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Closol-CZ Cream is used to treat fungal skin infections. It works by killing infection-causing fungi and inhibiting the release of certain chemical messengers in the body that cause redness, itching, and swelling. In some cases, this medicine may cause side effects such as dry skin, itching, irritation, redness, or burning sensation at the application site. It is for external use only.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CLOBETASOL-0.05%W/W+MICONAZOLE-2%W/W+ZINC SULFATE-2.5%W/W

Manufacturer/Marketer :

Dan Laboratories

Consume Type :

Topical

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Closol-CZ Cream

Closol-CZ Cream is a prescription-strength topical cream used to treat inflamed skin infections that are complicated by fungal growth. It is commonly prescribed for skin conditions like severe eczema, dermatitis, or other inflammatory skin issues where a fungal infection is also present. This medication works by clearing the fungal infection while rapidly calming down local swelling, redness, and intense itching.

For best results, apply Closol-CZ Cream consistently and exactly as directed by your doctor, usually once or twice daily. Make sure to clean and dry the affected area thoroughly before application. Keeping the skin dry, cool, and well-ventilated during treatment will help support your recovery.

While using Closol-CZ Cream, you may notice mild, temporary side effects at the application site, such as a slight burning sensation or dry skin. These symptoms usually go away as your skin adjusts to the medication, but you should contact your doctor immediately if you experience severe skin irritation, thinning of the skin, or signs of an allergic reaction.

Do not use this medicine if you have untreated viral skin infections (like herpes or chickenpox), bacterial skin infections, or tuberculosis of the skin. It is important to tell your doctor if you have a history of poor blood circulation, immune system problems, or skin thinning before starting this medication.

Although this is a topical cream with low absorption into the bloodstream, it is wise to avoid using other strong topical steroids or skin products on the same area without medical advice. If you are pregnant, planning to become pregnant, breastfeeding, or managing elderly care, consult your doctor or pharmacist to ensure this treatment is safe for your situation.

Uses of Closol-CZ Cream

Your doctor may prescribe this medicine to treat several conditions, including:

  • Inflamed fungal skin infections: Closol-CZ Cream helps by clearing the fungi causing the infection while simultaneously reducing severe inflammation, itching, and redness in the affected area.
  • Eczema and dermatitis with secondary fungal infection: It targets stubborn skin patches that have become swollen, dry, and irritated, especially when fungi have infected the compromised skin barrier.
  • Resistant ringworm or jock itch: It provides rapid relief for highly inflamed, itchy fungal infections in skin folds or body areas where simple antifungal treatments alone are not enough to calm the swelling.

Key Benefits

Closol-CZ Cream offers a combination of benefits that target both the symptoms and the root cause of your skin issue at the same time.

  • Rapid itching and redness relief: The strong anti-inflammatory component calms the skin quickly, helping you stop scratching and allowing the skin barrier to heal.
  • Effective clearance of fungal growth: By disrupting the protective outer layer of fungal cells, it stops the spread of the infection and clears it from your skin.
  • Skin protection and soothing: The mineral component in the cream forms a mild protective barrier over irritated skin, soothing raw areas and supporting healthy skin tissue recovery.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Apply as a thin layer on the clean and dry affected area and surrounding skin.
  • Avoid contact of Closol-CZ Cream with nose, mouth, or eyes. In case Closol-CZ Cream comes in contact with these areas accidentally, rinse with water thoroughly.
  • Wash your hands before and after using Closol-CZ Cream if your hands are not the affected area.

How Closol-CZ Cream Works

Closol-CZ Cream combines three distinct active mechanisms to clear skin infections and soothe severe irritation. When applied to the skin, these components work together to address the complex nature of inflamed fungal infections. The first component is clobetasol, which is a potent topical corticosteroid. It works by blocking the release of natural inflammatory chemicals in the body that cause blood vessels to widen, which directly reduces redness, swelling, and the intense urge to scratch. The second component is miconazole, an effective antifungal agent. It targets the fungi directly by preventing them from producing a vital substance needed to build their cell membranes. Without a stable membrane, the fungal cells leak and die, stopping the infection from spreading. The third component is zinc sulfate, which is a mild astringent and skin protectant mineral. It helps dry up oozing skin lesions, reduces local irritation, and creates a favourable environment for the skin to rebuild its natural defensive barrier.
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Alcohol

Caution

The interaction of Closol-CZ Cream with alcohol is unknown. However, it is advisable not to take or limit alcohol as a precautionary measure.

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Pregnancy

Caution

Please consult the doctor. There are no adequate and well-controlled studies on pregnant women. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor; there is no substantial research yet on using Closol-CZ Cream in breastfeeding/nursing mothers.

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Driving

Caution

Closol-CZ Cream usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Inform your doctor before receiving the Closol-CZ Cream if you have a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor before receiving the Closol-CZ Cream if you have a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

Closol-CZ Cream should be used with caution in children below 12 years if prescribed by a doctor. Closol-CZ Cream is not recommended for use in children below two years as in neonates and infants, absorption of Closol-CZ Cream by immature skin may be enhanced, and kidneys may be immature.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Closol-CZ Cream. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Closol-CZ Cream in elderly patients. Please consult your doctor.

What if I have taken an overdose of Closol-CZ Cream

Applying too much Closol-CZ Cream or using it over very large areas of skin for a prolonged period can lead to medication being absorbed into your body, which may cause systemic side effects. If you suspect an overdose, or if someone has accidentally swallowed the cream, seek immediate medical attention or contact a poison control centre right away.

Diet & Lifestyle Advise

  • Keep the skin dry: Fungi thrive in warm, moist environments. After bathing, gently pat your skin dry with a clean towel instead of rubbing it.
  • Wear breathable fabrics: Opt for loose-fitting clothing made of natural fibers like cotton. This prevents sweat build-up and reduces friction on inflamed skin.
  • Do not share personal items: To prevent spreading the fungal infection to other parts of your body or other people, use separate towels, clothing, and bedding, and wash them regularly in hot water.
  • Avoid scratching: Scratching itchy skin can break the skin barrier, introducing bacterial infections and making the inflammation worse. If itching is severe, apply a cold compress to the area for temporary relief.
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How Soon It Starts Working

The time required for Closol-CZ Cream to start to work: The effect of Closol-CZ Cream is observed within 1 to 2 hours of application. The time for which the effects of Closol-CZ Cream last: Closol-CZ Cream effect lasts for 12 to 24 hours.

What if you forget to take Closol-CZ Cream

If you forget to apply Closol-CZ Cream, apply it as soon as you remember. However, if it is almost time for your next scheduled application, skip the missed dose and resume your regular routine. Do not apply double the amount of cream to make up for a missed application.

Storage

• Store Closol-CZ Cream at room temperature, ideally between 15°C and 30°C (59°F to 86°F). • Keep the tube tightly closed when not in use, and protect it from direct heat, moisture, and light.

Drug Warnings

  • Apply only as directed: Do not use Closol-CZ Cream on your face, groin, underarms, or skin folds unless your doctor specifically instructs you to do so.
  • Avoid contact with the eyes and mouth: If the cream accidentally gets into your eyes, nose, or mouth, rinse thoroughly with plenty of cool water.
  • Check the product before use: Do not use the cream if the tube is damaged or if the cream appears discoloured, separated, or has an unusual texture.
  • Use for the prescribed duration only: Avoid prolonged use, especially on large areas of skin or under airtight dressings, as this may increase the risk of skin thinning and other steroid-related side effects.
  • Monitor your skin: Contact your doctor if your condition does not improve within 1 to 2 weeks, worsens, or if you develop signs of skin irritation or infection.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor about all the medicines you are using before starting Closol-CZ Cream, as they may interact with your treatment.

  • Other topical corticosteroids or medicated skin products: Using multiple steroid-containing creams or ointments together may increase the risk of skin thinning and steroid absorption.
  • Oral corticosteroids: Using topical and oral corticosteroids at the same time may increase your overall steroid exposure and the risk of side effects, particularly with prolonged use or application over large areas.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Closol-CZ Cream when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIFUNGALS - TOPICAL]

FAQs

Closol-CZ Cream is used to treat fungal skin infection.
Closol-CZ Cream is a combination of three drugs, namely Clobetasol, Miconazole, and Zinc sulfate. Clobetasol acts inside skin cells and inhibits certain chemical messenger's release in the body that cause redness, itching, and swelling. Miconazole causes holes in the fungal cell membranes and kills fungi. Zinc sulfate is antiseptic and astringent that heals skin wounds and ulcers.
Closol-CZ Cream is for topical (for skin use) application only. Avoid Closol-CZ Cream contact with eyes, nose, and mouth. Do not put a bandage or a dressing on the affected area while using Closol-CZ Cream unless advised by the doctor.
Closol-CZ Cream should be used with proper caution and doctor consultation if you have any active infections, history of liver, kidney diseases, glaucoma, cataract, poor blood circulation, immune system problems, diabetes, and adrenal gland diseases.
Closol-CZ Cream consists of Clobetasol, a corticosteroid that affects blood sugar levels. It is advised to consult your doctor before using Closol-CZ Cream and monitor your blood sugar levels regularly.
Closol-CZ Cream is not recommended for diaper rash since Clobetasol may be rapidly absorbed and can cause adrenal suppression, Cushing's syndrome (high cortisol levels), and intracranial hypertension (increased pressure around the brain) in infants. Your baby's pediatrician will suggest other medicines for the treatment of diaper rash.
Closol-CZ Cream, when used for longer periods, can cause thinning and weakening of the skin. Please stop using Closol-CZ Cream and immediately consult your doctor if you notice these symptoms.
Closol-CZ Cream should be used with caution in children if prescribed by a doctor as Closol-CZ Cream contains a steroid and may increase the risk of Cushing’s syndrome, HPA axis suppression (suppression of inflammatory and immune responses), adrenal insufficiency, delayed growth, and weight gain. However, please consult a doctor before using Closol-CZ Cream in children.
Yes, fungal infection is a contagious skin condition that spreads from one person to another through direct skin-to-skin contact or by contact with contaminated soil or surfaces and infected animals. Therefore, it is recommended to avoid close direct contact until the infection is clear and avoid sharing things with the infected person as it can also spread the infection.
No, you should not stop Closol-CZ Cream when your symptoms are relieved. It is important to continue using Closol-CZ Cream for the full prescribed duration. Stopping treatment early may cause the condition to return or worsen. Always consult the doctor before discontinuing any medication.
Closol-CZ Cream is for external use only. Apply a small amount of the cream to your finger and spread it in a thin layer on the clean, dry affected area and surrounding skin. Wash your hands before and after application, unless your hands are in the affected area, to prevent the spread of infection.
You should not use Closol-CZ Cream in higher than the recommended dose as it may cause adverse effects. Therefore, always use Closol-CZ Cream in the dose exactly as prescribed by the doctor to prevent adverse effects and to treat your condition effectively.
Closol-CZ Cream should be stored in a cool and dry place. Keep it out of sight and reach of children.
You should not use Closol-CZ Cream if you are allergic to any of its ingredients. Always check the product's ingredient list and consult the doctor if you're unsure about potential allergies.
The side effects of Closol-CZ Cream include itching, dry skin, irritation, redness, or burning sensation at the application site. Consult the doctor if any of these side effects persist or worsen.
No, you should not use Closol-CZ Cream on your face unless your doctor specifically prescribes it for a facial condition. The face has very delicate skin, and using a strong steroid cream can lead to acne flares, skin thinning, or discoloration. Talk to your doctor for appropriate face treatments.
The safety of using potent topical steroid and antifungal combinations during pregnancy has not been fully established. If you are pregnant or planning to become pregnant, you should only use this cream if the benefits outweigh the potential risks. Talk to your doctor to see if this is right for you.
If your skin condition worsens, spreads, or shows signs of a new bacterial infection (such as pus, oozing, or increased warmth), stop using the cream and contact your doctor immediately. This could indicate that the infection requires a different type of treatment. Talk to your doctor.
Since Closol-CZ Cream is a topical cream and very little of it enters the bloodstream, alcohol is unlikely to interact directly with the medication. However, maintaining a healthy lifestyle supports your immune system in fighting off infections. Talk to your doctor or pharmacist for personalised advice.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

8, Ff, Adharshila Complex, Beside Apex Honda Workshop, Kankaria Road, Ahmedabad-380028, Gujarat, India
Other Info - CLO1371

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