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compositionComposition:RETEPLASE-18MG
prescriptionPrescription Medicine
Cathlyse 18 Injection 1's

Cathlyse 18 Injection is used in the treatment of ST-elevation myocardial infarction (STEMI) to lower the risk of heart failure and death. It contains Reteplase, which works by dissolving the blood clot that is blocking the heart's blood vessels. It may also treat a recent left bundle branch block (a delay/blockage of electrical impulses to the left side of the heart). Common side effects of Cathlyse 18 Injection are bleeding, bruising at the injection site, nausea or vomiting.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

RETEPLASE-18MG

Manufacturer/Marketer :

Biochem Pharmaceutical Industries Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Cathlyse 18 Injection

Cathlyse 18 Injection is a tissue plasminogen activator indicated for the treatment of acute ST-elevation myocardial infarction (STEMI) to lower the risk of heart failure and death. STEMI is a very serious type of heart attack that occurs due to blockage of the heart’s major arteries.

Cathlyse 18 Injection contains Reteplase, which works by dissolving the blood clot that is blocking the heart blood vessel.

In some cases, Cathlyse 18 Injection may cause side effects such as bleeding, bruising at the injection site, nausea or vomiting. You are advised to talk to your doctor if any of the side effects persist or worsen.

Consult your doctor if you are pregnant or breastfeeding. The efficacy and safety of Cathlyse 18 Injection in children have not been established. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects/interactions.

Uses of Cathlyse 18 Injection

Cathlyse 18 Injection is used in the treatment of ST-elevation myocardial infarction (STEMI). The detailed uses of Cathlyse 18 Injection are as follows:

  • Acute myocardial infarction (heart attack): Cathlyse 18 Injection helps dissolve blood clots in the coronary arteries, restoring blood flow to the heart muscle and reducing the risk of heart failure or death.
  • ST-elevation myocardial infarction (STEMI): Cathlyse 18 Injection is specifically indicated for this type of heart attack, where quick clot dissolution is critical.

Key Benefits

Cathlyse 18 Injection is a tissue plasminogen activator indicated for the treatment of acute ST-elevation myocardial infarction (STEMI) to reduce the risk of heart failure and death. Cathlyse 18 Injection contains Reteplase that works by dissolving the blood clot that is blocking the heart blood vessel. It may also be indicated in the treatment of a recent left bundle branch block (a delay/blockage of electrical impulses to the left side of the heart).

Side effects of Cathlyse 18 Injection
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.
  • Regularly exercise and have a balanced diet to maintain a healthy weight.
  • Eat fruits and vegetables to maintain a healthy weight.
  • Include vitamin K-rich foods in your diet for stable anticoagulation control.
  • Limit red and processed meats.
  • Avoid smoking and consumption of alcohol to improve your condition.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Cathlyse 18 Injection will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Cathlyse 18 Injection Works

Cathlyse 18 Injection contains Reteplase, which works by dissolving the blood clot that is blocking the heart blood vessel.
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Alcohol

Consult your doctor

Limited information is available. Please consult your doctor.

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Pregnancy

Caution

Please consult your doctor if you are pregnant. Your doctor will prescribe only if the potential benefits outweigh the potential risk to the foetus.

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Breast Feeding

Caution

Please consult your doctor if you are breastfeeding. Caution should be exercised whilst administering Cathlyse 18 Injection to a nursing mother.

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Driving

Consult your doctor

Limited information is available. Please consult your doctor.

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Liver

Caution

The potential risks with the therapy of Cathlyse 18 Injection may be increased in patients with severe liver dysfunction and should be weighed against the anticipated benefits. Please consult your doctor.

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Kidney

Caution

The potential risks of Cathlyse 18 Injection therapy may be increased in patients with severe renal dysfunction and should be weighed against the anticipated benefits. Please consult your doctor.

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Children

Caution

The efficacy and safety of Cathlyse 18 Injection in children have not been established.

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Heart

Safe if prescribed

Cathlyse 18 Injection is generally safe for heart patients if prescribed, but should be used under medical supervision.

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Geriatrics

Caution

Cathlyse 18 Injection should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Cathlyse 18 Injection

Since Cathlyse 18 Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Diet & Lifestyle Advise

  • Include vegetables, fruits and whole grains in your diet.
  • Stop smoking.
  • Be physically active every day.
  • Aim for a healthy weight.
  • Limit the consumption of alcohol.
  • Manage stress with meditation.

Have a query?

How Soon It Starts Working

The time required for Cathlyse 18 Injection to start to work: Cathlyse 18 Injection ideally shows its action within 30 to 90 minutes after administration. The time for which the effects of Cathlyse 18 Injection last: The duration of action for Cathlyse 18 Injection is clinically unknown.

What if you forget to take Cathlyse 18 Injection

As this medication will be administered in a hospital by your healthcare professional, the chances of missing a dose are less. However, if you have any concerns, contact your doctor.

Storage

• Store in a cool and dry place away from sunlight. • Keep Cathlyse 18 Injection out of sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

Cathlyse 18 Injection should not be used if you are allergic to any of the components in Cathlyse 18 Injection, in patients with active internal bleeding, recent stroke, recent intracranial or intraspinal surgery or serious head trauma, intracranial neoplasm (brain tumour), arteriovenous malformation, or aneurysm (ballooning and weakened area in an artery), known bleeding diathesis (tendency to bleed or bruise easily), or severe uncontrolled hypertension. Cathlyse 18 Injection may cause bleeding, hypersensitivity reactions, or cholesterol embolism. Inform your doctor if you have/had recent major surgery, cerebrovascular disease, recent gastrointestinal/genitourinary bleeding, hypertension, subacute bacterial endocarditis, severe hepatic or renal disease, if you are over 75 years or if you are taking any oral anticoagulants. Consult your doctor if you are pregnant or breastfeeding. The safety and effectiveness of Cathlyse 18 Injection in children have not been established.

Drug-Drug Interactions

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Drug-Drug Interactions: Inform your doctor if you are taking anti-coagulants (heparin, enoxaparin, warfarin, phenindione, aspirin, dipyridamole, ticlopidine, clopidogrel, vitamin K antagonists).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have/had cancer, stroke, high blood pressure, active ulcer in the stomach or intestine, portal hypertension, inflammation of the pancreas, bleeding behind or in the eye, or severe liver or kidney problems.

ReteplaseCangrelor
Severe
ReteplasePrasugrel
Severe

Drug-Drug Interactions

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ReteplaseCangrelor
Severe
How does the drug interact with Cathlyse 18 Injection:
Co-administration of Cangrelor with Cathlyse 18 Injection can increase the risk of bleeding.

How to manage the interaction:
Although taking Cangrelor and Cathlyse 18 Injection together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these signs, it's important to contact a doctor right away: difficulty with bleeding, complications, bruising, feeling dizzy or lightheaded, dark or sticky stools, intense headache, weakness, or bleeding or vomiting. Do not stop using any medications without talking to a doctor.
ReteplasePrasugrel
Severe
How does the drug interact with Cathlyse 18 Injection:
Taking Prasugrel with Cathlyse 18 Injection can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Prasugrel with Cathlyse 18 Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
ReteplaseEnoxaparin
Severe
How does the drug interact with Cathlyse 18 Injection:
Combining Cathlyse 18 Injection with Enoxaparin can increase the risk or severity of bleeding.

How to manage the interaction:
Although there is a possible interaction between Enoxaparin and Cathlyse 18 Injection, you can take these medicines together if prescribed by your doctor. If you notice any symptoms like bleeding, bruising, dizziness, or severe headache, it's important to call a doctor right away. Do not stop using any medications without talking to a doctor.
ReteplaseApixaban
Severe
How does the drug interact with Cathlyse 18 Injection:
Coadministration of Cathlyse 18 Injection and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Cathlyse 18 Injection and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ReteplaseFondaparinux
Severe
How does the drug interact with Cathlyse 18 Injection:
Taking Cathlyse 18 Injection with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between fondaparinux and Cathlyse 18 Injection, you can take these medicines together if prescribed by your doctor. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
ReteplaseDabigatran etexilate
Severe
How does the drug interact with Cathlyse 18 Injection:
Taking Dabigatran etexilate with Cathlyse 18 Injection can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Cathlyse 18 Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
ReteplaseIbrutinib
Severe
How does the drug interact with Cathlyse 18 Injection:
Co-administration of Ibrutinib with Cathlyse 18 Injection can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Ibrutinib with Cathlyse 18 Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Cathlyse 18 Injection is used to treat ST-elevation myocardial infarction (STEMI).

Cathlyse 18 Injection works by dissolving the blood clot that is blocking the heart's blood vessels.

Cathlyse 18 Injection may increase the risk of bleeding. The sites of bleeding could be internal or external. Talk to your doctor if you have any concerns.

Heparin and Cathlyse 18 Injection are incompatible. Cathlyse 18 Injection should not be administered through an intravenous line containing heparin. Please consult your doctor if you have any concerns.

Cathlyse 18 Injection will be administered by a healthcare professional in a clinical setting. Do not attempt to administer it yourself. A trained healthcare professional will ensure safe and proper administration.

Yes, Cathlyse 18 Injection is safe when used under the doctor’s supervision. It is used in the treatment of ST-elevation myocardial infarction (STEMI). However, it may cause some side effects like bleeding, bruising at the injection site, nausea, or vomiting in some cases. You are advised to talk to your doctor if any of the side effects persist or worsen.

Cathlyse 18 Injection may interact with anti-coagulants like heparin, enoxaparin, warfarin, phenindione, aspirin, dipyridamole, ticlopidine, clopidogrel, and vitamin K antagonists. So, it’s best to consult your doctor before taking anti-coagulants or any other medications along with Cathlyse 18 Injection.

Cathlyse 18 Injection helps prevent blood clots from forming in your legs, lungs, heart, and brain. You may not feel any immediate effects after taking the medicine, but that doesn't mean it's not working. Continue taking the medicine exactly as prescribed by your doctor, even if you don't notice any difference.

The common side effects of Cathlyse 18 Injection may include bleeding, bruising at the injection site, nausea, or vomiting. You are advised to talk to your doctor if any of the side effects persist or worsen.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Biochem Pharma, Lg 113 / A, Xth Central Mall, Mahavir Nagar, 90Ft Road, Next To D Mart, Kandivali - West, Mumbai - 400067.
Other Info - CAT0157
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