatelet medicines: Medicines such as warfarin, apixaban, rivaroxaban, heparin, aspirin, or clopidogrel may increase the risk of bleeding, particularly if your platelet count becomes low during treatment.
  • Live vaccines: Live vaccines should generally be avoided because your immune system may not respond safely while receiving this treatment.
AzacitidineYellow fever vaccine
Critical

Drug-Drug Interactions

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AzacitidineYellow fever vaccine
Critical
How does the drug interact with Azashine 100 mg Injection:
Taking Yellow fever vaccine with Azashine 100 mg Injection can increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Azashine 100 mg Injection and the Yellow fever vaccine, you can take these medicines together if prescribed by a doctor. If you notice any signs of infection, it's important to contact a doctor right away. Do not stop using any medications without consulting a doctor.
How does the drug interact with Azashine 100 mg Injection:
The use of cladribine with Azashine 100 mg Injection can increase the risk of infections.

How to manage the interaction:
Taking Azashine 100 mg Injection with Cladribine together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience a fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Azashine 100 mg Injection:
Taking Infliximab with Azashine 100 mg Injection can increase the risk or severity of developing infection.

How to manage the interaction:
Although taking Azashine 100 mg Injection and Infliximab together can cause an interaction, it can be taken if a doctor has suggested it. If you experience symptoms like fever, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, and pain or burning during urination, it is recommended to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AzacitidineCertolizumab
Severe
How does the drug interact with Azashine 100 mg Injection:
Taking Azashine 100 mg Injection with Certolizumab may raise the risk of severe infections.

How to manage the interaction:
Co-administration of Azashine 100 mg Injection with Certolizumab can result in an interaction, but it can be taken if a doctor has advised it. However, if you have any of these symptom's fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Azashine 100 mg Injection:
Taking Azashine 100 mg Injection with Deferiprone can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Azashine 100 mg Injection with Deferiprone can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you have a fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. Do not stop using any medications without talking to a doctor.
How does the drug interact with Azashine 100 mg Injection:
Taking Azashine 100 mg Injection with Natalizumab can raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Azashine 100 mg Injection and Natalizumab, but it can be taken if prescribed by a doctor. However, if you have any of these symptoms- fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, blood in phlegm(a thick secretion in the airway during disease and inflammation), losing weight, or pain while peeing, progressive weakness on one side of the body, clumsiness of limbs, disturbance of vision, confusion, or changes in thinking, memory and personality, make sure to contact a doctor immediately. Do not stop using any medications without a doctor's advice.
AzacitidineEfalizumab
Severe
How does the drug interact with Azashine 100 mg Injection:
Using efalizumab together with Azashine 100 mg Injection may increase the risk of serious infections.

How to manage the interaction:
Taking Azashine 100 mg Injection with Efalizumab together can result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms - complications, infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, pain or burning during urination - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Azashine 100 mg Injection:
Taking thalidomide together with Azashine 100 mg Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Azashine 100 mg Injection together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
AzacitidineBCG vaccine
Severe
How does the drug interact with Azashine 100 mg Injection:
Taking BCG vaccine with Azashine 100 mg Injection can increase the risk of infection.

How to manage the interaction:
Co-administration of Azashine 100 mg Injection with BCG vaccine can result in an interaction, but it can be taken if a doctor has advised it. If you notice any signs of infection, it's important to contact a doctor right away. Do not stop using any medications without consulting a doctor.
How does the drug interact with Azashine 100 mg Injection:
Taking Azashine 100 mg Injection with Teriflunomide can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Azashine 100 mg Injection and Teriflunomide together can cause an interaction, it can be taken if a doctor has suggested it. However, consult a doctor immediately if you have a fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • There are no known clinically significant food interactions with azacitidine.
  • However, maintaining good food hygiene and avoiding raw or undercooked foods can help reduce the risk of infection if your white blood cell count is low.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Azashine 100 mg Injection is used to treat Myelodysplastic syndrome, chronic myelomonocytic leukaemia, and acute myeloid leukaemia.
Azashine 100 mg Injection works by preventing cancer cells from growing. Thereby, it helps treat cancer.
Men should avoid fathering a child whilst on treatment with Azashine 100 mg Injection. Consult the doctor if you wish to conserve your sperm before starting the treatment. Use effective contraception during the treatment with Azashine 100 mg Injection and for three months after stopping the treatment.
Azashine 100 mg Injection may cause a serious immune reaction known as differentiation syndrome. Consult the doctor immediately if you experience fever, rash, difficulty breathing, cough, decreased urine, rapid weight gain, low blood pressure, or swelling of the legs or arms.
No, Azashine 100 mg Injection is not a vesicant. It is a cytotoxic chemotherapy drug used to treat certain types of blood cancer, such as myelodysplastic syndrome (MDS). It is not known to cause severe tissue damage if it leaks from the injection site.
No, Azashine 100 mg Injection does not cause hair loss.
Yes, Azashine 100 mg Injection is a type of chemotherapy. It is used to treat certain types of blood cancers, such as myelodysplastic syndrome (MDS) and some forms of leukaemia.
Yes, Azashine 100 mg Injection is a cytotoxic drug. It works by interfering with the growth of cancer cells, which helps to slow down or stop their multiplication.
The common side effects of Azashine 100 mg Injection are nausea, vomiting, diarrhoea, constipation, weakness, headache, and injection site reactions. If any of these side effects persist or worsen, please consult your doctor.
Azashine 100 mg Injection is administered by a trained healthcare professional either as an injection under the skin (subcutaneous) or as an intravenous (IV) infusion. Your doctor will determine the most appropriate method based on your treatment plan.
This medicine can temporarily lower your red blood cells, white blood cells, and platelets. Regular blood tests help your doctor monitor your response to treatment, detect side effects early, and adjust your dose if necessary.
You should avoid live vaccines while receiving Azashine 100 mg Injection. Inactivated vaccines may be suitable in some cases, but always discuss vaccination plans with your doctor before receiving any vaccine.
Some people experience tiredness, weakness, or dizziness after treatment. If you notice these symptoms, avoid driving or operating machinery until you feel well again.
No. This medicine can harm an unborn baby and should not be used during pregnancy unless your doctor considers it absolutely necessary. Breastfeeding should be avoided during treatment and for at least one week after the last dose.
A fever may be an early sign of a serious infection because this medicine can lower your white blood cell count. Contact your healthcare provider immediately if your temperature reaches 38°C (100.4°F) or higher.

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Country of origin

India

Manufacturer/Marketer address

2Nd Floor, 8-3-166/7/1 Erragadda, Hyderabad-500018
Other Info - AZA0095
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