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  3. Combiflam Tablet 20's

Combiflam Tablet 20's, Pack of 20 TabletS
Combiflam Tablet 20's, Pack of 20 TabletS
Combiflam Tablet 20's, Pack of 20 TabletS
Combiflam Tablet 20's, Pack of 20 TabletS
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Combiflam Tablet is used to relieve symptoms of muscle pain, arthritis pain, dysmenorrhea (painful periods or menstrual cramps), and dental pain and reduces fever. Besides this, it is also useful for dental pain, which can occur due to damage to the tooth nerve, infection, decay, extraction or injury. It contains Ibuprofen and Paracetamol, which works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in our body. Also, it lowers the elevated body temperature and help to reduce mild to moderate pain in a shorter duration. It may cause side effects such as tightness of the chest, breathing difficulties, fever, skin rashes, increased heart rate and or in case of any signs of hypersensitivity. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

IBUPROFEN-400MG + PARACETAMOL-325MG

Manufacturer/Marketer :

Sanofi India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Combiflam Tablet

Combiflam Tablet is used to relieve symptoms of muscle pain, arthritis pain, dysmenorrhea (painful periods or menstrual cramps), and dental pain and reduces fever. Pain can be temporary (acute) or long-lasting (chronic). Acute pain is, for a short time, caused by damage to the tissues of the muscle, bone, or other organs. In contrast, chronic pain lasts for a long duration and is caused by pathologies like nerve damage, osteoarthritis, etc. Besides this, it is also useful for dental pain, which can occur due to damage to the tooth nerve, infection, decay, extraction or injury.

Combiflam Tablet is composed of two medicines, namely Ibuprofen and Paracetamol. Ibuprofen is known to have an analgesic and anti-inflammatory effect for reducing mild to moderate pain. It works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in our body. Paracetamol acts as a mild analgesic and antipyretic (fever reducer). It lowers the elevated body temperature and mild pain by inhibiting the synthesis of a chemical messenger (prostaglandin) and promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Together, these two medicines help reduce mild to moderate pain in a shorter duration.

Like all medicines, Combiflam Tablet may cause side effects, although not everybody gets them. Stop taking this medicine if you experience symptoms like tightness of the chest, breathing difficulties, fever, skin rashes, increased heart rate and or in case of any signs of hypersensitivity.

Do not take Combiflam Tablet if you are allergic to painkillers like aspirin, ibuprofen, naproxen, or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. Combiflam Tablet may be associated with a small increase in the risk of heart attack (myocardial infarction). Avoid consumption of alcohol as it may damage your liver and cause increased side effects on taking this drug. Consult your doctor if your pain, inflammation, and fever symptoms do not disappear even after ten days.

Uses of Combiflam Tablet

Combiflam Tablet is used for the treatment of Pain and Fever. The detailed uses of Combiflam Tablet are as follows:

  • Pain Relief: Combiflam Tablet is widely used to alleviate mild to moderate pain, such as headaches, toothaches, menstrual cramps, and muscle aches.
  • Fever Reduction: Combining Ibuprofen and Paracetamol, Combiflam Tablet effectively reduces fever caused by infections or other health conditions.
  • Anti-inflammatory Benefits: Its anti-inflammatory properties make Combiflam Tablet valuable for managing inflammation and swelling in conditions like arthritis and other inflammatory diseases.
  • Post-Surgical Pain Management: Combiflam Tablet is often prescribed to manage pain and discomfort following surgical procedures, aiding recovery.
  • Managing Chronic Pain: Combiflam Tablet is sometimes included in chronic pain management plans, particularly for conditions like osteoarthritis or persistent back pain, under a healthcare professional's supervision.

Directions for Use

• Combiflam Tablet should be taken with food. • Follow your doctor's instructions on the dosage and timing of this medication. • Swallow Combiflam Tablet as a whole with a glass of water. • Do not crush, break, or chew it.

Medicinal Benefits

Combiflam Tablet comprises Ibuprofen and Paracetamol primarily used to treat mild to moderate pain. Combiflam Tablet is prescribed mainly to treat pain and relieve discomfort caused by conditions like tooth pain, arthritis, period pain and other types of short-term pains. It helps treat pain by blocking the chemical messenger (prostaglandin) in the brain responsible for causing pain. Ibuprofen works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in our body. On the other hand, Paracetamol lowers the elevated body temperature and mild pain by inhibiting the synthesis of prostaglandin by promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Paracetamol has the advantage of producing less gastric irritation than other painkillers like aspirin.

How Combiflam Tablet Works

Combiflam Tablet is composed of two medicines, namely Ibuprofen and Paracetamol. Ibuprofen is known to have an analgesic and anti-inflammatory effect for reducing mild to moderate pain. It works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in our body. Paracetamol acts as a mild analgesic and antipyretic (fever reducer). It lowers the elevated body temperature and mild pain by inhibiting the synthesis of a chemical messenger (prostaglandin) and promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Together, these two medicines help reduce mild to moderate pain in a shorter duration.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Combiflam Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Drink fluids: Water, clear broth, or electrolyte-rich beverages.
  • Follow a balanced diet, which would be rich in fruits, vegetables, whole grains, lean proteins, and healthy fats.
  • Mindfulness: Manage stress with meditation, deep breathing or yoga.
  • Stay away from smoke, dust and other irritants.
  • Get adequate rest to facilitate recovery.
  • Wash hands and avoid close contact, do not share personal items.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.

What if I have taken an overdose of Combiflam Tablet

Do not take more than the prescribed dose of Combiflam Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Caution is advised in people with underlying sensitivity to aspirin and other pain killers. Combiflam Tablet is contraindicated in children below 12 years of age under 40 kg of weight. If treatment is required for more than three days, consult your doctor. Combiflam Tablet should be taken with caution if you have an allergy to paracetamol, ibuprofen, aspirin, or other pain killers, highly sensitive reactions (asthma, lip/face/throat swelling), existing stomach ulcer or bleeding associated pain killers, blood clotting disorder, heart diseases (like congestive heart failure), kidney disease, peptic ulcer, another active bleeding (like brain stroke bleeding), and severe dehydration (due to vomiting, diarrhoea). Liver damage might occur if taken for a longer duration as it contains paracetamol. The skin should be closely monitored as skin allergic reactions like Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) have been reported with Combiflam Tablet . Blood pressure and cardiovascular (heart) status should be monitored closely during the treatment with Combiflam Tablet , especially in people affected with high blood pressure and who have a history of heart failure.

Drug-Drug Interactions

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IbuprofenKetorolac
Critical
IbuprofenMeloxicam
Critical

Drug-Drug Interactions

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IbuprofenKetorolac
Critical
How does the drug interact with Combiflam Tablet:
Taking Ketorolac and Combiflam Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding and ulceration.

How to manage the interaction:
Taking Ketorolac and Combiflam Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenMeloxicam
Critical
How does the drug interact with Combiflam Tablet:
Combining Meloxicam and Combiflam Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.

How to manage the interaction:
Taking Meloxicam and Combiflam Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenDeferasirox
Severe
How does the drug interact with Combiflam Tablet:
The combined use of Deferasirox and Combiflam Tablet can increase the risk of developing gastrointestinal ulcers and bleeding.

How to manage the interaction:
Taking Deferasirox and Combiflam Tablet together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, black, tarry stools,swelling, shortness of breath, muscle cramps, tiredness, weakness, confusion, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenFenoprofen
Severe
How does the drug interact with Combiflam Tablet:
The combined use of Fenoprofen and Combiflam Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.

How to manage the interaction:
Taking Fenoprofen and Combiflam Tablet together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising,dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenCidofovir
Severe
How does the drug interact with Combiflam Tablet:
Taking cidofovir and Combiflam Tablet can increase the risk of Kidney problems.

How to manage the interaction:
Taking Cidofovir and Combiflam Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss , swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenAspirin
Severe
How does the drug interact with Combiflam Tablet:
Taking aspirin with Combiflam Tablet may impair the efficacy of aspirin and increase the risk of developing stomach ulcers and bleeding.

How to manage the interaction:
Although there is a possible interaction between aspirin and Combiflam Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience severe stomach discomfort, bloating, sudden dizziness or lightheadedness, nausea, vomiting (particularly with blood), loss of appetite, and/or black, tarry stools, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
IbuprofenTenofovir alafenamide
Severe
How does the drug interact with Combiflam Tablet:
The combined use of Tenofovir alafenamide and Combiflam Tablet can cause kidney problems.

How to manage the interaction:
Co-administration of Tenofovir alafenamide and Combiflam Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, irregular heart rhythm, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenDanaparoid
Severe
How does the drug interact with Combiflam Tablet:
The combined use of Danaparoid and Combiflam Tablet can increase the risk of bleeding complications.

How to manage the interaction:
Taking Danaparoid and Combiflam Tablet together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness during treatment with these medications, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenIndometacin
Severe
How does the drug interact with Combiflam Tablet:
The combined use of Indometacin and Combiflam Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.

How to manage the interaction:
Taking Indometacin and Combiflam Tablet together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenTacrolimus
Severe
How does the drug interact with Combiflam Tablet:
Taking tacrolimus and Combiflam Tablet can cause kidney problems.

How to manage the interaction:
Co-administration of Tacrolimus and Combiflam Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, irregular heart rhythm, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include more glucosamine, chondroitin sulphate, vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.

  • Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do low-impact aerobic exercises like walking on the treadmill, bike riding and swimming. You can also strengthen your muscles by lifting light weights.

  • In the chronic condition of arthritis or joint pain, try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimum level of chemical called cytokines, which ramp up inflammation.

  • Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short time. Long-term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel to minimise pain at the back of your spine curve. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.

Habit Forming

No

Therapeutic Class

ANALGESIC AND ANTIPYRETIC AGENT

Combiflam Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Taking Combiflam Tablet with alcohol may cause dizziness or drowsiness. Besides this, it can also damage your liver if taken for a longer duration. So, avoid or limit intake of alcoholic beverages with Combiflam Tablet .

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Pregnancy

Unsafe

Use of Combiflam Tablet during pregnancy is not recommended as taking this medicine during the last 3 months of pregnancy may harm the unborn baby.

bannner image

Breast Feeding

Safe if prescribed

Take Combiflam Tablet only if prescribed by your doctor.

bannner image

Driving

Unsafe

After taking Combiflam Tablet you may notice dizziness, sleepiness, drowsiness or fatigue.

bannner image

Liver

Caution

Combiflam Tablet to be taken with caution, especially if you have a history of liver disease. Dose may have to be adjusted by your doctor.

bannner image

Kidney

Caution

Combiflam Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. Dose may have to be adjusted by your doctor.

bannner image

Children

Caution

Combiflam Tablet is contraindicated in children below 20 kg body weight or younger than 6 years of age. It may cause kidney problems in children and adolescents who are dehydrated.

Have a query?

FAQs

Combiflam Tablet is used to relieve symptoms of muscle pain, arthritis pain, dysmenorrhea (painful periods or menstrual cramps), and dental pain and reduces fever.

Combiflam Tablet is comprised of two medications, Ibuprofen and Paracetamol. Combiflam Tablet  has analgesic and anti-inflammatory properties that help relieve mild to moderate pain. Combiflam Tablet functions by inhibiting the production of specific chemical messengers that induce fever, discomfort, and inflammation (redness and swelling).

No, it is not advisable to take Combiflam Tablet with depression medication. Please inform your doctor if you are taking depression medicine before starting Combiflam Tablet .

Yes, Combiflam Tablet is a short term medication and if you feel better you can stop taking Combiflam Tablet , but only after consulting your doctor.

Combiflam Tablet is known to be contra-indicated in patients with allergy to painkillers (NSAIDs) or any of the components or excipients of this medicine. Its use should also be avoided in patients with history of stomach ulcer and kidney/liver disease.

Yes, Combiflam Tablet is known to cause dizziness. If you feel dizzy, please take rest and also avoid driving while you take Combiflam Tablet as it can be harmful.

No, Combiflam Tablet is not indicated for stomach pain. Also, If you have stomach pain post ingestion it may be a sign of stomach ulcer, or gastric bleeding. Do not take Combiflam Tablet in this condition. It is better to inform your doctor in case of stomach pain post ingestion of this medication.

It depends on whether your cough and cold pills contain ibuprofen and paracetamol or not. If it contains these two medicines, do not take it. It may lead to overdosage, thereby producing unpleasant side effects. Consult your doctor before taking it in such cases.

Combiflam Tablet is known to cause stomach upset in some cases. So, please take Combiflam Tablet with a meal or a glass of milk to avoid upset stomach.

No, Combiflam Tablet should not be taken as a long-term medication as it may lead to stomach ulcers/bleeding and kidney problems. For best results of Combiflam Tablet , please take it in doses and duration mentioned by your doctor.

Country of origin

India

Manufacturer/Marketer address

CT Survey No.117-B, L&T Business Park, Saki Vihar Road, Powai, Mumbai 400072.
Other Info - COM0004

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 5, 2025 | 9:23 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.7020.pdf
  2. https://www.medicines.org.uk/emc/files/pil.1958.pdf
  3. https://www.ciplamed.com/content/ibugesic-plus-oral-suspension
  4. https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&cad=rja&uact=8&ved=2ahUKEwjdjZ6y3fXsAhVD6XMBHfAoDaYQFjAAegQIAxAC&url=https%3A%2F%2Fwww.sanofi.in%2F-%2Fmedia%2FProject%2FOne-Sanofi-Web%2FWebsites%2FAsia-Pacific%2FSanofi-IN%2FHome%2Fscience-and-innovation%2Ffor-healthcare-professionals%2Fproduct-information%2FCombiflam-tablets-PI_08072019.pdf&usg=AOvVaw0eY32ELNXM94knsmS25x-D

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