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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Cold Z 5mg/325mg/5mg Tablet is used to treat common cold and allergic symptoms like sneezing, watery eyes or itchy/watery nose and throat. It works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps relieve allergy symptoms. Also, it helps shrink the blood vessels in the nasal passage, reducing a stuffy nose. Some people may experience drowsiness, nausea, fatigue, dryness in the mouth, headache, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Consume Type :

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Not Returnable

About Cold Z 5mg/325mg/5mg Tablet

Cold Z 5mg/325mg/5mg Tablet belongs to a category of  'cough and cold medications' primarily used to treat common cold and allergic symptoms like sneezing, watery eyes or itchy/watery nose and throat. The common cold is a respiratory illness affecting the nose and throat, mostly caused by viruses known as 'rhinovirus'. The virus attacks the body through the mouth, nose, or eyes and spreads quickly through droplets in the air when a sick person sneezes, coughs or talks.

Cold Z 5mg/325mg/5mg Tablet contains Cetirizine (antihistamine/antiallergic), Phenylephrine (decongestant) and Paracetamol (mild analgesic and antipyretic). Cetirizine belongs to the class of antihistamines (antiallergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps relieve allergy symptoms such as sneezing, running nose, watery eyes, itching, swelling, congestion, or stiffness. Phenylephrine helps shrink the blood vessels in the nasal passage, reducing a stuffy nose. Paracetamol is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as 'prostaglandins' responsible for pain and fever.

Cold Z 5mg/325mg/5mg Tablet should be taken as prescribed by the doctor. Your doctor will recommend how often you take Cold Z 5mg/325mg/5mg Tablet based on your medical condition. Some people may experience drowsiness, nausea, fatigue, dryness in the mouth, headache, and vomiting. Everyone doesn't need to experience the above side effects. Most of these side effects of Cold Z 5mg/325mg/5mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are pregnant, planning for pregnancy or breastfeeding before starting Cold Z 5mg/325mg/5mg Tablet. If you have high blood pressure (hypertension),  liver or kidney disease, or coronary artery disease (heart disease), avoid using Cold Z 5mg/325mg/5mg Tablet as it may worsen your condition. Consumption of alcohol should be avoided as it may lead to excessive drowsiness and sleepiness. Do not take Cold Z 5mg/325mg/5mg Tablet if you have taken an MAO inhibitor (anti-depressant medication like Isocarboxazid, Phenelzine, Selegiline and Tranylcypromine) in the last 14 days. Intake of more than 4 gm of paracetamol can damage your liver, so it is better to avoid the use of Cold Z 5mg/325mg/5mg Tablet in severe liver damage. Cetirizine present in the Cold Z 5mg/325mg/5mg Tablet can make you sleepy, so do not drive or operate heavy machinery after taking Cold Z 5mg/325mg/5mg Tablet. Phenylephrine in Cold Z 5mg/325mg/5mg Tablet should be used with caution in patients with occlusive vascular disease (nerve/artery blockage), including Raynaud's phenomenon (decreased blood flow to the fingers).

Uses of Cold Z 5mg/325mg/5mg Tablet

Cold Z 5mg/325mg/5mg Tablet is used in the treatment of common cold and allergies (allergic rhinitis). The detailed uses of Cold Z 5mg/325mg/5mg Tablet are as follows:

  • Relief from nasal congestion: Cold Z 5mg/325mg/5mg Tablet helps to relieve nasal congestion by reducing swelling in the nasal passages, easing breathing, and providing comfort from stuffiness.
  • Decreasing symptoms of allergies: Cold Z 5mg/325mg/5mg Tablet can effectively work in alleviating allergy symptoms like a runny nose and sneezing, providing relief from common allergens.
  • Reducing fever: Cold Z 5mg/325mg/5mg Tablet is also involved in reducing fever associated with colds and flu, providing relief and comfort.
  • Easing sore throat symptoms: Cold Z 5mg/325mg/5mg Tablet provides temporary relief from sore throat discomfort, making swallowing and speaking easier.

Directions for Use

• Cold Z 5mg/325mg/5mg Tablet can be taken with or without food, as advised by your doctor • Follow your doctor's instructions on the dosage and timing of this medication. • Swallow Cold Z 5mg/325mg/5mg Tablet as a whole with a glass of water. • Do not crush, chew, or break it.

Medicinal Benefits

Cold Z 5mg/325mg/5mg Tablet is primarily used to treat the common cold and allergy symptoms such as runny nose, blocked nose, sneezing, congestion, pain & fever. It is composed of three medicines, namely, Cetirizine (antihistamine), Phenylephrine (decongestant), and Paracetamol (mild analgesic and antipyretic). Cetirizine belongs to the class of antihistamines (anti-allergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps relieve allergy symptoms such as sneezing, running nose, watery eyes, itching, swelling, congestion, or stiffness. Phenylephrine helps shrink the blood vessels in the nasal passage, reducing a stuffy nose. Paracetamol is a mild analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as 'prostaglandins' responsible for pain and fever.

How Cold Z 5mg/325mg/5mg Tablet Works

Cold Z 5mg/325mg/5mg Tablet contains Cetirizine (antihistamine/antiallergic), Phenylephrine (decongestant) and Paracetamol (mild analgesic and antipyretic). Cetirizine belongs to the class of antihistamines (antiallergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps relieve allergy symptoms such as sneezing, running nose, watery eyes, itching, swelling, congestion, or stiffness. Phenylephrine helps shrink the blood vessels in the nasal passage, reducing a stuffy nose. Paracetamol is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as 'prostaglandins' responsible for pain and fever.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Cold Z 5mg/325mg/5mg Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

What if I have taken an overdose of Cold Z 5mg/325mg/5mg Tablet

Do not take more than the prescribed dose of Cold Z 5mg/325mg/5mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Cold Z 5mg/325mg/5mg Tablet if you are allergic to Cold Z 5mg/325mg/5mg Tablet, anti-histamine (cetirizine), analgesics (paracetamol), a decongestant (phenylephrine), or any of its ingredients. Please inform your doctor if you are pregnant or breastfeeding before starting Cold Z 5mg/325mg/5mg Tablet. If you have high blood pressure,  kidney or liver disease, or coronary artery disease, please do not take Cold Z 5mg/325mg/5mg Tablet as it is known to interact. Also, inform your doctor about all other medications you have taken before starting Cold Z 5mg/325mg/5mg Tablet. Do not stop taking Cold Z 5mg/325mg/5mg Tablet even if you feel better without asking your doctor, as your symptoms may come back and even worsen your condition. Cold Z 5mg/325mg/5mg Tablet may cause drowsiness and sleepiness, so it is advised not to drive a car or operate machinery. Consumption of alcohol should be avoided as it may lead to excessive drowsiness and sleepiness. Do not take Cold Z 5mg/325mg/5mg Tablet if you have taken an MAO inhibitor (anti-depressant medication) in the past 14 days. Also, avoid tobacco consumption as it may worsen your condition further.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Cold Z 5mg/325mg/5mg Tablet:
Taking Furazolidone with Cold Z 5mg/325mg/5mg Tablet can cause an increase in high blood pressure.

How to manage the interaction:
Taking Furazolidone with Cold Z 5mg/325mg/5mg Tablet is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sweating, lightheadedness, fainting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, consult the doctor immediately. It is advised to use Cold Z 5mg/325mg/5mg Tablet only after 14 days of stopping Furazolidone.
How does the drug interact with Cold Z 5mg/325mg/5mg Tablet:
Co-administration of Selegiline with Cold Z 5mg/325mg/5mg Tablet together can raise blood pressure.

How to manage the interaction:
Taking Selegiline with Cold Z 5mg/325mg/5mg Tablet is not recommended, it can be taken together if prescribed by a doctor. However, consult a doctor immediately if you experience any symptoms such as severe headache, blurred vision, confusion, fits, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting Do not discontinue any medications without consulting a doctor.
How does the drug interact with Cold Z 5mg/325mg/5mg Tablet:
Taking Cold Z 5mg/325mg/5mg Tablet with Propofol may lead to increased levels of Cold Z 5mg/325mg/5mg Tablet leading to side effects like high blood pressure.

How to manage the interaction:
Taking Cold Z 5mg/325mg/5mg Tablet with Propofol is not recommended, but it can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Cold Z 5mg/325mg/5mg Tablet:
Taking Tranylcypromine with Cold Z 5mg/325mg/5mg Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Tranylcypromine with Cold Z 5mg/325mg/5mg Tablet is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and fainting Do not discontinue any medications without consulting a doctor.
How does the drug interact with Cold Z 5mg/325mg/5mg Tablet:
Co-administration of Cold Z 5mg/325mg/5mg Tablet with Sevoflurane can increase the levels of Cold Z 5mg/325mg/5mg Tablet and lead to side effects.

How to manage the interaction:
Taking Cold Z 5mg/325mg/5mg Tablet with Sevoflurane is not recommended, it can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
CetirizineEsketamine
Severe
How does the drug interact with Cold Z 5mg/325mg/5mg Tablet:
Co-administration of Cold Z 5mg/325mg/5mg Tablet with esketamine may increase the side effects.

How to manage the interaction:
Although there is an interaction, Cold Z 5mg/325mg/5mg Tablet can be taken with esketamine if prescribed by the doctor. Consult the prescriber if you experience drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Cold Z 5mg/325mg/5mg Tablet:
Co-administration of Cold Z 5mg/325mg/5mg Tablet may decrease the excretion rate of Oxazepam which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Oxazepam and Cold Z 5mg/325mg/5mg Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Cold Z 5mg/325mg/5mg Tablet:
Co-administration of ketamine and Cold Z 5mg/325mg/5mg Tablet may decrease the effectiveness of Ketamine which could result in a higher blood level.

How to manage the interaction:
Although taking Ketamine and Cold Z 5mg/325mg/5mg Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ParacetamolMipomersen
Severe
How does the drug interact with Cold Z 5mg/325mg/5mg Tablet:
Co-administration of Mipomersen with Cold Z 5mg/325mg/5mg Tablet may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Cold Z 5mg/325mg/5mg Tablet and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Cold Z 5mg/325mg/5mg Tablet:
Co-administration of Cold Z 5mg/325mg/5mg Tablet and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Cold Z 5mg/325mg/5mg Tablet and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • ​​​​​​Wash your hands with soap and water regularly to prevent the spread of germs.
  • Eat plenty of foods rich in good bacteria, like yoghurt, to improve overall health. 
  • Drink plenty of fluids to avoid dehydration.
  • Gargle with salt water for relief from sore throat.
  • Avoid alcohol consumption with Cold Z 5mg/325mg/5mg Tablet as it may cause tiredness, drowsiness, or lack of concentration.

Habit Forming

No

Therapeutic Class

RESPIRATORY STIMULANTS
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Alcohol

Unsafe

Avoid consumption of alcohol with Cold Z 5mg/325mg/5mg Tablet as it may increase drowsiness. Please consult a doctor before consuming alcohol with Cold Z 5mg/325mg/5mg Tablet.

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Pregnancy

Caution

The safety of Cold Z 5mg/325mg/5mg Tablet in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Caution

The safety of Cold Z 5mg/325mg/5mg Tablet in breastfeeding mothers is unknown. Therefore, it is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.

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Driving

Unsafe

Cold Z 5mg/325mg/5mg Tablet may cause drowsiness or tiredness in some people. Therefore, drive only if you are alert after taking Cold Z 5mg/325mg/5mg Tablet.

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Liver

Caution

Take Cold Z 5mg/325mg/5mg Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Cold Z 5mg/325mg/5mg Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Cold Z 5mg/325mg/5mg Tablet is not recommended for children below 12 years of age. However, please consult a doctor before giving Cold Z 5mg/325mg/5mg Tablet to children.

Have a query?

FAQs

Cold Z 5mg/325mg/5mg Tablet is used to treat the common cold and allergic symptoms like sneezing, watery eyes or itchy/watery nose and throat.

Cold Z 5mg/325mg/5mg Tablet is composed of three medicines, namely Cetirizine (antihistamine), Phenylephrine (decongestant), and Paracetamol (analgesic and antipyretic). Cetirizine belongs to the class of antihistamines (anti-allergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps relieve allergy symptoms such as sneezing, running nose, watery eyes, itching, swelling, congestion, or stiffness. Phenylephrine helps shrink the blood vessels in the nostrils and the passage and reduces stuffy noses. Paracetamol is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as 'prostaglandins' responsible for pain and fever.

Yes, Cold Z 5mg/325mg/5mg Tablet contains cetirizine, which is an antihistamine that is known to cause dry mouth. Increase the intake of fluids to avoid excessive dry mouth caused due to Cold Z 5mg/325mg/5mg Tablet as continued dryness can lead to dental disease (gum disease, fungal infection, tooth decay).

No, you are not recommended to take Cold Z 5mg/325mg/5mg Tablet with warfarin as co-administration of these two medicines may increase bleeding risk more easily. However, if you notice blood in urine or stools, dizziness, unusual bleeding or bruising, vomiting, weakness, or headache, please consult a doctor immediately. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted appropriately to use safely.

It is not recommended to take Cold Z 5mg/325mg/5mg Tablet along with any anti-depressant medication as it contains phenylephrine, which is known to be contra-indicated with anti-depressant medications, especially MAO inhibitors. Also, Cold Z 5mg/325mg/5mg Tablet should be taken at least 15 days after your last dose of anti-depressants.

Yes, the Cold Z 5mg/325mg/5mg Tablet is known to cause nausea or vomiting. In case you are experiencing excessive nausea while consuming Cold Z 5mg/325mg/5mg Tablet, speak with your doctor immediately.

Yes, the Cold Z 5mg/325mg/5mg Tablet may cause drowsiness. It is not necessary for everyone taking Cold Z 5mg/325mg/5mg Tablet to experience this side effect. Therefore, avoid driving if you feel drowsy after taking Cold Z 5mg/325mg/5mg Tablet.

Store Cold Z 5mg/325mg/5mg Tablet at room temperature, in a dry place. Keep it out of sight and reach of children.

Cold Z 5mg/325mg/5mg Tablet may cause side effects like drowsiness, nausea, fatigue, dryness in the mouth, headache, and vomiting. Most of these side effects of Cold Z 5mg/325mg/5mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Please consult the doctor if you are breastfeeding. The safety of Cold Z 5mg/325mg/5mg Tablet in breastfeeding mothers is unknown. Therefore, it is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.

Cold Z 5mg/325mg/5mg Tablet is contraindicated in people who are allergic to any of the components in Cold Z 5mg/325mg/5mg Tablet. Let the doctor know if you have heart problems, stomach ulcers or thyroid problems.

No, taking a higher than the recommended dose of Cold Z 5mg/325mg/5mg Tablet will not be more effective but may cause unpleasant side effects. Take Cold Z 5mg/325mg/5mg Tablet as per the dose advised by the doctor.

Serious side effects associated with Cold Z 5mg/325mg/5mg Tablet are allergic reactions, mouth ulcers, breathing problems, irregular heartbeat, or unexplained bleeding. Consult the doctor if you experience any of these side effects.

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