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  3. Benzigem EZ-1000 Injection 1's

Benzigem EZ-1000 Injection 1's, Pack of 1 INJECTION
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Composition :

GEMCITABINE-1000MG

Manufacturer/Marketer :

Admac Lifesciences(Oncology)

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Benzigem EZ-1000 Injection

Benzigem EZ-1000 Injection belongs to the group of anti-cancer drugs called cytotoxics used alone or in combination with other anti-cancer drugs to treat various types of cancers like breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer. Cancer is the uninhibited and uncontrolled growth of cells in the body.

Benzigem EZ-1000 Injection contains Gemcitabine which works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. Thus, Benzigem EZ-1000 Injection is very effective in controlling cancer cells from multiplying and is used in the treatment of various types of cancers. 

A healthcare professional will administer Benzigem EZ-1000 Injection. Do not self-administer. Benzigem EZ-1000 Injection may cause certain common side effects such as nausea, hair loss, skin rash, vomiting, and oedema. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist. 

It is advisable to inform the doctor if you are allergic to any of the components. Consult your doctor if you are pregnant, planning to get pregnant, or breastfeeding. Talk to your doctor if you are planning to father a child before taking Benzigem EZ-1000 Injection; your doctor may advise you regarding sperm storage. Avoid taking alcohol with Benzigem EZ-1000 Injection.

Directions for Use

• Your doctor will decide the dosage and timing of Benzigem EZ-1000 Injection based on the type of cancer and your body's response to the treatment.• Benzigem EZ-1000 Injection is administered by the doctor or nurse in a medical setting.• Do not self-administer it.

Medicinal Benefits

Benzigem EZ-1000 Injection is an anti-cancer drug used in the treatment of various types of cancers. Benzigem EZ-1000 Injection is used either independently or in conjunction with other chemotherapy medications to treat breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer. Benzigem EZ-1000 Injection works by interfering with DNA synthesis. It blocks the production of new DNA, by locking itself into the DNA strands and inhibiting any further proliferation or growth of the cell. Hence, Benzigem EZ-1000 Injection has widespread application in the field of oncology (cancer-related medicine) and chemotherapy.

How Benzigem EZ-1000 Injection Works

Benzigem EZ-1000 Injection contains Gemcitabine which works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. Thus, Benzigem EZ-1000 Injection is very effective in controlling cancer cells from multiplying and is used in the treatment of various types of cancers.

Storage

Store in a cool and dry place away from sunlight
Side effects of Benzigem EZ-1000 Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Your doctor may recommend regular liver function tests (LFT) to monitor liver enzyme levels.
  • To support your liver, eat a healthy diet with lots of fruits, vegetables, lean proteins, and healthy fats.
  • Avoid eating processed meats, sugary foods, and unhealthy fats.
  • Limit your alcohol consumption, since too much can worsen liver function and contribute to high levels of Alkaline Phosphatase (ALP).
  • Stay active with regular exercise, drink plenty of water, and try to avoid harmful chemicals that can damage your liver.
  • Quit smoking to lower the risk of elevated ALP levels.
  • Increased protein levels indicate the body is dehydrated and when blood plasma is concentrated.
  • Consume water and stay hydrated. Talk to your doctor and take an oral rehydrating salt (ORS).
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding hydration.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

What if I have taken an overdose of Benzigem EZ-1000 Injection

Since Benzigem EZ-1000 Injection is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience symptoms of overdose such as severe rash, pain, burning, or tingling in the hands or feet, unusual bleeding or bruising, red/black/tarry stools, pink/red/dark brown urine, coughing up or vomiting blood or material that looks like coffee grounds, signs of infection (fever, sore throat, ongoing cough and congestion), and extreme tiredness.

Drug Warnings

Benzigem EZ-1000 Injection should not be used in case of any known allergy to any of the components. Benzigem EZ-1000 Injection should be used with caution in case of high risk or previous history of heart disease, vascular disease, liver problems, kidney disease or alcoholism. Keep your doctor informed if you suffer from any shortness of breath, kidney problems, hypertension diabetes or epilepsy. Avoid Benzigem EZ-1000 Injection during pregnancy and breastfeeding. Offer a detailed medical history, vaccination history, and inform the doctor especially if you are on any radiotherapy.

Drug-Drug Interactions

verifiedApollotooltip
GemcitabineAdalimumab
Severe
GemcitabineKetoconazole
Severe

Drug-Drug Interactions

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GemcitabineAdalimumab
Severe
How does the drug interact with Benzigem EZ-1000 Injection:
Combining Adalimumab with Benzigem EZ-1000 Injection can increase the risk of side effects like developing serious infections.

How to manage the interaction:
Although taking Benzigem EZ-1000 Injection and Adalimumab together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms like feeling sick, having a fever, diarrhea, a sore throat, muscle aches, weight loss, pain when you pee, or having trouble breathing it's important to call a doctor right away. Do not stop using any medications without talking to a doctor.
GemcitabineKetoconazole
Severe
How does the drug interact with Benzigem EZ-1000 Injection:
Coadministration of Ketoconazole and Benzigem EZ-1000 Injection may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Benzigem EZ-1000 Injection together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience a fever, chills, joint pain or swelling, unusual bleeding or bruises, skin rash, itching, tiredness, nausea, vomiting, abdominal pain, dark urine, light stools, or yellowing of the skin or eyes, consult a doctor. Do not discontinue any medication without consulting a doctor.
GemcitabineTeriflunomide
Severe
How does the drug interact with Benzigem EZ-1000 Injection:
Combining Benzigem EZ-1000 Injection with Teriflunomide can increase the risk or severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Benzigem EZ-1000 Injection and Teriflunomide, but it can be taken if prescribed by a doctor. If you notice any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, pain or burning when urinating, joint pain, swelling, bruising, skin rash, itching, loss of appetite, tiredness, nausea, vomiting, dark urine or bleeding contact a doctor right away. Do not discontinue any medications without consulting a doctor.
GemcitabineThalidomide
Severe
How does the drug interact with Benzigem EZ-1000 Injection:
Taking thalidomide together with Benzigem EZ-1000 Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Benzigem EZ-1000 Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
GemcitabineGolimumab
Severe
How does the drug interact with Benzigem EZ-1000 Injection:
Combining Benzigem EZ-1000 Injection with Golimumab can increase the risk of infections.

How to manage the interaction:
Taking Benzigem EZ-1000 Injection with Golimumab together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain/burning when you urinate. Do not stop using any medications without a doctor's advice.
GemcitabineFingolimod
Severe
How does the drug interact with Benzigem EZ-1000 Injection:
Using Fingolimod together with Benzigem EZ-1000 Injection may increase the risk or severity of serious infection.

How to manage the interaction:
There may be a possibility of interaction between Benzigem EZ-1000 Injection and Fingolimod, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not discontinue any medications without consulting a doctor.
GemcitabineLomitapide
Severe
How does the drug interact with Benzigem EZ-1000 Injection:
When Benzigem EZ-1000 Injection is taken with Lomitapide, the amount of Benzigem EZ-1000 Injection in the blood can go up. This can increase the risk or severity of liver injury.

How to manage the interaction:
Co-administration of Benzigem EZ-1000 Injection with Lomitapide can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - liver problems, fever, joint pain, swelling, rash, itching, loss of appetite, tiredness, nausea, vomiting, stomach pain, dark urine, or bleeding please call a doctor right away. Do not stop using any medications without talking to a doctor.
GemcitabineLeflunomide
Severe
How does the drug interact with Benzigem EZ-1000 Injection:
Combining Benzigem EZ-1000 Injection with Leflunomide can increase the risk or severity of developing serious infection

How to manage the interaction:
There may be a possibility of interaction between Leflunomide and Benzigem EZ-1000 Injection, but it can be taken if prescribed by a doctor. If you notice any of these signs - like feeling sick, having a fever or chills, diarrhea, a sore throat, muscle pain, trouble breathing, weight loss, pain or burning urination, joint pain, swelling or bruising, a rash or itching, loss of appetite, feeling tired, or having nausea, vomiting, dark urine, or bleeding. Do not discontinue any medications without consulting a doctor.
GemcitabineMipomersen
Severe
How does the drug interact with Benzigem EZ-1000 Injection:
Coadministration of Benzigem EZ-1000 Injection with Mipomersen can lead to or increase the risk of liver injury.

How to manage the interaction:
Taking Benzigem EZ-1000 Injection with Mipomersen together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, or bleeding contact a doctor immediately. Do not stop using any medications without talking to a doctor.
GemcitabineVoclosporin
Severe
How does the drug interact with Benzigem EZ-1000 Injection:
When Benzigem EZ-1000 Injection is taken with Voclosporin, the amount of Benzigem EZ-1000 Injection in the blood can go up. This can increase the risk or severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Benzigem EZ-1000 Injection and Voclosporin, but it can be taken if prescribed by a doctor. If you have any of these symptoms fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination contact a doctor right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Cancer can take a toll on anyone. Make sure you regularly see a therapist and take care of your mental health.
  • Meditation and yoga have also proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy. 
  • Avoid taking Benzigem EZ-1000 Injection with alcohol as there may be an interaction.
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid tobacco use.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Benzigem EZ-1000 Injection Substitute

Substitutes safety advice

Product Substitutes

bannner image

Alcohol

Unsafe

It is not recommended to use alcohol with Benzigem EZ-1000 Injection as it might lead to increased drowsiness.

bannner image

Pregnancy

Unsafe

Benzigem EZ-1000 Injection should be avoided during pregnancy. Please consult your doctor if you have any concerns.

bannner image

Breast Feeding

Unsafe

Benzigem EZ-1000 Injection is not recommended during breastfeeding. Please consult your doctor in case of any concerns.

bannner image

Driving

Caution

Benzigem EZ-1000 Injection may cause drowsiness and sleepiness, which may affect your ability to drive. Do not drive if you experience any side effects after using Benzigem EZ-1000 Injection.

bannner image

Liver

Caution

Exercise caution before using Benzigem EZ-1000 Injection in case of established liver disease. Please consult your doctor to address any concerns.

bannner image

Kidney

Caution

Exercise caution before using Benzigem EZ-1000 Injection in case of established kidney disease. Please consult your doctor to address any concerns.

bannner image

Children

Unsafe

Benzigem EZ-1000 Injection is not recommended for use in children under 18 years of age. Please consult your doctor in case of any concerns.

Have a query?

FAQs

Benzigem EZ-1000 Injection belongs to the group of anti-cancer drugs called cytotoxics used alone or in combination with other anti-cancer drugs to treat various types of cancers like breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer.

Benzigem EZ-1000 Injection works blocking DNA synthesis and causing cell death, thereby preventing the cells from proliferating beyond normal.

Men taking Benzigem EZ-1000 Injection are advised not to father a child during the treatment with Benzigem EZ-1000 Injection and for 6months after the treatment. Consult your doctor before starting Benzigem EZ-1000 Injection if you are planning to father a child. Your doctor may advise you regarding sperm storage.

If you suffer from CKD, please consult with your doctor before using Benzigem EZ-1000 Injection and discuss any concerns with them. Benzigem EZ-1000 Injection is to be used with caution in those suffering from kidney and liver problems.

Benzigem EZ-1000 Injection might cause low white blood cell count leading to increased risk of infections. Consult your doctor if you have a fever, sweating, and any signs of infections.

Benzigem EZ-1000 Injection may cause bleeding and bruising due to less platelet count. Consult a doctor if you notice unexpected bruising, pinkish or reddish urine, bleeding from gums, mouth, or nose.

Benzigem EZ-1000 Injection contains Gemcitabine which works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. It is very effective in controlling cancer cells from multiplying and is used for the treatment of various types of cancers.

The side effects of Benzigem EZ-1000 Injection include hair loss, vomiting, nausea, skin rash and oedema. Consult the doctor if any of these symptoms persist or worsen.

Country of origin

India

Manufacturer/Marketer address

SCO 84, Sector 5, Panchkula (Haryana) 134112 INDIA.
Other Info - BEN0719

Disclaimer

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

May 9, 2025 | 5:02 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.2839.pdf
  2. https://chemocare.com/chemotherapy/drug-info/gemcitabine.aspx
  3. https://pubmed.ncbi.nlm.nih.gov/7481842/
  4. https://www.cancer.gov/about-cancer/understanding/what-is-cancer
  5. https://www.webmd.com/drugs/2/drug-13451/gemcitabine-intravenous/details
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649805/
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