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  3. Bibonate Injection 25 ml

Bibonate Injection 25 ml, Pack of 1 Injection
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Composition :

SODIUM BICARBONATE-8.4%W/V

Manufacturer/Marketer :

Medimark Biotech

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Bibonate Injection 25 ml

Bibonate Injection 25 ml is indicated in treating metabolic acidosis and other conditions requiring systemic alkalinisation. It is also used to increase urinary pH to increase the solubility of certain weak acids, in treatment of certain intoxications to decrease renal absorption of the drug, severe diarrhoea accompanied by loss of bicarbonate, and poisoning by salicylates or methyl alcohol. Bibonate Injection 25 ml may also be used to treat patients who have taken too many tricyclic antidepressants only after other resuscitation methods have been attempted.

Bibonate Injection 25 ml contains Sodium bicarbonate, which acts as an electrolyte replenisher and systemic alkaliser, reducing the acid in the blood. Bibonate Injection 25 ml helps reduce the amount of acid in the body after a heart attack in patients who have too much potassium in their blood or too much acid.

Bibonate Injection 25 ml will be administered by a healthcare professional; do not self-administer. In some cases, you may experience specific common side effects, such as injection site reactions, irritability, muscle spasms, and low levels of potassium in the blood. You should talk to your doctor if the side effects persist or worsen.

Consult your doctor if you are pregnant, planning for pregnancy or breastfeeding. Please consult your doctor if you have any concerns regarding the usage of Bibonate Injection 25 ml in children. Keep your doctor informed about your health condition and medications to rule out any side effects/interactions.

Uses of Bibonate Injection 25 ml

Treatment of Metabolic acidosis, severe diarrhoea, drug intoxication, and poisoning

Directions for Use

• The timing and frequency of Bibonate Injection 25 ml will be determined by your doctor, based on your medical condition and response to treatment.• Bibonate Injection 25 ml will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

Bibonate Injection 25 ml is indicated in the treatment of metabolic acidosis caused due to diabetes, hepatitis, starvation, shock, cardiac arrest, renal insufficiency, severe dehydration, severe primary lactic acidosis, Addison’s disease or administration of acidic drugs and other conditions requiring systemic alkalinisation. It is also used to increase urinary pH to increase the solubility of certain weak acids, in treatment of certain intoxications to decrease renal absorption of the drug, severe diarrhoea accompanied by loss of bicarbonate, and poisoning by salicylates or methyl alcohol. Bibonate Injection 25 ml may also be used to treat patients who have taken too many tricyclic antidepressants only after other resuscitation methods have been attempted. Bibonate Injection 25 ml acts as an electrolyte replenisher and systemic alkaliser. Thereby reducing the acid in the blood. Bibonate Injection 25 ml helps reduce the amount of acid in the body after a heart attack in patients who have too much potassium in their blood or too much acid.

How Bibonate Injection 25 ml Works

Bibonate Injection 25 ml contains Sodium bicarbonate, which acts as an electrolyte replenisher and systemic alkaliser, reducing the acid in the blood. Bibonate Injection 25 ml helps reduce the amount of acid in the body after a heart attack in patients who have too much potassium in their blood or too much acid.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Bibonate Injection 25 ml

Since Bibonate Injection 25 ml is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly. Overdose of Bibonate Injection 25 ml may cause irregular heartbeat, tiredness, mood changes, muscle weakness, muscle hypertonicity, slow breathing, and twitching and tetany may develop.

Drug Warnings

Do not take Bibonate Injection 25 ml if you are allergic to any of its components; if you have kidney failure, heart failure, high blood pressure, low blood calcium/potassium/chloride, high blood sodium/pH, kidney stones, fluid retention, or hypoventilation (breathing problems). Inform your doctor if you have congestive heart failure, oedema with sodium-retaining conditions, or renal insufficiency. Consult your doctor if you are pregnant, planning for pregnancy or breastfeeding.

Drug-Drug Interactions

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Sodium bicarbonateDolutegravir
Severe
Sodium bicarbonateGefitinib
Severe

Drug-Drug Interactions

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Sodium bicarbonateDolutegravir
Severe
How does the drug interact with Bibonate Injection 25 ml:
Co-administration of Bibonate Injection 25 ml and Dolutegravir reduces the levels of Dolutegravir, resulting in reduced effectiveness.

How to manage the interaction:
Although taking Dolutegravir and Bibonate Injection 25 ml together can result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience symptoms like fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, and pain or burning during urination, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium bicarbonateGefitinib
Severe
How does the drug interact with Bibonate Injection 25 ml:
Taking Bibonate Injection 25 ml with Gefitinib together can reduce the levels and treatment outcomes of Gefitinib.

How to manage the interaction:
Although taking Gefitinib and Bibonate Injection 25 ml together can cause an interaction, it can be taken if a doctor has suggested it. Contact your doctor if your symptoms do not improve. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Stay hydrated.
  • Avoid smoking and alcohol consumption. 
  • Maintain a healthy weight by regular exercising.
  • Include foods rich in nutrients and potassium.
  • Eat small, frequent meals slowly if you have diarrhoea.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Bibonate Injection 25 ml Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

It is unknown if alcohol affects Bibonate Injection 25 ml. Please consult your doctor.

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Pregnancy

Caution

Bibonate Injection 25 ml belongs to pregnancy category C. Please inform your doctor if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Inform your doctor if you are breastfeeding; your doctor will prescribe only if the benefits outweigh the risks.

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Driving

Consult your doctor

It is not known if Bibonate Injection 25 ml affects your ability to drive. however, drive or operate machinery only if you are alert.

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Liver

Caution

Inform your doctor if you have a liver impairment or any concerns before receiving Bibonate Injection 25 ml.

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Kidney

Caution

Inform your doctor if you have kidney impairment or any concerns. Bibonate Injection 25 ml is not recommended if you have conditions like kidney failure or kidney stones.

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Children

Caution

Please consult your doctor if you have any concerns regarding the usage of Bibonate Injection 25 ml in children. Rapid injection (10 mL/min) of hypertonic Sodium bicarbonate injection solutions in children below twoyears may cause hypernatremia (high sodium levels), a decrease in cerebrospinal fluid pressure and possible intracranial haemorrhage.

Have a query?

FAQs

Bibonate Injection 25 ml is used to treat Metabolic acidosis, severe diarrhoea, drug intoxication, and poisoning.

Bibonate Injection 25 ml acts as an electrolyte replenisher and systemic alkaliser. It reduces the acid in the blood.

Bibonate Injection 25 ml is used to treat metabolic acidosis caused due to diabetes, hepatitis, starvation, shock, cardiac arrest, renal insufficiency, severe dehydration, severe primary lactic acidosis, Addison’s disease or administration of acidic drugs. Metabolic acidosis is an electrolyte disorder characterised by an acid-base imbalance in the body.

Bibonate Injection 25 ml is indicated in severe diarrhoea, which is often accompanied by a significant loss of bicarbonate. Bibonate Injection 25 ml helps by compensating for the lost bicarbonate ions.

Bibonate Injection 25 ml is indicated for treating certain drug intoxication, such as barbiturates (in cases where barbiturate-protein complex dissociation is desired). Bibonate Injection 25 ml may also be used to treat patients who have taken too many tricyclic antidepressants only after other resuscitation methods have been attempted.

Bibonate Injection 25 ml is used in poisoning by methyl alcohol or salicylates and in haemolytic reactions that require the alkalinisation of urine to lower the nephrotoxicity of haemoglobin and its by-products.

Country of origin

India

Manufacturer/Marketer address

B/209, Shivalik Yash, Iind Floor, Opp. Shashtrinagar Brts Bus Stop, 132 Ft. Ring Road, Naranpura, Ahmedabad 380013, Gujarat (India)
Other Info - BIB0019

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 7:02 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/077394lbl.pdf
  2. https://www.phebra.com/wp-content/uploads/2018/10/Sodium-Bicarbonate-8.4-CMI-V04.pdf
  3. https://www.hpra.ie/img/uploaded/swedocuments/61152f49-1ddb-43e5-8b41-2042d91082f2.pdf
  4. https://www.athenexpharma.com/materials/SodiumBicarbonate/SodiumBicarbonate_PI.pdf
  5. https://www.drugs.com/pro/sodium-bicarbonate.html
  6. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=e9698a4f-1a95-4f28-a945-e8009d1d6dd4&type=display

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