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compositionComposition:CHOLESTYRAMINE-4GM
prescription
Prescription Medicine
info
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Clostran Sachet 9gm is used to treat high cholesterol levels. It supports healthy cholesterol balance by lowering harmful cholesterol levels, thereby protecting the heart and blood vessels. It also treats itching caused by partial biliary obstruction. It also helps relieve diarrhoea caused by excess bile acids in people with short bowel syndrome.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CHOLESTYRAMINE-4GM

Manufacturer/Marketer :

Medi Globe Corporation

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Clostran Sachet 9gm

Clostran Sachet 9gm is a suggested oral powder designed to help lower high levels of cholesterol in the blood. Lowering these fats helps reduce the risk of serious heart and blood vessel problems. It is also suggested to relieve severe skin itching that occurs when there is a partial blockage of the bile ducts in your liver.

To get the best results, you must take Clostran Sachet 9gm consistently every day exactly as directed by your doctor. It is typically taken once or twice a day, always mixed with liquid or wet food, and is best taken with meals to assist with digestion. Adopting a low-fat diet, staying active, and maintaining a healthy weight will greatly support the effectiveness of this treatment.

The most common side effects are digestive, including constipation, mild stomach discomfort, and bloating. If you experience severe abdominal pain, persistent nausea, or unusual bleeding and bruising, you should contact your doctor immediately.

Before starting this medicine, tell your doctor if you have a history of chronic constipation, kidney issues, or thyroid conditions. Do not take this if you have a complete bile duct obstruction, as the medication will not be able to work properly.

This medication can interfere with how your body absorbs other oral drugs and certain fat-soluble vitamins, which is why other substances must be taken at different times of the day. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your doctor to discuss if this medication is safe for your specific situation.

Uses of Clostran Sachet 9gm

Your doctor may prescribe this medicine to treat several conditions, including:

  • High cholesterol: Clostran Sachet 9gm helps lower 'bad' cholesterol (LDL) in your blood to help prevent heart attacks and strokes.
  • Itching from bile duct blockage: It relieves severe skin itching associated with partial bile duct obstruction by helping your body eliminate excess bile acids.
  • Bile acid diarrhoea: It helps control chronic diarrhoea caused by too much bile acid reaching the large intestine, often occurring after gallbladder surgery.

Key Benefits

Clostran Sachet 9gm helps manage conditions related to excess bile acids and elevated cholesterol by binding bile acids in the intestine, reducing symptoms and supporting long-term health. Key benefits include:

  • Relieves Itching Caused by Liver Disease: By binding excess bile acids, Clostran Sachet 9gm helps reduce the severe itching associated with certain liver and bile duct disorders, improving daily comfort and sleep quality.
  • Helps Lower Cholesterol Levels: When used together with a cholesterol-lowering diet, Clostran Sachet 9gm helps reduce LDL ('bad') cholesterol levels, supporting heart health and lowering the risk of cardiovascular disease.
  • Improves Bile Acid-Related Diarrhoea: By reducing excess bile acids in the intestines, Clostran Sachet 9gm helps firm stools, decrease the frequency of diarrhoea, and promote more regular bowel movements.
Side effects of Clostran Sachet 9gm
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Weak and brittle bones can be strengthened by regular exercise, like swimming, walking, and yoga.
  • Physical therapy, including stretching, strengthening exercises, TENS (a type of therapy using electrical pulses), and gentle massage, can help enhance and improve movement.
  • Swallow calcium-rich foods to make bones strong.
  • Rest well and avoid sudden jerky movements, which may lead to fractures.
  • Walk slowly and refrain from lifting heavy objects.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Clostran Sachet 9gm should be administered orally after mixing with milk, water or fruit juices. Stir well and swallow the mixture slowly. Do not store it for later use.
  • Do not mix it with very hot or cold liquids.

How Clostran Sachet 9gm Works

Clostran Sachet 9gm contains cholestyramine, which acts as a bile acid binder in your digestive tract. Bile acids are natural substances made by your liver using cholesterol, and they are essential for digesting dietary fats. Once inside your intestines, this medicine binds tightly to these bile acids, creating a large compound that your body cannot absorb. This bound complex is then safely eliminated from your body through your stool. To replace the lost bile acids, your liver is forced to pull more cholesterol out of your bloodstream to make new ones. This continuous cycle naturally lowers the level of 'bad' cholesterol circulating in your body.
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Alcohol

Caution

Interaction of Clostran Sachet 9gm with alcohol is unknown. Please consult a doctor before consuming alcohol while using Clostran Sachet 9gm.

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Pregnancy

Caution

Clostran Sachet 9gm is a category C pregnancy drug and is given to pregnant women only if the doctor thinks the benefits outweigh the risks. However, please consult a doctor if you are pregnant.

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Breast Feeding

Caution

It is unknown whether Clostran Sachet 9gm is excreted in human milk. Therefore, please consult a doctor if you are breastfeeding. Clostran Sachet 9gm is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.

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Driving

Safe

Clostran Sachet 9gm usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Take Clostran Sachet 9gm with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Clostran Sachet 9gm with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Clostran Sachet 9gm is not recommended for children below 6 years of age. However, Clostran Sachet 9gm should be used with caution in children above 6 years if recommended by a doctor.

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Heart

Safe if suggested

Clostran Sachet 9gm can be used in heart patients if suggested by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Caution

Clostran Sachet 9gm can be given in elderly patients with extreme caution, due to the increased risk of gastrointestinal problems.

What if I have taken an overdose of Clostran Sachet 9gm

If you take too much of this medication, seek immediate medical attention or call a poison control center. An overdose can cause severe constipation or blockages in your digestive tract.

Diet & Lifestyle Advise

  • Increase your fluid intake: Drink plenty of water throughout the day to help prevent constipation, which is a common side effect of this medication.
  • Eat more dietary fiber: Gradually add fiber-rich foods like whole grains, fruits, and vegetables to your diet to support healthy digestion.
  • Space out your vitamins: Because this medicine can interfere with the absorption of fat-soluble vitamins (A, D, E, and K), talk to your doctor about taking a multivitamin at a different time of day.
  • Follow a heart-healthy diet: Reduce your intake of saturated fats and cholesterol to maximise the cholesterol-lowering benefits of the medication.
health query

Have a query?

How Soon It Starts Working

The time required for Clostran Sachet 9gm to start to work: The time required for Clostran Sachet 9gm to show its action is clinically not established.

The time for which the effects of Clostran Sachet 9gm last: The duration of action for Clostran Sachet 9gm is clinically not established.

What if you forget to take Clostran Sachet 9gm

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Clostran Sachet 9gm at room temperature, ideally between 68°F and 77°F (20°C to 25°C). •Keep the container tightly closed to protect the powder from moisture, dampness, and direct light.

Drug Warnings

  • Time other medications carefully: Take your other oral medicines at least 1 hour before or 4 to 6 hours after taking Clostran Sachet 9gm to prevent them from being poorly absorbed.
  • Never swallow dry powder: Always mix the powder completely with liquid or soft, wet food before swallowing to avoid breathing it in or choking.
  • Monitor bowel movements: Speak to your doctor if you experience new or worsening constipation, as they may suggest a stool softener or dose adjustment.
  • Do not use carbonated drinks: Avoid mixing the powder with carbonated beverages, as this can cause excessive gas and foaming.
  • Regular lab tests: Keep all appointments for blood tests so your doctor can monitor your cholesterol levels and check for potential vitamin deficiencies.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Blood thinners (like warfarin): Clostran Sachet 9gm can decrease the absorption of blood thinners, reducing their effectiveness and increasing the risk of blood clots. It can also deplete Vitamin K, which could increase bleeding risk.
  • Thyroid medications (like levothyroxine): Taking these together can severely reduce how much thyroid hormone your body absorbs.
  • Heart medications (like digoxin and beta-blockers): This medicine can bind to these drugs, lowering their levels in your blood.
  • Thiazide diuretics: It can reduce the absorption and effectiveness of these water pills.
CholestyramineMycophenolic acid
Severe
CholestyramineMycophenolate Mofetil
Severe

Drug-Drug Interactions

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CholestyramineMycophenolic acid
Severe
How does the drug interact with Clostran Sachet 9gm:
Co-administration of Mycophenolic acid and Clostran Sachet 9gm may decrease the effectiveness of Mycophenolic acid.

How to manage the interaction:
Although there is an interaction between Mycophenolic acid and Clostran Sachet 9gm, it can be taken together if your doctor has prescribed them. Do not discontinue any medications without a doctor's advice.
CholestyramineMycophenolate Mofetil
Severe
How does the drug interact with Clostran Sachet 9gm:
Co-administration of Clostran Sachet 9gm and mycophenolate mofetil may interfere with the action of mycophenolate mofetil.

How to manage the interaction:
Although taking Clostran Sachet 9gm and mycophenolate mofetil together can result in an interaction, they can be taken together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
CholestyramineTeriflunomide
Severe
How does the drug interact with Clostran Sachet 9gm:
Co-administration of Clostran Sachet 9gm and teriflunomide may interfere with the effectiveness of teriflunomide.

How to manage the interaction:
Although taking Clostran Sachet 9gm and teriflunomide together can result in an interaction, they can be taken together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Clostran Sachet 9gm when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[BILE ACID SEQUESTRANTS]

FAQs

Clostran Sachet 9gm is used to lower bad cholesterol levels, thereby‚ reducing the risk of heart attack and stroke in future. It may also be used to help stop some types of diarrhoea or itching.
Clostran Sachet 9gm contains Cholestyramine that binds to bile acids (helps in the digestion of fats consumed in the diet) in the intestine and removes them from the body. This makes the liver produce more bile acids from the cholesterol in the blood and decreases cholesterol levels. Also, Clostran Sachet 9gm reduces the risk of stroke or heart attack by reducing the excess cholesterol deposition in the major blood vessels of the brain and heart.
You are not recommended to take Clostran Sachet 9gm with levothyroxine at the same time as it may reduce the absorption of levothyroxine and decrease its effectiveness. Therefore, you are recommended to take levothyroxine after 4 hours of taking Clostran Sachet 9gm. However, please consult a doctor before taking Clostran Sachet 9gm with any other medicines.
Clostran Sachet 9gm may be used to treat certain types of diarrhoea, such as bile acid diarrhoea, in which excess bile acids spill into the large intestine and trigger watery and loose stools. However, please consult a doctor before taking Clostran Sachet 9gm.
Clostran Sachet 9gm decreases the absorption of certain vitamins, such as fat-soluble vitamins (A, D and K), by the body, especially when taken in high doses or for long periods. Therefore, your doctor may recommend that you take vitamin supplements with Clostran Sachet 9gm.
You are not recommended to stop taking Clostran Sachet 9gm without consulting your doctor, as it may worsen the condition and increase the risk of heart attack and stroke. Therefore, take Clostran Sachet 9gm for as long as your doctor has recommended it, and if you experience any difficulty while taking Clostran Sachet 9gm, please consult your doctor so that the dose may be gradually reduced.
Clostran Sachet 9gm may cause constipation as a common adverse effect. You are advised to drink plenty of fluids while taking Clostran Sachet 9gm to prevent constipation. However, if the condition persists or worsens, please consult a doctor.
Clostran Sachet 9gm may cause side effects such as nausea, vomiting, diarrhoea, constipation, stomach pain or flatulence (gas). If these side effects persist or worsen, please consult your doctor.
Clostran Sachet 9gm should be avoided by patients with a blockage in the stomach or intestines. If you have any concerns, consult your doctor.
Cholesterol is a waxy fat, or lipid, which circulates throughout the body in blood. The liver makes cholesterol, but it can also be obtained from foods. There are two types of cholesterol, HDL (high-density lipoprotein) or the good cholesterol and LDL (low-density lipoprotein) or the bad cholesterol.
LDL (low-density lipoprotein) is called bad cholesterol as it accumulates cholesterol in the blood. This leads to blockage in the heart and is a direct cause of strokes, heart attacks, and peripheral artery disease.
HDL (high-density lipoprotein) is also called as good cholesterol as it transports cholesterol from blood to liver for elimination. Thus, lowers the risk of heart diseases.
You can book a lipid profile test with any recognised laboratory. With the help of this test, you can monitor your total cholesterol, triglycerides, HDL levels, LDL levels, and the ratio between cholesterol and HDL. Before giving your blood sample to the laboratory, you may need to fast for a period of 10-12 hours. After receiving your test report, consult a doctor to help you evaluate your test results.
The total cholesterol level should be 125 to 200 mg/dL, HDL should be 40mg/dL or higher and LDL should be less than 100 mg/dL.
If you have high cholesterol, it accumulates upon the artery walls. This narrows arteries and thus reduces blood flow to the heart. This can result in heart attack or stroke.
When your cholesterol levels are high enough (LDL level greater than 190mg/dL) to increase your risk for heart disease or if you already have a history of stroke or heart attack, medication is usually suggested. Always consult your doctor before taking any medicines.
Some of the symptoms of high cholesterol include pain in the neck, jaw, upper abdomen, or back; chest pain; difficulty breathing; extreme fatigue; and numbness or coldness in extremities.
Some of the foods that are high in cholesterol are red meat like pork, lamb, packaged food, full-fat dairy, fried foods, processed meat (sausage, bacon), etc.
In addition to taking Clostran Sachet 9gm, following a low-fat diet, reducing body weight, regular exercise, and limiting alcohol consumption can help improve the effectiveness of Clostran Sachet 9gm and lower cholesterol levels.
It is best to mix Clostran Sachet 9gm with cold or room-temperature liquids. Heat can alter the texture and effectiveness of the medication. Talk to your doctor or pharmacist if you have trouble mixing it.
Yes, you can mix the powder with liquid and store it in the refrigerator overnight. Be sure to stir it thoroughly again right before you drink it, as the powder will settle to the bottom. Talk to your doctor or pharmacist if you have concerns about preparation.
Clostran Sachet 9gm is not a weight-loss medication. While some digestive side effects might temporarily affect your appetite, any significant weight changes should be discussed with your healthcare provider. Talk to your doctor to understand your symptoms.
Because this medicine can interfere with the absorption of essential vitamins that you and your baby need, it should only be used during pregnancy or breastfeeding under strict medical supervision. Talk to your doctor before starting or continuing this medication.
Occasional, moderate alcohol consumption is generally safe, but heavy drinking can worsen liver conditions and increase your risk of high triglycerides. Talk to your doctor or pharmacist about safe alcohol limits for your specific condition.
Constipation is a common side effect. You can manage mild constipation by drinking more water and eating more fibre, but if it becomes severe, do not take laxatives without medical advice. Talk to your doctor right away for guidance.

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Country of origin

India

Manufacturer/Marketer address

Medi-Globe Corporation , Headquarters , Medi-Globe-Str. 1-5 , 83101 Achenm?hle - Germany
Other Info - CLO0130

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