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compositionComposition:BUSULFAN-6MG/ML
prescription
Prescription Medicine
info
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BU-Stim 60 mg Injection 10 ml is used to treat certain cancers. It contains Busulfan, which belongs to a group of medicines called cytotoxics (also called chemotherapy). It works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells. Thereby, it treats certain blood problems and cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BUSULFAN-6MG/ML

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About BU-Stim 60 mg Injection 10 ml

BU-Stim 60 mg Injection 10 ml is a specialised medicine used primarily to prepare patients for a bone marrow or stem cell transplant. It works by clearing out existing bone marrow cells to make room for healthy new donor cells. This critical preparation process is essential for treating certain serious blood and bone marrow conditions, such as leukemia.

Because this treatment is highly specialised, it is given as an injection in a hospital setting. It is not a daily at-home medicine, but rather a carefully timed series of infusions given over several consecutive days before your transplant. Your medical team will manage the schedule precisely, and maintaining this consistency is vital for the success of your transplant.

While this medicine is a crucial step in your treatment, it can cause side effects. Common issues include nausea, vomiting, mouth sores, and temporary hair loss. It can also cause more serious complications, such as liver damage, seizures, or lung problems. You must inform your healthcare team immediately if you experience any unusual symptoms during or after your treatment.

Do not receive this medicine if you have had a severe allergic reaction to it in the past. Before starting, tell your doctor if you have a history of seizures, liver disease, lung problems, or if you are pregnant or planning to become pregnant. This medicine is not suitable for pregnant women as it can harm the unborn baby.

This medication can interact with other substances, including certain anti-seizure drugs and common pain relievers like acetaminophen, which can increase the risk of liver damage. It is also important to talk to your doctor if you are breastfeeding or if you are an older adult, as special precautions may be needed.

Uses of BU-Stim 60 mg Injection 10 ml

BU-Stim 60 mg Injection 10 ml is used to prepare the body for a stem cell transplant. Your doctor may prescribe it for the following purposes:

  • Bone marrow transplant preparation: BU-Stim 60 mg Injection 10 ml is used to clear out a patient's existing bone marrow cells, creating space for new, healthy donor stem cells to grow.
  • Stem cell transplant conditioning: It helps suppress the body's immune system, which reduces the risk of the body rejecting the newly transplanted donor cells.

Key Benefits

Using BU-Stim 60 mg Injection 10 ml as prescribed helps prepare your body for a successful stem cell transplant. Here are the key benefits you can expect:

  • Prepares the bone marrow for transplantation: Destroys diseased or abnormal bone marrow cells, creating space for healthy donor stem cells to grow.
  • Helps reduce transplant rejection: Suppresses the immune system, helping your body accept the transplanted stem cells more successfully.
  • Supports recovery after transplantation: Promotes successful donor stem cell engraftment, helping rebuild a healthy blood and immune system.
Side effects of BU-Stim 60 mg Injection 10 ml
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Maintaining adequate hydration will help you control your magnesium levels and improve your general health.
  • Maintain a diet high in magnesium-rich foods such as spinach, almonds, chickpeas and brown rice.
  • Limit your alcohol intake because too much of it lowers your magnesium levels.
  • Plan blood testing on a regular basis to monitor magnesium levels.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure effective use.
  • The healthcare provider or nurse will administer BU-Stim 60 mg Injection 10 ml.
  • Do not self-administer.

How BU-Stim 60 mg Injection 10 ml Works

BU-Stim 60 mg Injection 10 ml contains busulfan, an alkylating medicine that works by attaching to the DNA of rapidly dividing cells, including diseased or cancerous cells in the bone marrow. This prevents these cells from growing and dividing, leading to their destruction. By clearing these cells from the bone marrow, busulfan creates space for healthy donor stem cells to settle, grow, and begin producing new, healthy blood cells. This helps prepare the body for a successful stem cell transplant.
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Alcohol

Caution

Avoid alcohol consumption while on treatment with BU-Stim 60 mg Injection 10 ml.

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Pregnancy

Unsafe

BU-Stim 60 mg Injection 10 ml should not be used during pregnancy because it can harm your fetus (newborn baby).

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Breast Feeding

Caution

Do not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for a certain period of time after the final medication is taken.

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Driving

Caution

BU-Stim 60 mg Injection 10 ml may make you feel dizzy or tired. Do not drive or use machines if you feel tired or dizzy.

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Liver

Caution

This treatment may affect how your liver works. Please inform your doctor before prescribing BU-Stim 60 mg Injection 10 ml if you have liver impairment. Your doctor will weigh the benefits and potential risks before prescribing BU-Stim 60 mg Injection 10 ml.

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Kidney

Caution

This treatment may affect how your kidneys work. Please inform your doctor before prescribing BU-Stim 60 mg Injection 10 ml if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing BU-Stim 60 mg Injection 10 ml.

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Children

Caution

Talk to your care team about the use of this medication in children. Special care may be needed.

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Heart

Caution

Exercise caution before using BU-Stim 60 mg Injection 10 ml in case of heart problems. Please consult your doctor if you have any concerns.

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Geriatrics

Caution

BU-Stim 60 mg Injection 10 ml should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of BU-Stim 60 mg Injection 10 ml

Since this medicine is prepared and injected under strict clinical supervision, an overdose is extremely rare. In the unlikely event that an overdose occurs, your hospital team is fully trained to manage it immediately. If you suspect an issue or experience severe symptoms, inform your care team right away.

Diet & Lifestyle Advise

  • Follow a clean diet: To protect your weakened immune system, avoid raw or undercooked meats, seafood, and unpasteurised dairy. Wash all fresh fruits and vegetables thoroughly before eating.
  • Practice gentle mouth care: Use a soft-bristled toothbrush and rinse your mouth frequently with a gentle salt or baking soda solution to prevent and soothe mouth sores. Avoid spicy, acidic, or extremely hot foods.
  • Stay hydrated: Drink plenty of fluids like water or clear broths as tolerated to help support your liver and kidneys as they process the medication.
  • Protect your skin: Your skin may become highly sensitive. Use mild, fragrance-free soaps and moisturisers, and avoid direct exposure to sunlight by wearing protective clothing.
health query

Have a query?

How Soon It Starts Working

The time required for BU-Stim 60 mg Injection 10 ml to start to work: BU-Stim 60 mg Injection 10 ml ideally shows its action within 1 to 2 weeks after administration. The time for which the effects of BU-Stim 60 mg Injection 10 ml last: The effect of BU-Stim 60 mg Injection 10 ml lasts for 24 hours.

What if you forget to take BU-Stim 60 mg Injection 10 ml

Because this medication is injected by healthcare professionals in a highly controlled hospital setting, a missed dose is very unlikely. However, if your scheduled infusion is delayed or missed, contact your transplant coordinator or medical team immediately to adjust your treatment timeline.

Storage

• BU-Stim 60 mg Injection 10 ml is stored, prepared, and administered by healthcare professionals in a hospital or clinic.

Drug Warnings

  • Take prescribed anti-seizure medicine: Ensure you take any anti-seizure medication your doctor prescribes before your infusion, as this helps prevent potential seizures.
  • Monitor the injection site: Tell your nurse immediately if you feel any burning, pain, swelling, or redness where the IV is placed.
  • Avoid live vaccines: Do not receive any live vaccines during your treatment or for several months afterward, as your body's immune defenses will be very low.
  • Use strict birth control: Both men and women should use highly effective birth control during and for some time after treatment to prevent pregnancy, as the drug can harm a developing baby.
  • Keep up with blood tests: Attend all scheduled blood tests so your medical team can closely monitor your liver function and blood cell levels.
  • Watch for liver complications: Contact your medical team urgently if you develop rapid weight gain, swelling of the abdomen, pain in the upper right side of your abdomen, or yellowing of the skin or eyes, as these may be signs of sinusoidal obstruction syndrome (SOS), also called veno-occlusive disease (VOD).
  • Discuss fertility preservation early: If you may wish to have children in the future, speak with your healthcare team before treatment starts about options such as sperm banking, egg freezing, or embryo freezing.

Drug-Drug Interactions

verifiedApollotooltip
  • Acetaminophen: Taking acetaminophen close to your infusion can increase the risk of liver damage.
  • Anti-seizure medications: Drugs like phenytoin can speed up how your body processes BU-Stim 60 mg Injection 10 ml, potentially making it less effective.
  • Certain antifungal medicines: Drugs like itraconazole can slow down the clearance of BU-Stim 60 mg Injection 10 ml, increasing the risk of severe side effects.
BusulfanFilgrastim
Severe
BusulfanIdelalisib
Severe

Drug-Drug Interactions

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BusulfanFilgrastim
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Coadministration of Filgrastim with BU-Stim 60 mg Injection 10 ml can reduce the effects of Filgrastim.

How to manage the interaction:
Although there is a possible interaction between Filgrastim and BU-Stim 60 mg Injection 10 ml, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without talking to your doctor.
BusulfanIdelalisib
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Coadministration of BU-Stim 60 mg Injection 10 ml with Idelalisib can increase the risk of side effects.

How to manage the interaction:
Although taking BU-Stim 60 mg Injection 10 ml and Idelalisib can result in an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms like severe diarrhea, stomach pain, fever, or vomiting, contact your doctor right away. Do not stop using any medications without a doctor's advice.
BusulfanAdalimumab
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Coadministration of Adalimumab with BU-Stim 60 mg Injection 10 ml may increase the risk of developing infections.

How to manage the interaction:
Although taking BU-Stim 60 mg Injection 10 ml and Adalimumab together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, diarrhea, sore throat, muscle aches, or pain while urinating, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
BusulfanInfliximab
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Coadministration of BU-Stim 60 mg Injection 10 ml and Infliximab can increase the risk or severity of developing infections.

How to manage the interaction:
Although taking BU-Stim 60 mg Injection 10 ml and Infliximab together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while peeing contact a doctor right away. Do not discontinue any medications without consulting a doctor.
BusulfanTofacitinib
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Coadministration of tofacitinib with BU-Stim 60 mg Injection 10 ml may increase the risk of serious infections.

How to manage the interaction:
Taking BU-Stim 60 mg Injection 10 ml with Tofacitinib together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, diarrhea, sore throat, muscle aches, shortness of breath, or burning during urination. Do not discontinue any medications without consulting your doctor.
BusulfanNatalizumab
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Taking these two medications may raise the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between BU-Stim 60 mg Injection 10 ml and Natalizumab, you can take these medicines together if prescribed by your doctor. It is important to be aware of any symptoms such as infections, neurological problems, fever, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, weakness on one side of the body, clumsiness, vision problems, or confusion. If you experience any of these symptoms, contact your doctor right away. Do not stop using any medications without talking to your doctor.
BusulfanDeferiprone
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Coadministration of Deferiprone with BU-Stim 60 mg Injection 10 ml can increase the risk of developing infections.

How to manage the interaction:
Taking BU-Stim 60 mg Injection 10 ml with Deferiprone together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms, like fever, chills, sore throat, or muscle aches, contact your doctor immediately. Do not stop using any medications without a doctor's advice.
BusulfanTioguanine
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Combining Tioguanine with BU-Stim 60 mg Injection 10 ml can increase the likelihood and seriousness of side effects.

How to manage the interaction:
There may be a possibility of interaction between Tioguanine and BU-Stim 60 mg Injection 10 ml, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to your doctor.
BusulfanClozapine
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Coadministration of BU-Stim 60 mg Injection 10 ml with Clozapine can increase the risk of developing infection.

How to manage the interaction:
Although there is an interaction between BU-Stim 60 mg Injection 10 ml and Clozapine, it can be taken if prescribed by a doctor. However, consult a doctor if you experience fever, diarrhea, sore throat, muscle pain, or pain while urinating, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
BusulfanBaricitinib
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Coadministration of Baricitinib and BU-Stim 60 mg Injection 10 ml can increase the risk of developing infections.

How to manage the interaction:
Although Baricitinib with BU-Stim 60 mg Injection 10 ml can lead to an interaction, it can be taken if advised by the doctor. However, if you experience fever, sore throat, shortness of breath, body sores, or burning on urination, consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with BU-Stim 60 mg Injection 10 ml when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

BU-Stim 60 mg Injection 10 ml is used to treat Cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis.
BU-Stim 60 mg Injection 10 ml contains Busulfan, which works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells.
Suppose you have polycythaemia vera (PV). Busulfan can control your blood count, which helps to reduce the risk of both blood clots and bleeding.
If you have essential thrombocythemia (ET), using busulfan to reduce and control platelet counts minimises the risk of blood clotting, bleeding and developing MF.
It is recommended not to be used in the population who are allergic to Busulfan or any other ingredients in this medication, is a pregnant woman, has too low blood cell counts, or suffers from severe liver or hepatic impairment.
Yes, BU-Stim 60 mg Injection 10 ml can cause a severe decrease in the number of blood cells in your bone marrow. Your doctor will monitor peripheral blood cell counts and adjust the dose as appropriate.
It is injected directly into a vein (intravenously) by a trained healthcare professional in a hospital or transplant clinic, usually over several hours for a few consecutive days. Talk to your doctor.
Yes, temporary hair loss is a very common side effect of this treatment. Your hair will typically begin to grow back after your transplant process and recovery are complete. Talk to your doctor.
This medication can temporarily increase your risk of experiencing a seizure. Your healthcare team will typically prescribe an anti-seizure medicine beforehand to keep you safe during your infusions. Talk to your doctor.
You should avoid receiving live vaccines during and for several months after your treatment, as your immune system will be highly weakened. Always consult your transplant specialist before getting any vaccine. Talk to your doctor.
It can cause stress or damage to your liver, including a serious condition where the small blood vessels in the liver become blocked. Your healthcare team will perform regular blood tests to monitor your liver health. Talk to your doctor.
You should avoid alcohol entirely during this treatment, as both alcohol and the medicine are processed by your liver, and combining them significantly increases your risk of liver damage. Talk to your doctor.
The medicine is processed and cleared from your bloodstream relatively quickly, usually within 24 hours after your last dose, though its effects on your bone marrow and immune system will last much longer. Talk to your doctor.
Yes. BU-Stim 60 mg Injection 10 ml can reduce fertility in both men and women and may sometimes cause permanent infertility. If future pregnancy is important to you, discuss fertility-preservation options with your healthcare team before starting treatment.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Zydus Corporate Park, 4Th Floor, B Wing, Plot No 103, Near Nirma University,S G Highway, Ahmedabad, 382481
Other Info - BUS0057
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