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BUPRIGESIC INJECTION is used to treat opioid dependence (addiction to opioid drugs). It contains Buprenorphine, which prevents withdrawal symptoms in patients who stop receiving opioid drugs by producing similar effects to these drugs. It may also provide pain relief by acting on specific receptors in the brain. This medicine may sometimes cause side effects such as dry mouth, vomiting, blurred vision, constipation, dizziness, tiredness and injection site reactions. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BUPRENORPHINE-0.3MG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About BUPRIGESIC INJECTION

BUPRIGESIC INJECTION is a prescription injection used to treat severe pain that does not respond to non-opioid pain relievers. It is also utilised under medical supervision as an important component of treatment programs for opioid dependence. This medication works directly on the central nervous system to safely manage severe discomfort and help stabilise brain chemistry during recovery.

This injection is given at precise intervals scheduled by your healthcare provider to ensure consistent drug levels in your body. Because this medication is injected directly, it is not affected by food, meaning you do not need to coordinate your doses with meals. To support your treatment, incorporating lifestyle adjustments such as physical therapy, stress management, and gentle, regular movement can significantly improve your recovery results.

While using BUPRIGESIC INJECTION, you may experience mild side effects like drowsiness, mild dizziness, or nausea as your body adjusts. These are typically temporary, but you must contact your doctor immediately if you experience serious side effects, such as extreme sleepiness, slowed breathing, or symptoms of an allergic reaction.

Before you begin treatment, tell your doctor if you have a history of brain pressure, kidney problems, or lung conditions. Do not take this if you have severe breathing difficulties, severe asthma, or if you have had a life-threatening allergic reaction to similar opioid medications. Extreme caution is also required if you are taking sleeping medicines, alcohol, or other central nervous system (CNS) depressants, as combining these with BUPRIGESIC INJECTION can cause profound sedation, severe respiratory depression, or coma unless carefully supervised by your healthcare provider.

This medication can interact dangerously with alcohol, sleeping aids, or anxiety medications because combining them can severely slow down your breathing and brain activity. If you are pregnant, breastfeeding, or are an elderly individual, consult your doctor before starting BUPRIGESIC INJECTION to ensure it is safe for your specific situation.

Uses of BUPRIGESIC INJECTION

BUPRIGESIC INJECTION is used in the treatment of Opioid (drug) addiction and pain. The detailed uses of BUPRIGESIC INJECTION are as follows:

  • Severe pain relief: BUPRIGESIC INJECTION helps relieve moderate to severe pain by binding to opioid receptors in the brain and spinal cord, reducing the perception of pain when alternative treatments cannot provide adequate relief.
  • Opioid dependence treatment: It helps reduce withdrawal symptoms and intense cravings in individuals undergoing supervised treatment for opioid use disorder.

Key Benefits

BUPRIGESIC INJECTION helps relieve severe pain and supports treatment for opioid dependence, helping you feel more stable and comfortable.

Benefits may include:

  • Helps provide long-lasting relief from severe pain.
  • Reduces withdrawal symptoms during opioid dependence treatment.
  • Improves comfort and ability to perform daily activities.
  • Supports long-term recovery from opioid dependence.
  • Promotes better participation in rehabilitation and counselling programs.
  • Provides greater physical stability to improve overall quality of life.
Side effects of Buprigesic Injection 1 ml

Directions for Use

  • This medication is injected into a muscle, under the skin, or directly into a vein by a trained healthcare professional in a clinical setting.
  • If your doctor has authorised you to self-inject this medication at home, carefully follow the exact preparation and injection steps demonstrated by your healthcare team.
  • Always use a fresh, sterile needle and syringe for every single injection, and rotate your injection sites to prevent skin irritation, hard lumps, or tissue damage.
  • Never inject the liquid if it appears cloudy, discoloured, or contains visible floating particles.
  • Always follow your doctor's exact instructions regarding your treatment schedule and never alter your dose on your own.

How BUPRIGESIC INJECTION Works

BUPRIGESIC INJECTION contains 'Buprenorphine', which works by attaching to specific opioid receptors in the brain and spinal cord. Unlike many other opioids, it only partially activates these receptors. This helps relieve pain and reduce withdrawal symptoms and cravings without producing the same strong effects as full opioid medications. Because of the way it works, BUPRIGESIC INJECTION has a lower risk of causing severe breathing problems, physical dependence, and misuse than many other opioids. However, this risk is not completely eliminated, so it should always be used exactly as prescribed.
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Alcohol

Unsafe

BUPRIGESIC INJECTION may cause dizziness, drowsiness, blurred vision, or impaired thinking in some people. Alcohol consumption may even worsen these effects. Hence, do not consume alcohol while on treatment with this medicine.

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Pregnancy

Unsafe

BUPRIGESIC INJECTION is not recommended during pregnancy as it may cause life-threatening withdrawal symptoms in the newborn. Hence, inform your doctor before administering BUPRIGESIC INJECTION if you are pregnant or planning pregnancy. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Unsafe

It may be unsafe to use during breastfeeding as it passes into breastmilk and may cause sleepiness and decreased heart rate in your infant. It is not recommended for use in breastfeeding. Hence, if you are breastfeeding, inform your doctor before receiving BUPRIGESIC INJECTION. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Unsafe

BUPRIGESIC INJECTION may cause dizziness, blurred vision or drowsiness in some people. It is an offence to drive if BUPRIGESIC INJECTION affects you. Therefore, avoid driving if you feel drowsy, dizzy or experience vision problems after administration of BUPRIGESIC INJECTION.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving BUPRIGESIC INJECTION. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving BUPRIGESIC INJECTION. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

BUPRIGESIC INJECTION is not recommended for use in children below 18 years of age as the safety and effectiveness have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using BUPRIGESIC INJECTION. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of BUPRIGESIC INJECTION in elderly patients. Please consult your doctor.

What if I have taken an overdose of BUPRIGESIC INJECTION

If you suspect an overdose, seek emergency medical help immediately. Symptoms of an overdose can include extreme drowsiness, cold or clammy skin, pinpoint pupils, severe muscle weakness, and dangerously slowed breathing.

Diet & Lifestyle Advise

  • Prevent constipation: Opioid medications commonly slow down bowel movements. Drink plenty of water throughout the day and eat a diet rich in fibre, including whole grains, fruits, and vegetables, to maintain healthy digestion.
  • Stand up slowly: This medication can lower your blood pressure, particularly when changing positions. Rise slowly from sitting or lying down to reduce the risk of dizziness, fainting, and falls.
  • Stay well-hydrated: Drinking adequate fluids supports your kidneys and liver, helping your body process and eliminate the medication efficiently.
  • Engage in guided movement: Participate in gentle, low-impact exercises like walking or stretching, as advised by your healthcare provider, to keep your muscles active and manage chronic pain naturally.
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How Soon It Starts Working

  • The time required for BUPRIGESIC INJECTION to start to work: BUPRIGESIC INJECTION ideally shows its action within 15 minutes after an intramuscular administration and 1 hour after intravenous administration of the dose.
  • The time for which the effects of BUPRIGESIC INJECTION last: The effect of BUPRIGESIC INJECTION lasts for 6 hours.

What if you forget to take BUPRIGESIC INJECTION

If you miss an appointment for your scheduled injection, contact your healthcare provider's office immediately to reschedule. If you self-inject at home and miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled injection, skip the missed dose and resume your regular schedule. Do not inject a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep BUPRIGESIC INJECTION out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Check the solution before use: Make sure the injection solution is clear and free of particles. Do not use it if it looks cloudy or has changed in appearance.
  • Rotate injection sites: Use a different injection site each time, such as different areas of your abdomen or thighs. This helps protect your skin and underlying tissue from damage.
  • Never share injection equipment: Do not share needles, syringes, or medicine vials with anyone. Sharing can spread serious blood-borne infections.
  • Be careful with activities requiring alertness: Avoid driving, cycling, or operating machinery until you know how this medicine affects you. It may reduce your concentration or make you feel drowsy.
  • Keep an injection record: Write down the date, time, and injection site each time you use the medicine. Share this record with your healthcare provider during your regular check-ups.
  • Keep naloxone available if advised: If you or your caregiver is using this medicine at home, ask your healthcare provider whether you should keep naloxone on hand. Make sure your family members or caregivers know how to recognise the signs of an opioid overdose and use naloxone while waiting for emergency medical help.

Drug-Drug Interactions

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  • Benzodiazepines and sleeping pills (e.g., diazepam, zolpidem): Combining BUPRIGESIC INJECTION with medications used to treat anxiety or sleep disorders can lead to extreme drowsiness, severe breathing difficulties, coma, or death.
  • Other opioid pain relievers (e.g., morphine, tramadol): Taking other opioids alongside this medication can trigger sudden withdrawal symptoms or reduce the pain-relieving effects of BUPRIGESIC INJECTION.
  • Antifungal medications (e.g., ketoconazole): These drugs can slow down how your body processes BUPRIGESIC INJECTION, leading to higher levels of the medication in your blood and increasing your risk of side effects.
BuprenorphineAlvimopan
Critical

Drug-Drug Interactions

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How does the drug interact with Buprigesic Injection 1 ml:
Taking Ziprasidone with Buprigesic Injection 1 ml can increase the risk of serious side effects.

How to manage the interaction:
Taking Ziprasidone with Buprigesic Injection 1 ml is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment. Do not discontinue any medications without consulting a doctor.
BuprenorphineAlvimopan
Critical
How does the drug interact with Buprigesic Injection 1 ml:
Using alvimopan together with Buprigesic Injection 1 ml can cause side effects (abdominal pain, nausea, vomiting, and diarrhea).

How to manage the interaction:
Taking Alvimopan with Buprigesic Injection 1 ml is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Buprigesic Injection 1 ml:
Using Buprigesic Injection 1 ml together with Levetiracetam can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Concomitant administration of levetiracetam alongside Buprigesic Injection 1 ml can result in an interaction, it can be taken if a doctor has advised it. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating hazardous machinery. Do not stop using any medications without talking to a doctor.
How does the drug interact with Buprigesic Injection 1 ml:
When Buprigesic Injection 1 ml is taken with Selegiline, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in body).

How to manage the interaction:
There's an interaction between Buprigesic Injection 1 ml alongside Selegiline that can result in an interaction but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
BuprenorphineParaldehyde
Severe
How does the drug interact with Buprigesic Injection 1 ml:
Using Buprigesic Injection 1 ml together with Paraldehyde can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Paraldehyde and Buprigesic Injection 1 ml together can cause an interaction, it can be taken if a doctor has suggested it. Doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without talking to a doctor.
How does the drug interact with Buprigesic Injection 1 ml:
When Buprigesic Injection 1 ml is used with pentazocine, it may lead to significant adverse effects such as respiratory difficulties, unconsciousness.

How to manage the interaction:
Concomitant administration of Buprigesic Injection 1 ml alongside pentazocine can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Buprigesic Injection 1 ml:
When Buprigesic Injection 1 ml is used with oxazepam, it may possibly lead to significant adverse effects.

How to manage the interaction:
Concomitant administration of Buprigesic Injection 1 ml alongside oxazepam can result in an interaction, but it can be taken if a doctor has advised it. You should avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buprigesic Injection 1 ml:
When Buprigesic Injection 1 ml is used with diazepam, it may lead to significant adverse effects such as respiratory difficulties.

How to manage the interaction:
Concomitant administration of Buprigesic Injection 1 ml alongside diazepam can result in an interaction, it can be taken if a doctor has advised it. You should avoid driving or operating hazardous machinery until you're aware of how these drugs affect you. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buprigesic Injection 1 ml:
The combination of Buprigesic Injection 1 ml and midazolam can result in central nervous system depression (slowing of the body's neurological functioning).

How to manage the interaction:
Concomitant administration of Buprigesic Injection 1 ml along with Midazolam can result in an interaction. However, it can be taken if a doctor has advised it. If you experience any symptoms of breathing problems and unconsciousness, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buprigesic Injection 1 ml:
Co-administration of Buprigesic Injection 1 ml with tramadol may increase the risk and severity of the seizure.

How to manage the interaction:
Taking Buprigesic Injection 1 ml with tramadol together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any symptoms such as confusion, hallucination, seizure, increased heart rate, blurred vision, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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  • Alcohol: Drinking alcohol while using this injection is highly dangerous and can cause life-threatening breathing problems, extreme sedation, and severe dizziness.
  • Grapefruit juice: Avoid consuming large quantities of grapefruit or grapefruit juice, as it can raise the level of the medication in your system and increase side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[OPIOID ANTAGONISTS]

FAQs

BUPRIGESIC INJECTION is used to treat opioid addiction.
BUPRIGESIC INJECTION consists of Buprenorphine is an opioid partial agonist. It prevents withdrawal symptoms in patients who stop receiving opioid drugs by producing similar effects to these drugs. It also provides pain relief by acting on specific receptors in the brain that change how your body feels and responds to pain.
Yes, BUPRIGESIC INJECTION may cause withdrawal symptoms such as sweating, feeling hot and cold, runny eyes and nose, feeling or being sick, diarrhoea, stomach cramps, poor sleep, and just feeling awful. Therefore, if you experience any difficulty while receiving BUPRIGESIC INJECTION, do not stop administration suddenly and consult your doctor so that the dose may be reduced gradually to avoid withdrawal symptoms.
Chronic use of opioids may cause reduced fertility (ability to have children) in females and males of reproductive potential. It is not known whether these effects on fertility are reversible. However, it is essential to talk to your doctor before starting treatment with BUPRIGESIC INJECTION if you think you may want to have a baby in the future.
No, you are not recommended to use BUPRIGESIC INJECTION with antidepressants (medicines used to treat depression), and antipsychotics (medicines used to treat bipolar disorder and psychosis), as co-administration of these medicines with BUPRIGESIC INJECTION may cause life-threatening respiratory depression and death has occurred. However, please consult a doctor before receiving BUPRIGESIC INJECTION with other medicines.
Yes, BUPRIGESIC INJECTION may cause addiction, especially if used for a prolonged time. Therefore, BUPRIGESIC INJECTION should be given only for a short duration under strict medical supervision, particularly to patients susceptible to drug abuse. BUPRIGESIC INJECTION should be administered only as advised by a doctor as overuse, or misuse of BUPRIGESIC INJECTION can lead to overdose or death.
Mild redness, warmth, or soreness at the injection site is common and usually resolves within a few days. However, if you notice spreading redness, significant swelling, leaking fluid, or experience worsening pain, it could indicate an infection. Talk to your doctor right away.
No, you must completely avoid alcohol while using this medication. Combining alcohol with this injection can cause life-threatening respiratory depression, extreme drowsiness, coma, or death. Talk to your doctor if you need support in avoiding alcohol.
Using this medication during pregnancy can lead to your baby experiencing opioid withdrawal symptoms after birth, which can be serious. However, stopping treatment suddenly can also carry severe risks for both you and the pregnancy. Talk to your doctor to carefully weigh the benefits and risks for your situation.
Unlike many other opioid medicines, BUPRIGESIC INJECTION is a partial opioid agonist. This means it activates opioid receptors just enough to provide effective pain relief while producing less intense effects than full opioids. Because of the way it works, it has a lower risk of causing severe breathing problems than many other opioid medicines. However, this protection is not complete. Serious or life-threatening breathing problems can still occur, especially if BUPRIGESIC INJECTION is taken in higher-than-prescribed doses or combined with alcohol, benzodiazepines, sleeping medicines, or other drugs that slow the central nervous system. Always take this medicine exactly as prescribed, and speak with your doctor if you have any questions or concerns.
Yes. Your healthcare provider may recommend keeping naloxone readily available, especially if you use opioids at home, have other risk factors for overdose, or take medicines such as benzodiazepines that can slow breathing. Family members and caregivers should know where naloxone is stored, how to administer it, recognise the signs of an opioid overdose, and call emergency medical services immediately after giving it. Naloxone is an emergency treatment and does not replace medical care.

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Country of origin

INDIA

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - BUP0003
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