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compositionComposition:CISPLATIN-1MG
prescription
Prescription Medicine
info
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Ciszest 50Mg/50Ml Inj is used for the treatment of tumours of the ovary, testis, bladder, neck and head epithelial tumour, lung cancer, and cervical cancer. Ciszest 50Mg/50Ml Inj contains Cisplatin, which works by preventing the growth of cancer cells and eventually destroying them. Thereby, it helps treat cancer. In some cases, Ciszest 50Mg/50Ml Inj may cause side effects such as nausea, vomiting, tiredness, hair loss, pain or redness at the site of injection.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CISPLATIN-1MG

Manufacturer/Marketer :

Zee Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Ciszest 50Mg/50Ml Inj

Ciszest 50Mg/50Ml Inj is an injectable prescription medicine used to treat advanced cancers of the bladder, ovaries, and testicles. It is a chemotherapy treatment that helps stop cancer cells from growing and multiplying in the body. Doctors typically prescribe it when these types of cancer have spread or have not responded well to other therapies.

This medicine is given as an injection directly into a vein, usually in treatment cycles that take place every three to four weeks. Because it is injected directly into your bloodstream, you do not need to worry about food affecting how well it is absorbed. However, staying highly hydrated before, during, and after your treatment is one of the most important steps you can take to help protect your body during therapy.

While this medicine is highly effective, it can cause common side effects like severe nausea, vomiting, and a temporary loss of appetite. It is important to watch for more serious symptoms, such as ringing in your ears or a sudden decrease in how much you urinate. If you notice any of these serious signs, you must contact your doctor right away.

Before you begin treatment, you should talk to your doctor if you have a history of kidney disease, hearing difficulties, or low blood cell counts. Do not take this medicine if you have severe kidney problems, pre-existing hearing loss, or severely weakened bone marrow activity.

This medication can interact with certain strong antibiotics and water pills, which can increase the risk of kidney and hearing damage. It is also important to talk to your doctor if you drink alcohol or smoke, as these habits can worsen nausea and dehydration. Pregnant or breastfeeding individuals must not receive this medicine, and elderly patients may require closer monitoring by their healthcare team.

Uses of Ciszest 50Mg/50Ml Inj

Ciszest 50Mg/50Ml Inj is used to treat advanced cancers of the bladder, ovaries, and testicles. The detailed uses of Ciszest 50Mg/50Ml Inj are as follows:

  • Testicular cancer: Helps treat advanced cancers of the testicles, often working alongside other medicines to stop cancer cells from multiplying.
  • Ovarian cancer: Helps manage advanced ovarian cancer that has spread, aiding in shrinking tumours and slowing down the progress of the disease.
  • Bladder cancer: Helps treat advanced bladder cancer when local treatments are no longer effective.

Key Benefits

Ciszest 50Mg/50Ml Inj helps treat certain types of cancer by slowing or stopping the growth of rapidly dividing cancer cells. With regular use as prescribed, it helps control disease progression, reduce tumour-related symptoms, and support better treatment outcomes.

  • Helps Control Cancer Growth: By interfering with the division of rapidly growing cancer cells, this medicine helps shrink tumours and slow the progression of the disease.
  • Relieves Cancer-Related Symptoms: As tumour growth is controlled, this medicine may help reduce pain, pressure, and discomfort caused by advanced cancers, improving daily comfort.
  • Supports Long-Term Disease Management: By helping prevent the spread of cancer to other parts of the body, this medicine supports ongoing cancer control, improves quality of life, and contributes to better overall treatment outcomes.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Ciszest 50Mg/50Ml Inj will be administered in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents.
  • Do not self-administer.

How Ciszest 50Mg/50Ml Inj Works

Ciszest 50Mg/50Ml Inj contains cisplatin, which is an anticancer medicine that targets the genetic material, or DNA, inside cancer cells. Once injected into the bloodstream, it travels throughout the body and enters the cancer cells. Inside these cells, it binds to the DNA, creating abnormal cross-links that damage the genetic structure. This structural damage prevents the cancer cells from copying their DNA and dividing. Because cancer cells grow and multiply much faster than normal healthy cells, they are highly sensitive to this action. When the cancer cells are unable to divide, they trigger a natural cell death process, which helps stop the tumour from growing.
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Alcohol

Consult your doctor

It is not known if alcohol affects Ciszest 50Mg/50Ml Inj. Please consult your doctor.

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Pregnancy

Unsafe

Cisplatin belongs to pregnancy category D. Ciszest 50Mg/50Ml Inj may cause foetal harm. Therefore, it should not be used during pregnancy.

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Breast Feeding

Unsafe

Cisplatin has been reported to be found in human milk. Breastfeeding is not recommended during treatment and for four weeks after the treatment with Ciszest 50Mg/50Ml Inj.

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Driving

Caution

Ciszest 50Mg/50Ml Inj may cause dizziness and tiredness. Avoid driving if you experience any side effects that might lessen your ability to do so.

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Liver

Consult your doctor

If you have a history of liver disease, inform your doctor before receiving Ciszest 50Mg/50Ml Inj.

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Kidney

Caution

Ciszest 50Mg/50Ml Inj should not be used if you have severe kidney disease or pre-existing renal impairment. If you have a history of kidney disease, inform your doctor before receiving Ciszest 50Mg/50Ml Inj.

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Children

Caution

Ciszest 50Mg/50Ml Inj is not recommended for children as safety and effectiveness have not been established.

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Heart

Caution

Ciszest 50Mg/50Ml Inj should be used with caution and under medical supervision in patients with heart problems. Therefore, please consult your doctor before using Ciszest 50Mg/50Ml Inj.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Ciszest 50Mg/50Ml Inj to geriatric patients. Your doctor will prescribe Ciszest 50Mg/50Ml Inj if the benefits outweigh the risks.

What if I have taken an overdose of Ciszest 50Mg/50Ml Inj

Because healthcare professionals prepare and inject this medicine, an overdose is highly unlikely. However, if you suspect an error or experience severe, sudden symptoms after your infusion, tell your healthcare team or seek emergency medical attention right away.

Diet & Lifestyle Advise

  • Drink plenty of fluids: Drink at least 8 to 12 cups of water or clear broths daily, especially in the days surrounding your treatment, to help flush your kidneys and protect them from damage.
  • Eat small, frequent meals: To manage nausea, try eating five or six small meals throughout the day instead of three large ones. Stick to dry, bland foods like toast, crackers, or rice.
  • Avoid infections: Wash your hands frequently, avoid crowds, and stay away from people who are sick, as this medicine can temporarily lower your white blood cell count.
  • Practice gentle mouth care: Use a soft-bristled toothbrush and rinse your mouth with water or a mild baking soda solution to help prevent painful mouth sores.
  • Protect your ears: Avoid very loud environments and wear ear protection when necessary, as your ears may be more sensitive to damage during therapy.
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How Soon It Starts Working

The time required for Ciszest 50Mg/50Ml Inj to start to work: The time required for Ciszest 50Mg/50Ml Inj to show its action is not clinically established. The time for which the effects of Ciszest 50Mg/50Ml Inj last: The duration of action for Ciszest 50Mg/50Ml Inj is not clinically established.

What if you forget to take Ciszest 50Mg/50Ml Inj

Since this medication is given on a strict clinical schedule, missing an appointment is rare. If you miss a scheduled infusion session, contact your doctor or clinic immediately to reschedule your treatment as soon as possible.

Storage

• In the clinic or hospital setting, Ciszest 50Mg/50Ml Inj is stored at a controlled room temperature between 15°C to 25°C (59°F to 77°F).

Drug Warnings

  • Check the solution before your infusion; it should be clear, colourless, and free of any visible floating particles.
  • Tell your nurse immediately if you feel any burning, stinging, coldness, or pain around the injection site while the medicine is being injected.
  • Keep all your scheduled appointments for blood tests and hearing checks, as your doctor needs these to monitor your kidneys, blood counts, and hearing.
  • Use reliable birth control during your treatment and for several months afterwards, as this medicine can cause severe harm to an unborn baby.
  • Do not get any live vaccines while receiving this medicine without talking to your doctor first.
     

Drug-Drug Interactions

verifiedApollotooltip

  • Strong antibiotics (like gentamicin): May increase the risk of severe kidney damage and hearing loss.
    Water pills (like furosemide): Can increase the risk of hearing damage when used at the same time as this medication.
CisplatinTofacitinib
Severe
CisplatinBaricitinib
Severe

Drug-Drug Interactions

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CisplatinTofacitinib
Severe
How does the drug interact with Ciszest 50Mg/50Ml Inj:
Taking Tofacitinib with Ciszest 50Mg/50Ml Inj may increase the risk of serious infection.

How to manage the interaction:
Although there is a possible interaction between Tofacitinib and Ciszest 50Mg/50Ml Inj, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
CisplatinBaricitinib
Severe
How does the drug interact with Ciszest 50Mg/50Ml Inj:
Coadministration of Ciszest 50Mg/50Ml Inj with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Baricitinib and Ciszest 50Mg/50Ml Inj together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CisplatinSirolimus
Severe
How does the drug interact with Ciszest 50Mg/50Ml Inj:
Co-administration of Ciszest 50Mg/50Ml Inj with Sirolimus can increase the risk or severity of kidney damage.

How to manage the interaction:
Although taking Sirolimus and Ciszest 50Mg/50Ml Inj together can evidently cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
CisplatinEtanercept
Severe
How does the drug interact with Ciszest 50Mg/50Ml Inj:
When Etanercept is used with Ciszest 50Mg/50Ml Inj, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Etanercept and Ciszest 50Mg/50Ml Inj, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
CisplatinTacrolimus
Severe
How does the drug interact with Ciszest 50Mg/50Ml Inj:
Taking tacrolimus with Ciszest 50Mg/50Ml Inj can increase the risk of kidney problems.

How to manage the interaction:
Although taking tacrolimus and Ciszest 50Mg/50Ml Inj together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
CisplatinZiprasidone
Severe
How does the drug interact with Ciszest 50Mg/50Ml Inj:
Using Ciszest 50Mg/50Ml Inj with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Ciszest 50Mg/50Ml Inj and Ziprasidone together can evidently cause an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, dizziness, nausea, or vomiting. Do not discontinue any medications without consulting a doctor.
CisplatinCidofovir
Severe
How does the drug interact with Ciszest 50Mg/50Ml Inj:
Taking cidofovir and Ciszest 50Mg/50Ml Inj can increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Ciszest 50Mg/50Ml Inj and cidofovir, you can take these medicines together if prescribed by your doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Before beginning cidofovir medication, you might need to wait at least seven days if you have been receiving Ciszest 50Mg/50Ml Inj. Do not discontinue any medications without consulting a doctor
CisplatinClozapine
Severe
How does the drug interact with Ciszest 50Mg/50Ml Inj:
Combining Ciszest 50Mg/50Ml Inj with Clozapine can increase the risk of neutropenia (Infection).

How to manage the interaction:
Although there is a possible interaction between Ciszest 50Mg/50Ml Inj and Clozapine, you can take these medicines together if prescribed by your doctor. If you experience symptoms such as infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain during urination, contact your doctor immediately." Do not discontinue any medications without first consulting your doctor.
CisplatinCladribine
Severe
How does the drug interact with Ciszest 50Mg/50Ml Inj:
The combined use of cladribine with Ciszest 50Mg/50Ml Inj can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladribine with Ciszest 50Mg/50Ml Inj together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CisplatinTenofovir alafenamide
Severe
How does the drug interact with Ciszest 50Mg/50Ml Inj:
The combined use of Ciszest 50Mg/50Ml Inj and Tenofovir alafenamide can increase the risk of kidney problems.

How to manage the interaction:
Taking Ciszest 50Mg/50Ml Inj and Tenofovir alafenamide together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Ciszest 50Mg/50Ml Inj when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

You should consult your doctor before receiving any vaccines while being treated with Ciszest 50Mg/50Ml Inj. Live vaccines are generally avoided because this medicine may weaken your immune system and increase the risk of infection. Your doctor will advise which vaccines are safe and when they should be given.
Yes. Ciszest 50Mg/50Ml Inj can cause hearing problems, including ringing in the ears (tinnitus) and hearing loss, which may sometimes be permanent. Inform your doctor if you already have hearing problems before starting treatment. Your doctor may perform hearing tests before and during treatment and adjust therapy if necessary. Contact your doctor immediately if you notice changes in your hearing.
Yes. Hair thinning or hair loss is a common side effect of Ciszest 50Mg/50Ml Inj. It is usually temporary, and hair generally grows back after treatment ends. Be gentle when brushing and washing your hair, and speak with your healthcare team if you have concerns or would like advice on managing hair loss.
This medicine is given as a slow drip into a vein (an intravenous infusion) by a healthcare professional in a hospital or clinic. Talk to your doctor if you have questions about the infusion process.
Staying deeply hydrated helps flush the medicine through your kidneys, which is critical for protecting them from damage. Talk to your doctor about exactly how much water you should drink.
Tell your nurse or doctor immediately if you feel pain, burning, coldness, or swelling around the needle. Talk to your doctor or nurse right away if this occurs.
No, this medicine can harm an unborn baby and must not be used during pregnancy. Talk to your doctor about effective birth control options during your treatment.
It is typically given in treatment cycles, often once every 3 to 4 weeks, to allow your body time to rest and recover between sessions. Talk to your doctor about your specific treatment schedule.

Disclaimer

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.3788 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 018057S080Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. MedlinePlus. A684036 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  4. Cisplatin 1 mg/ml Sterile Concentrate - Latex free vial stopper - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 30 Dec 2025]Check here
  5. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 27 Mar. 2019]Check here
  6. Chaves RG, Lamounier JA Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198Check here

Country of origin

India

Manufacturer/Marketer address

Uchani, G.T. Road, Karnal-132001 Haryana (India).
Other Info - CIS0116
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