It is not recommended to take monoamine oxidase inhibitors (MAOI) and IMIPRAMINE+DIAZEPAM simultaneously. You should wait for at least 14 days after discontinuing MAOI before using IMIPRAMINE+DIAZEPAM. Before taking IMIPRAMINE+DIAZEPAM, inform your doctor if you have any mental illness, personality disorder, are withdrawing from alcohol or any other medicines, enlarged prostate gland, overactive thyroid, fits, brain damage, poor blood circulation, severe kidney disease, tumors in the adrenal gland, panic attacks, long-term constipation, low levels of albumin, and a habit of smoke. Inform your doctor if you have suicidal thoughts as IMIPRAMINE+DIAZEPAM may worsen suicidal tendencies, especially in young adults. While taking IMIPRAMINE+DIAZEPAM, inform your doctor if you experience agitation, restlessness, nightmares, and hallucinations as this medicine may cause these side-effects, especially in children and the elderly. IMIPRAMINE+DIAZEPAM may cause total or partial memory loss when taken in high doses. IMIPRAMINE+DIAZEPAM may cause dependence, so it should be used for the shortest time possible in patients with a history of alcohol or drug abuse. After a few weeks of treatment, if the tablets are not working for you, inform your doctor immediately, as it can be a sign of tolerance. IMIPRAMINE+DIAZEPAM should not be used in combination with an opioid pain killer (buprenorphine). Concomitant use of these drugs may lead to serotonin syndrome (a life-threatening condition that causes high blood pressure and fast heart rate).

Drug-Drug Interactions: IMIPRAMINE+DIAZEPAM may interact with an opioid pain killer (buprenorphine), a medicine used to treat sleep problems (sodium oxybate), other antidepressants (fluvoxamine, fluoxetine, phenelzine, moclobemide, and Hypericum perforatum), antipsychotics (clozapine), medicines used to treat allergies, general anesthetics, medicines used to induce sleep (alprazolam), antibiotics (erythromycin and rifampicin), medicines used to relax muscles (suxamethonium and tubocurarin), strong pain killer (morphine), medicines used to treat fits or mental disorders (phenobarbital), medicines used to treat high blood pressure, antacids (cimetidine, omeprazole, and esomeprazole), a medicine used to treat alcohol addiction (disulfiram), medicines used to treat fits (phenytoin, carbamazepine, and sodium valproate), medicine used to treat asthma (theophylline), antivirals (atazanavir, ritonavir, efavirenz, indinavir, and zidovudine, etc.), antitubercular (isoniazid), oral contraceptives, steroid medicines, anesthetic (ketamine), medicines to treat nausea and vomiting (nabilone), and medicines used to treat heart conditions (diltiazem, verapamil, and quinidine, etc.).

Drug-Food Interactions: Alcohol may increase the risk of side-effects such as drowsiness.

Drug-Disease Interactions: IMIPRAMINE+DIAZEPAM should not be used in patients with severe liver disease, heart disease, mania (exaggerated behavior or hyperactivity), porphyria (an inherited blood disorder), difficulty passing urine, glaucoma (increased pressure inside the eye), severe breathing problems, phobia (a fear of particular object), myasthenia gravis (a condition in which muscles weaken), and sleep apnoea (a sleep disorder).

• Maintain a healthy diet and exercise regularly helps in improving overall health and boosts self-esteem.
• Regularly attend therapy sessions.
• Perform meditation and yoga. This helps in relieving stress and provides relaxation.
• Follow a regular sleep pattern to improve the amount and quality of sleep you get.
• Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables, and olive oils.
• Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help maintain neurotransmitter's proper maintenance.
• Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges, and pears.
• Exercising helps in the production of the body’s natural antidepressants. It also helps in relieving stress, improving mood, boosts self-esteem, and provides restful sleep.
• Avoid smoking and alcohol consumption.
• Learn about your condition, understand the risk factors, and follow the doctor’s treatment plan.

• IMIPRAMINE+DIAZEPAM may reduce some blood cell counts and impair liver function. So, your doctor may monitor blood cell levels and liver function while using this medicine.
• IMIPRAMINE+DIAZEPAM may cause problems with teeth, so your doctor may advise you to undergo regular dental check-ups throughout the treatment.
• It is not recommended to abruptly stop IMIPRAMINE+DIAZEPAM, as it may cause withdrawal reactions such as irritability, excess sweating, nervousness, stomach upset, difficulty sleeping, and worsening of depression. Children may experience changes in behavior. Your doctor may gradually reduce the dose before completely stopping the medicine.
• IMIPRAMINE+DIAZEPAM may cause orthostatic hypotension (sudden drop in blood pressure on standing). So, it is advised to rise-up slowly from a sitting or lying position.