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  3. Biomus-1 Capsule 10's

Biomus-1 Capsule 10's, Pack of 10 CAPSULES
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Biomus-1 Capsule is used to prevent rejection of a transplanted organ such as a liver, kidney, or heart. It contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body in accepting the new organ.

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Composition :

TACROLIMUS-1MG

Manufacturer/Marketer :

Alniche Life Sciences Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Biomus-1 Capsule

Biomus-1 Capsule is used to prevent rejection of a transplanted organ such as a liver, kidney, or heart. Organ rejection occurs when a patient’s immune system recognizes the donor organ as foreign and tries to eliminate it.

Biomus-1 Capsule contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body in accepting the new organ.

Take Biomus-1 Capsule as prescribed. You are advised to use Biomus-1 Capsule for as long as your doctor has recommended it for you based on your medical condition. Some people may experience nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. Most of these side effects of Biomus-1 Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Tacrolimus or any other medicines, please tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Biomus-1 Capsule . Avoid alcohol consumption with Biomus-1 Capsule . Drive only if you are alert, as Biomus-1 Capsule may cause some people vision problems or nervous disturbances. If you are about to get vaccinated, inform your doctor before taking Biomus-1 Capsule . Biomus-1 Capsule may increase the risk of infections or skin cancer as it lowers the body’s immune defence system.

Uses of Biomus-1 Capsule

Biomus-1 Capsule is used for prevention of transplanted organ rejection

Directions for Use

Take the capsule as advised by the doctor. Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Biomus-1 Capsule contains Tacrolimus, an immunosuppressant used to prevent organ rejection after a transplant. Biomus-1 Capsule suppresses the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.

Storage

Store in a cool and dry place away from sunlight
Side effects of Biomus-1 Capsule
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

What if I have taken an overdose of Biomus-1 Capsule

Please do not exceed the recommended dose, as it might cause an overdose. Using more medication will not improve your symptoms; instead, they may cause serious side effects or poisoning. This medicine may be harmful if swallowed. Seek emergency medical attention or call your doctor if you notice any unusual symptoms or if anyone has accidentally swallowed the medication.

Drug Warnings

Please tell your doctor if you are allergic to Tacrolimus or other medicines. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Biomus-1 Capsule . Avoid alcohol consumption with Biomus-1 Capsule . Drive only if you are alert, as Biomus-1 Capsule may cause vision problems or nervous disturbances in some people. If you are about to get vaccinated, inform your doctor before taking Biomus-1 Capsule . Biomus-1 Capsule may increase the risk of infections or skin cancer as it lowers the body’s immune defence system. While taking Biomus-1 Capsule , you are advised to wear protective clothing and sunscreen while going out. You are recommended to use glass or metal materials to prepare the oral suspension. Avoid using plastic (PVC) materials to prepare the suspension, as the granules will stick to a plastic container, and your child may not receive their full dose. Do not inhale or let the granules or prepared oral suspension come in contact with your skin or eyes. In case of accidental contact with skin, wash the area well with soap and water, and if it comes in contact with the eyes, rinse with plain water.

Drug-Drug Interactions

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TacrolimusThioridazine
Critical
TacrolimusZiprasidone
Critical

Drug-Drug Interactions

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TacrolimusThioridazine
Critical
How does the drug interact with Biomus-1 Capsule:
Combining Biomus-1 Capsule with Thioridazine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Biomus-1 Capsule with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusZiprasidone
Critical
How does the drug interact with Biomus-1 Capsule:
Taking Biomus-1 Capsule with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Biomus-1 Capsule with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
TacrolimusSaquinavir
Critical
How does the drug interact with Biomus-1 Capsule:
Taking Biomus-1 Capsule with saquinavir can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Biomus-1 Capsule with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusCidofovir
Critical
How does the drug interact with Biomus-1 Capsule:
Taking cidofovir with Biomus-1 Capsule can increase the risk of kidney problems.

How to manage the interaction:
Taking Biomus-1 Capsule with Cidofovir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.
TacrolimusDronedarone
Critical
How does the drug interact with Biomus-1 Capsule:
Taking Biomus-1 Capsule with dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Biomus-1 Capsule with Dronedarone is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusMifepristone
Critical
How does the drug interact with Biomus-1 Capsule:
Taking Biomus-1 Capsule with Mifepristone may significantly increase the blood levels of Biomus-1 Capsule, which may increase the risk and/or severity of side effects.

How to manage the interaction:
Taking Biomus-1 Capsule with Mifepristone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
TacrolimusEfavirenz
Severe
How does the drug interact with Biomus-1 Capsule:
Taking Biomus-1 Capsule together with efavirenz can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Although taking Biomus-1 Capsule and efavirenz together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.
TacrolimusInfliximab
Severe
How does the drug interact with Biomus-1 Capsule:
Taking Biomus-1 Capsule together with infliximab may increase the risk of serious infections.

How to manage the interaction:
Although taking Biomus-1 Capsule and infliximab together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
TacrolimusTobramycin
Severe
How does the drug interact with Biomus-1 Capsule:
Taking Biomus-1 Capsule with tobramycin may increase risk of kidney problems.

How to manage the interaction:
Although taking Biomus-1 Capsule and tobramycin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
TacrolimusEnzalutamide
Severe
How does the drug interact with Biomus-1 Capsule:
Taking Biomus-1 Capsule with Enzalutamide may reduce the levels of Biomus-1 Capsule, which may make Biomus-1 Capsule less effective in treating your condition.

How to manage the interaction:
Although taking Biomus-1 Capsule and Enzalutamide together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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TACROLIMUS-1MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TACROLIMUS-1MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking of grapefruit or grapefruit juice while on Biomus-1 Capsule treatment may lead to increased Biomus-1 Capsule levels in blood. Avoid or limit grapefruit or grapefruit juice intake during treatment with Biomus-1 Capsule.

Diet & Lifestyle Advise

  • Include fruits and vegetables in your daily routine.
  • Follow a vitamin-C-rich diet.
  • Reduce salt intake.
  • Eat a handful of walnuts and almonds every day.
  • Reduce intake of unhealthy cholesterol and fats.
  • Consume dark chocolate with at least 70% cocoa.

Liver and Heart transplant:

  • Eat whole-grain bread, cereals and other grains, fruits and vegetables, lean meats, fish and poultry.
  • Maintain a low-fat and low-salt diet.
  • Drink low-fat milk or eat other low-fat dairy products to maintain adequate calcium.
  • Stay hydrated by drinking sufficient water and other fluids.
  • Avoid alcohol consumption.
  • Avoid grapefruit and grapefruit juice. 

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Biomus-1 Capsule Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid alcohol consumption with Biomus-1 Capsule as it may increase the risk of adverse effects. Please consult a doctor before consuming alcohol with Biomus-1 Capsule .

bannner image

Pregnancy

Caution

Using Tacrolimus during pregnancy may cause kidney dysfunction or neonatal hyperkalemia (high potassium levels in the blood). Therefore, please consult a doctor if you are pregnant before taking Biomus-1 Capsule and if you are a woman of childbearing age, use effective contraceptive methods while using Biomus-1 Capsule .

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Breast Feeding

Consult your doctor

Biomus-1 Capsule may be excreted in breast milk. Therefore, please inform your doctor if you are a breastfeeding mother before taking Biomus-1 Capsule . You should avoid taking Biomus-1 Capsule during breastfeeding or avoid breastfeeding while on treatment with Biomus-1 Capsule .

bannner image

Driving

Caution

Biomus-1 Capsule may cause vision problems or nervous disturbances in a few people. Therefore, avoid driving if you experience any of these symptoms after taking Biomus-1 Capsule .

bannner image

Liver

Consult your doctor

Please consult a doctor if you have liver diseases/conditions before taking Biomus-1 Capsule .

bannner image

Kidney

Consult your doctor

Please consult a doctor if you have Kidney diseases/conditions before taking Biomus-1 Capsule .

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Children

Safe if prescribed

Biomus-1 Capsule should be used in children in doses as advised by a doctor only.

Have a query?

FAQs

Biomus-1 Capsule is used to prevent rejection of a transplanted organ such as a liver, kidney, or heart.

Biomus-1 Capsule contains Tacrolimus, an immunosuppressant that works by the activity of T and B lymphocytes (cells in the immune system) that normally attacks foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.

Biomus-1 Capsule may increase the risk of infections as it may weaken the immune system. Therefore, consult a doctor immediately if you have any signs of infection, such as sore throat or fever.

Biomus-1 Capsule may increase the risk of skin cancer. Therefore, avoid or limit exposure to the sun for a long time or artificial light such as tanning beds. Wear protective clothing and use sunscreen before going out in the sun.

If you are about to receive any vaccinations, especially live vaccines such as measles, mumps, rubella (MMR), oral polio, varicella, yellow fever, intranasal influenza, BCG and TY21a typhoid vaccines, inform your doctor that you are taking Biomus-1 Capsule because it may reduce the effectiveness of the vaccine and increase your risk of contracting the infection that the vaccine is meant to protect against.

Using Biomus-1 Capsule with Sirolimus is not recommended in patients who have had heart or liver transplants. It is unknown if kidney transplant recipients can use it safely. Hence, please seek medical advice before combining Biomus-1 Capsule with other medications.

Biomus-1 Capsule may cause tremors, trembling and shaking of hands. Consult the doctor if this becomes bothersome.

Biomus-1 Capsule is usually taken on an empty stomach or 2 to 3 hours after a meal. Wait at least 1 hour until the next meal.

Biomus-1 Capsule is a macrolide antibiotic with immunosuppressant properties.

Biomus-1 Capsule should not be taken by people who are allergic to any of its components, allergic to sirolimus or any macrolide-antibiotic, during breastfeeding, and receiving live vaccines.

Let the doctor know if you have long QT syndrome, low or high levels of potassium, low levels of calcium or magnesium, an irregular heartbeat, high blood pressure, high cholesterol levels, cystic fibrosis (an inborn disease), heart, kidney, or liver disease. Inform the doctor if you have a weak immune system or if you are due to undergo any vaccination.

Biomus-1 Capsule decreases the activity of your immune system, increasing the risk of serious infection and cancer (lymphoma cancer). Consult the doctor if you experience symptoms of infection (sore throat, extreme tiredness, cough, flu-like symptoms, fever,) or cancer (weight loss, swollen lymph nodes in the neck, armpits, or groin, fever, excessive tiredness or weakness, night sweats, cough, chest pain, trouble breathing, or pain, swelling, or fullness in the stomach area).

No, Biomus-1 Capsule does not have an abuse potential as it is not a controlled substance.

Side effects of Biomus-1 Capsule include nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. If the side effects persist or worsen, please consult your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

Alniche Life Sciences Pvt. Ltd., S-14, 2nd Floor, Janta Market Rajouri Garden, New Delhi ? 110 027.
Other Info - BIO0332

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Apr 29, 2025 | 10:54 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050709s031lbl.pdf
  2. https://www.medsafe.govt.nz/consumers/cmi/t/tacrolimussandozcap.pdf
  3. https://www.astellas.com/us/system/files/prografwpi_3.pdf
  4. https://www.medicines.org.uk/emc/product/461/smpc
  5. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210115s000,050708s047,050709s040lbl.pdf
  6. https://www.drugs.com/cdi/tacrolimus-granules-for-suspension.html
  7. https://www.astellas.com/us/system/files/prografinstructionstouse_2.pdf
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