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compositionComposition:BUTORPHANOL-2MG
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Prescription Medicine
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Butrum 2 mg Injection is used to treat moderate to severe pain. It contains Butorphanol which works by blocking the transmission of pain signals and changing the way body senses pain. In some cases, this medicine may cause side effects such as headache, dizziness, sleepiness, vomiting, nausea, and constipation. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BUTORPHANOL-2MG

Manufacturer/Marketer :

Aristo Pharmaceuticals Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Butrum 2 mg Injection

Butrum 2 mg Injection is a prescription opioid pain relief medication given as an injection. It is primarily used to manage severe pain when other treatments are not enough, such as pain from surgery or childbirth. It is also used as part of anesthesia to help you relax before a medical procedure.

Because Butrum 2 mg Injection is an injection, it is typically injected by a healthcare provider in a hospital or clinic setting. The frequency of your doses will depend on your specific pain levels and medical condition as decided by your doctor. While food does not affect how this injection works, eating light meals and drinking plenty of water can help prevent stomach upset during your recovery.

Some people may experience mild side effects like drowsiness, dizziness, or a feeling of warmth after receiving this injection. It is important to tell your medical team right away if you experience serious side effects, such as shallow breathing, a very slow heartbeat, or severe confusion.

Talk to your doctor before receiving Butrum 2 mg Injection if you have a history of drug or alcohol addiction, breathing problems, head injuries, or kidney disease. Do not use Butrum 2 mg Injection if you have severe asthma or serious breathing problems, a blockage of the stomach or intestines (bowel obstruction), have taken monoamine oxidase inhibitors (MAOIs) within the past 14 days, or are allergic to Butrum 2 mg Injection or any of its ingredients.

This medication can interact dangerously with alcohol, sleeping pills, and other pain medicines because they can cause severe drowsiness and slow down your breathing to dangerous levels. Smoking can also affect how your body processes pain medicines, so discuss your habits with your healthcare provider. If you are pregnant, planning to breastfeed, or are an older adult, consult your doctor to ensure this treatment is safe for you.

Uses of Butrum 2 mg Injection

Butrum 2 mg Injection is used in the treatment of moderate to severe pain and for pain relief during labor and pre-operative sedation. The detailed uses of Butrum 2 mg Injection are as follows:

  • Severe Pain Management: Helps relieve moderate to severe pain when alternative non-opioid pain relievers are not effective or cannot be tolerated.
  • Labor Pain: Helps manage moderate to severe pain during childbirth, providing relief for the mother during labor.
  • Pre-operative Sedation: Helps reduce anxiety, promote relaxation, and support anesthesia before surgical procedures.

Key Benefits

Butrum 2 mg Injection helps provide rapid relief from moderate to severe pain and supports patient comfort during medical procedures. By relieving pain quickly, it helps improve recovery and overall well-being.

Benefits may include:

  • Helps provide fast relief from moderate to severe pain.
  • Supports patient comfort before surgery, anesthesia, or certain medical procedures.
  • Helps reduce pain and discomfort after surgery or other painful medical conditions.
  • Promotes greater comfort during recovery and medical care.
  • Helps improve the ability to rest and participate in recovery.
  • Supports effective pain management under medical supervision.
     
Side effects of Butrum 2 mg Injection
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • A blocked nose can be relieved by drinking more water, which helps clear fluids.
  • Use saline nasal spray available over the counter to relieve blockage or blow harder to remove the mucus.
  • Use nasal strips that can be placed on the nose to widen nostrils and increase airflow.
  • Keep a humidifier around to moisten air at home/workplace.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Butrum 2 mg Injection will be administered by the doctor or nurse in a healthcare setting.
  • Do not self-administer.

How Butrum 2 mg Injection Works

Butrum 2 mg Injection belongs to a group of medicines called opioid agonist-antagonists. This means it activates some pain receptors while blocking others, helping relieve pain in a different way from traditional opioids such as morphine.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Butrum 2 mg Injection. Alcohol intake, along with Butrum 2 mg Injection, may cause increased drowsiness and dizziness.

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Pregnancy

Caution

Please consult your doctor before taking Butrum 2 mg Injection if you are pregnant or planning to conceive.

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Breast Feeding

Caution

Butrum 2 mg Injection is excreted into the breast milk. Please consult your doctor before taking Butrum 2 mg Injection if you are a nursing mother.

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Driving

Unsafe

Butrum 2 mg Injection may make you feel dizzy and drowsy. Do not drive or operate machinery if you experience these side effects.

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Liver

Caution

Please consult your doctor since Butrum 2 mg Injection should be used with caution in patients with liver impairment/liver disease.

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Kidney

Caution

Please consult your doctor since Butrum 2 mg Injection should be used with caution in patients with kidney impairment/kidney disease.

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Children

Unsafe

Butrum 2 mg Injection is not recommended in anyone below 18 years of age.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Butrum 2 mg Injection. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Butrum 2 mg Injection in elderly patients. Please consult your doctor.

What if I have taken an overdose of Butrum 2 mg Injection

An overdose of Butrum 2 mg Injection is a medical emergency. Call emergency services (112 in India) or go to the nearest emergency department immediately. Signs of overdose include extreme sleepiness, pinpoint pupils, slow or stopped breathing, cold or clammy skin, and a slow heartbeat. Healthcare professionals may treat an opioid overdose with naloxone, a medicine that rapidly reverses its effects.

Diet & Lifestyle Advise

  • Stay hydrated: Pain medications can cause constipation. Drink plenty of water throughout the day to help keep your digestive system moving.
  • Eat high-fiber foods: Incorporate fruits, vegetables, and whole grains into your daily diet to help prevent bowel slow-downs.
  • Avoid sudden movements: Because this medication causes dizziness, stand up slowly from a sitting or lying position to prevent falls.
  • Prioritize rest: Allow your body ample time to sleep and recover, especially if Butrum 2 mg Injection is used after a surgical procedure.
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How Soon It Starts Working

The time required for Butrum 2 mg Injection to start to work: Butrum 2 mg Injection ideally shows its action within 5-10 minutes on intramuscular administration, and less than 10 minutes on intravenous administration. The time for which the effects of Butrum 2 mg Injection last: The effect of Butrum 2 mg Injection lasts for 3 to 4 hours.

What if you forget to take Butrum 2 mg Injection

Since this medication is usually given by a healthcare provider in a hospital, a missed dose is unlikely. If you are using it on a regular schedule at home and miss a dose, inject it as soon as you remember. However, if it is almost time for your next dose, skip the missed one and return to your regular schedule. Do not double the dose to make up for a missed one.

Storage

• Store Butrum 2 mg Injection at room temperature, safely between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the vial: Before injecting, check the liquid to ensure it is completely clear, colorless, and free of floating particles.
  • Rotate injection sites: If you are receiving multiple muscle injections, rotate the injection site each time to prevent tissue damage and soreness.
  • Avoid driving: Do not drive, operate heavy machinery, or perform dangerous activities until you know how this medication affects you, as it can cause severe drowsiness.
  • Do not stop suddenly: If you have been using Butrum 2 mg Injection for a long time, stopping it suddenly may cause withdrawal symptoms such as anxiety, sweating, muscle aches, stomach cramps, nausea, and difficulty sleeping. Your doctor will gradually reduce your dose to help prevent withdrawal.
  • Use clean equipment: Always use a new, sterile syringe and needle for every injection if injecting at home, and safely discard them in a puncture-proof sharps container.

Drug-Drug Interactions

verifiedApollotooltip
  • Medicines that cause drowsiness (e.g., sleeping pills, muscle relaxants, anti-anxiety medicines): Taking these medicines alongside Butrum 2 mg Injection may cause excessive drowsiness, slow breathing, and, in severe cases, coma.
  • Monoamine oxidase inhibitors (MAOIs): Combining these with Butrum 2 mg Injection may cause dangerously high blood pressure, severe agitation, seizures, or a rapid heartbeat.
     
ButorphanolHydroxyzine
Severe
ButorphanolNevirapine
Severe

Drug-Drug Interactions

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ButorphanolHydroxyzine
Severe
How does the drug interact with Butrum 2 mg Injection:
Using Hydroxyzine together with Butrum 2 mg Injection can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
There may be a possibility of interaction between Hydroxyzine and Butrum 2 mg Injection, but it can be taken if prescribed by a doctor. Since these medications may induce dizziness, sleepiness, trouble focusing, and impairment in judgment, response speed, and motor coordination, you should avoid driving or operating dangerous machinery until you know how they affect you. Do not discontinue any medications without consulting a doctor.
ButorphanolNevirapine
Severe
How does the drug interact with Butrum 2 mg Injection:
When Butrum 2 mg Injection is taken with Nevirapine may reduce the blood levels of Butrum 2 mg Injection. This can lead to low treatment outcomes.

How to manage the interaction:
Although taking Nevirapine and Butrum 2 mg Injection together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience watery eyes, runny nose, sneezing, yawning, excessive sweating, goose bumps, fever, chills, flushing, restlessness, irritability, anxiety, depression, pupil dilation, tremor, rapid heartbeat, body aches, involuntary twitching and kicking, abdominal cramping, loss of appetite, nausea, vomiting, diarrhea, and weight loss call a doctor right away. Do not discontinue any medications without consulting a doctor.
ButorphanolFentanyl
Severe
How does the drug interact with Butrum 2 mg Injection:
Taking fentanyl and Butrum 2 mg Injection together can increase the risk of side effects.

How to manage the interaction:
Although taking Fentanyl together with Butrum 2 mg Injection can result in an interaction, they can be taken together if prescribed by your doctor. Do not stop using any medications without talking to your doctor.
ButorphanolClotrimazole
Severe
How does the drug interact with Butrum 2 mg Injection:
Coadministration of Butrum 2 mg Injection with clotrimazole may increase the blood levels of Butrum 2 mg Injection. This may increase side effects such as sleepiness, feeling dizzy and lightheadedness, difficulty concentrating, and impairment in thinking and judgement.

How to manage the interaction:
Although taking Clotrimazole with Butrum 2 mg Injection may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor if you experience dizziness, confusion, drowsiness, or difficulty breathing. Avoid tasks that require mental awareness, such as driving, and use care when rising from a sitting or laying position. Do not discontinue any medication without consulting your doctor.
ButorphanolFosphenytoin
Severe
How does the drug interact with Butrum 2 mg Injection:
Combining Butrum 2 mg Injection with Fosphenytoin can increase the risk or severity of side effects.

How to manage the interaction:
Co-administration of Fosphenytoin with Butrum 2 mg Injection can result in an interaction, but it can be taken if your doctor has advised it. If you're having symptoms like watery eyes, runny nose, sneezing, yawning, sweating, fever, chills, restlessness, irritability, anxiety, depression, dilated pupils, trembling, fast heartbeat, twitching, loss of appetite, nausea, vomiting, diarrhoea, weight loss it's important to contact your doctor right away. Do not stop using any medications without talking to a doctor.
ButorphanolFluconazole
Severe
How does the drug interact with Butrum 2 mg Injection:
Co-administration of Butrum 2 mg Injection with Fluconazole may increase the blood levels of Butrum 2 mg Injection and may increase side effects.

How to manage the interaction:
Although there is a possible interaction between Fluconazole and Butrum 2 mg Injection, you can take these medicines together if prescribed by a doctor. If you notice any symptoms like feeling tired, dizzy, or having trouble breathing, it's important to call a doctor right away. Do not stop using any medications without talking to a doctor.
ButorphanolZiprasidone
Severe
How does the drug interact with Butrum 2 mg Injection:
Coadministration of Butrum 2 mg Injection with Ziprasidone can increase the risk of serious side effects.

How to manage the interaction:
Although there is a possible interaction between Ziprasidone and Butrum 2 mg Injection, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment. Do not discontinue any medications without consulting a doctor.
ButorphanolHaloperidol
Severe
How does the drug interact with Butrum 2 mg Injection:
Coadministration of Haloperidol with Butrum 2 mg Injection can increase the risk of developing side effects like reduced heart rate, respiratory rate, or loss of consciousness.

How to manage the interaction:
Although taking Haloperidol with Butrum 2 mg Injection can cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like dizziness, drowsiness, difficulty concentrating, impairment in judgment, reaction speed, and motor coordination, make sure to contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
ButorphanolBaclofen
Severe
How does the drug interact with Butrum 2 mg Injection:
Co-administration of Baclofen with Butrum 2 mg Injection can increase the risk of developing side effects.

How to manage the interaction:
Although there is a possible interaction between Baclofen and Butrum 2 mg Injection, you can take these medicines together if prescribed by your doctor. If you notice any symptoms like dizziness, shortness of breath, palpitations, or chest discomfort, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ButorphanolQuetiapine
Severe
How does the drug interact with Butrum 2 mg Injection:
Coadministration of quetiapine with Butrum 2 mg Injection can increase the risk of side effects such as breathing problems.

How to manage the interaction:
Co-administration of Quetiapine with Butrum 2 mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience dizziness, sleepiness, difficulties concentrating, and judgement impairment, contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Do not consume alcohol while taking Butrum 2 mg Injection, as it may greatly increase the risk of severe drowsiness, slow breathing, and other life-threatening side effects.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Butrum 2 mg Injection is used to treat moderate to severe pain post-surgery, muscle pain, and migraine-related headaches. It is also used as an anaesthesia adjunct during surgery and early labour.
Butrum 2 mg Injection contains 'Butorphanol', an opioid pain reliever that blocks the transmission of pain signals by acting on specific centres of the brain. Thus Butrum 2 mg Injection reduces pain associated with various conditions like surgery pain, muscle pain, migraine headaches, arthritis pain and toothache.
Butrum 2 mg Injection may cause your blood pressure to drop upon administration of nasal spray. This may lead to fainting, light-headedness and dizziness after its use in the first hour. To prevent this from happening, remain sitting or lying down after using Butrum 2 mg Injection.
It is not recommended to suddenly stop taking Butrum 2 mg Injection since it may produce withdrawal symptoms, especially when you used Butrum 2 mg Injection for a longer time or in high doses. Please seek medical advice on how to stop taking Butrum 2 mg Injection safely. Your doctor may lower your dose slowly to prevent withdrawal symptoms.
Butrum 2 mg Injection can cause side effects like dizziness and drowsiness, hence it is advised to remain sitting or lying after taking Butrum 2 mg Injection. You are also advised not to drive or operate machinery until you are mentally alert.
If you have liver or kidney issues, you should use Butrum 2 mg Injection with caution as it is primarily excreted through the kidneys, and its use may pose a higher risk of side effects in patients with impaired kidney function. Butrum 2 mg Injection is also extensively metabolized in the liver. Always consult your doctor before using Butrum 2 mg Injection if you have liver or kidney problems.
If you suddenly stop using Butrum 2 mg Injection, you may experience withdrawal symptoms such as nausea, vomiting, fatigue, dizziness, drowsiness, irritability, insomnia or runny nose. It is important to consult your doctor before discontinuing Butrum 2 mg Injection, as they can provide guidance on safely minimizing withdrawal effects.
While on therapy with Butrum 2 mg Injection, be cautious if you experience drowsiness and dizziness, or if you have breathing problems, and avoid driving or operating heavy machinery. Be aware of the potential for dependence or withdrawal symptoms with prolonged use of Butrum 2 mg Injection. Inform your doctor if you have a history of liver, kidney or heart diseases, abdominal problems (gallbladder disease, pancreatitis), adrenal gland diseases (Addison's disease), brain disorders (fits, tumours, increased intracranial pressure), heart problems (irregular heartbeat, chest pain, a recent history of heart attack), high blood pressure and breathing problems (asthma, chronic obstructive pulmonary disease-COPD, sleep apnoea) before starting Butrum 2 mg Injection.
Butrum 2 mg Injection causes side effects such as constipation, nausea, vomiting, dizziness, drowsiness, and headache. These do not require any medical attention as they will gradually reduce over time. Please, contact a doctor if these persist longer
This medication is sometimes used to manage pain during labor. However, using it long-term during pregnancy is generally not recommended as it may cause withdrawal symptoms in the newborn baby. Talk to your doctor to understand the risks and benefits.
Yes, because it is an opioid pain reliever, Butrum 2 mg Injection carries a risk of dependence and addiction, especially with long-term use. Your healthcare team will monitor your use closely to minimize this risk. Talk to your doctor if you have concerns about dependency.
No, you must not drink alcohol while using this medication. Combining alcohol with this injection can lead to dangerous side effects, including extreme drowsiness, slowed breathing, or even death. Talk to your doctor if you have questions about alcohol use.
If the liquid in the vial or syringe looks cloudy, discolored, or contains tiny particles, do not inject it. Dispose of it safely and use a new vial. Talk to your pharmacist if you need assistance with checking your medication.
This medication is often used during labor because it relieves pain effectively while having a lower risk of causing severe breathing problems in the mother compared to some other opioids. However, every birth is different, so talk to your doctor about the best options for your delivery.
Yes, like most opioid medications, it can slow down your bowel movements and cause constipation. Drinking plenty of fluids and eating high-fiber foods can help manage this side effect. Talk to your doctor or pharmacist if constipation becomes severe.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Butorphanol Injection Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 19890S17Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. Bethesda. Butorphanol. NIH National Library of Medicine. National Centre for Biotechnology Information. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. April 2019. [Assessed on 7th September 2022]Check here
  5. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 02 Apr. 2019]Check here
  6. Chaves RG, Lamounier JA Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198Check here
  7. AA Pharma Inc. Butorphanol Nasal Spray. [Revised in March 2015] [Assessed on 7th September 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Mercantile Chamber, 3rd Floor, 12, J.N. Heredia Marg, Ballard Estate, Mumbai – 400 001, India.
Other Info - BUT0005

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