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compositionComposition:BUPRENORPHINE-20MCG
prescription
Prescription Medicine
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Buvalor 20mcg H 2 patch is primarily used to treat pain. It contains 'Buprenorphine', an opioid partial agonist-antagonist. It works by blocking a chemical messenger in the brain that is responsible for causing pain. This provides pain relief by acting on specific receptors in the brain. Common side effects of Buvalor 20mcg H 2 patch are drowsiness, dry mouth, vomiting, blurred vision, constipation, application site reactions, dizziness, or tiredness.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BUPRENORPHINE-20MCG

Manufacturer/Marketer :

Modi Mundipharma Pvt Ltd

Consume Type :

Topical

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Buvalor 20mcg H 2 patch

Buvalor 20mcg H 2 patch is a prescription transdermal patch used to manage severe, persistent pain that requires continuous, around-the-clock treatment for an extended period. It is generally prescribed when other pain medicines are ineffective, not tolerated, or unsuitable. By delivering medicine steadily through the skin, it provides continuous pain relief throughout the prescribed wear period.

To achieve the best results, apply Buvalor 20mcg H 2 patch exactly as directed by your doctor and replace the patch according to your prescribed schedule. Apply it only to clean, dry, intact, hairless skin. Because the medicine is absorbed through your skin, food does not affect its action. Staying physically active within your doctor's recommendations and maintaining adequate hydration may help improve overall pain control.

While using this medicine, you may experience mild side effects such as redness at the application site, constipation, nausea, sleepiness, or dizziness. These are often temporary. However, seek immediate medical attention if you develop slow or difficult breathing, extreme drowsiness, inability to wake up, or signs of a severe allergic reaction.

Do not use this medicine if you have severe breathing problems, paralytic ileus (intestinal blockage), or a known allergy to the medicine or any of its ingredients. Tell your doctor before starting treatment if you have asthma, COPD, liver disease, head injury, seizures, heart rhythm disorders, or a history of substance misuse.

This medicine can interact with alcohol, sedatives, sleeping tablets, other opioid medicines, and certain antidepressants, increasing the risk of serious side effects. If you are pregnant, breastfeeding, an older adult, or have other chronic medical conditions, discuss the risks and benefits with your healthcare provider before using this patch.
 

Uses of Buvalor 20mcg H 2 patch

Your doctor may prescribe Buvalor 20mcg H 2 patch to treat the following condition:

  • Severe chronic pain: Provides continuous, long-term pain relief for persistent pain requiring around-the-clock opioid treatment.
     

Key Benefits

Buvalor 20mcg H 2 patch provides continuous pain control by releasing medicine slowly through the skin over several days.

  • Provides long-lasting pain relief: Delivers a steady amount of medicine to help control persistent pain throughout the prescribed wear period.
  • Reduces pain fluctuations: Helps minimise breakthrough pain that may occur as oral pain medicines wear off.
  • Improves daily comfort: Better pain control can make sleeping, walking, and performing everyday activities easier.
  • Convenient dosing: The transdermal patch reduces the need for multiple daily doses of pain medicine.
  • Supports long-term pain management: Provides continuous symptom control as part of an overall pain management plan.
     

Directions for Use

  • Follow the timing and schedule given by your doctor.
  • Apply the patch to clean, dry, and hairless skin on the upper torso or upper arm. Press the patch firmly in place and ensure it sticks well.
  • Wash your hands after applying the patch to avoid accidental contact with your eyes or mucous membranes.
  • Do not cut, crush, or break the patch.
  • Avoid applying the patch to broken, irritated, or oily skin.
  • Change the patch as instructed, and avoid wearing more than one patch at a time unless directed by your doctor.

How Buvalor 20mcg H 2 patch Works

Buvalor 20mcg H 2 patch contains buprenorphine which is an opioid analgesic delivered through a transdermal patch. After the patch is applied to your skin, the medicine is slowly absorbed into your bloodstream over several days. It works by binding to opioid receptors in the brain and spinal cord. This reduces the transmission of pain signals and changes how your brain perceives pain, providing continuous relief for persistent moderate to severe pain.
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Alcohol

Unsafe

Consuming alcohol or other illicit drugs during treatment with Buvalor 20mcg H 2 patch increases your chances of experiencing these significant, life-threatening adverse effects. Throughout your therapy, do not consume alcohol, use alcohol-containing prescription or nonprescription medicines, or use street drugs.

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Pregnancy

Unsafe

If you are pregnant or planning pregnancy, inform your doctor. If you use Buvalor 20mcg H 2 patch often throughout your pregnancy, your baby may suffer from potentially fatal withdrawal symptoms after birth. If your infant exhibits any of the following symptoms, contact your doctor straight away: irritability, hyperactivity, disturbed sleep, high-pitched scream, excessive shaking of a portion of the body, vomiting, diarrhoea, or failure to gain weight.

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Breast Feeding

Unsafe

If you are nursing, you should avoid using Buvalor 20mcg H 2 patch. Buprenorphine passes into breast milk in small amounts and might cause respiratory issues in your infant. Talk with your doctor; they may prescribe a different pain reliever.

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Driving

Unsafe

Buvalor 20mcg H 2 patch may cause dizziness, blurred vision or drowsiness in some people. Therefore, avoid driving if you feel drowsy, dizzy or experience any vision problems after using Buvalor 20mcg H 2 patch.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before using Buvalor 20mcg H 2 patch.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before using Buvalor 20mcg H 2 patch.

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Children

Unsafe

Buvalor 20mcg H 2 patch is not recommended for children below 18 years of age as safety and effectiveness have not been established.

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Heart

Caution

Buvalor 20mcg H 2 patch should be used with caution in individuals with heart disease and only under medical supervision. If you have any cardiac conditions, please consult your doctor before using this medication.

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Geriatrics

Safe if prescribed

Buvalor 20mcg H 2 patch is generally considered safe for use in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of Buvalor 20mcg H 2 patch

If too many patches are applied or someone accidentally swallows or applies a patch, remove the patch immediately and seek emergency medical attention. Symptoms of overdose include extreme sleepiness, pinpoint pupils, slow breathing, inability to wake up, or loss of consciousness.

Diet & Lifestyle Advise

  • Prevent constipation: Drink plenty of fluids, eat fibre-rich foods such as fruits, vegetables, and whole grains, and remain physically active if your doctor advises it.
  • Avoid heat exposure: Do not use heating pads, electric blankets, hot tubs, saunas, or prolonged hot baths over or near the patch, as heat can increase medicine absorption.
  • Stay active safely: Gentle exercise or physical therapy, as recommended by your healthcare provider, may help improve mobility and chronic pain management.
  • Avoid alcohol: Drinking alcohol while using Buvalor 20mcg H 2 patch can greatly increase the risk of dangerous drowsiness and breathing problems.
     
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How Soon It Starts Working

The time required for Buvalor 20mcg H 2 patch to start to work: The exact onset time of Buvalor 20mcg H 2 patch has not been clinically established. The time for which the effects of Buvalor 20mcg H 2 patch last: The peak effect of Buvalor 20mcg H 2 patch lasts for 7 days after administration.

What if you forget to take Buvalor 20mcg H 2 patch

If you forget to replace your patch, apply a new one as soon as you remember and continue according to your doctor's instructions. Do not apply extra patches to make up for a missed dose.

Storage

• Store Buvalor 20mcg H 2 patch in its original sealed pouch at room temperature according to the manufacturer's instructions. Protect the patches from excessive heat, moisture, and direct sunlight. Do not freeze.

Drug Warnings

  • Inspect the pouch: Do not use the patch if the protective pouch is damaged or already opened.
  • Rotate application sites: Apply each new patch to a different skin area and avoid reusing the same site for several weeks.
  • Never cut the patch: Cutting or damaging the patch may release the medicine too quickly and increase the risk of overdose.
  • Check the patch regularly: Make sure the patch remains firmly attached, especially after bathing or showering.
  • Keep patches away from children: Even used patches may contain enough medicine to cause serious or fatal poisoning if accidentally handled or swallowed.
     

Drug-Drug Interactions

verifiedApollotooltip

Sedatives, sleeping tablets, benzodiazepines, and opioid pain medicines: May greatly increase the risk of severe drowsiness, respiratory depression, coma, and death.

  • Monoamine oxidase inhibitors (MAOIs) and certain antidepressants: May increase the risk of serious adverse effects, including excessive sedation or serotonin syndrome with susceptible opioids.
  • Medicines that affect CYP3A4 enzymes (where applicable, e.g., fentanyl or buprenorphine): May increase or decrease opioid levels, affecting safety and pain control.
     
BuprenorphineAlvimopan
Critical
BuprenorphineZiprasidone
Critical

Drug-Drug Interactions

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BuprenorphineAlvimopan
Critical
How does the drug interact with Buvalor 20mcg H 2 patch:
Using alvimopan together with Buvalor 20mcg H 2 patch can cause side effects (abdominal pain, nausea, vomiting, and diarrhea).

How to manage the interaction:
Taking Alvimopan with Buvalor 20mcg H 2 patch is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
BuprenorphineZiprasidone
Critical
How does the drug interact with Buvalor 20mcg H 2 patch:
Taking Ziprasidone with Buvalor 20mcg H 2 patch can increase the risk of serious side effects.

How to manage the interaction:
Taking Ziprasidone with Buvalor 20mcg H 2 patch is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment. Do not discontinue any medications without consulting a doctor.
BuprenorphineZolpidem
Severe
How does the drug interact with Buvalor 20mcg H 2 patch:
Taking Zolpidem with Buvalor 20mcg H 2 patch can cause central nervous system depression, leading to breathing difficulty and unconsciousness.

How to manage the interaction:
Although taking Buvalor 20mcg H 2 patch and Zolpidem together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment, or reaction speed, consult a doctor. You should avoid driving or operating dangerous machinery. Do not stop using any medications without a doctor's advice.
BuprenorphineTizanidine
Severe
How does the drug interact with Buvalor 20mcg H 2 patch:
Coadministration of Buvalor 20mcg H 2 patch with Tizanidine may increase the risk of side effects like decreased breathing rate, irregular heart rhythms, or problems with movement and memory.

How to manage the interaction:
Coadministration of Buvalor 20mcg H 2 patch with Tizanidine can result in an interaction, it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, dizziness, palpitations, or sweating, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
BuprenorphineEslicarbazepine
Severe
How does the drug interact with Buvalor 20mcg H 2 patch:
Using Buvalor 20mcg H 2 patch together with Eslicarbazepine can cause central nervous system depression.

How to manage the interaction:
Concomitant administration of Buvalor 20mcg H 2 patch alongside eslicarbazepine can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
BuprenorphineClomipramine
Severe
How does the drug interact with Buvalor 20mcg H 2 patch:
Using Buvalor 20mcg H 2 patch together with Clomipramine can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking clomipramine and Buvalor 20mcg H 2 patch together can cause an interaction, it can be taken if a doctor has suggested it. However, contact a doctor immediately if you experience any symptoms such as confusion, hallucinations, seizures, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination. Do not discontinue any medications without consulting a doctor.
BuprenorphineVigabatrin
Severe
How does the drug interact with Buvalor 20mcg H 2 patch:
When Buvalor 20mcg H 2 patch is used with Vigabatrin, it may increase the risk of side effects such as respiratory difficulties.

How to manage the interaction:
Co-administration of Buvalor 20mcg H 2 patch alongside Vigabatrin can result in an interaction, it can be taken if a doctor has advised it. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating hazardous machinery. Do not discontinue any medications without consulting a doctor.
BuprenorphinePrimidone
Severe
How does the drug interact with Buvalor 20mcg H 2 patch:
Coadministration of Buvalor 20mcg H 2 patch with primidone can increase the risk or severity of side effects such as breathing problems.

How to manage the interaction:
Although there is an interaction between Buvalor 20mcg H 2 patch and primidone, it can be taken if your doctor has advised it. However, if you experience abdominal cramping, loss of appetite, nausea, vomiting, diarrhea, weight loss, excessive sweating, goose bumps, fever, chills, watery eyes, runny nose, sneezing, or yawning, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
BuprenorphineSelegiline
Severe
How does the drug interact with Buvalor 20mcg H 2 patch:
When Buvalor 20mcg H 2 patch is taken with Selegiline, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in body).

How to manage the interaction:
There's an interaction between Buvalor 20mcg H 2 patch alongside Selegiline that can result in an interaction but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
BuprenorphineTapentadol
Severe
How does the drug interact with Buvalor 20mcg H 2 patch:
Using Tapentadol together with Buvalor 20mcg H 2 patch can increase the risk or severity of side effects like decreased breathing rate, irregular heart rhythms, or problems with movement and memory.

How to manage the interaction:
Taking Buvalor 20mcg H 2 patch with Tapentadol can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience signs such as drowsiness, lightheadedness, palpitations, confusion, severe weakness, or difficulty breathing. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid alcohol completely, as it significantly increases the risk of excessive sedation, breathing difficulties, and overdose.
  • Grapefruit or grapefruit juice (where applicable): May increase blood levels of certain opioid patches (such as fentanyl or buprenorphine), increasing the risk of side effects.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[OPIOID ANTAGONISTS]

FAQs

Buvalor 20mcg H 2 patch is used to treat Pain.
Buvalor 20mcg H 2 patch consists of Buprenorphine is an opioid partial agonist. It provides pain relief by acting on specific receptors in the brain that change how your body feels and responds to pain.
No, you are not recommended to take Buvalor 20mcg H 2 patch with antidepressants (medicines used to treat depression), and antipsychotics (medicines used to treat bipolar disorder and psychosis) as co-administration of these medicines with Buvalor 20mcg H 2 patch may cause life-threatening respiratory depression and death have occurred. However, please consult a doctor before taking Buvalor 20mcg H 2 patch with other medicines.
Yes, Buvalor 20mcg H 2 patch may cause withdrawal symptoms such as sweating, feeling hot and cold, runny eyes and nose, feeling or being sick, diarrhoea, stomach cramps, poor sleep, and just feeling awful. Therefore, if you experience any difficulty while using Buvalor 20mcg H 2 patch, do not stop using it suddenly and consult your doctor so that the dose may be reduced gradually to avoid withdrawal symptoms.
Yes, Buvalor 20mcg H 2 patch may cause addiction, especially if taken for a prolonged time. Therefore, Buvalor 20mcg H 2 patch should be given only for a short duration under strict medical supervision, particularly to patients susceptible to drug abuse. Take Buvalor 20mcg H 2 patch only as advised by a doctor, as overuse or misuse of Buvalor 20mcg H 2 patch can lead to overdose or death.
Because the patch releases medication slowly through the skin, it can take 24 to 72 hours for you to feel the full pain-relieving effects after applying your first patch. Talk to your doctor if your pain is not well controlled during this initial period.
Yes, you can shower, bathe, or swim while wearing the patch. However, avoid exposing the patch to hot water, steam, or hot tubs, as excessive heat can cause too much medication to be absorbed into your body. Talk to your doctor or pharmacist if you have concerns about patch adhesion.
If a patch falls off before it is time to change it, apply a new patch to a different, clean skin site. Do not reuse the fallen patch. Contact your doctor or pharmacist to let them know and to clarify your new patch-changing schedule.
No, you must never cut, slice, or damage the patch. Damaging the patch destroys its slow-release system, which can cause a rapid and potentially life-threatening release of the medication into your body. Talk to your doctor if you think your dose needs to be adjusted.
No, drinking alcohol while using this medicine is highly dangerous. Alcohol increases the risk of severe side effects, such as extreme drowsiness, dangerously slow or shallow breathing, coma, and even death. Talk to your doctor if you have questions about this.
Used patches still contain active medicine. Fold the used patch in half with the sticky side facing inward, and dispose of it safely out of reach of children and pets, or flush it down the toilet if local regulations permit. Talk to your pharmacist about the safest disposal methods in your area.
No, you should never apply heating pads, hot water bottles, or other direct heat sources directly over or near the patch. Heat increases skin blood flow, which can cause the medication to enter your bloodstream too quickly, leading to a dangerous overdose. Talk to your doctor if you need advice on managing localised pain.
Yes, regular use of this medication can lead to physical dependence. Do not stop using the patch suddenly without consulting your healthcare provider, as this can cause uncomfortable withdrawal symptoms. Your doctor will help you by gradually decreasing the dose when it is time to stop treatment.

Disclaimer

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Reference

  1. MedlinePlus. A613042 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  2. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  3. National Health Service (NHS). Buprenorphine For Pain - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Rachna Kumar; Omar Viswanath; Abdolreza Saadabadi. Buprenorphine. NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls [Internet]. May 2022. [Accessed on 9th September 2022]Check here
  5. Bard Pharmaceuticals Limited. Electronic Medicines Compendium (EMC). [Revised in September 2021] [Accessed on 9th September 2022]Check here
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 02 Apr. 2019]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Ground Floor Modi Tower, 98, Nehru Place, New Delhi, Delhi 110019
Other Info - BUV0003

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