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  1. Home
  2. Medicine

  3. Brufen MR Capsule 10's

Prescription drug
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Brufen MR Capsule 10's, Pack of 10 CapsuleS
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Extra 15% Off with Bank Offers

Composition :

IBUPROFEN-400MG + TIZANIDINE-2MG

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Brufen MR Capsule

Brufen MR Capsule belongs to the class of medications called ‘analgesics’ used in treating acute muscle spasms associated with low back pain. Low back pain, also called lumbago, is a condition that affects the lower portion of the spine. It often occurs due to injury, strain, or sprain in the muscles, bones, or ligaments present in the lower back. In most cases, the only symptom of this condition is a pain in the lower back.

Brufen MR Capsule contains Ibuprofen and Tizanidine. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing prostaglandins' production (chemical substances that cause pain and inflammation) at the affected site (muscle) and reduce pain. Tizanidine is a short-acting muscle relaxant. It works by reducing the activity of the nerves in the brain that control muscles. This effect helps to reduce muscle spasms, thereby improving pain and muscle movements.

You should take this medicine exactly as prescribed by the doctor. The common side-effects of Brufen MR Capsule are drowsiness, tiredness, dizziness, low blood pressure, dry mouth, nausea, stomach upset, heartburn, abdominal pain, indigestion, and decrease or increase in heart rate. These side-effects are usually mild and temporary. However, if any of these side-effects persist or get worse, inform your doctor immediately.

It is not recommended to take Brufen MR Capsule if you are allergic to ibuprofen, tizanidine, NSAIDs, or any contents of this medicine. Do not take Brufen MR Capsule if you have bleeding or ulcers in the stomach or intestine, severe liver, kidney, or heart problems, severe dehydration (due to vomiting or diarrhoea), active bleeding (including in the brain), and conditions that cause the abnormal formation of red blood cells. It is not recommended for use in children, adolescents, pregnant women, and breastfeeding mothers. It should be used with caution in elderly people as dose adjustments are necessary. Alcohol consumption may increase the risk of side-effects. Brufen MR Capsule may cause drowsiness and dizziness, so do not drive or operate heavy machinery if you are fully alert.

Uses of Brufen MR Capsule

Brufen MR Capsule is used to treat pain, inflammation, and muscle spasms associated with various musculoskeletal conditions. The detailed uses of Brufen MR Capsule are as follows:

  • Muscle spasm relief: Brufen MR Capsule relaxes muscles and reduces painful spasms.
  • Back and neck pain: Brufen MR Capsule is used to reduce stiffness and discomfort in the spinal muscles.
  • Joint and muscle pain: Brufen MR Capsule provides relief from pain due to sprains or injuries.

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Directions for Use

  • Take Brufen MR Capsule with food or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow it as a whole with water.
  • Do not crush, break or chew it.

Medicinal Benefits

Brufen MR Capsule is used to treat acute pain associated with muscle spasms that usually occur due to muscle strains, sprains or injuries in the lower back. It contains ibuprofen and tizanidine. Ibuprofen can reduce pain, swelling and inflammation in the muscles, whereas tizanidine can reduce muscle spasms and pain.  It provides fast relief from pain, within a few hours after taking this medicine. It reduces muscle stiffness and enables the easy movement of the muscle. It is well tolerated when taken at recommended doses. For the best results, rest and physical therapy are also essential along with this medicine as it will help to strengthen your back.

How Brufen MR Capsule Works

Brufen MR Capsule contains Ibuprofen and Tizanidine. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing prostaglandins' production (chemical substances that cause pain and inflammation) at the affected site (muscle) and reduce pain. Tizanidine is a short-acting muscle relaxant. It works by reducing the activity of the nerves in the brain that control muscles. This effect helps to reduce muscle spasms, thereby improving pain and muscle movements.

Storage

• Store in a cool and dry place away from sunlight.• Keep this medicine out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Brufen MR Capsule
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.

What if I have taken an overdose of Brufen MR Capsule

Avoid exceeding the recommended dose as it could lead to an overdose. This medicine may increase the risk of ulcers, bleeding, and perforation in the stomach or intestine when taken in high doses. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Before taking Brufen MR Capsule , inform your doctor if you have any liver, kidney, or heart problems, diabetes, high cholesterol, high blood pressure, respiratory problems, systemic lupus erythematosus (a skin disease), porphyria (an inherited blood disorder), blood clotting problems, and ulcerative colitis (inflammation of the colon). Brufen MR Capsule increases the risk of ulcers, bleeding, and perforation in the stomach or intestine when taken in high doses. It may also increase the risk of heart attack or stroke when used in high doses. Brufen MR Capsule may increase the risk of kidney damage, especially in patients who have liver, kidney, or heart problems, and who are taking water pills. Brufen MR Capsule may affect the function of platelets (form clots) and prolong bleeding time, so it should be used with caution in patients with blood clotting problems. Brufen MR Capsule is an anti-inflammatory and can mask the symptoms of an infection, so consult your doctor if you feel unwell while using this medicine.

Drug-Drug Interactions

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IbuprofenMeloxicam
Critical
IbuprofenKetorolac
Critical

Drug-Drug Interactions

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IbuprofenMeloxicam
Critical
How does the drug interact with Brufen MR Capsule:
Combining Meloxicam and Brufen MR Capsule can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.

How to manage the interaction:
Taking Meloxicam and Brufen MR Capsule together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenKetorolac
Critical
How does the drug interact with Brufen MR Capsule:
Taking Ketorolac and Brufen MR Capsule can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding and ulceration.

How to manage the interaction:
Taking Ketorolac and Brufen MR Capsule together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
TizanidineCisapride
Critical
How does the drug interact with Brufen MR Capsule:
Coadministration of Brufen MR Capsule with Cisapride can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Brufen MR Capsule with Cisapride is avoided as it can result in an interaction, it can be taken if your doctor has advised it. Contact your doctor immediately if you experience sudden dizziness, shortness of breath, palpitations, or vomiting. Do not discontinue any medications without consulting your doctor.
TizanidineDronedarone
Critical
How does the drug interact with Brufen MR Capsule:
Coadministration of Brufen MR Capsule with Dronedarone can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Brufen MR Capsule with Dronedarone is generally avoided as it can result in an interaction, it can be taken when prescribed by a doctor. If you experience sudden dizziness, shortness of breath, palpitations, or chest pain, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
TizanidineZiprasidone
Critical
How does the drug interact with Brufen MR Capsule:
Co-administration of Brufen MR Capsule with Ziprasidone can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Brufen MR Capsule with Ziprasidone is not recommended, as it can result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
TizanidineFluvoxamine
Critical
How does the drug interact with Brufen MR Capsule:
Taking Fluvoxamine with Brufen MR Capsule it can increases the risk of side effects.

How to manage the interaction:
Although Fluvoxamine with Brufen MR Capsule is not recommended, but can be taken together if prescribed by a doctor. However, if you experience drowsiness, dizziness, low blood pressure, slurred speech, confusion, or severe weakness, contact your doctor immediately. Do not stop using any medications without consulting a doctor.
TizanidineSaquinavir
Critical
How does the drug interact with Brufen MR Capsule:
Combining Brufen MR Capsule with Saquinavir can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Brufen MR Capsule with Saquinavir is not recommended, as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhoea or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TizanidineCiprofloxacin
Critical
How does the drug interact with Brufen MR Capsule:
Coadministration of Ciprofloxacin and Brufen MR Capsule together can increase the risk of side effects.

How to manage the interaction:
Using Ciprofloxacin and Brufen MR Capsule together is avoided, as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience drowsiness, weakness, sweating, or palpitations contact the doctor immediately. Do not discontinue any medications without consulting the doctor.
IbuprofenAspirin
Severe
How does the drug interact with Brufen MR Capsule:
Taking aspirin with Brufen MR Capsule may impair the efficacy of aspirin and increase the risk of developing stomach ulcers and bleeding.

How to manage the interaction:
Although there is a possible interaction between aspirin and Brufen MR Capsule, you can take these medicines together if prescribed by a doctor. However, if you experience severe stomach discomfort, bloating, sudden dizziness or lightheadedness, nausea, vomiting (particularly with blood), loss of appetite, and/or black, tarry stools, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
IbuprofenDasatinib
Severe
How does the drug interact with Brufen MR Capsule:
Coadministration of Dasatinib and Brufen MR Capsule can increase the risk of bleeding.

How to manage the interaction:
Using Dasatinib and Brufen MR Capsule together can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like bruising, headache, dizziness, or weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear, and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Deep tissue massages with the help of muscle massagers are considered helpful.
  • Avoid wearing tight-fitting clothes, instead, wear loose garments.
  • Rest well and get optimal sleep (at least 8 hours for adults).
  • Hot or cold therapy can help treat muscle spasms.
  • Apply an ice-pack or hot-pack on the muscle for 15-20 minutes.
  • Try to include glycine (protein) in your daily diet, which is good food for your muscle.

Habit Forming

No

Therapeutic Class

ANALGESICS
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Alcohol

Unsafe

Consumption of alcohol increases the risk of side-effects, such as drowsiness, liver damage, and bleeding in the stomach.

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Pregnancy

Unsafe

Brufen MR Capsule is usually not recommended during pregnancy, especially if you are more than six months pregnant as it may cause harmful effects to the unborn baby.

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Breast Feeding

Unsafe

Brufen MR Capsule may pass into breastmilk and cause unwanted effects in the nursing baby. So, it is not prescribed in breastfeeding mothers. However, if prescribed, the doctor may advise you to stop breastfeeding while using this medicine.

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Driving

Unsafe

Brufen MR Capsule may cause dizziness or drowsiness, so do not drive or operate heavy machinery if you are not fully alert.

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Liver

Caution

Brufen MR Capsule should be used with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Brufen MR Capsule should be used with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Brufen MR Capsule is not recommended for use in children and adolescents.

FAQs

Brufen MR Capsule is used to relieve acute muscle spasms associated with low back pain.

Brufen MR Capsule contains Ibuprofen and Tizanidine. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing prostaglandins' production (chemical substances that cause pain and inflammation) at the affected site (muscle) and reduce pain. Tizanidine is a short-acting muscle relaxant. It works by reducing the activity of the nerves in the brain that control muscles. It helps to reduce muscle spasms, thereby improving pain and muscle movements. Together, Brufen MR Capsule can effectively reduce low back pain.

Brufen MR Capsule is probably safe and well-tolerated in diabetic patients when taken at recommended doses. However, higher doses or prolonged use may affect sugar levels and cause unwanted effects. So, let your doctor know that you have diabetes before taking Brufen MR Capsule .

Brufen MR Capsule may cause drowsiness and dizziness. So, it is advised not to consume alcohol as it may cause excessive drowsiness. It is also not advised to drive or operate heavy machinery if you are not fully alert.

Brufen MR Capsule may cause kidney damage when taken in high doses for a long duration. So, do not increase the dose or use it for prolonged periods than intended by the doctor.

Brufen MR Capsule should not be used in patients with stomach ulcers as it may elevate the symptoms and worsen the condition. So, inform your doctor that you have a stomach ulcer before taking this medicine.

Country of origin

India

Manufacturer/Marketer address

16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
Other Info - BRU0004

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 10, 2025 | 3:14 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.7020.pdf
  2. https://www.hpra.ie/img/uploaded/swedocuments/2188598.PPA0465_168_001.a8263158-055a-45a9-a0c4-78a88025a375.000001Zanaflex%20Combined%20PIL.170214.pdf

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