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Clofalon 20mg Injection used to treat acute lymphoblastic leukemia (ALL). It contains Clofarabine, which works by inhibiting the DNA polymerase enzyme that is responsible for DNA elongation, synthesis, and repair. In general, it inhibits the production of genetic material (DNA) in the cancer cells that are essential for cell growth, repair and multiplication. Thus, it stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes the death of cells.
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About Clofalon 20mg Injection
Clofalon 20mg Injection is an anti-cancer medicine used in pediatric patients aged 1 - 21 years for the treatment of acute lymphoblastic leukaemia, a blood cancer that primarily affects the blood and bone marrow. Clofalon 20mg Injection is used in patients with relapsed or refractory acute lymphoblastic leukaemia (ALL) after receiving at least two prior therapies.
Clofalon 20mg Injection contains Clofarabine as an active ingredient in the class of antimetabolites. It works by inhibiting the DNA polymerase enzyme responsible for DNA elongation, synthesis, and repair.
Clofalon 20mg Injection may cause certain side effects, such as skin rash, fatigue, headache, decreased platelet count, nausea, vomiting, diarrhoea, fever, anxiety, flushing, and injection site reactions. These side effects do not require medical attention and gradually resolve over time. A trained oncologist will administer Clofalon 20mg Injection. Do not self-administer.
Clofalon 20mg Injection should be avoided if you are allergic to it or any other components present in it. It should be used with caution in patients with a pre-existing or history of liver/kidney disease, gastrointestinal disorders, skin problems, and bleeding disorders, as it may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. It is not recommended for use in pregnancy or breastfeeding.
Uses of Clofalon 20mg Injection
Directions for Use
Medicinal Benefits
Clofalon 20mg Injection contains Clofarabine, which is used in the treatment of acute lymphoblastic leukemia (ALL). It works by inhibiting the DNA polymerase enzyme that is responsible for DNA elongation, synthesis, and repair. In general, it inhibits the production of genetic material (DNA) in the cancer cells that are essential for cell growth, repair and multiplication. Thus, Clofalon 20mg Injection stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes the death of cells.
How Clofalon 20mg Injection Works
Storage
What if I have taken an overdose of Clofalon 20mg Injection
Drug Warnings
Clofalon 20mg Injection should be avoided if you are allergic to it or any other components present in it. Before receiving, if the child has/had any history of liver/kidney disease, gastrointestinal disorders, skin problems, and bleeding disorders, as it may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Clofalon 20mg Injection is given in children above one year of age only if prescribed by the doctor. Clofalon 20mg Injection may cause myelosuppression, QT prolongation, hepatotoxicity, renal toxicity, cerebral, gastrointestinal and pulmonary haemorrhage, Tumor Lysis syndrome, severe infections, Systemic Inflammatory Response Syndrome (SIRS), enterocolitis, and skin reactions in some patients. Hence, inform your doctor about your complete medical and medication history before receiving this medicine.
Diet & Lifestyle Advise
Habit Forming
Therapeutic Class
Product Substitutes
Alcohol
Unsafe
Avoid consuming alcohol while on treatment with Clofalon 20mg Injection as it may cause severe side effects.
Pregnancy
Unsafe
Clofalon 20mg Injection is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are under 21 and pregnant or planning pregnancy, inform your doctor before receiving Clofalon 20mg Injection. You should not become pregnant while you are taking Clofalon 20mg Injection. Using effective birth control methods while on treatment is suggested.
Breast Feeding
Unsafe
There are no data on the presence of clofarabine in human milk, its effects on breastfed children, or its impact on milk supply; due to the possibility of serious adverse events in breastfed children, including genotoxicity, patients are advised not to breastfeed during therapy and for at least two weeks following the final dosage.
Driving
Not applicable
Clofalon 20mg Injection is administered to hospitalized patients.
Liver
Caution
Clofalon 20mg Injection has not been studied in patients with liver impairment. However, inform your doctor if you have liver problems.
Kidney
Caution
If you have a history of kidney disease or have a pre-existing condition, notify your doctor before getting Clofalon 20mg Injection. Based on your situation, your doctor may adjust the dose of this medication or prescribe a suitable alternative. Clofalon 20mg Injection has the potential to cause renal toxicity, which presents as high creatinine levels and sudden renal failure. Monitor renal function and adjust or discontinue Clolar as needed.
Children
Safe if prescribed
Clofalon 20mg Injection is recommended for children and adolescents below 21 years of age only if prescribed by the oncologist.
Have a query?
Clofalon 20mg Injection is used to treat Acute lymphocytic leukemia (ALL).
Clofalon 20mg Injection contains Clofarabine, which works by inhibiting the DNA transcription that is essential for cancer cell growth. This helps prevent the growth and further spread of cancerous or non-cancerous cells.
Clofalon 20mg Injection is used only in children and adolescents 1-21 years. It is not recommended for adults.
Treatment with Clofalon 20mg Injection may result in cerebral, gastric, and pulmonary hemorrhage that is severe and fatal. Keep track of platelets and coagulation parameters and treat as needed.
The common side effects of Clofalon 20mg Injection include skin rash, fatigue, headache, decreased platelet count, nausea, vomiting, diarrhoea, fever, anxiety, flushing, and injection site reactions. These side effects do not require medical attention and gradually resolve over time. However, if they persist or worsen, please consult your doctor.
Call your doctor immediately if you notice any signs of an allergic reaction, like a rash, swelling of your face or throat, or difficulty breathing. Also, contact your doctor if you develop a fever, unusual bleeding or bruising, signs of infection, or any other side effects. Always inform your doctor about any new or concerning symptoms during your treatment to ensure prompt care.
Although liver damage from Clofalon 20mg Injection is rare, serious liver problems such as hepatitis (inflammation of the liver) and liver failure have been reported. Your doctor will monitor your liver function during treatment and watch for signs such as yellowing of the skin or eyes (jaundice). Your doctor may stop the therapy if liver enzyme or bilirubin levels increase. Be sure to inform your doctor if you have any pre-existing liver problems before starting Clofalon 20mg Injection, as they may conduct additional tests and adjust your treatment if needed.
Yes, nausea and extreme tiredness (fatigue) are common side effects of Clofalon 20mg Injection. If these symptoms persist or become severe, please tell your doctor. Your doctor may adjust your treatment, provide medication to help with these symptoms or suggest lifestyle changes.
If you experience diarrhoea while receiving Clofalon 20mg Injection, it is important to stay hydrated by drinking plenty of fluids daily, such as water or oral rehydration solutions. However, if the diarrhoea becomes severe or continues, you should inform your doctor immediately. Your doctor may adjust your treatment plan or recommend additional treatments to help manage this side effect.
Some individuals may experience skin changes such as a rash, peeling, lesions, or blisters after taking Clofalon 20mg Injection. If you notice any skin changes, contact your doctor right away. They will help determine the cause and recommend the best course of action.
Yes, feeling a slight warmth (flushing) in your face, ears, or neck is a common side effect after receiving Clofalon 20mg Injection. This is temporary and usually goes away shortly after the treatment is stopped. However, if it becomes uncomfortable or you notice anything unusual, contact your doctor immediately for guidance.
You should avoid fast food, fried foods, processed meats, refined carbs, and added sugars while taking Clofalon 20mg Injection. It is also important to avoid alcohol, as it may cause severe side effects when combined with the treatment.
During your treatment with Clofalon 20mg Injection, you should avoid alcohol, as it may increase the risk of severe side effects. It is also recommended to avoid becoming pregnant, as Clofalon 20mg Injection can harm an unborn baby. If you are breastfeeding, you should stop breastfeeding during treatment and for at least two weeks after the last dose, as it could harm your child. Always follow your doctor’s advice regarding other medications, herbal supplements, or vaccines that should be avoided while receiving Clofalon 20mg Injection.
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