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compositionComposition:AMANTADINE-100MG
prescription
Prescription Medicine
info
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Comantrel-T Tablet is used to treat Parkinson's disease symptoms. It plays a vital role in treating symptoms such as difficulty moving, muscle stiffness, and tremors. It contains Amantadine, which increases dopamine (a chemical) levels in the brain, responsible for improving body movement coordination. Thus, it effectively helps in performing daily functions more efficiently and improves the quality of life. In some cases, it may cause side effects like dry mouth, constipation, balance disorder (loss of balance), blurred vision, insomnia (difficulty sleeping), and peripheral oedema. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AMANTADINE-100MG

Manufacturer/Marketer :

Consern Pharma Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Comantrel-T Tablet

Comantrel-T Tablet is a prescription medicine used to treat the symptoms of Parkinson's disease, such as muscle stiffness, tremors, and shaky movements. It is also prescribed to control movement difficulties that occur as side effects of certain psychiatric medicines. By helping to balance natural chemicals in the brain, it allows for smoother and more controlled physical activities.

For the best results, you must take Comantrel-T Tablet consistently at the same times every day as directed by your doctor. It can be taken with or without food, though taking it with a meal or a glass of milk can help prevent a mild upset stomach. To support your treatment, incorporating daily stretching exercises and staying well-hydrated can significantly improve your mobility.

While taking Comantrel-T Tablet, you may experience mild side effects like dry mouth, sleep problems, or light dizziness. However, you must contact your doctor immediately if you notice serious symptoms such as confusion, hallucinations, or unusual swelling in your ankles and feet. Monitoring how your body responds to the medication is key to staying safe during your treatment.

Before starting Comantrel-T Tablet, tell your doctor if you have a history of kidney disease, heart failure, seizures, or mental health conditions. Do not take this medicine if you have severe kidney failure or certain untreated eye conditions like narrow-angle glaucoma. Your doctor will help determine if this medication is safe for your specific health profile.

This medicine can interact with alcohol, which can cause severe drowsiness, and certain cold medications that can worsen dry mouth or confusion. If you are pregnant, breastfeeding, or an older adult, talk to your doctor or pharmacist before using Comantrel-T Tablet, as special dosage adjustments or monitoring may be required to protect your health.

Uses of Comantrel-T Tablet

Your doctor may prescribe this medicine to treat several conditions, including:

  • Parkinson's disease: Comantrel-T Tablet helps reduce muscle stiffness, tremors, and slow body movements by restoring the balance of certain chemical messengers in the brain.
  • Drug-induced movement issues: Comantrel-T Tablet helps control involuntary shaking, muscle spasms, and restlessness caused by taking certain psychiatric medications.
  • Influenza A: In some cases, Comantrel-T Tablet is used to treat or prevent respiratory infections caused by specific strains of the influenza A virus.
     

Key Benefits

Comantrel-T Tablet offers meaningful, real-world relief that helps you regain control over your body and daily routine. By targeting the root causes of stiffness and shaking, this medication makes physical actions much easier and more comfortable.

  • Improved mobility: It reduces muscle stiffness and slow movements, allowing you to walk, rise from a chair, and change positions more easily.
  • Better coordination: By calming tremors and involuntary muscle spasms, it helps you perform fine motor tasks like writing, buttoning clothes, or eating.
  • Enhanced daily independence: With fewer movement restrictions, you can manage your daily chores and activities with greater confidence and less discomfort.
     

Directions for Use

Please read these instructions carefully before starting your medication, and always follow your doctor's exact guidance.

  • Swallow the capsule or tablet whole with a full glass of water. Do not crush, chew, or break the medication unless specifically instructed by your doctor.
  • You may take this medicine with or without food. If you experience an upset stomach, taking it with a meal or milk can help.
  • Take your doses at the same time every day to maintain a steady level of the medicine in your body. If you take this medicine twice a day, try to take your second dose in the afternoon.
  • Avoid taking it close to bedtime, as it can cause sleep problems.

Your doctor will determine the right way for you to take this medicine based on your medical condition and response to treatment. Do not change your dose or stop taking it without consulting them first.
 

How Comantrel-T Tablet Works

Comantrel-T Tablet contains amantadine. It works by altering the activity of certain chemical messengers in your brain that control muscle movement. In conditions like Parkinson's disease, there is a shortage of dopamine, a chemical essential for smooth coordination. This medicine increases the release of dopamine and prevents it from being reabsorbed, making more of it available to your brain cells. Additionally, Comantrel-T Tablet blocks a specific brain receptor known as the NMDA receptor. By blocking this receptor, the medicine helps reduce overactivity of glutamate, another brain chemical that can contribute to muscle stiffness and involuntary movements. This combined action helps restore balance in your brain's movement control centres, leading to steadier and more relaxed muscles.
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Alcohol

Unsafe

Intake of alcohol with Comantrel-T Tablet may damage your liver. Therefore, you are recommended to avoid consumption of alcohol with Comantrel-T Tablet.

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Pregnancy

Consult your doctor

Comantrel-T Tablet is a pregnancy Category C medicine. It is not known whether Comantrel-T Tablet will affect pregnant women or fetus. Therefore, Comantrel-T Tablet is given to pregnant women only if doctor thinks benefits are greater than risks.

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Breast Feeding

Unsafe

Comantrel-T Tablet is excreted in human milk. But the amount of Comantrel-T Tablet absorbed by the nursing infant is unknown. So, it should not be taken while breastfeeding.

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Driving

Unsafe

Comantrel-T Tablet can affect alertness and coordination. So, operating machinery which requires concentration should be avoided.

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Liver

Unsafe

Comantrel-T Tablet is unsafe, especially if you have a history of liver diseases/conditions. Your doctor may have to adjust the dose if there are symptoms of nausea, vomiting, loss of appetite, dark-colored urine, or yellowing of skin/eye.

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Kidney

Caution

Comantrel-T Tablet to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

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Children

Safe if prescribed

Comantrel-T Tablet can be given to children but under medical supervision. Comantrel-T Tablet is prescribed to the children to treat complicated urinary tract infections, anthrax infection, or plague infection.

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Heart

Caution

Exercise caution while taking Comantrel-T Tablet, if you have any heart problems. Please consult your physician.

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Geriatrics

Safe if prescribed

Comantrel-T Tablet is safe for use in elderly patients if recommended by the doctor.

What if I have taken an overdose of Comantrel-T Tablet

Do not take more than the prescribed dose of Comantrel-T Tablet as it may cause overdose. The symptoms of overdose include difficulty breathing, decreased urination, irregular or fast heartbeat, confusion, problems with coordination, stiff or rigid arms/legs, hallucinations and fear/irritability/aggressive behaviour. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Stand up slowly: To prevent dizziness or fainting caused by a sudden drop in blood pressure, take your time when getting out of bed or rising from a chair.
  • Stay hydrated: Drink plenty of water throughout the day to help relieve dry mouth and manage constipation, unless your doctor has advised you to limit fluids due to a heart or kidney condition.
  • Incorporate physical therapy: Engage in regular, gentle exercises like walking, stretching, or yoga to help maintain joint flexibility and muscle strength.
  • Limit sodium: Since this medicine can cause fluid retention and ankle swelling, reducing your dietary salt intake may help manage these symptoms. Talk to your doctor before making major dietary changes.
     
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How Soon It Starts Working

  • The time required for Comantrel-T Tablet to start to work: Comantrel-T Tablet ideally shows its action within 48 hours after administration.
  • The time for which the effects of Comantrel-T Tablet last: The duration of action for Comantrel-T Tablet is unknown.

What if you forget to take Comantrel-T Tablet

If you miss a dose of Comantrel-T Tablet, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

Store Comantrel-T Tablet at room temperature, ideally between 20°C to 25°C (68°F to 77°F). •Keep the medication in its original container to protect it from moisture and direct light. Avoid storing this medicine in damp areas like the bathroom cabinet.

Drug Warnings

  • Do not stop taking this medicine suddenly: Stopping abruptly can trigger a rare but life-threatening reaction featuring high fever, severe muscle stiffness, and confusion. Always talk to your doctor to safely plan a way of gradually decreasing your dose.
  • Avoid driving initially: This medicine can cause blurred vision, drowsiness, or impaired reaction times. Avoid driving, operating machinery, or performing dangerous tasks until you know how this medicine affects you.
  • Watch for behaviour changes: Some people taking this medication experience intense urges to gamble, spend money, or engage in other compulsive behaviours. Report any unusual mood or behaviour changes to your healthcare provider immediately.
  • Extra caution for older adults: Elderly individuals are more sensitive to the mental side effects of this medicine, such as confusion or hallucinations. Extra care should be taken to prevent falls.
  • Inspect liquid solutions: If you are taking the liquid form of this medicine, always inspect it before use. It should be clear and free of particles. Do not use it if it is cloudy or discoloured.
     

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Drug-Drug Interactions:

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Anticholinergic drugs: Taking these medicines (used for allergies, bladder control, or spasms) with Comantrel-T Tablet can increase the risk of dry mouth, blurred vision, constipation, and confusion.
  • Certain water pills (diuretics): Medications like hydrochlorothiazide combined with triamterene can slow down the removal of Comantrel-T Tablet from your body, which may increase your risk of side effects.
  • Live flu vaccines: This medicine may interfere with the effectiveness of live, nasal-spray influenza vaccines. It is generally recommended to avoid live vaccines while taking this medicine.
  • Central nervous system stimulants: Combining these with Comantrel-T Tablet can cause increased restlessness, anxiety, or sleep disturbances.

Drug-Food Interactions:

  • Alcohol: Avoid drinking alcohol while taking this medicine. Alcohol can worsen dizziness, lightheadedness, and mental confusion, making activities like walking or driving highly dangerous.

Drug-Disease Interactions:

Inform your doctor if you have a history of the following conditions before taking Comantrel-T Tablet, as it may worsen your condition or cause complications.

  • Kidney disease: Your kidneys clear this medicine from your body. If your kidneys are not working properly, the drug can build up to dangerous levels, requiring a lower dose.
  • Heart failure or high blood pressure: This medicine can cause fluid buildup and swelling, which may worsen symptoms of heart failure.
  • Mental health conditions: If you have a history of depression, hallucinations, or psychosis, this medicine may worsen your mental health symptoms.
  • Seizures: This medication may increase your risk of experiencing a seizure, especially if you have a history of epilepsy.
     

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIPARKINSON AGENTS]

FAQs

Comantrel-T Tablet is used to treat Parkinson's disease symptoms. It plays a vital role in treating symptoms such as difficulty moving, muscle stiffness, and tremors.
Comantrel-T Tablet works by increasing dopamine (a chemical) level in the brain, responsible for improving body movement coordination. Thus, it effectively helps in performing daily functions in a better way and improving quality of life.
No, Comantrel-T Tablet should be taken in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor.
If you miss a dose of Comantrel-T Tablet, take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.
No, Comantrel-T Tablet should not be taken if you have epilepsy as it might increase your chances of seizures. Please consults your doctor before starting Comantrel-T Tablet.
You should inform your doctor, and he might stop the use of Comantrel-T Tablet before the surgery.
Amantadine may cause constipation as a common side effect. Usually, it is temporary, does not require medical attention, and gradually resolves over time. However, if this persistent, reach out to your doctor.
Yes, in some cases, Comantrel-T Tablet has been used for neuropathic pain.
Comantrel-T Tablet contains Amantadine as an active ingredient.
Comantrel-T Tablet may cause some people to become dizzy, drowsy, or lightheaded, leading to tiredness or fatigue.
If you suddenly stop taking Comantrel-T Tablet, you may experience confusion, fever, mental state changes, or severe muscle stiffness. Depending on your disease condition, your doctor will decrease your dose gradually, if necessary.
Comantrel-T Tablet is not a dopamine agonist. It may inhibit the reuptake of dopamine and increase the synthesis and release of dopamine.
Individual needs may vary from person to person, so it should be used as directed by the physician.
Yes, Comantrel-T Tablet can be taken with or without food.
In rare cases, Comantrel-T Tablet may cause anxiety and feeling overexcited. If you experience any of these symptoms or if they persist, please consult the doctor.
Overdose symptoms may include confusion, agitation, behaviour changes, hallucinations, severe headache or pounding in your ears, muscle stiffness, problems with balance or walking, trouble breathing, Tachycardia (fast heartbeats) and seizures.
Limited research is available. Consult your doctor if you have any questions or concerns regarding this.
With continued Comantrel-T Tablet use, decreased weight and body mass index may occur. Seek medical attention if you observe any significant or sudden changes.
Comantrel-T Tablet may cause side effects like dry mouth, constipation, balance disorder (loss of balance), blurred vision, insomnia (difficulty sleeping), and peripheral oedema. Most of these side effects of Comantrel-T Tablet are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects persist, contact your doctor.
No, you must not stop taking Comantrel-T Tablet suddenly. Doing so can cause a severe, life-threatening reaction with symptoms like a very high fever, muscle stiffness, and mental confusion. If you need to stop this medication, your doctor will guide you through gradually decreasing your dose. Talk to your doctor before making any changes.
Yes, dry mouth is a very common side effect of Comantrel-T Tablet. Sucking on ice chips or sugarless hard candy, chewing sugarless gum, and drinking plenty of water can help relieve this discomfort. Talk to your doctor or pharmacist if dry mouth becomes severe or causes dental issues.
You should avoid alcohol while taking Comantrel-T Tablet. Alcohol can interact with this medicine to cause extreme drowsiness, severe dizziness, and confusion, increasing your risk of falls or accidents. Talk to your doctor if you have concerns about avoiding alcohol.
To manage this dizziness, try to rise very slowly from sitting or lying positions. Give your body a moment to adjust by dangling your legs over the edge of the bed or chair before standing up. Talk to your doctor if you continue to feel lightheaded or if you experience fainting.
Yes, Comantrel-T Tablet can cause difficulty falling or staying asleep (insomnia). To help prevent this, try to take your second daily dose in the afternoon rather than late in the evening or close to bedtime. Talk to your doctor about the best schedule for your doses.
The safety of Comantrel-T Tablet during pregnancy is not fully established, and it may cause harm to an unborn baby. Tell your doctor immediately if you are pregnant, suspect you might be pregnant, or are planning to become pregnant. Talk to your doctor to weigh the benefits and risks of this treatment.
Yes, Comantrel-T Tablet can cause a drop in blood pressure when you change positions quickly, such as standing up from a lying position. This is known as orthostatic hypotension and can cause dizziness. Talk to your doctor if you experience severe dizziness, blurred vision, or confusion.
Some people may begin to notice an improvement in their movement symptoms within a few days of starting Comantrel-T Tablet, while for others, it may take several weeks to feel the full benefits. Talk to your doctor if your symptoms do not improve or if they seem to get worse..

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Country of origin

India

Manufacturer/Marketer address

Plot No. 132, Industrial Area, Phase-1, Panchkula (Haryana)
Other Info - CO81345
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