apollo
0

Welcome User

Login/Sign Up

Home
Buy Medicines
Lab Tests
Doctor Consult
Circle Membership
insurance
Blogs
Contact Us
Privacy Policy
Return & Refunds
Need Help
Terms and Conditions
  1. Home
  2. Medicine

  3. Cfara 20 mg Injection 20 ml

Cfara 20 mg Injection 20 ml, Pack of 1
Offers on medicine orders
All offers
axis icici
rxMedicinePrescription drug

Whats That

tooltip

Also Explore

Momverse
Ask Apollo
insurance

Composition :

CLOFARABINE-20MG

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Cfara 20 mg Injection 20 ml

Cfara 20 mg Injection 20 ml is an anti-cancer medicine used in pediatric patients aged 1 - 21 years for the treatment of acute lymphoblastic leukaemia, a blood cancer that primarily affects the blood and bone marrow. Cfara 20 mg Injection 20 ml is used in patients with relapsed or refractory acute lymphoblastic leukaemia (ALL) after receiving at least two prior therapies.

Cfara 20 mg Injection 20 ml contains Clofarabine as an active ingredient in the class of antimetabolites. It works by inhibiting the DNA polymerase enzyme responsible for DNA elongation, synthesis, and repair.

Cfara 20 mg Injection 20 ml may cause certain side effects, such as skin rash, fatigue, headache, decreased platelet count, nausea, vomiting, diarrhoea, fever, anxiety, flushing, and injection site reactions. These side effects do not require medical attention and gradually resolve over time. A trained oncologist will administer Cfara 20 mg Injection 20 ml. Do not self-administer.

Cfara 20 mg Injection 20 ml should be avoided if you are allergic to it or any other components present in it. It should be used with caution in patients with a pre-existing or history of liver/kidney disease, gastrointestinal disorders, skin problems, and bleeding disorders, as it may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. It is not recommended for use in pregnancy or breastfeeding.

Uses of Cfara 20 mg Injection 20 ml

Cfara 20 mg Injection 20 ml is used in the treatment of Acute lymphocytic leukemia (ALL). The detailed use of Cfara 20 mg Injection 20 ml is as follows:<br/>• Acute Lymphoblastic Leukemia (ALL): Cfara 20 mg Injection 20 ml is for use in children and young adults up to 21 years old who have relapsed or refractory ALL, especially when other treatments have failed.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication.• Cfara 20 mg Injection 20 ml will be administered by a nurse or doctor.• Do not self-administer.

Medicinal Benefits

Cfara 20 mg Injection 20 ml contains Clofarabine, which is used in the treatment of acute lymphoblastic leukemia (ALL). It works by inhibiting the DNA polymerase enzyme that is responsible for DNA elongation, synthesis, and repair. In general, it inhibits the production of genetic material (DNA) in the cancer cells that are essential for cell growth, repair and multiplication. Thus, Cfara 20 mg Injection 20 ml stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes the death of cells.

How Cfara 20 mg Injection 20 ml Works

Cfara 20 mg Injection 20 ml contains Clofarabine as an active ingredient in the class of antimetabolites. It works by inhibiting the DNA polymerase enzyme responsible for DNA elongation, synthesis, and repair.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Cfara 20 mg Injection 20 ml

As Cfara 20 mg Injection 20 ml is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Cfara 20 mg Injection 20 ml may cause rash, vomiting and yellowing of the skin or eyes.

Drug Warnings

Cfara 20 mg Injection 20 ml should be avoided if you are allergic to it or any other components present in it. Before receiving, if the child has/had any history of liver/kidney disease, gastrointestinal disorders, skin problems, and bleeding disorders, as it may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Cfara 20 mg Injection 20 ml is given in children above one year of age only if prescribed by the doctor. Cfara 20 mg Injection 20 ml may cause myelosuppression, QT prolongation, hepatotoxicity, renal toxicity, cerebral, gastrointestinal and pulmonary haemorrhage, Tumor Lysis syndrome, severe infections, Systemic Inflammatory Response Syndrome (SIRS), enterocolitis, and skin reactions in some patients. Hence, inform your doctor about your complete medical and medication history before receiving this medicine.

Drug-Drug Interactions

verifiedApollotooltip
ClofarabineBaricitinib
Severe
ClofarabineEtanercept
Severe

Drug-Drug Interactions

Login/Sign Up

ClofarabineBaricitinib
Severe
How does the drug interact with Cfara 20 mg Injection 20 ml:
Coadministration of Cfara 20 mg Injection 20 ml with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Taking Baricitinib with Cfara 20 mg Injection 20 ml together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
ClofarabineEtanercept
Severe
How does the drug interact with Cfara 20 mg Injection 20 ml:
When Etanercept is used with Cfara 20 mg Injection 20 ml, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Etanercept and Cfara 20 mg Injection 20 ml together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
ClofarabineLeflunomide
Severe
How does the drug interact with Cfara 20 mg Injection 20 ml:
Combining Cfara 20 mg Injection 20 ml with Leflunomide can increase the risk of negative side effects.

How to manage the interaction:
Although taking Leflunomide and Cfara 20 mg Injection 20 ml together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these symptoms - such as fever, diarrhea, or muscle aches - contact your doctor immediately. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

Diet & Lifestyle Advise

  • After beginning your treatment, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Cfara 20 mg Injection 20 ml Substitute

Substitutes safety advice

Product Substitutes

bannner image

Alcohol

Unsafe

Avoid consuming alcohol while on treatment with Cfara 20 mg Injection 20 ml as it may cause severe side effects.

bannner image

Pregnancy

Unsafe

Cfara 20 mg Injection 20 ml is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are under 21 and pregnant or planning pregnancy, inform your doctor before receiving Cfara 20 mg Injection 20 ml. You should not become pregnant while you are taking Cfara 20 mg Injection 20 ml. Using effective birth control methods while on treatment is suggested.

bannner image

Breast Feeding

Unsafe

There are no data on the presence of clofarabine in human milk, its effects on breastfed children, or its impact on milk supply; due to the possibility of serious adverse events in breastfed children, including genotoxicity, patients are advised not to breastfeed during therapy and for at least two weeks following the final dosage.

bannner image

Driving

Not applicable

Cfara 20 mg Injection 20 ml is administered to hospitalized patients.

bannner image

Liver

Caution

Cfara 20 mg Injection 20 ml has not been studied in patients with liver impairment. However, inform your doctor if you have liver problems.

bannner image

Kidney

Caution

If you have a history of kidney disease or have a pre-existing condition, notify your doctor before getting Cfara 20 mg Injection 20 ml. Based on your situation, your doctor may adjust the dose of this medication or prescribe a suitable alternative. Cfara 20 mg Injection 20 ml has the potential to cause renal toxicity, which presents as high creatinine levels and sudden renal failure. Monitor renal function and adjust or discontinue Clolar as needed.

bannner image

Children

Safe if prescribed

Cfara 20 mg Injection 20 ml is recommended for children and adolescents below 21 years of age only if prescribed by the oncologist.

Have a query?

FAQs

Cfara 20 mg Injection 20 ml is used to treat Acute lymphocytic leukemia (ALL).

Cfara 20 mg Injection 20 ml contains Clofarabine, which works by inhibiting the DNA transcription that is essential for cancer cell growth. This helps prevent the growth and further spread of cancerous or non-cancerous cells.

Cfara 20 mg Injection 20 ml is used only in children and adolescents 1-21 years. It is not recommended for adults.

Treatment with Cfara 20 mg Injection 20 ml may result in cerebral, gastric, and pulmonary hemorrhage that is severe and fatal. Keep track of platelets and coagulation parameters and treat as needed.

The common side effects of Cfara 20 mg Injection 20 ml include skin rash, fatigue, headache, decreased platelet count, nausea, vomiting, diarrhoea, fever, anxiety, flushing, and injection site reactions. These side effects do not require medical attention and gradually resolve over time. However, if they persist or worsen, please consult your doctor.

Call your doctor immediately if you notice any signs of an allergic reaction, like a rash, swelling of your face or throat, or difficulty breathing. Also, contact your doctor if you develop a fever, unusual bleeding or bruising, signs of infection, or any other side effects. Always inform your doctor about any new or concerning symptoms during your treatment to ensure prompt care.

Although liver damage from Cfara 20 mg Injection 20 ml is rare, serious liver problems such as hepatitis (inflammation of the liver) and liver failure have been reported. Your doctor will monitor your liver function during treatment and watch for signs such as yellowing of the skin or eyes (jaundice). Your doctor may stop the therapy if liver enzyme or bilirubin levels increase. Be sure to inform your doctor if you have any pre-existing liver problems before starting Cfara 20 mg Injection 20 ml, as they may conduct additional tests and adjust your treatment if needed.

Yes, nausea and extreme tiredness (fatigue) are common side effects of Cfara 20 mg Injection 20 ml. If these symptoms persist or become severe, please tell your doctor. Your doctor may adjust your treatment, provide medication to help with these symptoms or suggest lifestyle changes.

If you experience diarrhoea while receiving Cfara 20 mg Injection 20 ml, it is important to stay hydrated by drinking plenty of fluids daily, such as water or oral rehydration solutions. However, if the diarrhoea becomes severe or continues, you should inform your doctor immediately. Your doctor may adjust your treatment plan or recommend additional treatments to help manage this side effect.

Some individuals may experience skin changes such as a rash, peeling, lesions, or blisters after taking Cfara 20 mg Injection 20 ml. If you notice any skin changes, contact your doctor right away. They will help determine the cause and recommend the best course of action.

Yes, feeling a slight warmth (flushing) in your face, ears, or neck is a common side effect after receiving Cfara 20 mg Injection 20 ml. This is temporary and usually goes away shortly after the treatment is stopped. However, if it becomes uncomfortable or you notice anything unusual, contact your doctor immediately for guidance.

You should avoid fast food, fried foods, processed meats, refined carbs, and added sugars while taking Cfara 20 mg Injection 20 ml. It is also important to avoid alcohol, as it may cause severe side effects when combined with the treatment.

During your treatment with Cfara 20 mg Injection 20 ml, you should avoid alcohol, as it may increase the risk of severe side effects. It is also recommended to avoid becoming pregnant, as Cfara 20 mg Injection 20 ml can harm an unborn baby. If you are breastfeeding, you should stop breastfeeding during treatment and for at least two weeks after the last dose, as it could harm your child. Always follow your doctor’s advice regarding other medications, herbal supplements, or vaccines that should be avoided while receiving Cfara 20 mg Injection 20 ml.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad 380015 Gujarat, India.
Other Info - CFA0006

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:22 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://medlineplus.gov/druginfo/meds/a607012.html
  2. https://reference.medscape.com/drug/clolar-clofarabine-342196
  3. https://www.mayoclinic.org/drugs-supplements/clofarabine-intravenous-route/description/drg-20063034
  4. https://www.oncolink.org/cancer-treatment/oncolink-rx/clofarabine-clolar-r
  5. https://www.pediatriconcall.com/drugs/clofarabine/118
  6. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021673s024lbl.pdf

Buy best Neoplastic Disorders products by

whatsapp Floating Button