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Composition :

CLOMIPRAMINE-75MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Clofranil SR Tablet

Clofranil SR Tablet belongs to a class of drugs called 'antidepressants' used to treat obsessive-compulsive disorder (OCD), depression, panic and anxiety disorder. OCD is a mental disorder with symptoms such as excessive thoughts or ideas (obsessions), leading to repetitive behaviours (compulsions). Depression is a mood disorder associated with symptoms such as sadness and the inability to sleep properly or enjoy life as you used to do. Panic or anxiety disorder is linked to anxiety with sudden feelings of unnecessary fear or worries even when there is no danger in reality.

Clofranil SR Tablet contains Clomipramine, which works by increasing the activity of serotonin and noradrenaline (chemical messengers) in the brain, which is involved in regulating mood, behaviour, and emotions. Thereby, Clofranil SR Tablet helps relieve depression, lighten the mood and relieve anxiety symptoms such as fear and panic.

Take Clofranil SR Tablet with food as prescribed by your doctor and swallow whole with a glass of water. Do not break, crush or chew it. Your doctor will advise you how often you take Clofranil SR Tablet based on your medical condition. Some people may experience dizziness, headache, drowsiness, dry mouth, nausea, weight gain, increased sweating, constipation, shaking, blurred vision, erectile dysfunction or difficulty in urination. Most of these side effects of Clofranil SR Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Clofranil SR Tablet or any other medicines, please tell your doctor. Clofranil SR Tablet is not recommended for children below 17 years of age. Avoid taking Clofranil SR Tablet if you are pregnant, as it may cause harm to the foetus. Avoid breastfeeding while taking Clofranil SR Tablet as it may be excreted in human milk and cause adverse effects in the baby. If you have any self-harming or suicidal thoughts before taking Clofranil SR Tablet , inform your doctor as they may worsen in the initial days of taking Clofranil SR Tablet .

Uses of Clofranil SR Tablet

Clofranil SR Tablet is used in the treatment of Obsessive-Compulsive Disorder (OCD), Depression, Panic Disorder, and Anxiety Disorder. The detailed uses of Clofranil SR Tablet are as follows:

  • Manages Obsessive-Compulsive Disorder (OCD): Clofranil SR Tablet helps to reduce persistent unwanted thoughts (obsessions) and repetitive behaviors (compulsions) by restoring chemical balance in the brain.
  • Treats Depression: Clofranil SR Tablet improves mood, energy, and motivation by increasing levels of serotonin and norepinephrine in the brain.
  • Controls Panic Disorder: Clofranil SR Tablet can reduce sudden episodes of intense fear, palpitations, and shortness of breath associated with panic disorder.
  • Relieves Anxiety Symptoms: Clofranil SR Tablet helps to manage both physical and psychological symptoms of anxiety, such as nervousness, restlessness, and excessive worry.

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Directions for Use

  • Take Clofranil SR Tablet with food to reduce gastrointestinal side effects or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

Clofranil SR Tablet contains Clomipramine, an antidepressant used to treat obsessive-compulsive disorder (OCD), depression, and panic disorder. Clofranil SR Tablet increases the activity of serotonin and noradrenaline (chemical messengers) in the brain, which is involved in regulating mood, behaviour, and emotions. Thereby, Clofranil SR Tablet helps in relieving depression, lightening the mood and relieving anxiety symptoms such as fear and panic. Clofranil SR Tablet , in combination with other medicines, may be used to treat cataplexy (a disorder that causes muscle weakness), which usually affects people suffering from narcolepsy (uncontrollable sleepiness during daytime).

How Clofranil SR Tablet Works

Clofranil SR Tablet contains Clomipramine, which works by increasing the activity of serotonin and noradrenaline (chemical messengers) in the brain, which is involved in regulating mood, behaviour, and emotions. Thereby, Clofranil SR Tablet helps relieve depression, lighten the mood and relieve anxiety symptoms such as fear and panic.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Clofranil SR Tablet
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

What if I have taken an overdose of Clofranil SR Tablet

Do not take more than the prescribed dose of Clofranil SR Tablet as it may cause overdose. The symptoms of overdose include irregular heartbeats, low blood pressure, fits, drowsiness, muscle stiffness, restlessness, sweating, shortness of breath, dilated pupil or a decrease or absence of urine production. Severe overdose may lead to coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

If you are allergic to Clofranil SR Tablet or any other medicines, please tell your doctor. Clofranil SR Tablet is not recommended for children below 17 years of age. Avoid taking Clofranil SR Tablet if you are pregnant as it may cause harm to the fetus. Avoid breastfeeding while taking Clofranil SR Tablet as Clofranil SR Tablet may be excreted in human milk and cause adverse effects in the baby. Therefore, please consult a doctor if you are pregnant, planning for pregnancy, or breastfeeding. Clofranil SR Tablet should be used with caution in elderly patients as there is an increased risk of low sodium levels in the blood.  If you have any self-harming or suicidal thoughts before taking Clofranil SR Tablet , inform your doctor as they may worsen in the initial days of taking Clofranil SR Tablet . Do not take Clofranil SR Tablet with monoamine oxidase inhibitors (MAOIs) such as moclobemide, tranylcypromine and phenelzine used to treat depression as it may cause severe adverse effects. Also, avoid taking Clofranil SR Tablet with buprenorphine as it may cause a serious life-threatening condition. If you have fits, low blood pressure, mania, glaucoma, difficulty in urination, a blood disorder, hyperthyroidism (overactive thyroid gland), severe constipation, pheochromocytoma (tumor of the adrenal gland), low potassium levels in blood, kidney, liver, or heart problems, inform your doctor before taking Clofranil SR Tablet .

Drug-Drug Interactions

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ClomipramineIsocarboxazid
Critical

Drug-Drug Interactions

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ClomipramineIsocarboxazid
Critical
How does the drug interact with Clofranil SR Tablet:
When Clofranil SR Tablet is taken with Isocarboxazid, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Clofranil SR Tablet and Isocarboxazid, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-contact a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Clofranil SR Tablet:
When Clofranil SR Tablet is taken with Furazolidone, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Clofranil SR Tablet and Furazolidone, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-call a doctor right away. Do not stop using any medications without a doctor's advice.
ClomipramineHalofantrine
Critical
How does the drug interact with Clofranil SR Tablet:
When Clofranil SR Tablet is taken with Halofantrine, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Clofranil SR Tablet and Halofantrine, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
ClomipramineMesoridazine
Critical
How does the drug interact with Clofranil SR Tablet:
When Clofranil SR Tablet is taken with Mesoridazine, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Clofranil SR Tablet and Mesoridazine, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, contact a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Clofranil SR Tablet:
Coadministration of Clofranil SR Tablet with Ziprasidone can increase the risk of irregular heat rhythm.

How to manage the interaction:
Taking Clofranil SR Tablet with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
ClomipraminePhenelzine
Critical
How does the drug interact with Clofranil SR Tablet:
When Clofranil SR Tablet is taken with Phenelzine, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Clofranil SR Tablet and Phenelzine, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-call a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Clofranil SR Tablet:
When Clofranil SR Tablet is taken with Bepridil, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Clofranil SR Tablet and Cisapride, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, contact a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Clofranil SR Tablet:
When Clofranil SR Tablet is taken with Dronedarone, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Clofranil SR Tablet and Dronedarone, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Clofranil SR Tablet:
Co-administration of Selegiline can increase the effects of Clofranil SR Tablet on serotonin levels (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Selegiline with Clofranil SR Tablet together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Clofranil SR Tablet:
When Clofranil SR Tablet is taken with Linezolid, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Clofranil SR Tablet and Linezolid, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-contact a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a diet rich in fruits, vegetables, and whole grains. Avoid fried foods, high-fat dairy products, pastries, and processed foods as they may worsen anxiety. Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables, and olive oils.

  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in proper maintenance of neurotransmitters.

  • Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges, and pears.

  • Exercising helps in the production of the body’s natural antidepressants. It also helps in relieving stress, improving mood, boosting self-esteem, and providing restful sleep.

  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.

  • Regularly attend therapy sessions.

  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIDEPRESSANT
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Alcohol

Unsafe

Avoid consumption of alcohol with Clofranil SR Tablet as it may increase the risk of adverse effects such as drowsiness, blurred vision, or confusion.

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Pregnancy

Unsafe

Clofranil SR Tablet is a Category C pregnancy drug and is not recommended for use during pregnancy as it may cause harm to the unborn baby. Therefore, please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Clofranil SR Tablet as Clofranil SR Tablet may be excreted in human milk and cause adverse effects in the baby. Therefore, please consult a doctor if you are a breastfeeding mother.

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Driving

Unsafe

Clofranil SR Tablet may cause dizziness, tiredness, confusion, difficulty in concentrating or blurred vision. Therefore, avoid driving if you experience any of these symptoms after taking Clofranil SR Tablet .

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Liver

Caution

Take Clofranil SR Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

If you have any concerns regarding the use of Clofranil SR Tablet in patients with kidney problems, please consult a doctor.

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Children

Unsafe

Clofranil SR Tablet is not recommended for children below 17 years of age, as the safety and effectiveness were not established. Please consult a doctor before using Clofranil SR Tablet .

FAQs

Clofranil SR Tablet is used to treat obsessive-compulsive disorder (OCD), depression, panic and anxiety disorder.

Clofranil SR Tablet contains Clomipramine that works by increasing the activity of serotonin and noradrenaline (chemical messengers) in the brain that are involved in regulating mood, behavior, and emotions. Thereby, Clofranil SR Tablet helps in relieving depression, lighten the mood and relieve anxiety symptoms such as fear and panic.

Yes, Clofranil SR Tablet may be used to treat panic disorder by reducing fear. However, please consult a doctor before using Clofranil SR Tablet .

You are not recommended to take Clofranil SR Tablet with buprenorphine as co-administration of these medicines may lead to a severe condition called ‘serotonin syndrome’ and cause symptoms such as blurred vision, stomach cramps, fits, diarrhea, hallucination, extreme changes in blood pressure, confusion, excessive sweating, increased heart rate, fever, shivering or shaking, tremor, incoordination, muscle spasm or stiffness. However, please consult a doctor before taking Clofranil SR Tablet with other medicines.

Yes, Clofranil SR Tablet may cause self-harming or suicidal thoughts especially in patients aged less than 25 years or who have a history of self-harming thoughts. Therefore, please consult a doctor immediately if you experience any such thoughts while taking Clofranil SR Tablet .

Clofranil SR Tablet may cause impotence (inability to maintain an erection) in males and may decrease sexual desire (libido) in both men and women. However, if you experience any such problems while taking Clofranil SR Tablet , please consult a doctor immediately.

It takes about 2 weeks or longer usually for Clofranil SR Tablet to work. However, it is recommended to use Clofranil SR Tablet for as long as your doctor has prescribed it for you.

Yes, Clofranil SR Tablet may cause weight gain due to an increase in the appetite. Regular exercise and a healthy diet are recommended while taking Clofranil SR Tablet to maintain proper body weight. However, if you notice any major changes in weight, please consult a doctor.

Yes, Clofranil SR Tablet is safe if used as prescribed by your doctor. Do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects persist or worsen.

Clofranil SR Tablet may cause side effects such as drowsiness, dizziness, constipation, erectile dysfunction, difficulty in urination, and dry mouth. If these side effects persist or worsen, please consult your doctor.

If you take an overdose of Clofranil SR Tablet , you may experience symptoms such as irregular heartbeats, low blood pressure, fits, drowsiness, muscle stiffness, restlessness, sweating, shortness of breath, dilated pupil or a decrease or absence of urine production. Severe overdose may lead to coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

No, do not stop taking Clofranil SR Tablet without consulting your doctor as discontinuing suddenly may worsen your condition and also cause withdrawal symptoms such as vomiting, nausea, dizziness, headache, weakness, fever, sleep problems, and irritability. Therefore, take Clofranil SR Tablet for duration advised by your doctor for best results. If you any of these side effects are bothering you, contact your doctor.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - CLO0122

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