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compositionComposition:TACROLIMUS-0.5MG
prescription
Prescription Medicine
info
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Cograf-0.5 Capsule 10's is used to prevent rejection of a transplanted organ, such as a liver, kidney, or heart. It contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body to accept the new organ.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

TACROLIMUS-0.5MG

Manufacturer/Marketer :

Cognitus Life Sciences Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Cograf-0.5 Capsule 10's

Cograf-0.5 Capsule 10's is a prescription medicine used to keep your immune system from attacking a newly transplanted kidney, liver, or heart. By calming your body's natural defenses, it helps your body accept the new organ so it can function properly.

You will typically take Cograf-0.5 Capsule 10's twice a day, exactly 12 hours apart, to keep a steady level in your blood. It is highly important to take it consistently either always with food or always without food, as changes in your diet can alter how much medicine your body absorbs. Alongside taking Cograf-0.5 Capsule 10's, eating a heart-healthy diet, staying hydrated, and avoiding raw or undercooked foods can support your recovery.

While taking Cograf-0.5 Capsule 10's, you may experience some common side effects like mild hand shaking, headaches, or nausea. However, you must contact your doctor immediately if you experience serious symptoms such as signs of an infection, changes in how much you urinate, or severe stomach pain.

Do not take Cograf-0.5 Capsule 10's if you have had a severe allergic reaction to it or any of its inactive ingredients in the past. Talk to your doctor before starting if you have pre-existing kidney disease, liver damage, high blood pressure, or a history of heart rhythm issues.

Cograf-0.5 Capsule 10's can interact with alcohol, smoking, and many other prescriptions by changing how your body processes the drug, which can lead to kidney damage or make Cograf-0.5 Capsule 10's less effective. Pregnant women, breastfeeding mothers, and elderly individuals should consult their healthcare team before starting this treatment to ensure it is safe for their specific needs.

Uses of Cograf-0.5 Capsule 10's

Cograf-0.5 Capsule 10's is used to treat various medical conditions. The detailed uses are as follows:

  • Kidney transplant rejection: Helps prevent your body's immune system from identifying a new kidney as foreign and attacking it.
  • Liver transplant rejection: Controls your immune response to ensure your new liver can safely perform its vital functions.
  • Heart transplant rejection: Works to protect a donor heart by calming the body's natural defense mechanisms.

Key Benefits

Cograf-0.5 Capsule 10's helps prevent organ rejection after transplantation by controlling the body's immune response. It plays an important role in protecting transplanted organs and supporting long-term health after transplant surgery.

Benefits may include:

  • Helps prevent rejection of transplanted organs such as the kidney, liver, or heart.
  • Supports the long-term function and survival of the transplanted organ.
  • Helps improve quality of life by allowing patients to return to many of their normal daily activities.
  • Provides ongoing immune system control to help protect the transplanted organ.
  • Supports successful recovery and long-term health following organ transplantation.
  • Plays a vital role in comprehensive post-transplant care when taken regularly as prescribed.

Directions for Use

  • Take Cograf-0.5 Capsule 10's at least 1 hour before or 2 to 3 hours after a meal or as advised by your doctor.
  • Strictly follow your doctor's recommendation regarding the dosage and duration.
  • Swallow it as a whole with water.
  • Do not crush, break or chew it.

How Cograf-0.5 Capsule 10's Works

Cograf-0.5 Capsule 10's belongs to a group of medicines known as immunosuppressants. It works by blocking a specific protein in your body called calcineurin, which is responsible for activating white blood cells called T-lymphocytes (T-cells). T-cells are the primary defense cells your immune system uses to attack foreign invaders. By temporarily blocking these cells, Cograf-0.5 Capsule 10's prevents your immune system from recognizing your new organ as a threat, stopping it from launching an attack. This protective effect is essential for keeping your transplanted organ safe and functional.
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Alcohol

Unsafe

Avoid alcohol consumption with Cograf-0.5 Capsule 10's as it may increase the risk of adverse effects. Please consult a doctor before consuming alcohol with Cograf-0.5 Capsule 10's.

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Pregnancy

Caution

Using Tacrolimus during pregnancy may cause kidney dysfunction or neonatal hyperkalemia (high potassium levels in the blood). Therefore, please consult a doctor if you are pregnant before taking Cograf-0.5 Capsule 10's and if you are a woman of childbearing age, use effective contraceptive methods while using Cograf-0.5 Capsule 10's.

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Breast Feeding

Consult your doctor

Cograf-0.5 Capsule 10's may be excreted in breast milk. Therefore, please inform your doctor if you are a breastfeeding mother before taking Cograf-0.5 Capsule 10's. You should avoid taking Cograf-0.5 Capsule 10's during breastfeeding or avoid breastfeeding while on treatment with Cograf-0.5 Capsule 10's.

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Driving

Caution

Cograf-0.5 Capsule 10's may cause vision problems or nervous disturbances in a few people. Therefore, avoid driving if you experience any of these symptoms after taking Cograf-0.5 Capsule 10's.

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Liver

Consult your doctor

Please consult a doctor if you have liver diseases/conditions before taking Cograf-0.5 Capsule 10's.

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Kidney

Consult your doctor

Please consult a doctor if you have Kidney diseases/conditions before taking Cograf-0.5 Capsule 10's.

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Children

Safe if prescribed

Cograf-0.5 Capsule 10's should be used in children in doses as advised by a doctor only.

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Heart

Consult your doctor

Cograf-0.5 Capsule 10's can be used in heart patients, especially post-transplant, but it require close monitoring due to risks like arrhythmias, hypertension, and kidney strain. Always consult your cardiologist before starting, as dose adjustments and regular ECG and blood tests may be necessary.

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Geriatrics

Caution

Cograf-0.5 Capsule 10's can be taken by geriatric patients, but they require careful monitoring due to increased sensitivity to side effects like kidney dysfunction and high blood pressure. Dose adjustments and regular blood tests are essential to ensure safety and effectiveness.

What if I have taken an overdose of Cograf-0.5 Capsule 10's

If you take too much of Cograf-0.5 Capsule 10's, seek immediate medical attention or contact your local poison control center right away. An overdose can lead to serious kidney issues and other health complications.

Diet & Lifestyle Advise

  • Avoid grapefruit products: Do not eat grapefruit or drink grapefruit juice, as they can significantly increase the levels of Cograf-0.5 Capsule 10's in your blood.
  • Protect yourself from infections: Wash your hands frequently, avoid close contact with people who are unwell, and stay away from large crowds whenever possible.
  • Protect your skin from sunlight: Use a high-SPF sunscreen and wear wide-brimmed hats and protective clothing when outdoors, as Cograf-0.5 Capsule 10's can increase sensitivity to sunlight and raise the risk of skin cancer.
  • Avoid raw or undercooked foods: Do not consume raw or undercooked meats, seafood, or eggs, as a weakened immune system can increase the risk of serious foodborne illnesses.
  • Stay well hydrated: Drink plenty of water throughout the day to help support kidney health and overall wellbeing.
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Have a query?

How Soon It Starts Working

The time required for Cograf-0.5 Capsule 10's to start to work: The peak effect of Cograf-0.5 Capsule 10's can be observed in 6 hours. The time for which the effects of Cograf-0.5 Capsule 10's last: Cograf-0.5 Capsule 10's effect lasts for about 2 to 4 days in immediate release, and 3 to 5 days in extended release.

What if you forget to take Cograf-0.5 Capsule 10's

If you miss a dose of Cograf-0.5 Capsule 10's, take it as soon as you remember if it is within a few hours of your scheduled time. However, if your next scheduled dose is less than 4 hours away, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure.

Storage

• Store Cograf-0.5 Capsule 10's oral capsules at controlled room temperature between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Avoid live vaccines during treatment: Do not receive live vaccines, such as yellow fever or oral polio vaccines, while taking Cograf-0.5 Capsule 10's, as they may increase the risk of serious infections.
  • Attend regular monitoring appointments: Keep all scheduled blood tests so your doctor can monitor medicine levels, kidney function, blood sugar, and your overall response to treatment.
  • Handle capsules carefully: If you are pregnant or planning to become pregnant, avoid handling open or broken capsules, as the contents may be harmful if inhaled or absorbed through the skin.
  • Monitor your blood pressure: Check your blood pressure regularly at home and inform your healthcare provider if you consistently record elevated readings.
  • Inform healthcare providers before procedures: Tell all healthcare professionals, including your doctor, dentist, and surgeon, that you are taking this immunosuppressive medicine before any medical, surgical, or dental procedure.

verifiedApollotooltip
  • Blood pressure medicines (e.g., diltiazem, verapamil): These medicines may increase Cograf-0.5 Capsule 10's levels in the body and raise the risk of side effects.
  • Certain antibiotics (e.g., erythromycin, clarithromycin): These antibiotics can increase Cograf-0.5 Capsule 10's levels and may increase the risk of toxicity. Your doctor may monitor Cograf-0.5 Capsule 10's blood levels more closely.
  • Medicines that may affect kidney function (e.g., NSAIDs such as ibuprofen): Taking these medicines alongside Cograf-0.5 Capsule 10's may increase the risk of kidney damage.
  • Anti-seizure medicines (e.g., carbamazepine, phenytoin): These medicines may reduce Cograf-0.5 Capsule 10's levels and decrease its effectiveness in preventing organ rejection.

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verifiedApollotooltip
  • Grapefruit and grapefruit juice: Avoid consuming grapefruit products while taking Cograf-0.5 Capsule 10's, as they may increase the amount of Cograf-0.5 Capsule 10's in your bloodstream and lead to toxic levels.
  • Potassium-rich foods and potassium-containing salt substitutes: Consuming large amounts of foods such as bananas and spinach or using potassium-containing salt substitutes may increase the risk of high potassium levels in the blood.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[IMMUNOSUPPRESSANTS]

FAQs

Cograf-0.5 Capsule 10's is used to prevent rejection of a transplanted organ, such as a liver, kidney, or heart.
Cograf-0.5 Capsule 10's contains Tacrolimus, an immunosuppressant that works by inhibiting the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.
Cograf-0.5 Capsule 10's may increase the risk of infections as it may weaken the immune system. Therefore, consult a doctor immediately if you have any signs of infection, such as a sore throat or fever.
Cograf-0.5 Capsule 10's may increase the risk of skin cancer. Therefore, avoid or limit exposure to the sun for extended periods or artificial light such as tanning beds. Wear protective clothing and use sunscreen before going out in the sun.
If you are about to receive any vaccinations, especially live vaccines such as measles, mumps, rubella (MMR), oral polio, varicella, yellow fever, intranasal influenza, BCG and TY21a typhoid vaccines, inform your doctor that you are taking Cograf-0.5 Capsule 10's because it may reduce the effectiveness of the vaccine and increase your risk of contracting the infection that the vaccine is meant to protect against.
Using Cograf-0.5 Capsule 10's with Sirolimus is not recommended in patients who have had heart or liver transplants. It is unknown if kidney transplant recipients can use it safely. Hence, please seek medical advice before combining Cograf-0.5 Capsule 10's with other medications.
Cograf-0.5 Capsule 10's may cause tremors, trembling and shaking of hands. Consult the doctor if this becomes bothersome.
Cograf-0.5 Capsule 10's is usually taken on an empty stomach or 2 to 3 hours after a meal. Wait at least 1 hour until the next meal.
Cograf-0.5 Capsule 10's is a macrolide antibiotic with immunosuppressant properties.
Cograf-0.5 Capsule 10's should not be taken by people who are allergic to any of its components, allergic to sirolimus or any macrolide-antibiotic, during breastfeeding, and receiving live vaccines.
Let the doctor know if you have long QT syndrome, low or high levels of potassium, low levels of calcium or magnesium, an irregular heartbeat, high blood pressure, high cholesterol levels, cystic fibrosis (an inborn disease), heart, kidney, or liver disease. Inform the doctor if you have a weak immune system or if you are due to undergo any vaccination.
Cograf-0.5 Capsule 10's decreases the activity of your immune system, increasing the risk of serious infection and cancer (lymphoma cancer). Consult the doctor if you experience symptoms of infection (sore throat, extreme tiredness, cough, flu-like symptoms, fever,) or cancer (weight loss, swollen lymph nodes in the neck, armpits, or groin, fever, excessive tiredness or weakness, night sweats, cough, chest pain, trouble breathing, or pain, swelling, or fullness in the stomach area).
No, Cograf-0.5 Capsule 10's does not have an abuse potential as it is not a controlled substance.
Side effects of Cograf-0.5 Capsule 10's include nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. If the side effects persist or worsen, please consult your doctor.
It is best to avoid alcohol while taking Cograf-0.5 Capsule 10's. Alcohol can increase the risk of side effects like dizziness and can interact unpredictably with your medication. Talk to your doctor for personalized advice.
If you vomit shortly after taking your dose, do not take another dose. Contact your doctor or transplant coordinator immediately for instructions on what to do.
Your doctor needs to measure the exact amount of Cograf-0.5 Capsule 10's in your blood because the safe and effective range is very narrow. Too little medicine can lead to organ rejection, while too much can cause kidney damage. Talk to your doctor if you have questions about your blood test results.
You should never switch between different brands or formulations of Cograf-0.5 Capsule 10's without your doctor's direct supervision. Even minor differences can change how much medicine gets into your blood. Talk to your doctor before making any changes.
You should avoid pain relievers like ibuprofen or naproxen, as they can significantly increase the risk of kidney damage when combined with Cograf-0.5 Capsule 10's. Acetaminophen is generally safer, but you should always talk to your doctor or pharmacist before taking any new over-the-counter medicine.
Yes, some patients experience temporary hair thinning or loss while taking Cograf-0.5 Capsule 10's. This is a recognized side effect, but it is important not to stop taking your medicine. Talk to your doctor if this concern is affecting you.
Typically, you will need to take Cograf-0.5 Capsule 10's for as long as you have the transplanted organ to prevent rejection. Stopping Cograf-0.5 Capsule 10's can lead to rapid organ failure. Talk to your doctor about your long-term treatment plan.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 050709S031Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 210115S000,050708S047,050709S040Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Tacrolimus Granules For Suspension Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Tacrolimus monohydrate [EMC SmPC]. 2018. [Accessed on 17 Apr. 2019]Check here
  6. Tacrolimus [Prescribing Information]. 2022. [Accessed on 01 Aug. 2023]Check here
  7. EMA. PIL. Tacrolimus. [[Accessed on 26.Feb].2020]Check here

Country of origin

India

Manufacturer/Marketer address

SHOP NO.24, GROUND FLOOR, PLOT NO 07,TDI CENTRE, JASOLA,NEW DELHI-110025
Other Info - COG0226
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