Apollo
logo

Welcome User

Login/Sign Up

Home
Buy Medicines
Lab Tests
Doctor Consult
Circle Membership
insurance
Blogs
Contact Us
Privacy Policy
Return & Refunds
Need Help
Terms and Conditions
Select Delivery Location
image icons
Best Price

₹83 with coupons & bank offers*

View

Cobatus Injection 2ml is used to treat nutritional deficiencies and as adjuvant therapy for various medical conditions. It contains methylcobalamin (vitamin B12), niacinamide (nicotinamide), and pyridoxine (vitamin B6). Together, they provide essential nutrients for adequate growth and proper organ functioning. Cobatus Injection 2ml may cause side effects such as upset stomach, constipation, diarrhoea, nausea, and injection site reactions.

Read more
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
OffersOffers & Discounts

Get Free delivery (₹99) with circle icon

Join Circle
coupon
Get 18% Off with Coupons
coupon
Extra 10% Off with Bank Offers
bank offer
bank offer
bank offer

More about the Product

Composition :

METHYLCOBALAMIN-1000MCG+NIACINAMIDE-100MG+PYRIDOXINE-100MG

Manufacturer/Marketer :

Icon Life Sciences

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Cobatus Injection 2ml

Cobatus Injection 2ml is an injectable prescription medicine used to treat peripheral neuropathy and clinical conditions caused by vitamin B6, vitamin B12, and niacin deficiencies. It is especially useful when oral therapy is not feasible, such as in critically ill patients, ICU patients, or people with excessive vomiting. By delivering these vitamins directly into the body, it helps restore depleted nutrient levels more quickly. 

To achieve the best results, you should receive Cobatus Injection 2ml exactly as prescribed by your doctor. In severe cases, it may be given daily until symptoms improve and then reduced to maintenance dosing. Because it is administered by injection, food does not affect how it works. This medicine is intended for adult use and is for single use only. 

While using this injection, some people may experience mild side effects such as pain or redness at the injection site, nausea, vomiting, diarrhoea, dizziness, headache, or flushing. Seek medical attention immediately if you develop difficulty breathing, facial swelling, severe rash, or other signs of a serious allergic reaction. Long-term high-dose pyridoxine exposure can also cause peripheral sensory neuropathy, so new tingling or numbness should be reported promptly. 

Do not use this medicine if you are allergic to any of its ingredients. Tell your doctor before treatment if you have hypertension, cardiovascular disease, lung disease, diabetes, liver disease, or a history of bleeding-related problems, because extra caution may be needed in these settings. 

This medicine can interact with several drugs, including metformin, phenytoin, phenobarbital, isoniazid, hydralazine, penicillamine, oral contraceptives, levodopa, carbamazepine, diazepam, and sodium valproate. If you are pregnant, breastfeeding, or an older adult, consult your doctor before starting treatment. Large doses of nicotinamide should be avoided in pregnancy, and caution is advised in nursing mothers.

Uses of Cobatus Injection 2ml

Your doctor may prescribe Cobatus Injection 2ml to treat the following conditions:

  • Peripheral neuropathy: Helps relieve nerve pain, tingling, numbness, and burning sensations in the hands and feet.
  • Clinical conditions resulting in B6, B12, or niacin deficiencies: Used when these deficiencies need parenteral correction, especially when oral therapy is not feasible.

Key Benefits

By bypassing the digestive tract, Cobatus Injection 2ml provides rapid delivery of essential vitamins, which is helpful when absorption is poor or oral treatment cannot be used. This supports faster correction of deficiency states and helps the body recover more reliably than oral supplements in selected patients. 

  • Supports nerve health: Methylcobalamin helps with myelin-related processes and nerve repair, while pyridoxine supports neurotransmitter and amino-acid metabolism.
  • Helps reduce neuropathic symptoms: May help ease numbness, tingling, and burning pain associated with peripheral neuropathy.
  • Supports energy metabolism: Niacinamide helps form NAD, which is important for cellular energy production and neuronal function.
  • Corrects deficiency states: Replenishes depleted B-vitamin stores when dietary intake or oral absorption is inadequate.
Side effects of Cobatus Injection 2ml

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication, to improve effectiveness.
  • Cobatus Injection 2ml will be administered by a healthcare professional.
  • Do not self-administer it.

How Cobatus Injection 2ml Works

Cobatus Injection 2ml combines three essential vitamins that work together to support nervous system and metabolic health. Methylcobalamin supports methylation reactions involved in myelin formation and nerve regeneration. Pyridoxine is converted in the body to pyridoxal 5’-phosphate, an active coenzyme required for amino-acid, neurotransmitter, and haem-related metabolism. Niacinamide contributes to NAD/NADH production, which is important for cellular energy and neuronal maintenance. Together, these nutrients help restore depleted stores, support nerve repair, and improve metabolic function in patients with deficiency-related symptoms.
bannner image

Alcohol

Caution

No interaction was found. However, it is advisable not to take or limit alcohol as a precautionary measure.

bannner image

Pregnancy

Caution

Limited data are available on the effect of Cobatus Injection 2ml in pregnancy. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Cobatus Injection 2ml. Your doctor may prescribe this medicine if the benefits outweigh the risks.

bannner image

Breast Feeding

Caution

Limited data are available on the effect of Cobatus Injection 2ml on breastfeeding. Hence, if you are a nursing mother, inform your doctor before receiving Cobatus Injection 2ml. Your doctor may prescribe this medicine if the benefits outweigh the risks.

bannner image

Driving

Safe

Cobatus Injection 2ml does not impact your ability to drive or use machinery.

bannner image

Liver

Caution

Inform your doctor if you have had any history of liver diseases before taking Cobatus Injection 2ml. Your doctor will weigh the benefits and potential risks before prescribing Cobatus Injection 2ml.

bannner image

Kidney

Caution

Inform your doctor if you have had any history of kidney diseases before taking Cobatus Injection 2ml. Your doctor will weigh the benefits and potential risks before prescribing Cobatus Injection 2ml.

bannner image

Children

Unsafe

There was limited information about the usage of Cobatus Injection 2ml in paediatric patients. Please seek medical advice. Only if the benefits exceed the dangers will your doctor prescribe.

bannner image

Heart

Caution

Cobatus Injection 2ml is generally safe for heart patients and supports nerve and metabolic health. However, it's important to consult your doctor to avoid any interaction with cardiac medications.

bannner image

Geriatrics

Caution

Geriatric patients can receive Cobatus Injection 2ml, as it's generally safe and supports nerve and metabolic health. However, age-related organ changes may increase sensitivity, so medical supervision is important.

What if I have taken an overdose of Cobatus Injection 2ml

An overdose is unlikely when the medicine is administered by a healthcare professional. However, excessive pyridoxine exposure over time can cause sensory neuropathy, and very high nicotinamide doses may cause adverse effects such as nausea, vomiting, or liver-related problems. Seek medical attention if an overdose is suspected or if severe symptoms develop.

Diet & Lifestyle Advise

  • Eat a balanced diet: Include B-vitamin-rich foods such as lean meats, fish, eggs, dairy, whole grains, and leafy green vegetables to support recovery.
  • Limit alcohol intake: Excessive alcohol can worsen vitamin deficiency states and should be avoided or strictly limited.
  • Quit smoking: Smoking can hinder recovery and worsen overall vascular and nerve health.
  • Stay hydrated: Drink enough water each day to support general health while receiving parenteral vitamin therapy.
  • Keep follow-up appointments: Routine monitoring helps your doctor assess treatment response and adjust dosing if needed.
health query

Have a query?

How Soon It Starts Working

The time required for Cobatus Injection 2ml to start to work: Cobatus Injection 2ml ideally shows its action within 2 hours after administration. The time for which the effects of Cobatus Injection 2ml last: The duration of action for Cobatus Injection 2ml is unknown.

What if you forget to take Cobatus Injection 2ml

If you miss an appointment for your injection, contact your doctor or clinic as soon as possible to reschedule. Do not inject a double dose to make up for a missed one.

Storage

• Store Cobatus Injection 2ml at or below 30°C and protect it from light. Keep the ampoule in its original carton, and do not freeze the medicine.

Drug Warnings

  • Inspect the vial before use: Do not use the injection if the liquid is cloudy, discoloured, or contains visible particles.
  • Use only once: The ampoule is for single use only and should be discarded after opening.
  • Rotate injection sites: If injections are given regularly, changing the site can help reduce pain and local irritation.
  • Watch for allergic signs: Seek help promptly if you develop itching, rash, facial swelling, or breathing changes after an injection.
  • Keep up with routine blood tests: Your doctor may monitor your vitamin status and related labs to confirm the treatment is working.

Drug-Drug Interactions

verifiedApollotooltip
  • Metformin: Long-term use may be associated with reduced vitamin B12 levels, so monitoring may be needed.
  • Phenytoin and phenobarbital: Serum concentrations have been reported to decrease with concomitant use of mecobalamin.
  • Isoniazid, hydralazine, penicillamine, and oral contraceptives: May increase pyridoxine requirements.
  • Levodopa: Pyridoxine can reduce its effect unless used with an appropriate decarboxylase inhibitor.
  • Carbamazepine, diazepam, and sodium valproate: Niacinamide may potentiate anticonvulsant action and may decrease carbamazepine clearance.
Mecobalamin + Pyridoxine (vit b6) + NicotinamideLomitapide
Severe
Mecobalamin + Pyridoxine (vit b6) + NicotinamideAtorvastatin
Severe

Drug-Drug Interactions

Login/Sign Up

Mecobalamin + Pyridoxine (vit b6) + NicotinamideLomitapide
Severe
How does the drug interact with Cobatus Injection 2ml:
Coadministration of Nicotinamide and Lomitapide can increase the risk of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Nicotinamide and Lomitapide, but it can be taken if prescribed by a doctor. It is important to keep an eye out for any signs of liver damage. If you notice any symptoms like fever, joint pain, or loss of appetite, it's a good idea to contact a doctor right away. They can help determine if there is any liver damage and provide appropriate treatment. Do not discontinue any medications without consulting a doctor.
Mecobalamin + Pyridoxine (vit b6) + NicotinamideAtorvastatin
Severe
How does the drug interact with Cobatus Injection 2ml:
Coadministration of Nicotinamide with Atorvastatin can increase the risk and severity of side effects like rhabdomyolysis (breakdown of skeletal muscle) or kidney damage.

How to manage the interaction:
Taking Nicotinamide with Atorvastatin together is used with caution as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unexplained muscle pain, muscle stiffness or tenderness, fever, dark-colored urine, or weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + Pyridoxine (vit b6) + NicotinamideTeriflunomide
Severe
How does the drug interact with Cobatus Injection 2ml:
Coadministration of Nicotinamide and Teriflunomide can increase the risk of liver damage.

How to manage the interaction:
Taking Nicotinamide with Teriflunomide together can result in an interaction, but it can be taken if your doctor has advised it. It is important to keep a close eye on any signs of liver problems. If you notice any symptoms like fever, joint pain, or loss of appetite, it's best to call a doctor right away. They can help determine if there is any liver damage or bleeding and provide the necessary treatment. Do not stop using any medications without a doctor's advice.
Mecobalamin + Pyridoxine (vit b6) + NicotinamideLeflunomide
Severe
How does the drug interact with Cobatus Injection 2ml:
Coadministration of nicotinamide with leflunomide can increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between nicotinamide and leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Mecobalamin + Pyridoxine (vit b6) + NicotinamideRosuvastatin
Severe
How does the drug interact with Cobatus Injection 2ml:
Coadministration of Nicotinamide with Rosuvastatin may increase the risk and severity of side effects like rhabdomyolysis (breakdown of skeletal muscle) or kidney damage which can be fatal.

How to manage the interaction:
Taking Nicotinamide with Rosuvastatin together can result in an interaction, but it can be taken if your doctor has advised it. If you notice any symptoms like unexplained muscle pain, muscle stiffness or tenderness, fever, dark-coloured urine, or weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
Mecobalamin + Pyridoxine (vit b6) + NicotinamideLovastatin
Severe
How does the drug interact with Cobatus Injection 2ml:
Coadministration of Nicotinamide with Lovastatin can increase the risk and severity of side effects like rhabdomyolysis (breakdown of skeletal muscle) or kidney damage.

How to manage the interaction:
Taking high-dose Nicotinamide with Lovastatin together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unexplained muscle pain, muscle stiffness or tenderness, fever, dark-colored urine, or weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + Pyridoxine (vit b6) + NicotinamideMipomersen
Severe
How does the drug interact with Cobatus Injection 2ml:
Coadministration of Nicotinamide and Mipomersen can increase the risk of liver damage.

How to manage the interaction:
Co-administration of Nicotinamide with Mipomersen can result in an interaction, but it can be taken if your doctor has advised it. It is important to keep a close eye on any signs of liver problems. If you notice any symptoms like fever, joint pain, or loss of appetite, it's best to call a doctor right away. They can help determine if there is any liver damage and provide the necessary treatment. Do not stop using any medications without a doctor's advice.
Mecobalamin + Pyridoxine (vit b6) + NicotinamideKetoconazole
Severe
How does the drug interact with Cobatus Injection 2ml:
Taking Nicotinamide with Ketoconazole can increase the risk or severity of liver injury.

How to manage the interaction:
Taking Nicotinamide with Ketoconazole together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any symptoms of fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + Pyridoxine (vit b6) + NicotinamideSimvastatin
Severe
How does the drug interact with Cobatus Injection 2ml:
Coadministration of Nicotinamide with Simvastatin can increase the risk and severity of side effects like rhabdomyolysis (breakdown of skeletal muscle) or kidney damage.

How to manage the interaction:
Taking Nicotinamide with Simvastatin together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unexplained muscle pain, muscle stiffness or tenderness, fever, dark-colored urine, or weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + Pyridoxine (vit b6) + NicotinamidePitavastatin
Severe
How does the drug interact with Cobatus Injection 2ml:
Co-administration of Nicotinamide with Pitavastatin can increase the risk and severity of side effects like rhabdomyolysis (breakdown of skeletal muscle).

How to manage the interaction:
Taking Nicotinamide with Pitavastatin together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unexplained muscle pain, muscle stiffness or tenderness, fever, dark-colored urine, or weakness, contact a doctor immediately. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: No direct food interaction is established, but heavy alcohol use can worsen deficiency states and reduce treatment effectiveness.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[VITAMINS]

FAQs

The frequency of Cobatus Injection 2ml injections depends on your nutritional deficiency, medical condition, and your doctor's treatment plan. Your doctor will determine the appropriate dose and schedule, which may vary from person to person. Do not take or receive Cobatus Injection 2ml more frequently than prescribed.
Many patients begin to feel an increase in energy levels within a few days, but nerve healing is a gradual process. It may take several weeks of consistent treatment to notice a significant reduction in nerve pain or numbness. Talk to your doctor if you do not notice any improvement after a few weeks.
Yes, this medicine generally does not affect your ability to drive. However, if you experience temporary dizziness or lightheadedness immediately after the injection, wait until you feel fully alert before driving. Talk to your doctor if these symptoms persist.
While the nutrients in this injection are essential, high-dose parenteral vitamins should only be used during pregnancy if clearly needed and prescribed by your obstetrician. Talk to your doctor to determine if this treatment is safe for you and your baby.
An injection delivers the nutrients directly into your bloodstream, completely bypassing the digestive tract. This is highly beneficial for people who have gut absorption issues, severe deficiencies, or conditions that make swallowing oral pills difficult. Talk to your doctor about which form is best for your health needs.
It is highly recommended to avoid or limit alcohol while using this medicine. Alcohol impairs your body’s ability to absorb and utilize these essential nutrients, which can make the treatment much less effective. Talk to your doctor for advice on safe alcohol consumption.
Mild pain, redness, or swelling at the injection site is common and usually goes away within a few hours. Applying a cold compress to the area can help relieve discomfort. Talk to your doctor if the pain worsens, or if you notice signs of infection like pus or warmth around the site.
This medicine is not known to cause weight gain directly. However, as it helps restore your energy levels and normal metabolic function, your appetite may improve, which could lead to healthy weight maintenance if you were previously underweight due to illness. Talk to your doctor if you have concerns about weight changes.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

3M India Ltd, Concorde Block, UB City, #24, Vittal Mallya Road, Bangalore, Karnataka - 560001 India
Other Info - COB0116

Buy best Health & Nutrition products by

whatsapp Floating Button
Buy Now
Add to Cart