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Butodol Injection 1 ml is used to treat moderate to severe pain. It contains Butorphanol which works by blocking the transmission of pain signals and changing the way body senses pain. In some cases, this medicine may cause side effects such as headache, dizziness, sleepiness, vomiting, nausea, and constipation. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BUTORPHANOL-1MG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Butodol Injection 1 ml

Butodol Injection 1 ml is a prescription opioid pain relief medication given as an injection. It is primarily used to manage severe pain when other treatments are not enough, such as pain from surgery or childbirth. It is also used as part of anesthesia to help you relax before a medical procedure.

Because Butodol Injection 1 ml is an injection, it is typically injected by a healthcare provider in a hospital or clinic setting. The frequency of your doses will depend on your specific pain levels and medical condition as decided by your doctor. While food does not affect how this injection works, eating light meals and drinking plenty of water can help prevent stomach upset during your recovery.

Some people may experience mild side effects like drowsiness, dizziness, or a feeling of warmth after receiving this injection. It is important to tell your medical team right away if you experience serious side effects, such as shallow breathing, a very slow heartbeat, or severe confusion.

Talk to your doctor before receiving Butodol Injection 1 ml if you have a history of drug or alcohol addiction, breathing problems, head injuries, or kidney disease. Do not use Butodol Injection 1 ml if you have severe asthma or serious breathing problems, a blockage of the stomach or intestines (bowel obstruction), have taken monoamine oxidase inhibitors (MAOIs) within the past 14 days, or are allergic to Butodol Injection 1 ml or any of its ingredients.

This medication can interact dangerously with alcohol, sleeping pills, and other pain medicines because they can cause severe drowsiness and slow down your breathing to dangerous levels. Smoking can also affect how your body processes pain medicines, so discuss your habits with your healthcare provider. If you are pregnant, planning to breastfeed, or are an older adult, consult your doctor to ensure this treatment is safe for you.

Uses of Butodol Injection 1 ml

Butodol Injection 1 ml is used in the treatment of moderate to severe pain and for pain relief during labor and pre-operative sedation. The detailed uses of Butodol Injection 1 ml are as follows:

  • Severe Pain Management: Helps relieve moderate to severe pain when alternative non-opioid pain relievers are not effective or cannot be tolerated.
  • Labor Pain: Helps manage moderate to severe pain during childbirth, providing relief for the mother during labor.
  • Pre-operative Sedation: Helps reduce anxiety, promote relaxation, and support anesthesia before surgical procedures.

Key Benefits

Butodol Injection 1 ml helps provide rapid relief from moderate to severe pain and supports patient comfort during medical procedures. By relieving pain quickly, it helps improve recovery and overall well-being.

Benefits may include:

  • Helps provide fast relief from moderate to severe pain.
  • Supports patient comfort before surgery, anesthesia, or certain medical procedures.
  • Helps reduce pain and discomfort after surgery or other painful medical conditions.
  • Promotes greater comfort during recovery and medical care.
  • Helps improve the ability to rest and participate in recovery.
  • Supports effective pain management under medical supervision.
     
Side effects of Butodol Injection 1 ml
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • A blocked nose can be relieved by drinking more water, which helps clear fluids.
  • Use saline nasal spray available over the counter to relieve blockage or blow harder to remove the mucus.
  • Use nasal strips that can be placed on the nose to widen nostrils and increase airflow.
  • Keep a humidifier around to moisten air at home/workplace.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Butodol Injection 1 ml will be administered by the doctor or nurse in a healthcare setting.
  • Do not self-administer.

How Butodol Injection 1 ml Works

Butodol Injection 1 ml belongs to a group of medicines called opioid agonist-antagonists. This means it activates some pain receptors while blocking others, helping relieve pain in a different way from traditional opioids such as morphine.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Butodol Injection 1 ml. Alcohol intake, along with Butodol Injection 1 ml, may cause increased drowsiness and dizziness.

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Pregnancy

Caution

Please consult your doctor before taking Butodol Injection 1 ml if you are pregnant or planning to conceive.

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Breast Feeding

Caution

Butodol Injection 1 ml is excreted into the breast milk. Please consult your doctor before taking Butodol Injection 1 ml if you are a nursing mother.

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Driving

Unsafe

Butodol Injection 1 ml may make you feel dizzy and drowsy. Do not drive or operate machinery if you experience these side effects.

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Liver

Caution

Please consult your doctor since Butodol Injection 1 ml should be used with caution in patients with liver impairment/liver disease.

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Kidney

Caution

Please consult your doctor since Butodol Injection 1 ml should be used with caution in patients with kidney impairment/kidney disease.

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Children

Unsafe

Butodol Injection 1 ml is not recommended in anyone below 18 years of age.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Butodol Injection 1 ml. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Butodol Injection 1 ml in elderly patients. Please consult your doctor.

What if I have taken an overdose of Butodol Injection 1 ml

An overdose of Butodol Injection 1 ml is a medical emergency. Call emergency services (112 in India) or go to the nearest emergency department immediately. Signs of overdose include extreme sleepiness, pinpoint pupils, slow or stopped breathing, cold or clammy skin, and a slow heartbeat. Healthcare professionals may treat an opioid overdose with naloxone, a medicine that rapidly reverses its effects.

Diet & Lifestyle Advise

  • Stay hydrated: Pain medications can cause constipation. Drink plenty of water throughout the day to help keep your digestive system moving.
  • Eat high-fiber foods: Incorporate fruits, vegetables, and whole grains into your daily diet to help prevent bowel slow-downs.
  • Avoid sudden movements: Because this medication causes dizziness, stand up slowly from a sitting or lying position to prevent falls.
  • Prioritize rest: Allow your body ample time to sleep and recover, especially if Butodol Injection 1 ml is used after a surgical procedure.
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How Soon It Starts Working

The time required for Butodol Injection 1 ml to start to work: Butodol Injection 1 ml ideally shows its action within 5-10 minutes on intramuscular administration, and less than 10 minutes on intravenous administration. The time for which the effects of Butodol Injection 1 ml last: The effect of Butodol Injection 1 ml lasts for 3 to 4 hours.

What if you forget to take Butodol Injection 1 ml

Since this medication is usually given by a healthcare provider in a hospital, a missed dose is unlikely. If you are using it on a regular schedule at home and miss a dose, inject it as soon as you remember. However, if it is almost time for your next dose, skip the missed one and return to your regular schedule. Do not double the dose to make up for a missed one.

Storage

• Store Butodol Injection 1 ml at room temperature, safely between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the vial: Before injecting, check the liquid to ensure it is completely clear, colorless, and free of floating particles.
  • Rotate injection sites: If you are receiving multiple muscle injections, rotate the injection site each time to prevent tissue damage and soreness.
  • Avoid driving: Do not drive, operate heavy machinery, or perform dangerous activities until you know how this medication affects you, as it can cause severe drowsiness.
  • Do not stop suddenly: If you have been using Butodol Injection 1 ml for a long time, stopping it suddenly may cause withdrawal symptoms such as anxiety, sweating, muscle aches, stomach cramps, nausea, and difficulty sleeping. Your doctor will gradually reduce your dose to help prevent withdrawal.
  • Use clean equipment: Always use a new, sterile syringe and needle for every injection if injecting at home, and safely discard them in a puncture-proof sharps container.

Drug-Drug Interactions

verifiedApollotooltip
  • Medicines that cause drowsiness (e.g., sleeping pills, muscle relaxants, anti-anxiety medicines): Taking these medicines alongside Butodol Injection 1 ml may cause excessive drowsiness, slow breathing, and, in severe cases, coma.
  • Monoamine oxidase inhibitors (MAOIs): Combining these with Butodol Injection 1 ml may cause dangerously high blood pressure, severe agitation, seizures, or a rapid heartbeat.
     

Drug-Drug Interactions

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How does the drug interact with Butodol Injection 1 ml:
Eslicarbazepine can lower the levels of Butodol Injection 1 ml in the blood, resulting in decreased effectiveness of Butodol Injection 1 ml in treating pain. Furthermore, if you have been receiving Butodol Injection 1 ml as part of your treatment, adding eslicarbazepine could result in unpleasant withdrawal symptoms.

How to manage the interaction:
Although taking Eslicarbazepine and Butodol Injection 1 ml can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience body aches, involuntary kicking and twitching, abdominal cramping, loss of appetite, nausea, vomiting, diarrhoea, watery eyes, runny nose, sneezing, yawning, excessive sweating, fever, chills, flushing, restlessness, irritability, anxiety, and depression consult your doctor immediately. You should avoid tasks requiring attentiveness, such as driving or using dangerous machinery. It is advised not to drink alcohol, self-medicate, or overdose on these drugs. Do not stop taking any medications without consulting your doctor.
How does the drug interact with Butodol Injection 1 ml:
When Butodol Injection 1 ml is taken with Nevirapine may reduce the blood levels of Butodol Injection 1 ml. This can lead to low treatment outcomes.

How to manage the interaction:
Although taking Nevirapine and Butodol Injection 1 ml together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience watery eyes, runny nose, sneezing, yawning, excessive sweating, goose bumps, fever, chills, flushing, restlessness, irritability, anxiety, depression, pupil dilation, tremor, rapid heartbeat, body aches, involuntary twitching and kicking, abdominal cramping, loss of appetite, nausea, vomiting, diarrhea, and weight loss call a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Butodol Injection 1 ml:
Co-administration of Butodol Injection 1 ml with chlordiazepoxide can increase the risk of side effects like decreased breathing rate, irregular heart rhythms, or problems with movement and memory.

How to manage the interaction:
Taking Butodol Injection 1 ml and chlordiazepoxide together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience drowsiness, shortness of breath, palpitations, numbness in hands and feet, or hypersensitivity to light and noise, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Butodol Injection 1 ml:
Coadministration of Fosaprepitant with Butodol Injection 1 ml can reduce the metabolism and increase the levels of Ivabradine in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Co-administration of Fosaprepitant with Butodol Injection 1 ml can result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms like dizziness, confusion, faintness, tiredness, irregular heartbeat, trouble breathing, feeling lightheaded, trouble focusing, or having trouble breathing make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Butodol Injection 1 ml:
Coadministration of Butodol Injection 1 ml with Ziprasidone can increase the risk of serious side effects.

How to manage the interaction:
Although there is a possible interaction between Ziprasidone and Butodol Injection 1 ml, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Butodol Injection 1 ml:
Taking Butodol Injection 1 ml with Voriconazole may significantly increase the blood levels of Butodol Injection 1 ml which increases risk of side effects.

How to manage the interaction:
Although taking Butodol Injection 1 ml and Voriconazole together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience dizziness, or difficulty concentrating consult a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Butodol Injection 1 ml:
Butodol Injection 1 ml blood levels may rise if Aprepitant and Butodol Injection 1 ml are used together.

How to manage the interaction:
Although taking Aprepitant with Butodol Injection 1 ml could result in an interaction, it is safe to do so if advised by your doctor. Consult a doctor if you have sleepiness, dizziness, lightheadedness, difficulties concentrating, fainting, confusion, extreme drowsiness, slow heart rate, and/or shallow or difficult breathing. Do not discontinue any medications without talking to a doctor.
How does the drug interact with Butodol Injection 1 ml:
Coadministration of Itraconazole with Butodol Injection 1 ml may significantly raise Butodol Injection 1 ml levels in the blood.

How to manage the interaction:
Despite the possibility of an interaction, Butodol Injection 1 ml and itraconazole can be used if a doctor orders them. Consult a doctor if you feel dizziness, fainting, confusion, extreme sleepiness, a slow heartbeat, or breathing difficulties. Never stop taking any medications without talking to a doctor.
How does the drug interact with Butodol Injection 1 ml:
Taking Chloramphenicol and Butodol Injection 1 ml can significantly increase the blood levels of Butodol Injection 1 ml that may increase the risk of side effects.

How to manage the interaction:
Although taking Chloramphenicol with Butodol Injection 1 ml can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience dizziness, lightheadedness, headache, flushing, fainting, and heart palpitations feeling tired, having trouble moving, difficulty swallowing or having seizures contact your doctor know. Do not stop using any medications without a doctor's advice.
How does the drug interact with Butodol Injection 1 ml:
Using Morphine together with Butodol Injection 1 ml can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Co-administration of Morphine with Butodol Injection 1 ml can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, or poor speed and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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  • Alcohol: Do not consume alcohol while taking Butodol Injection 1 ml, as it may greatly increase the risk of severe drowsiness, slow breathing, and other life-threatening side effects.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[OPIOID ANALGESIC AND ANESTHESIA ADJUNCT]

FAQs

Butodol Injection 1 ml is used to treat moderate to severe pain post-surgery, muscle pain, and migraine-related headaches. It is also used as an anaesthesia adjunct during surgery and early labour.
Butodol Injection 1 ml contains 'Butorphanol', an opioid pain reliever that blocks the transmission of pain signals by acting on specific centres of the brain. Thus Butodol Injection 1 ml reduces pain associated with various conditions like surgery pain, muscle pain, migraine headaches, arthritis pain and toothache.
Butodol Injection 1 ml may cause your blood pressure to drop upon administration of nasal spray. This may lead to fainting, light-headedness and dizziness after its use in the first hour. To prevent this from happening, remain sitting or lying down after using Butodol Injection 1 ml.
It is not recommended to suddenly stop taking Butodol Injection 1 ml since it may produce withdrawal symptoms, especially when you used Butodol Injection 1 ml for a longer time or in high doses. Please seek medical advice on how to stop taking Butodol Injection 1 ml safely. Your doctor may lower your dose slowly to prevent withdrawal symptoms.
Butodol Injection 1 ml can cause side effects like dizziness and drowsiness, hence it is advised to remain sitting or lying after taking Butodol Injection 1 ml. You are also advised not to drive or operate machinery until you are mentally alert.
If you have liver or kidney issues, you should use Butodol Injection 1 ml with caution as it is primarily excreted through the kidneys, and its use may pose a higher risk of side effects in patients with impaired kidney function. Butodol Injection 1 ml is also extensively metabolized in the liver. Always consult your doctor before using Butodol Injection 1 ml if you have liver or kidney problems.
If you suddenly stop using Butodol Injection 1 ml, you may experience withdrawal symptoms such as nausea, vomiting, fatigue, dizziness, drowsiness, irritability, insomnia or runny nose. It is important to consult your doctor before discontinuing Butodol Injection 1 ml, as they can provide guidance on safely minimizing withdrawal effects.
While on therapy with Butodol Injection 1 ml, be cautious if you experience drowsiness and dizziness, or if you have breathing problems, and avoid driving or operating heavy machinery. Be aware of the potential for dependence or withdrawal symptoms with prolonged use of Butodol Injection 1 ml. Inform your doctor if you have a history of liver, kidney or heart diseases, abdominal problems (gallbladder disease, pancreatitis), adrenal gland diseases (Addison's disease), brain disorders (fits, tumours, increased intracranial pressure), heart problems (irregular heartbeat, chest pain, a recent history of heart attack), high blood pressure and breathing problems (asthma, chronic obstructive pulmonary disease-COPD, sleep apnoea) before starting Butodol Injection 1 ml.
Butodol Injection 1 ml causes side effects such as constipation, nausea, vomiting, dizziness, drowsiness, and headache. These do not require any medical attention as they will gradually reduce over time. Please, contact a doctor if these persist longer
This medication is sometimes used to manage pain during labor. However, using it long-term during pregnancy is generally not recommended as it may cause withdrawal symptoms in the newborn baby. Talk to your doctor to understand the risks and benefits.
Yes, because it is an opioid pain reliever, Butodol Injection 1 ml carries a risk of dependence and addiction, especially with long-term use. Your healthcare team will monitor your use closely to minimize this risk. Talk to your doctor if you have concerns about dependency.
No, you must not drink alcohol while using this medication. Combining alcohol with this injection can lead to dangerous side effects, including extreme drowsiness, slowed breathing, or even death. Talk to your doctor if you have questions about alcohol use.
If the liquid in the vial or syringe looks cloudy, discolored, or contains tiny particles, do not inject it. Dispose of it safely and use a new vial. Talk to your pharmacist if you need assistance with checking your medication.
This medication is often used during labor because it relieves pain effectively while having a lower risk of causing severe breathing problems in the mother compared to some other opioids. However, every birth is different, so talk to your doctor about the best options for your delivery.
Yes, like most opioid medications, it can slow down your bowel movements and cause constipation. Drinking plenty of fluids and eating high-fiber foods can help manage this side effect. Talk to your doctor or pharmacist if constipation becomes severe.

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Country of origin

INDIA

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - BUT0007
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